Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_C09
(697 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma p... 109 8e-24
sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma pre... 103 6e-22
sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma p... 100 5e-21
sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasm... 100 5e-21
sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinas... 94 3e-19
sp|Q5U405|TMPSD_MOUSE Transmembrane protease, serine 13 (Mo... 90 5e-18
sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase)... 90 6e-18
sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasm... 89 1e-17
sp|P55091|CLCR_RAT Caldecrin precursor (Chymotrypsin C) (Se... 89 1e-17
sp|Q5G271|NETR_PANTR Neurotrypsin precursor 88 2e-17
>sp|P26262|KLKB1_MOUSE Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 109 bits (272), Expect = 8e-24
Identities = 70/191 (36%), Positives = 101/191 (52%), Gaps = 5/191 (2%)
Frame = +3
Query: 12 RISHIIIHPKYETIKLEYDVALLKLEIPVKNYLNFP---CIPKSKNFTMDDHPKCYAIGW 182
RI +IIH +Y+ + YD+AL+KL+ P+ NY F C+P SK T + C+ GW
Sbjct: 465 RIKELIIHQEYKVSEGNYDIALIKLQTPL-NYTEFQKPICLP-SKADTNTIYTNCWVTGW 522
Query: 183 GYLSSQIPNLDWNLELDFDLERWQRNIKKKTSHILQEVEIPLVELQRCRERHTEFNLNDD 362
GY Q +T +ILQ+ IPLV + C++++ ++ +N
Sbjct: 523 GYTKEQ----------------------GETQNILQKATIPLVPNEECQKKYRDYVINKQ 560
Query: 363 IHLCAG--NAFKDTCKGDSGGGLFCLDINAGRWYLHGITSFGSSKGCGIGYGVYTKVSKI 536
+ +CAG D CKGDSGG L C ++GRW L GITS+G G GVYTKVS+
Sbjct: 561 M-ICAGYKEGGTDACKGDSGGPLVCK--HSGRWQLVGITSWGEGCGRKDQPGVYTKVSEY 617
Query: 537 YPWIKEAIKTN 569
WI E +++
Sbjct: 618 MDWILEKTQSS 628
>sp|P14272|KLKB1_RAT Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 103 bits (256), Expect = 6e-22
Identities = 67/193 (34%), Positives = 100/193 (51%), Gaps = 5/193 (2%)
Frame = +3
Query: 6 YRRISHIIIHPKYETIKLEYDVALLKLEIPVKNYLNFP---CIPKSKNFTMDDHPKCYAI 176
+ I +IIH KY+ + YD+AL+KL+ P+ NY F C+P SK T + C+
Sbjct: 463 FSSIKELIIHQKYKMSEGSYDIALIKLQTPL-NYTEFQKPICLP-SKADTNTIYTNCWVT 520
Query: 177 GWGYLSSQIPNLDWNLELDFDLERWQRNIKKKTSHILQEVEIPLVELQRCRERHTEFNLN 356
GWGY + +T +ILQ+ IPLV + C++++ ++ +
Sbjct: 521 GWGYTKE----------------------RGETQNILQKATIPLVPNEECQKKYRDYVIT 558
Query: 357 DDIHLCAG--NAFKDTCKGDSGGGLFCLDINAGRWYLHGITSFGSSKGCGIGYGVYTKVS 530
+ +CAG D CKGDSGG L C ++GRW L GITS+G GVYTKV+
Sbjct: 559 KQM-ICAGYKEGGIDACKGDSGGPLVCK--HSGRWQLVGITSWGEGCARKEQPGVYTKVA 615
Query: 531 KIYPWIKEAIKTN 569
+ WI E I+++
Sbjct: 616 EYIDWILEKIQSS 628
>sp|P03952|KLKB1_HUMAN Plasma kallikrein precursor (Plasma prekallikrein) (Kininogenin)
(Fletcher factor) [Contains: Plasma kallikrein heavy
chain; Plasma kallikrein light chain]
Length = 638
Score = 100 bits (248), Expect = 5e-21
Identities = 66/193 (34%), Positives = 98/193 (50%), Gaps = 5/193 (2%)
Frame = +3
Query: 6 YRRISHIIIHPKYETIKLEYDVALLKLEIPVKNYLNFP---CIPKSKNFTMDDHPKCYAI 176
+ +I IIIH Y+ + +D+AL+KL+ P+ NY F C+P SK T + C+
Sbjct: 463 FSQIKEIIIHQNYKVSEGNHDIALIKLQAPL-NYTEFQKPICLP-SKGDTSTIYTNCWVT 520
Query: 177 GWGYLSSQIPNLDWNLELDFDLERWQRNIKKKTSHILQEVEIPLVELQRCRERHTEFNLN 356
GWG+ K + +ILQ+V IPLV + C++R+ ++ +
Sbjct: 521 GWGFSKE----------------------KGEIQNILQKVNIPLVTNEECQKRYQDYKIT 558
Query: 357 DDIHLCAG--NAFKDTCKGDSGGGLFCLDINAGRWYLHGITSFGSSKGCGIGYGVYTKVS 530
+ +CAG KD CKGDSGG L C + G W L GITS+G GVYTKV+
Sbjct: 559 QRM-VCAGYKEGGKDACKGDSGGPLVCK--HNGMWRLVGITSWGEGCARREQPGVYTKVA 615
Query: 531 KIYPWIKEAIKTN 569
+ WI E +++
Sbjct: 616 EYMDWILEKTQSS 628
>sp|Q91Y47|FA11_MOUSE Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 624
Score = 100 bits (248), Expect = 5e-21
Identities = 68/190 (35%), Positives = 95/190 (50%), Gaps = 5/190 (2%)
Frame = +3
Query: 12 RISHIIIHPKYETIKLEYDVALLKLEIPVKNYLNFP---CIPKSKNFTMDDHPKCYAIGW 182
R +IIH +Y T + YD+ALLKLE + NY +F C+P SK H +C+ GW
Sbjct: 461 REQEMIIHDQYTTAESGYDIALLKLESAM-NYTDFQRPICLP-SKGDRNAVHTECWVTGW 518
Query: 183 GYLSSQIPNLDWNLELDFDLERWQRNIKKKTSHILQEVEIPLVELQRCRERHTEFNLNDD 362
GY + ++ + LQ+ ++PLV + C+ R+ + +
Sbjct: 519 GYTA----------------------LRGEVQSTLQKAKVPLVSNEECQTRYRRHKITNK 556
Query: 363 IHLCAG--NAFKDTCKGDSGGGLFCLDINAGRWYLHGITSFGSSKGCGIGYGVYTKVSKI 536
+ +CAG KDTCKGDSGG L C G W+L GITS+G G GVYT V+K
Sbjct: 557 M-ICAGYKEGGKDTCKGDSGGPLSCK--YNGVWHLVGITSWGEGCGQKERPGVYTNVAKY 613
Query: 537 YPWIKEAIKT 566
WI E +T
Sbjct: 614 VDWILEKTQT 623
>sp|P98073|ENTK_HUMAN Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic heavy chain; Enteropeptidase catalytic
light chain]
Length = 1019
Score = 94.0 bits (232), Expect = 3e-19
Identities = 59/185 (31%), Positives = 95/185 (51%), Gaps = 4/185 (2%)
Frame = +3
Query: 9 RRISHIIIHPKYETIKLEYDVALLKLEIPVK--NYLNFPCIPKSKNFTMDDHPKCYAIGW 182
R I I+I+P Y + + D+A++ LE V +Y+ C+P+ +N C GW
Sbjct: 857 RLIDEIVINPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPE-ENQVFPPGRNCSIAGW 915
Query: 183 GYLSSQIPNLDWNLELDFDLERWQRNIKKKTSHILQEVEIPLVELQRCRERHTEFNLNDD 362
G + Q T++ILQE ++PL+ +RC+++ E+N+ ++
Sbjct: 916 GTVVYQ----------------------GTTANILQEADVPLLSNERCQQQMPEYNITEN 953
Query: 363 IHLCAG--NAFKDTCKGDSGGGLFCLDINAGRWYLHGITSFGSSKGCGIGYGVYTKVSKI 536
+ +CAG D+C+GDSGG L C + N RW+L G+TSFG GVY +VS+
Sbjct: 954 M-ICAGYEEGGIDSCQGDSGGPLMCQENN--RWFLAGVTSFGYKCALPNRPGVYARVSRF 1010
Query: 537 YPWIK 551
WI+
Sbjct: 1011 TEWIQ 1015
>sp|Q5U405|TMPSD_MOUSE Transmembrane protease, serine 13 (Mosaic serine protease)
(Membrane-type mosaic serine protease)
Length = 543
Score = 90.1 bits (222), Expect = 5e-18
Identities = 58/192 (30%), Positives = 99/192 (51%), Gaps = 4/192 (2%)
Frame = +3
Query: 15 ISHIIIHPKYETIKLEYDVALLKLEIPV--KNYLNFPCIPKSKNFTMDDHPKCYAIGWGY 188
IS III+ Y + +YD+AL++L P+ +++ C+P T + C+ G+G
Sbjct: 373 ISQIIINGNYTDEQDDYDIALIRLSKPLTLSAHIHPACLPMHGQ-TFGLNETCWITGFGK 431
Query: 189 LSSQIPNLDWNLELDFDLERWQRNIKKKTSHILQEVEIPLVELQRCRERHTEFNLNDDIH 368
+ +KTS L+EV++ L++ ++C + +
Sbjct: 432 T---------------------KETDEKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRM 470
Query: 369 LCAGN--AFKDTCKGDSGGGLFCLDINAGRWYLHGITSFGSSKGCGIGYGVYTKVSKIYP 542
+CAG+ +D+C+GDSGG L C N RWYL G+TS+G+ G GVYTKV+++ P
Sbjct: 471 MCAGDLRGGRDSCQGDSGGPLVCEQNN--RWYLAGVTSWGTGCGQKNKPGVYTKVTEVLP 528
Query: 543 WIKEAIKTNIKF 578
WI +++ ++F
Sbjct: 529 WIYRKMESEVRF 540
>sp|P98074|ENTK_PIG Enteropeptidase precursor (Enterokinase) [Contains: Enteropeptidase
non-catalytic mini chain; Enteropeptidase non-catalytic
heavy chain; Enteropeptidase catalytic light chain]
Length = 1034
Score = 89.7 bits (221), Expect = 6e-18
Identities = 59/187 (31%), Positives = 93/187 (49%), Gaps = 4/187 (2%)
Frame = +3
Query: 3 IYRRISHIIIHPKYETIKLEYDVALLKLEIPVK--NYLNFPCIPKSKNFTMDDHPKCYAI 176
+ R I I+I+P Y + + D+A++ LE V +Y+ C+P+ +N C
Sbjct: 870 VTRLIDEIVINPHYNRRRKDSDIAMMHLEFKVNYTDYIQPICLPE-ENQVFPPGRICSIA 928
Query: 177 GWGYLSSQIPNLDWNLELDFDLERWQRNIKKKTSHILQEVEIPLVELQRCRERHTEFNLN 356
GWG + Q D ILQE ++PL+ ++C+++ E+N+
Sbjct: 929 GWGKVIYQGSPAD----------------------ILQEADVPLLSNEKCQQQMPEYNIT 966
Query: 357 DDIHLCAG--NAFKDTCKGDSGGGLFCLDINAGRWYLHGITSFGSSKGCGIGYGVYTKVS 530
+++ +CAG D+C+GDSGG L CL+ N RW L G+TSFG GVY +V
Sbjct: 967 ENM-MCAGYEEGGIDSCQGDSGGPLMCLENN--RWLLAGVTSFGYQCALPNRPGVYARVP 1023
Query: 531 KIYPWIK 551
K WI+
Sbjct: 1024 KFTEWIQ 1030
>sp|P03951|FA11_HUMAN Coagulation factor XI precursor (Plasma thromboplastin antecedent)
(PTA) (FXI) [Contains: Coagulation factor XIa heavy
chain; Coagulation factor XIa light chain]
Length = 625
Score = 89.0 bits (219), Expect = 1e-17
Identities = 64/185 (34%), Positives = 88/185 (47%), Gaps = 5/185 (2%)
Frame = +3
Query: 15 ISHIIIHPKYETIKLEYDVALLKLEIPVKNYLNFP---CIPKSKNFTMDDHPKCYAIGWG 185
+ IIIH +Y+ + YD+ALLKLE V NY + C+P SK + C+ GWG
Sbjct: 463 VQEIIIHDQYKMAESGYDIALLKLETTV-NYTDSQRPICLP-SKGDRNVIYTDCWVTGWG 520
Query: 186 YLSSQIPNLDWNLELDFDLERWQRNIKKKTSHILQEVEIPLVELQRCRERHTEFNLNDDI 365
Y R ++ K + LQ+ +IPLV + C++R+ + +
Sbjct: 521 Y----------------------RKLRDKIQNTLQKAKIPLVTNEECQKRYRGHKITHKM 558
Query: 366 HLCAG--NAFKDTCKGDSGGGLFCLDINAGRWYLHGITSFGSSKGCGIGYGVYTKVSKIY 539
+CAG KD CKGDSGG L C W+L GITS+G GVYT V +
Sbjct: 559 -ICAGYREGGKDACKGDSGGPLSCKHNEV--WHLVGITSWGEGCAQRERPGVYTNVVEYV 615
Query: 540 PWIKE 554
WI E
Sbjct: 616 DWILE 620
>sp|P55091|CLCR_RAT Caldecrin precursor (Chymotrypsin C) (Serum calcium-decreasing
factor)
Length = 268
Score = 88.6 bits (218), Expect = 1e-17
Identities = 61/192 (31%), Positives = 86/192 (44%), Gaps = 5/192 (2%)
Frame = +3
Query: 3 IYRRISHIIIHPKYETIKLEYDVALLKLEIPVK--NYLNFPCIPKSKNFTMDDHPKCYAI 176
+Y + I +H K+ + L D+A++KL PV+ N + CIP+ + D+P CY
Sbjct: 100 VYAEVDTIYVHEKWNRLFLWNDIAIIKLAEPVELSNTIQVACIPEEGSLLPQDYP-CYVT 158
Query: 177 GWGYLSSQIPNLDWNLELDFDLERWQRNIKKKTSHILQEVEIPLVELQRCRERHTEFNLN 356
GWG L + P + +LQ+ P+V C F
Sbjct: 159 GWGRLWTNGP----------------------IAEVLQQGLQPIVSHATCSRLDWWFIKV 196
Query: 357 DDIHLCAG-NAFKDTCKGDSGGGLFCLDINAGRWYLHGITSFGSSKGCGIGYG--VYTKV 527
+CAG + C GDSGG L C G W +HGI SFGSS GC + V+T+V
Sbjct: 197 RKTMVCAGGDGVISACNGDSGGPLNC-QAEDGSWQVHGIVSFGSSSGCNVHKKPVVFTRV 255
Query: 528 SKIYPWIKEAIK 563
S WI E I+
Sbjct: 256 SAYNDWINEKIQ 267
>sp|Q5G271|NETR_PANTR Neurotrypsin precursor
Length = 875
Score = 88.2 bits (217), Expect = 2e-17
Identities = 61/195 (31%), Positives = 88/195 (45%), Gaps = 12/195 (6%)
Frame = +3
Query: 15 ISHIIIHPKYETIKLEYDVALLKLEIPVKNYLNFP------CIPKSKNFTMDDHPKCYAI 176
+ I+IH +Y + +YD+AL++L+ P + F C+P + CY
Sbjct: 709 VQQIVIHREYRPDRSDYDIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYIT 768
Query: 177 GWGYLSSQIPNLDWNLELDFDLERWQRNIKKKTSHILQEVEIPLVELQRCRERHTEFNLN 356
GWG + + S LQ+ IPL+ + C ER+
Sbjct: 769 GWG------------------------DTGRAYSRTLQQAAIPLLPKRFCEERYKRRFTG 804
Query: 357 DDIHLCAGNAFK----DTCKGDSGGGLFCLDINAGRWYLHGITSFGSSKGCGI--GYGVY 518
LCAGN + D+C+GDSGG L C + W ++G+TS+G GCG+ GVY
Sbjct: 805 R--MLCAGNLHEHKRVDSCQGDSGGPLMC-ERPGESWVVYGVTSWGY--GCGVKDSPGVY 859
Query: 519 TKVSKIYPWIKEAIK 563
TKVS PWIK K
Sbjct: 860 TKVSAFVPWIKSVTK 874
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 77,054,255
Number of Sequences: 369166
Number of extensions: 1572053
Number of successful extensions: 4782
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3871
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4096
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6024953540
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)