Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_C08
(911 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9D5U8|CT152_MOUSE Protein C20orf152 homolog 94 5e-19
sp|Q96M20|CT152_HUMAN Protein C20orf152 87 6e-17
sp|Q95JR6|CT152_MACFA Protein C20orf152 homolog 86 1e-16
sp|P31320|KAPR_BLAEM cAMP-dependent protein kinase regulato... 64 8e-10
sp|P10644|KAP0_HUMAN cAMP-dependent protein kinase type I-a... 63 1e-09
sp|Q61410|KGP2_MOUSE cGMP-dependent protein kinase 2 (CGK 2... 62 2e-09
sp|P31319|KAPR_APLCA cAMP-dependent protein kinase regulato... 62 3e-09
sp|Q64595|KGP2_RAT cGMP-dependent protein kinase 2 (CGK 2) ... 61 5e-09
sp|P00514|KAP0_BOVIN cAMP-dependent protein kinase type I-a... 60 6e-09
sp|Q13237|KGP2_HUMAN cGMP-dependent protein kinase 2 (CGK 2... 60 8e-09
>sp|Q9D5U8|CT152_MOUSE Protein C20orf152 homolog
Length = 556
Score = 94.0 bits (232), Expect = 5e-19
Identities = 63/228 (27%), Positives = 112/228 (49%), Gaps = 1/228 (0%)
Frame = +2
Query: 146 LSFNVSDYKAQKEKTLSIEATKILKTHKSLRTPHQIRSVVLALTEAVEAFSEFPIAMQEA 325
+SF D+ AQ E A I + S RT +I+ + L +A++ + + ++Q
Sbjct: 43 ISFVTEDFAAQ-EGHFPPRAISITQKKPSWRTHQEIQDLCNIL-QALDCYRSYTESLQLL 100
Query: 326 LVQHGWYEKYNPKQVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGN 505
L + +E++ ++VI+++G +FYFI G V++ + S L +G
Sbjct: 101 LAKVIRFERFGRRRVIVKKGQMGNSFYFIYLGT--VAITEDEDGSSAFLDPHPTLLHRGG 158
Query: 506 SFGELALMYGGKRSASVICINSVELLSVTREDFIEIFMSLSANTEPEH-ITFLRNVSILD 682
SFGE+ L+ RSA+V+C+ E L V REDF+ + E ++ F RN+ I
Sbjct: 159 SFGEMGLLSTTVRSATVVCMEETEFLVVDREDFVANKLGDEVQKETQYRYNFFRNLDIFQ 218
Query: 683 GWPIDALPYDDPKICLFTYFRRGTVLCRDSSNSEWIYIICTGSCKVIK 826
W + L + + F G ++ +D NS +I IC G+C++++
Sbjct: 219 SWSEEKL-WKLVALGRIERFSYGQMVSKDFMNSAFITFICQGNCEILR 265
>sp|Q96M20|CT152_HUMAN Protein C20orf152
Length = 576
Score = 87.0 bits (214), Expect = 6e-17
Identities = 58/239 (24%), Positives = 118/239 (49%), Gaps = 1/239 (0%)
Frame = +2
Query: 146 LSFNVSDYKAQKEKTLSIEATKILKTHKSLRTPHQIRSVVLALTEAVEAFSEFPIAMQEA 325
++F+ D+ A+ E +A +I++ S RT +I++V L + ++++ + +Q
Sbjct: 70 VTFDTMDFIAE-EGHFPPKAIQIMQKKPSWRTEDEIQAVCNIL-QVLDSYRNYAEPLQLL 127
Query: 326 LVQHGWYEKYNPKQVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGN 505
L + +E++ ++VII++G +FYFI G V++ + + S L KG+
Sbjct: 128 LAKVMRFERFGRRRVIIKKGQKGNSFYFIYLGT--VAITKDEDGSSAFLDPHPKLLHKGS 185
Query: 506 SFGELALMYGGKRSASVICINSVELLSVTREDFIEIFMSLSANTEPEH-ITFLRNVSILD 682
FGE+ +++ R ++++C+ E L V REDF + + ++ F R + +
Sbjct: 186 CFGEMDVLHASVRRSTIVCMEETEFLVVDREDFFANKLDQEVQKDAQYRFEFFRKMELFA 245
Query: 683 GWPIDALPYDDPKICLFTYFRRGTVLCRDSSNSEWIYIICTGSCKVIKGLTESSGKSYQ 859
W + L + + F G ++ +D S +I I GSC+V++ L + SY+
Sbjct: 246 SWSDEKL-WQLVAMAKIERFSYGQLISKDFGESPFIMFISKGSCEVLRLLDLGASPSYR 303
>sp|Q95JR6|CT152_MACFA Protein C20orf152 homolog
Length = 585
Score = 85.9 bits (211), Expect = 1e-16
Identities = 61/240 (25%), Positives = 118/240 (49%), Gaps = 3/240 (1%)
Frame = +2
Query: 146 LSFNVSDYKAQKEKTLSIEATKILKTHKSLRTPHQIRSVVLALTEAVEAFSEFPIAMQEA 325
++F+ D+ A+ E +A +I++ S RT +I++V L + ++++ + +Q
Sbjct: 70 VTFDTMDFIAE-EGHFPPKAIQIMQKKPSWRTEDEIQTVCNIL-QVLDSYRNYAEPLQLL 127
Query: 326 LVQHGWYEKYNPKQVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGN 505
L + +E++ ++VII++G +FYFI G V++ + S L+KG+
Sbjct: 128 LAKVMRFERFGRRRVIIKKGQKGNSFYFIYLGT--VAITNDEDGSSAFLDPHPKLLQKGS 185
Query: 506 SFGELALMYGGKRSASVICINSVELLSVTREDFIEIFMSLSANTEPEH-ITFLRNVSILD 682
FGE + + R ++++C+ E L V REDF + + ++ F R + +
Sbjct: 186 CFGETDIQHASLRRSTIVCMEETEFLVVDREDFFANKLDQEVQKDAQYRFEFFRKMDLFA 245
Query: 683 GWPIDAL--PYDDPKICLFTYFRRGTVLCRDSSNSEWIYIICTGSCKVIKGLTESSGKSY 856
W + L + KI F+Y G ++ +D S +I I GSC+V++ L + SY
Sbjct: 246 SWSDEKLWQLVNMSKIERFSY---GQLISKDFGESSFIMFISKGSCEVLRLLDLGASPSY 302
>sp|P31320|KAPR_BLAEM cAMP-dependent protein kinase regulatory subunit (PKA regulatory
subunit)
Length = 403
Score = 63.5 bits (153), Expect = 8e-10
Identities = 52/170 (30%), Positives = 74/170 (43%), Gaps = 3/170 (1%)
Frame = +2
Query: 365 QVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGNSFGELALMYGGKR 544
+V+IRQG FY + +G V V R N + V G SFGELALMY R
Sbjct: 181 EVVIRQGGVGDYFYVVETGALDVFVNRNGNGDVK-----VTDYSAGGSFGELALMYNAPR 235
Query: 545 SASVICINSVELLSVTREDFIEIFMSLSANTEPEHITFLRNVSILDGWPIDALPYDDPKI 724
+A+V+ L ++ R F I M ++ + FL V +L PY+ KI
Sbjct: 236 AATVVATAESVLWALDRVTFRRILMDHTSRKRRMYEAFLEEVPLLSSLE----PYERHKI 291
Query: 725 C---LFTYFRRGTVLCRDSSNSEWIYIICTGSCKVIKGLTESSGKSYQLR 865
+ G V+ R E YII G +VIK + +G+ + R
Sbjct: 292 ADALESVAYADGDVVIRQGDVGENFYIIEAGDAEVIK--IDENGEEHHFR 339
Score = 40.8 bits (94), Expect = 0.005
Identities = 29/92 (31%), Positives = 45/92 (48%)
Frame = +2
Query: 353 YNPKQVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGNSFGELALMY 532
Y V+IRQG +NFY I +G V K + +GE + L KGN FGELAL+
Sbjct: 300 YADGDVVIRQGDVGENFYIIEAGDAEVI---KIDENGEEH--HFRPLHKGNYFGELALLS 354
Query: 533 GGKRSASVICINSVELLSVTREDFIEIFMSLS 628
R A++ ++ + ++ F + L+
Sbjct: 355 DKPRVATIRAKGKLKCAKLGKKAFTRLLGPLA 386
>sp|P10644|KAP0_HUMAN cAMP-dependent protein kinase type I-alpha regulatory subunit
(Tissue-specific extinguisher 1) (TSE1)
Length = 381
Score = 62.8 bits (151), Expect = 1e-09
Identities = 54/166 (32%), Positives = 76/166 (45%), Gaps = 7/166 (4%)
Frame = +2
Query: 365 QVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGNSFGELALMYGGKR 544
+ +I+QG NFY I G+T V V NN S GE G SFGELAL+YG R
Sbjct: 162 ETVIQQGDEGDNFYVIDQGETDVYV---NNEWATSVGE-------GGSFGELALIYGTPR 211
Query: 545 SASVICINSVELLSVTREDFIEIFMSLSANTEPEHITFLRNVSI---LDGWP----IDAL 703
+A+V +V+L + R+ + I M + + FL VSI LD W DAL
Sbjct: 212 AATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADAL 271
Query: 704 PYDDPKICLFTYFRRGTVLCRDSSNSEWIYIICTGSCKVIKGLTES 841
+P F G + + +II GS V++ +E+
Sbjct: 272 ---EP-----VQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 309
>sp|Q61410|KGP2_MOUSE cGMP-dependent protein kinase 2 (CGK 2) (cGKII) (Type II
cGMP-dependent protein kinase)
Length = 762
Score = 62.0 bits (149), Expect = 2e-09
Identities = 48/168 (28%), Positives = 78/168 (46%), Gaps = 3/168 (1%)
Frame = +2
Query: 326 LVQHGWYEKYNPKQVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGN 505
+V+ + EK + +I+QG + + + G+ V K SS +
Sbjct: 180 MVECMYGEKLSTGSYVIKQGEPGNHIFVLAEGRLEVFQGEKLLSS----------IPMWT 229
Query: 506 SFGELALMYGGKRSASVICINSVELLSVTREDFIEIFMSLSANTEPEHITFLRNVSILDG 685
+FGELA++Y R+ASV I +V+ ++ RE F I + + E+ FLR+VS+L
Sbjct: 230 TFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKN 289
Query: 686 WPIDALPYDDPKI--CL-FTYFRRGTVLCRDSSNSEWIYIICTGSCKV 820
P D L KI CL Y+ +G + R+ +I+ G KV
Sbjct: 290 LPEDKL----TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKV 333
Score = 46.2 bits (108), Expect = 1e-04
Identities = 29/87 (33%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Frame = +2
Query: 347 EKYNPKQVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGNSFGELAL 526
E Y+ IIR+G F+ + GK V+ ++ G + + L+KG FGE AL
Sbjct: 305 EYYDKGDYIIREGEEGSTFFILAKGKVKVT----QSTEGHDQPQLIKTLQKGEYFGEKAL 360
Query: 527 MYGGKRSASVIC-INSVELLSVTREDF 604
+ RSA++I N V L + RE F
Sbjct: 361 ISDDVRSANIIAEENDVACLVIDRETF 387
>sp|P31319|KAPR_APLCA cAMP-dependent protein kinase regulatory subunit (N4 subunit of
protein kinase A)
Length = 378
Score = 61.6 bits (148), Expect = 3e-09
Identities = 56/166 (33%), Positives = 75/166 (45%), Gaps = 7/166 (4%)
Frame = +2
Query: 365 QVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGNSFGELALMYGGKR 544
+VII+QG NFY I G+ V V NN S GE G SFGELAL+YG R
Sbjct: 159 EVIIQQGDEGDNFYVIDQGEVDVYV---NNVHVTSIGE-------GGSFGELALIYGTPR 208
Query: 545 SASVICINSVELLSVTREDFIEIFMSLSANTEPEHITFLRNVSI---LDGWP----IDAL 703
+A+V V+L + R+ + I M + + FL VSI LD W DAL
Sbjct: 209 AATVKAKTDVKLWGIDRDSYRRILMGSTIRKRKIYEDFLSKVSILENLDKWERLTVADAL 268
Query: 704 PYDDPKICLFTYFRRGTVLCRDSSNSEWIYIICTGSCKVIKGLTES 841
+P F + R E +II GS V++ +E+
Sbjct: 269 ---EP-----VQFEDKEEIVRQGEPGEDFFIILEGSAAVLQRRSEN 306
>sp|Q64595|KGP2_RAT cGMP-dependent protein kinase 2 (CGK 2) (cGKII) (Type II
cGMP-dependent protein kinase)
Length = 762
Score = 60.8 bits (146), Expect = 5e-09
Identities = 47/168 (27%), Positives = 76/168 (45%), Gaps = 3/168 (1%)
Frame = +2
Query: 326 LVQHGWYEKYNPKQVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGN 505
+V+ + Y I++QG + + + G+ V K SS +
Sbjct: 180 MVECMYGRNYQQGSYIVKQGEPGNHIFVLAEGRLEVFQGEKLLSS----------IPMWT 229
Query: 506 SFGELALMYGGKRSASVICINSVELLSVTREDFIEIFMSLSANTEPEHITFLRNVSILDG 685
+FGELA++Y R+ASV I +V+ ++ RE F I + + E+ FLR+VS+L
Sbjct: 230 TFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEEYRNFLRSVSLLKN 289
Query: 686 WPIDALPYDDPKI--CL-FTYFRRGTVLCRDSSNSEWIYIICTGSCKV 820
P D L KI CL Y+ +G + R+ +I+ G KV
Sbjct: 290 LPEDKL----TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKV 333
Score = 46.2 bits (108), Expect = 1e-04
Identities = 29/87 (33%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Frame = +2
Query: 347 EKYNPKQVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGNSFGELAL 526
E Y+ IIR+G F+ + GK V+ ++ G + + L+KG FGE AL
Sbjct: 305 EYYDKGDYIIREGEEGSTFFILAKGKVKVT----QSTEGHDQPQLIKTLQKGEYFGEKAL 360
Query: 527 MYGGKRSASVIC-INSVELLSVTREDF 604
+ RSA++I N V L + RE F
Sbjct: 361 ISDDVRSANIIAEENDVACLVIDRETF 387
>sp|P00514|KAP0_BOVIN cAMP-dependent protein kinase type I-alpha regulatory subunit
Length = 379
Score = 60.5 bits (145), Expect = 6e-09
Identities = 53/166 (31%), Positives = 75/166 (45%), Gaps = 7/166 (4%)
Frame = +2
Query: 365 QVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGNSFGELALMYGGKR 544
+ +I+QG NFY I G+ V V NN S GE G SFGELAL+YG R
Sbjct: 160 ETVIQQGDEGDNFYVIDQGEMDVYV---NNEWATSVGE-------GGSFGELALIYGTPR 209
Query: 545 SASVICINSVELLSVTREDFIEIFMSLSANTEPEHITFLRNVSI---LDGWP----IDAL 703
+A+V +V+L + R+ + I M + + FL VSI LD W DAL
Sbjct: 210 AATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADAL 269
Query: 704 PYDDPKICLFTYFRRGTVLCRDSSNSEWIYIICTGSCKVIKGLTES 841
+P F G + + +II GS V++ +E+
Sbjct: 270 ---EP-----VQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSEN 307
>sp|Q13237|KGP2_HUMAN cGMP-dependent protein kinase 2 (CGK 2) (cGKII) (Type II
cGMP-dependent protein kinase)
Length = 762
Score = 60.1 bits (144), Expect = 8e-09
Identities = 47/168 (27%), Positives = 76/168 (45%), Gaps = 3/168 (1%)
Frame = +2
Query: 326 LVQHGWYEKYNPKQVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGN 505
+V+ + Y II+QG + + + G+ V K SS +
Sbjct: 180 MVECMYGRNYQQGSYIIKQGEPGNHIFVLAEGRLEVFQGEKLLSS----------IPMWT 229
Query: 506 SFGELALMYGGKRSASVICINSVELLSVTREDFIEIFMSLSANTEPEHITFLRNVSILDG 685
+FGELA++Y R+ASV I +V+ ++ RE F I + + ++ FLR+VS+L
Sbjct: 230 TFGELAILYNCTRTASVKAITNVKTWALDREVFQNIMRRTAQARDEQYRNFLRSVSLLKN 289
Query: 686 WPIDALPYDDPKI--CL-FTYFRRGTVLCRDSSNSEWIYIICTGSCKV 820
P D L KI CL Y+ +G + R+ +I+ G KV
Sbjct: 290 LPEDKL----TKIIDCLEVEYYDKGDYIIREGEEGSTFFILAKGKVKV 333
Score = 46.2 bits (108), Expect = 1e-04
Identities = 29/87 (33%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Frame = +2
Query: 347 EKYNPKQVIIRQGHAAQNFYFIISGKTMVSVARKNNSSGESYGETVAFLKKGNSFGELAL 526
E Y+ IIR+G F+ + GK V+ ++ G + + L+KG FGE AL
Sbjct: 305 EYYDKGDYIIREGEEGSTFFILAKGKVKVT----QSTEGHDQPQLIKTLQKGEYFGEKAL 360
Query: 527 MYGGKRSASVIC-INSVELLSVTREDF 604
+ RSA++I N V L + RE F
Sbjct: 361 ISDDVRSANIIAEENDVACLVIDRETF 387
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 102,934,722
Number of Sequences: 369166
Number of extensions: 2155161
Number of successful extensions: 6242
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5922
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6190
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9270587090
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)