Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_B18
(788 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 220 4e-57
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 206 6e-53
sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (C... 206 8e-53
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 205 1e-52
sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein) 204 3e-52
sp|Q9GLE3|CATK_PIG Cathepsin K precursor 204 3e-52
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 203 5e-52
sp|Q9JIA9|CATR_MOUSE Cathepsin R precursor 203 5e-52
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 202 7e-52
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 202 8e-52
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 220 bits (560), Expect = 4e-57
Identities = 105/252 (41%), Positives = 154/252 (61%), Gaps = 2/252 (0%)
Frame = +1
Query: 37 WKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLNQFADLTNEEF 216
W +K ++ KEY D+ RR IWE+N+++IQ+HNL DLG T+TLGLNQF D+T EEF
Sbjct: 21 WHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEF 80
Query: 217 RSKYLSKNLMSRSQINSKFVMPYKT--KLNDDEVDWRKKGVVTPVKNQYGCNAGWAFAAT 390
++KYL++ MSR+ +PY+ + D++DWR+ G VT VK+Q C + WAF+ T
Sbjct: 81 KAKYLTE--MSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTT 138
Query: 391 GSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPYGMNNEETYPYF 570
G+ EG+Y +SFSE+QL+DCS +GN+GC GG +N++ Y K +G+ E +YPY
Sbjct: 139 GTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYT 198
Query: 571 GIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIY 750
++ +C+YN +A V + V +E+++ V A P +D F YR GIY
Sbjct: 199 AVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVDVE-SDFMMYRSGIY 257
Query: 751 NDPTCSKTSPNH 786
TCS NH
Sbjct: 258 QSQTCSPLRVNH 269
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 206 bits (524), Expect = 6e-53
Identities = 107/257 (41%), Positives = 152/257 (59%), Gaps = 3/257 (1%)
Frame = +1
Query: 25 LNNEWKAFKLLFKKEYEP-IDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLNQFADL 201
L+ W+ +K +K+Y +DE+ RRLIWE+NL+YI HNLEA LG HT+ L +N D+
Sbjct: 22 LDTHWELWKKTHRKQYNSKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDM 81
Query: 202 TNEEFRSKYLSKNL-MSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCNAGWA 378
TNEE K + S S+ N +P D VD+RKKG VTPVKNQ C + WA
Sbjct: 82 TNEEVVQKMTGLKVPASHSRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWA 141
Query: 379 FAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYY-KPYGMNNEE 555
F++ G+ EG+ +TG L++ S + L+DC N GC GG N+F Y K G+++E+
Sbjct: 142 FSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSED 199
Query: 556 TYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFY 735
YPY G ++ C YN A + ++ NE + AV+ GP++ IDASL SFQFY
Sbjct: 200 AYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFY 259
Query: 736 REGIYNDPTCSKTSPNH 786
+G+Y D +C+ + NH
Sbjct: 260 SKGVYYDESCNSDNLNH 276
>sp|P43235|CATK_HUMAN Cathepsin K precursor (Cathepsin O) (Cathepsin X) (Cathepsin O2)
Length = 329
Score = 206 bits (523), Expect = 8e-53
Identities = 106/257 (41%), Positives = 153/257 (59%), Gaps = 3/257 (1%)
Frame = +1
Query: 25 LNNEWKAFKLLFKKEYE-PIDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLNQFADL 201
L+ W+ +K +K+Y +DE+ RRLIWE+NL+YI HNLEA LG HT+ L +N D+
Sbjct: 22 LDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDM 81
Query: 202 TNEEFRSKYLSKNL-MSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCNAGWA 378
T+EE K + +S S+ N +P D VD+RKKG VTPVKNQ C + WA
Sbjct: 82 TSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWA 141
Query: 379 FAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYY-KPYGMNNEE 555
F++ G+ EG+ +TG L++ S + L+DC N GC GG N+F Y K G+++E+
Sbjct: 142 FSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSED 199
Query: 556 TYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFY 735
YPY G ++ C YN A + ++ NE + AV+ GP++ IDASL SFQFY
Sbjct: 200 AYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFY 259
Query: 736 REGIYNDPTCSKTSPNH 786
+G+Y D +C+ + NH
Sbjct: 260 SKGVYYDESCNSDNLNH 276
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 205 bits (522), Expect = 1e-52
Identities = 109/262 (41%), Positives = 155/262 (59%), Gaps = 2/262 (0%)
Frame = +1
Query: 7 PTINAQLNNEWKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLN 186
P + LN +W +K ++ Y +E RR +WE+N++ I+ HN E GKH FT+ +N
Sbjct: 19 PKFDQSLNAQWYQWKATHRRLYGMNEEGWRRAVWEKNMKMIELHNREYSQGKHGFTMAMN 78
Query: 187 QFADLTNEEFRSKYLSKNLMSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCN 366
F D+TNEEFR + ++ + + F P ++ VDWR+KG VTPVKNQ C
Sbjct: 79 AFGDMTNEEFR-QVMNGFQNQKHKKGKMFQEPLFAEI-PKSVDWREKGYVTPVKNQGQCG 136
Query: 367 AGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPY-GM 543
+ WAF+ATG+ EG+ +TG L+S SE+ L+DCS A GN GC GG DN+F Y K G+
Sbjct: 137 SCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGL 196
Query: 544 NNEETYPYFG-IKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLP 720
++EE+YPY G + C Y A+ F+D+ + E + AV+ GP++ IDA
Sbjct: 197 DSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ-REKALMKAVATLGPISVAIDAGHQ 255
Query: 721 SFQFYREGIYNDPTCSKTSPNH 786
SFQFY+ GIY DP CS +H
Sbjct: 256 SFQFYKSGIYFDPDCSSKDLDH 277
>sp|P43236|CATK_RABIT Cathepsin K precursor (OC-2 protein)
Length = 329
Score = 204 bits (518), Expect = 3e-52
Identities = 105/257 (40%), Positives = 151/257 (58%), Gaps = 3/257 (1%)
Frame = +1
Query: 25 LNNEWKAFKLLFKKEYEP-IDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLNQFADL 201
L+ +W+ +K + K+Y +DE+ RRLIWE+NL++I HNLEA LG HT+ L +N D+
Sbjct: 22 LDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDM 81
Query: 202 TNEEFRSKYLSKNLM-SRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCNAGWA 378
T+EE K + SRS N +P D +D+RKKG VTPVKNQ C + WA
Sbjct: 82 TSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWA 141
Query: 379 FAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYY-KPYGMNNEE 555
F++ G+ EG+ +TG L++ S + L+DC N GC GG N+F Y + G+++E+
Sbjct: 142 FSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NYGCGGGYMTNAFQYVQRNRGIDSED 199
Query: 556 TYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFY 735
YPY G + C YN A + ++ NE + AV+ GP++ IDASL SFQFY
Sbjct: 200 AYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFY 259
Query: 736 REGIYNDPTCSKTSPNH 786
+G+Y D CS + NH
Sbjct: 260 SKGVYYDENCSSDNVNH 276
>sp|Q9GLE3|CATK_PIG Cathepsin K precursor
Length = 330
Score = 204 bits (518), Expect = 3e-52
Identities = 104/257 (40%), Positives = 152/257 (59%), Gaps = 3/257 (1%)
Frame = +1
Query: 25 LNNEWKAFKLLFKKEYEP-IDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLNQFADL 201
L+ +W+ +K ++K+Y +DE+ RRLIWE+NL++I HNLEA LG HT+ L +N D+
Sbjct: 23 LDTQWELWKKTYRKQYNSKVDEISRRLIWEKNLKHISIHNLEASLGVHTYELAMNHLGDM 82
Query: 202 TNEEFRSKYLSKNLM-SRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCNAGWA 378
T+EE K + S S+ N +P D +D+RKKG VTPVKNQ C + WA
Sbjct: 83 TSEEVVQKMTGLKVPPSHSRSNDTLYIPDWEGRTPDSIDYRKKGYVTPVKNQGQCGSCWA 142
Query: 379 FAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYY-KPYGMNNEE 555
F++ G+ EG+ +TG L++ S + L+DC N GC GG N+F Y K G+++E+
Sbjct: 143 FSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSED 200
Query: 556 TYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFY 735
YPY G + C YN A + ++ NE + AV+ GP++ IDASL SFQFY
Sbjct: 201 AYPYVGQDENCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFY 260
Query: 736 REGIYNDPTCSKTSPNH 786
+G+Y D C+ + NH
Sbjct: 261 SKGVYYDENCNSDNLNH 277
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 203 bits (516), Expect = 5e-52
Identities = 108/262 (41%), Positives = 151/262 (57%), Gaps = 2/262 (0%)
Frame = +1
Query: 7 PTINAQLNNEWKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLN 186
P + L+ +W +K ++ Y +E RR +WE+N++ I+ HN E GKH FT+ +N
Sbjct: 19 PKFDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMN 78
Query: 187 QFADLTNEEFRSKY-LSKNLMSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGC 363
F D+TNEEFR +N R F P L VDWRKKG VTPVKNQ C
Sbjct: 79 AFGDMTNEEFRQMMGCFRNQKFRK--GKVFREPLFLDL-PKSVDWRKKGYVTPVKNQKQC 135
Query: 364 NAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPY-G 540
+ WAF+ATG+ EG+ +TG L+S SE+ L+DCS GN GC GG +F Y K G
Sbjct: 136 GSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGG 195
Query: 541 MNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLP 720
+++EE+YPY + + CKY + +A+ F VA E + AV+ GP++ +DA
Sbjct: 196 LDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHS 255
Query: 721 SFQFYREGIYNDPTCSKTSPNH 786
SFQFY+ GIY +P CS + +H
Sbjct: 256 SFQFYKSGIYFEPDCSSKNLDH 277
>sp|Q9JIA9|CATR_MOUSE Cathepsin R precursor
Length = 334
Score = 203 bits (516), Expect = 5e-52
Identities = 105/262 (40%), Positives = 159/262 (60%), Gaps = 2/262 (0%)
Frame = +1
Query: 7 PTINAQLNNEWKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLN 186
P +++ L+ EW+ +K+ + K Y +E ++R++WEE L+ I+ HN E LGK+ FT+ +N
Sbjct: 19 PVLDSSLDAEWQDWKIKYNKSYSLKEEKLKRVVWEEKLKMIKLHNRENSLGKNGFTMKMN 78
Query: 187 QFADLTNEEFRSKYLSKNLMSRSQINSKFVMPYKT-KLNDDEVDWRKKGVVTPVKNQYGC 363
+F D T+EEFR + ++ + + K +M + + VDWRKKG VTPV+ Q C
Sbjct: 79 EFGDQTDEEFRKMMIEISVWTHRE--GKSIMKREAGSILPKFVDWRKKGYVTPVRRQGDC 136
Query: 364 NAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNY-YKPYG 540
+A WAFA TG+ E + QTG L S + L+DCS GN+GC GG N+F Y G
Sbjct: 137 DACWAFAVTGAIEAQAIWQTGKLTPLSVQNLVDCSKPQGNNGCLGGDTYNAFQYVLHNGG 196
Query: 541 MNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLP 720
+ +E TYPY G C+YN + A + F+ + ++ +I + AAV+ GP+TA IDAS
Sbjct: 197 LESEATYPYEGKDGPCRYNPKNSKAEITGFVSLPQSEDI-LMAAVATIGPITAGIDASHE 255
Query: 721 SFQFYREGIYNDPTCSKTSPNH 786
SF+ Y+ GIY++P CS + H
Sbjct: 256 SFKNYKGGIYHEPNCSSDTVTH 277
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 202 bits (515), Expect = 7e-52
Identities = 107/261 (40%), Positives = 154/261 (59%), Gaps = 1/261 (0%)
Frame = +1
Query: 7 PTINAQLNNEWKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLN 186
P + + EW +K ++ Y +E RR IWE+N+R IQ HN E G+H F++ +N
Sbjct: 19 PKFDQTFSAEWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMN 78
Query: 187 QFADLTNEEFRSKYLSKNLMSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCN 366
F D+TNEEFR + ++ + + F P K+ VDWR+KG VTPVKNQ C
Sbjct: 79 AFGDMTNEEFR-QVVNGYRHQKHKKGRLFQEPLMLKI-PKSVDWREKGCVTPVKNQGQCG 136
Query: 367 AGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPY-GM 543
+ WAF+A+G EG+ ++TG L+S SE+ L+DCS A GN GC GG D +F Y K G+
Sbjct: 137 SCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGL 196
Query: 544 NNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPS 723
++EE+YPY CKY +A+ F+D+ + E + AV+ GP++ +DAS PS
Sbjct: 197 DSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPS 255
Query: 724 FQFYREGIYNDPTCSKTSPNH 786
QFY GIY +P CS + +H
Sbjct: 256 LQFYSSGIYYEPNCSSKNLDH 276
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 202 bits (514), Expect = 8e-52
Identities = 104/260 (40%), Positives = 151/260 (58%), Gaps = 1/260 (0%)
Frame = +1
Query: 10 TINAQLNNEWKAFKLLFKKEYEPIDEVVRRLIWEENLRYIQKHNLEADLGKHTFTLGLNQ 189
T + L +W +K + + Y +E RR +WE+N++ I+ HN E GKH+FT+ +N
Sbjct: 20 TFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNA 79
Query: 190 FADLTNEEFRSKYLSKNLMSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCNA 369
F D+T+EEFR + +R K VDWR+KG VTPVKNQ C +
Sbjct: 80 FGDMTSEEFRQ--VMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGS 137
Query: 370 GWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPY-GMN 546
WAF+ATG+ EG+ +TG L+S SE+ L+DCS GN GC GG D +F Y + G++
Sbjct: 138 CWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLD 197
Query: 547 NEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSF 726
+EE+YPY ++ CKYN +A+ F+D+ + E + AV+ GP++ IDA SF
Sbjct: 198 SEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESF 256
Query: 727 QFYREGIYNDPTCSKTSPNH 786
FY+EGIY +P CS +H
Sbjct: 257 LFYKEGIYFEPDCSSEDMDH 276
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.316 0.133 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,007,807
Number of Sequences: 369166
Number of extensions: 1717941
Number of successful extensions: 5113
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4619
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4762
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7454154400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)