Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_B08
(847 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P16970|ABCD3_RAT ATP-binding cassette sub-family D membe... 334 2e-91
sp|P28288|ABCD3_HUMAN ATP-binding cassette sub-family D mem... 333 3e-91
sp|P55096|ABCD3_MOUSE ATP-binding cassette sub-family D mem... 323 4e-88
sp|Q9UBJ2|ABCD2_HUMAN ATP-binding cassette sub-family D mem... 260 4e-69
sp|P33897|ABCD1_HUMAN ATP-binding cassette sub-family D mem... 259 7e-69
sp|Q61285|ABCD2_MOUSE ATP-binding cassette sub-family D mem... 256 4e-68
sp|P48410|ABCD1_MOUSE ATP-binding cassette sub-family D mem... 253 5e-67
sp|P34230|PXA2_YEAST Peroxisomal long-chain fatty acid impo... 193 6e-49
sp|P41909|PXA1_YEAST Peroxisomal long-chain fatty acid impo... 160 5e-39
sp|Q55774|Y182_SYNY3 Hypothetical ABC transporter ATP-bindi... 160 5e-39
>sp|P16970|ABCD3_RAT ATP-binding cassette sub-family D member 3 (70 kDa peroxisomal
membrane protein) (PMP70)
Length = 659
Score = 334 bits (856), Expect = 2e-91
Identities = 158/262 (60%), Positives = 196/262 (74%), Gaps = 4/262 (1%)
Frame = +2
Query: 2 LNEINYGIYNPKLPIGASETKENEKPIQAI----NVAYKDNIIKFEDVPIITPNGDVLIN 169
L ++N+G Y + + E + I + DNIIKF+ VP+ TPNGD+LI
Sbjct: 398 LKDLNHGKYERTMVSQQDKGIEGAQASPLIPGAGEIINADNIIKFDHVPLATPNGDILIQ 457
Query: 170 KISFEVKSGCNVLICGPNGCGKSSLFRILSGIWPQFGGKISKPTNFKLFYIPQKPYMTIG 349
+SFEV+SG NVLICGPNGCGKSSLFR+L +WP FGG ++KP KLFY+PQ+PYMT+G
Sbjct: 458 DLSFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGHLTKPERGKLFYVPQRPYMTLG 517
Query: 350 NLRDQIIYPDSINIMKMIEFEDHHLYTIMKKVELEYIITREGGWDSLRDWSEVLSGGEKQ 529
LRDQ+IYPD K D L + V+L +I+ REGGWDS++DW +VLSGGEKQ
Sbjct: 518 TLRDQVIYPDGKEDQKKKGISDQVLKGYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQ 577
Query: 530 RVAMARLFYHKPQFAILDECTSAVSVDVEDILYAYCREIGITLFTVSHRKSLWKHHEYYL 709
R+AMARLFYHKPQFAILDECTSAVSVDVED +Y++CR++GITLFTVSHRKSLWKHHEYYL
Sbjct: 578 RMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHRKSLWKHHEYYL 637
Query: 710 YMDGKGGYSFQHISEEANIFGS 775
+MDG+G Y F+ I+E+ FGS
Sbjct: 638 HMDGRGNYEFKKITEDTVEFGS 659
>sp|P28288|ABCD3_HUMAN ATP-binding cassette sub-family D member 3 (70 kDa peroxisomal
membrane protein) (PMP70)
Length = 659
Score = 333 bits (855), Expect = 3e-91
Identities = 158/265 (59%), Positives = 200/265 (75%), Gaps = 7/265 (2%)
Frame = +2
Query: 2 LNEINYGIYNPKLPIGASETKENEKPIQAI-------NVAYKDNIIKFEDVPIITPNGDV 160
L ++N+G Y + S+ ++ + +Q I + DNIIKF+ VP+ TPNGDV
Sbjct: 398 LKDLNHGKYERTM---VSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDV 454
Query: 161 LINKISFEVKSGCNVLICGPNGCGKSSLFRILSGIWPQFGGKISKPTNFKLFYIPQKPYM 340
LI ++FEV+SG NVLICGPNGCGKSSLFR+L +WP FGG+++KP KLFY+PQ+PYM
Sbjct: 455 LIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYM 514
Query: 341 TIGNLRDQIIYPDSINIMKMIEFEDHHLYTIMKKVELEYIITREGGWDSLRDWSEVLSGG 520
T+G LRDQ+IYPD K D L + V+L +I+ REGGWDS++DW +VLSGG
Sbjct: 515 TLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGG 574
Query: 521 EKQRVAMARLFYHKPQFAILDECTSAVSVDVEDILYAYCREIGITLFTVSHRKSLWKHHE 700
EKQR+AMARLFYHKPQFAILDECTSAVSVDVE +Y++CR++GITLFTVSHRKSLWKHHE
Sbjct: 575 EKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHE 634
Query: 701 YYLYMDGKGGYSFQHISEEANIFGS 775
YYL+MDG+G Y F+ I+E+ FGS
Sbjct: 635 YYLHMDGRGNYEFKQITEDTVEFGS 659
>sp|P55096|ABCD3_MOUSE ATP-binding cassette sub-family D member 3 (70 kDa peroxisomal
membrane protein) (PMP70) (PMP68)
Length = 659
Score = 323 bits (828), Expect = 4e-88
Identities = 153/262 (58%), Positives = 194/262 (74%), Gaps = 4/262 (1%)
Frame = +2
Query: 2 LNEINYGIYNPKLPIGASETKENEKPIQAI----NVAYKDNIIKFEDVPIITPNGDVLIN 169
L ++N+G Y + + E + + + DNIIKF+ VP+ TPNGD+LI
Sbjct: 398 LKDLNHGRYERTMVSQQGKGIEGAQASPLVPGAGEIINTDNIIKFDHVPLATPNGDILIQ 457
Query: 170 KISFEVKSGCNVLICGPNGCGKSSLFRILSGIWPQFGGKISKPTNFKLFYIPQKPYMTIG 349
+SFEV+SG +VLICGPNG GKSSLFR+L +WP FGG+++KP KLFY+PQ+PYMT+G
Sbjct: 458 DLSFEVRSGNHVLICGPNGRGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLG 517
Query: 350 NLRDQIIYPDSINIMKMIEFEDHHLYTIMKKVELEYIITREGGWDSLRDWSEVLSGGEKQ 529
LRDQ+IYPD K D L + V+L +I+ REGGWDS++DW +VLSGGEKQ
Sbjct: 518 TLRDQVIYPDGKEDQKKRGISDQVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQ 577
Query: 530 RVAMARLFYHKPQFAILDECTSAVSVDVEDILYAYCREIGITLFTVSHRKSLWKHHEYYL 709
R+AMARLFYHKPQFAILDECTSAVSVDVED +Y++CR++GITLFTVSH K LWKHHEYYL
Sbjct: 578 RMAMARLFYHKPQFAILDECTSAVSVDVEDYIYSHCRKVGITLFTVSHTKCLWKHHEYYL 637
Query: 710 YMDGKGGYSFQHISEEANIFGS 775
+MDG+G Y F+ I+E+ FGS
Sbjct: 638 HMDGRGNYEFKKITEDTVEFGS 659
>sp|Q9UBJ2|ABCD2_HUMAN ATP-binding cassette sub-family D member 2
(Adrenoleukodystrophy-related protein) (hALDR)
(Adrenoleukodystrophy-like 1)
Length = 740
Score = 260 bits (664), Expect = 4e-69
Identities = 126/259 (48%), Positives = 180/259 (69%), Gaps = 11/259 (4%)
Frame = +2
Query: 5 NEINYGIYNPKLPIGASETKEN-----EKPIQAINVAYKDNIIKF------EDVPIITPN 151
+E+ GIY I SE+ E P+ +A K +I E+VPIITP
Sbjct: 431 DEVKRGIYKRTAVIQESESHSKNGAKVELPLSD-TLAIKGKVIDVDHGIICENVPIITPA 489
Query: 152 GDVLINKISFEVKSGCNVLICGPNGCGKSSLFRILSGIWPQFGGKISKPTNFKLFYIPQK 331
G+V+ ++++F+V+ G ++LI GPNGCGKSSLFRILSG+WP + G + KP +FYIPQ+
Sbjct: 490 GEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQR 549
Query: 332 PYMTIGNLRDQIIYPDSINIMKMIEFEDHHLYTIMKKVELEYIITREGGWDSLRDWSEVL 511
PYM++G+LRDQ+IYPDS++ M + D L I+ V L +I+ REGGWD++ DW +VL
Sbjct: 550 PYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDAVMDWKDVL 609
Query: 512 SGGEKQRVAMARLFYHKPQFAILDECTSAVSVDVEDILYAYCREIGITLFTVSHRKSLWK 691
SGGEKQR+ MAR+FYHKP++A+LDECTSAVS+DVE ++ + GI+L +++HR SLWK
Sbjct: 610 SGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLSITHRPSLWK 669
Query: 692 HHEYYLYMDGKGGYSFQHI 748
+H + L DG+GG+ F+ +
Sbjct: 670 YHTHLLQFDGEGGWRFEQL 688
>sp|P33897|ABCD1_HUMAN ATP-binding cassette sub-family D member 1 (Adrenoleukodystrophy
protein) (ALDP)
Length = 745
Score = 259 bits (662), Expect = 7e-69
Identities = 109/214 (50%), Positives = 163/214 (76%)
Frame = +2
Query: 125 EDVPIITPNGDVLINKISFEVKSGCNVLICGPNGCGKSSLFRILSGIWPQFGGKISKPTN 304
E++PI+TP+G+V++ ++ V+ G ++LI GPNGCGKSSLFRIL G+WP +GG + KP
Sbjct: 477 ENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPP 536
Query: 305 FKLFYIPQKPYMTIGNLRDQIIYPDSINIMKMIEFEDHHLYTIMKKVELEYIITREGGWD 484
++FYIPQ+PYM++G+LRDQ+IYPDS+ M+ + + L I+ V L +I+ REGGW+
Sbjct: 537 QRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWE 596
Query: 485 SLRDWSEVLSGGEKQRVAMARLFYHKPQFAILDECTSAVSVDVEDILYAYCREIGITLFT 664
++ DW +VLSGGEKQR+ MAR+FYH+P++A+LDECTSAVS+DVE ++ ++ GI L +
Sbjct: 597 AMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLS 656
Query: 665 VSHRKSLWKHHEYYLYMDGKGGYSFQHISEEANI 766
++HR SLWK+H + L DG+GG+ F+ + A +
Sbjct: 657 ITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARL 690
>sp|Q61285|ABCD2_MOUSE ATP-binding cassette sub-family D member 2
(Adrenoleukodystrophy-related protein)
Length = 741
Score = 256 bits (655), Expect = 4e-68
Identities = 116/214 (54%), Positives = 164/214 (76%)
Frame = +2
Query: 107 DNIIKFEDVPIITPNGDVLINKISFEVKSGCNVLICGPNGCGKSSLFRILSGIWPQFGGK 286
D+ I E+VPIITP G+V+ ++++F+V+ G ++LI GPNGCGKSSLFRILSG+WP + G
Sbjct: 476 DHGIICENVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGV 535
Query: 287 ISKPTNFKLFYIPQKPYMTIGNLRDQIIYPDSINIMKMIEFEDHHLYTIMKKVELEYIIT 466
+ KP +FYIPQ+PYM++G+LRDQ+IYPDS + M+ + D L I+ V L +I+
Sbjct: 536 LYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDSADDMREKGYTDQDLERILHSVHLYHIVQ 595
Query: 467 REGGWDSLRDWSEVLSGGEKQRVAMARLFYHKPQFAILDECTSAVSVDVEDILYAYCREI 646
REGGWD++ DW +VLSGGEKQR+ MAR+FYHKP++A+LDECTSAVS+DVE ++
Sbjct: 596 REGGWDAVMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAIGA 655
Query: 647 GITLFTVSHRKSLWKHHEYYLYMDGKGGYSFQHI 748
GI+L +++HR SLWK+H + L DG+GG+ F+ +
Sbjct: 656 GISLLSITHRPSLWKYHTHLLQFDGEGGWRFEQL 689
>sp|P48410|ABCD1_MOUSE ATP-binding cassette sub-family D member 1 (Adrenoleukodystrophy
protein) (ALDP)
Length = 736
Score = 253 bits (646), Expect = 5e-67
Identities = 109/214 (50%), Positives = 159/214 (74%)
Frame = +2
Query: 125 EDVPIITPNGDVLINKISFEVKSGCNVLICGPNGCGKSSLFRILSGIWPQFGGKISKPTN 304
E++PIITP G+V++ ++ V+ G ++LI GPNGCGKSSLFRIL G+WP + G + KP
Sbjct: 477 ENIPIITPTGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPP 536
Query: 305 FKLFYIPQKPYMTIGNLRDQIIYPDSINIMKMIEFEDHHLYTIMKKVELEYIITREGGWD 484
++FYIPQ+PYM++G+LRDQ+IYPDS M+ + L I+ V L +I+ REGGW+
Sbjct: 537 QRMFYIPQRPYMSVGSLRDQVIYPDSAEDMRRKGCSEQQLEAILGIVHLRHILQREGGWE 596
Query: 485 SLRDWSEVLSGGEKQRVAMARLFYHKPQFAILDECTSAVSVDVEDILYAYCREIGITLFT 664
++ DW +VLSGGEKQR+ MAR+FYH+P++A+LDECTSAVS+DVE ++ ++ GI L +
Sbjct: 597 AVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLS 656
Query: 665 VSHRKSLWKHHEYYLYMDGKGGYSFQHISEEANI 766
++HR SLWK+H + L DG+GG+ F+ + A +
Sbjct: 657 ITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARL 690
>sp|P34230|PXA2_YEAST Peroxisomal long-chain fatty acid import protein 1 (Peroxisomal ABC
transporter 2)
Length = 853
Score = 193 bits (490), Expect = 6e-49
Identities = 112/276 (40%), Positives = 155/276 (56%), Gaps = 51/276 (18%)
Frame = +2
Query: 65 ENEKPIQAINVAYKDNIIKFEDVPIITPNGDVLINKISFEVKSGCNVLICGPNGCGKSSL 244
E E + V Y D+ IKFE++P+ITP VL+ ++SF++K G ++LI GPNGCGKSSL
Sbjct: 455 EKEPRDERCIVEYDDSRIKFENIPLITPANQVLVPELSFDLKHGNHLLIIGPNGCGKSSL 514
Query: 245 FRILSGIWP-------QFGGKISKPT-----NFKLFYIPQKPYMTIGN---LRDQIIYPD 379
FRIL G+WP K+ P + +FY+PQ+PYM GN R+QIIYPD
Sbjct: 515 FRILGGLWPIRATPNKNHQSKLIMPRRTVDRDCAIFYLPQRPYM--GNRSTFREQIIYPD 572
Query: 380 SINIMKM-----IEFEDHHLYTIMKKVELEYIITRE------------------------ 472
SI K + D L I++ ++LE ++T
Sbjct: 573 SIEQFKERYHNDYDLGDADLIKILQLLDLEDLVTENMSLLLAQRTSKNDSQQLSTEDNQS 632
Query: 473 -------GGWDSLRDWSEVLSGGEKQRVAMARLFYHKPQFAILDECTSAVSVDVEDILYA 631
+ +R+WSE L+ G +QR+AMAR++YHKP+FA+LDECTSAV+ ++E +Y
Sbjct: 633 PCAIKVRDAFSIVRNWSEELTIGVQQRLAMARMYYHKPKFAVLDECTSAVAPEMEQRMYE 692
Query: 632 YCREIGITLFTVSHRKSLWKHHEYYLYMDGKGGYSF 739
+ GI+L +V HR SLW H Y L DGKGGY F
Sbjct: 693 NAQNFGISLISVCHRTSLWHFHNYLLKFDGKGGYQF 728
>sp|P41909|PXA1_YEAST Peroxisomal long-chain fatty acid import protein 2 (Peroxisomal ABC
transporter 1)
Length = 758
Score = 160 bits (404), Expect = 5e-39
Identities = 96/249 (38%), Positives = 141/249 (56%), Gaps = 44/249 (17%)
Frame = +2
Query: 110 NIIKFEDVPIITPN-----GDVLINKISFEVK---------------------------- 190
N I+ E++ +I P+ G LINK++F++
Sbjct: 464 NGIRLENIDVIIPSVRASEGIKLINKLTFQIPLHIDPITSKSNSIQDLSKANDIKLPFLQ 523
Query: 191 -SGCNVLICGPNGCGKSSLFRILSGIWPQFG--GKISKPTNFKLFYIPQKPYMTIGN-LR 358
SG ++LI GPNGCGKSS+ RI++ IWP + G +S P+ +F+IPQKPY + G LR
Sbjct: 524 GSGSSLLILGPNGCGKSSIQRIIAEIWPVYNKNGLLSIPSENNIFFIPQKPYFSRGGTLR 583
Query: 359 DQIIYPDSINIMKMIEFEDHHLYTIMKKVELEYIITREGGW---DSLRDWSEVLSGGEKQ 529
DQIIYP S + F D L I+ +V+L+Y++ R G D++ DW ++LSGGEKQ
Sbjct: 584 DQIIYPMSSDEFFDRGFRDKELVQILVEVKLDYLLKRGVGLTYLDAIADWKDLLSGGEKQ 643
Query: 530 RVAMARLFYHKPQFAILDECTSAVSVDVEDILYAYCREIGITLFTVSHRKSLWKHHEYYL 709
RV AR+ +HKP + +LDE T+A+SVD+ED L+ + ++S R +L K+HE L
Sbjct: 644 RVNFARIMFHKPLYVVLDEATNAISVDMEDYLFNLLKRYRFNFISISQRPTLIKYHEMLL 703
Query: 710 YM----DGK 724
+ DGK
Sbjct: 704 EIGENRDGK 712
>sp|Q55774|Y182_SYNY3 Hypothetical ABC transporter ATP-binding protein sll0182
Length = 661
Score = 160 bits (404), Expect = 5e-39
Identities = 85/213 (39%), Positives = 128/213 (60%), Gaps = 1/213 (0%)
Frame = +2
Query: 116 IKFEDVPIITPNGD-VLINKISFEVKSGCNVLICGPNGCGKSSLFRILSGIWPQFGGKIS 292
+ E+V + PN +L+ +S V G ++LI GP+G GKSSL R ++G+W G I
Sbjct: 453 VALENVTLSPPNSSRILVRDLSLAVAPGNHLLIMGPSGSGKSSLLRAIAGLWDSGQGTIE 512
Query: 293 KPTNFKLFYIPQKPYMTIGNLRDQIIYPDSINIMKMIEFEDHHLYTIMKKVELEYIITRE 472
+P L ++PQ+PYM +G LR+Q+IYP + +I +D L + KV L + R
Sbjct: 513 RPELADLLFLPQRPYMILGTLREQLIYPSAQSIA-----DDDFLLETLNKVNLPDLAERF 567
Query: 473 GGWDSLRDWSEVLSGGEKQRVAMARLFYHKPQFAILDECTSAVSVDVEDILYAYCREIGI 652
GG DSL +WS VLS GE+QR+A+AR+F ++P++AILDE TSA+ V+ E LY ++G
Sbjct: 568 GGLDSLENWSSVLSLGEQQRIALARVFINQPRYAILDEATSALDVNNEAELYHALTDLGT 627
Query: 653 TLFTVSHRKSLWKHHEYYLYMDGKGGYSFQHIS 751
T +V HR +L H L + +G + I+
Sbjct: 628 TFISVGHRPTLRNFHRQCLEVQAEGRWQISPIN 660
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 100,307,694
Number of Sequences: 369166
Number of extensions: 2155807
Number of successful extensions: 9930
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 8224
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 9371
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8293644780
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)