Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_B01
(884 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y6W6|DUS10_HUMAN Dual specificity protein phosphatase ... 165 2e-40
sp|Q9ESS0|DUS10_MOUSE Dual specificity protein phosphatase ... 165 2e-40
sp|Q05923|DUS2_HUMAN Dual specificity protein phosphatase 2... 115 2e-25
sp|Q16828|DUS6_HUMAN Dual specificity protein phosphatase 6... 115 2e-25
sp|Q64346|DUS6_RAT Dual specificity protein phosphatase 6 (... 115 2e-25
sp|Q9DBB1|DUS6_MOUSE Dual specificity protein phosphatase 6... 115 2e-25
sp|Q05922|DUS2_MOUSE Dual specificity protein phosphatase 2... 115 2e-25
sp|P28562|DUS1_HUMAN Dual specificity protein phosphatase 1... 113 6e-25
sp|Q99956|DUS9_HUMAN Dual specificity protein phosphatase 9... 113 8e-25
sp|Q16829|DUS7_HUMAN Dual specificity protein phosphatase 7... 112 1e-24
>sp|Q9Y6W6|DUS10_HUMAN Dual specificity protein phosphatase 10 (Mitogen-activated protein
kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5)
Length = 482
Score = 165 bits (417), Expect = 2e-40
Identities = 79/154 (51%), Positives = 109/154 (70%), Gaps = 2/154 (1%)
Frame = +1
Query: 127 DVLNATISEILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVPFYRED--LFIYKRLSA 300
D+ NA ++ ILPFLFLGNE D+ D++ +Q I +++NVTT++P Y + LF YKRL A
Sbjct: 316 DIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPA 375
Query: 301 TDCNKQDMRAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTI 480
TD NKQ++R Y+ EA +FI+EA+ +L+HC AGVSRSATIV AYL+KHT++ +
Sbjct: 376 TDSNKQNLRQYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAY 435
Query: 481 TFLQSKRPIVEPNFNFLGQLERYYCDLERGVESR 582
F++ KRPI+ PN NF+GQL + DL GV R
Sbjct: 436 KFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPR 469
>sp|Q9ESS0|DUS10_MOUSE Dual specificity protein phosphatase 10 (Mitogen-activated protein
kinase phosphatase 5) (MAP kinase phosphatase 5) (MKP-5)
Length = 483
Score = 165 bits (417), Expect = 2e-40
Identities = 79/154 (51%), Positives = 109/154 (70%), Gaps = 2/154 (1%)
Frame = +1
Query: 127 DVLNATISEILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVPFYRED--LFIYKRLSA 300
D+ NA ++ ILPFLFLGNE D+ D++ +Q I +++NVTT++P Y + LF YKRL A
Sbjct: 317 DIENAELTPILPFLFLGNEQDAQDLDTMQRLNIGYVINVTTHLPLYHYEKGLFNYKRLPA 376
Query: 301 TDCNKQDMRAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTI 480
TD NKQ++R Y+ EA +FI+EA+ +L+HC AGVSRSATIV AYL+KHT++ +
Sbjct: 377 TDSNKQNLRRYFEEAFEFIEEAHQCGKGLLIHCQAGVSRSATIVIAYLMKHTRMTMTDAY 436
Query: 481 TFLQSKRPIVEPNFNFLGQLERYYCDLERGVESR 582
F++ KRPI+ PN NF+GQL + DL GV R
Sbjct: 437 KFVKGKRPIISPNLNFMGQLLEFEEDLNNGVTPR 470
>sp|Q05923|DUS2_HUMAN Dual specificity protein phosphatase 2 (Dual specificity protein
phosphatase PAC-1)
Length = 314
Score = 115 bits (288), Expect = 2e-25
Identities = 57/133 (42%), Positives = 89/133 (66%)
Frame = +1
Query: 151 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVPFYREDLFIYKRLSATDCNKQDMRA 330
EILP+LFLG+ S+D++ LQ IT +LNV+ + P + E LF YK + D ++ A
Sbjct: 175 EILPYLFLGSCSHSSDLQGLQACGITAVLNVSASCPNHFEGLFRYKSIPVEDNQMVEISA 234
Query: 331 YYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRPIV 510
++ EAI FID + G+VLVHC AG+SRSATI AYL++ ++ + + F++ +R ++
Sbjct: 235 WFQEAIGFIDWVKNSGGRVLVHCQAGISRSATICLAYLMQSRRVRLDEAFDFVKQRRGVI 294
Query: 511 EPNFNFLGQLERY 549
PNF+F+GQL ++
Sbjct: 295 SPNFSFMGQLLQF 307
>sp|Q16828|DUS6_HUMAN Dual specificity protein phosphatase 6 (Mitogen-activated protein
kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
(Dual specificity protein phosphatase PYST1)
Length = 381
Score = 115 bits (287), Expect = 2e-25
Identities = 65/150 (43%), Positives = 92/150 (61%), Gaps = 2/150 (1%)
Frame = +1
Query: 97 SPTNESNRSTDVLNATISEILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVP--FYRE 270
SP + S S V EILPFL+LG DS +++VL+E I +ILNVT N+P F
Sbjct: 197 SPLSNSQPSFPV------EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENA 250
Query: 271 DLFIYKRLSATDCNKQDMRAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLK 450
F YK++ +D Q++ ++ EAI FIDEA +N VLVHC AG+SRS T+ AYL++
Sbjct: 251 GEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQ 310
Query: 451 HTKLNVLQTITFLQSKRPIVEPNFNFLGQL 540
L++ ++ K+ + PNFNF+GQL
Sbjct: 311 KLNLSMNDAYDIVKMKKSNISPNFNFMGQL 340
>sp|Q64346|DUS6_RAT Dual specificity protein phosphatase 6 (Mitogen-activated protein
kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Length = 381
Score = 115 bits (287), Expect = 2e-25
Identities = 65/150 (43%), Positives = 92/150 (61%), Gaps = 2/150 (1%)
Frame = +1
Query: 97 SPTNESNRSTDVLNATISEILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVP--FYRE 270
SP + S S V EILPFL+LG DS +++VL+E I +ILNVT N+P F
Sbjct: 197 SPLSNSQPSFPV------EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENA 250
Query: 271 DLFIYKRLSATDCNKQDMRAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLK 450
F YK++ +D Q++ ++ EAI FIDEA +N VLVHC AG+SRS T+ AYL++
Sbjct: 251 GEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQ 310
Query: 451 HTKLNVLQTITFLQSKRPIVEPNFNFLGQL 540
L++ ++ K+ + PNFNF+GQL
Sbjct: 311 KLNLSMNDAYDIVKMKKSNISPNFNFMGQL 340
>sp|Q9DBB1|DUS6_MOUSE Dual specificity protein phosphatase 6 (Mitogen-activated protein
kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
Length = 381
Score = 115 bits (287), Expect = 2e-25
Identities = 65/150 (43%), Positives = 92/150 (61%), Gaps = 2/150 (1%)
Frame = +1
Query: 97 SPTNESNRSTDVLNATISEILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVP--FYRE 270
SP + S S V EILPFL+LG DS +++VL+E I +ILNVT N+P F
Sbjct: 197 SPLSNSQPSFPV------EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENA 250
Query: 271 DLFIYKRLSATDCNKQDMRAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLK 450
F YK++ +D Q++ ++ EAI FIDEA +N VLVHC AG+SRS T+ AYL++
Sbjct: 251 GEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQ 310
Query: 451 HTKLNVLQTITFLQSKRPIVEPNFNFLGQL 540
L++ ++ K+ + PNFNF+GQL
Sbjct: 311 KLNLSMNDAYDIVKMKKSNISPNFNFMGQL 340
>sp|Q05922|DUS2_MOUSE Dual specificity protein phosphatase 2 (Dual specificity protein
phosphatase PAC-1)
Length = 318
Score = 115 bits (287), Expect = 2e-25
Identities = 56/130 (43%), Positives = 87/130 (66%)
Frame = +1
Query: 151 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVPFYREDLFIYKRLSATDCNKQDMRA 330
EILP+L+LG+ S+D++ LQ IT +LNV+ + P + E LF YK + D ++ A
Sbjct: 179 EILPYLYLGSCNHSSDLQGLQACGITAVLNVSASCPNHFEGLFHYKSIPVEDNQMVEISA 238
Query: 331 YYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRPIV 510
++ EAI FID + G+VLVHC AG+SRSATI AYL++ ++ + + F++ +R ++
Sbjct: 239 WFQEAISFIDSVKNSGGRVLVHCQAGISRSATICLAYLIQSHRVRLDEAFDFVKQRRGVI 298
Query: 511 EPNFNFLGQL 540
PNF+F+GQL
Sbjct: 299 SPNFSFMGQL 308
>sp|P28562|DUS1_HUMAN Dual specificity protein phosphatase 1 (MAP kinase phosphatase 1)
(MKP-1) (Protein-tyrosine phosphatase CL100) (Dual
specificity protein phosphatase hVH1)
Length = 367
Score = 113 bits (283), Expect = 6e-25
Identities = 56/147 (38%), Positives = 92/147 (62%), Gaps = 7/147 (4%)
Frame = +1
Query: 151 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVPFYREDLFIYKRLSATDCNKQDMRA 330
EILPFL+LG+ ++ ++L IT ++NV+ N P + E + YK + D +K D+ +
Sbjct: 176 EILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISS 235
Query: 331 YYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRPIV 510
+++EAI FID + G+V VHC AG+SRSATI AYL++ ++ + + F++ +R I+
Sbjct: 236 WFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSII 295
Query: 511 EPNFNFLGQLERY-------YCDLERG 570
PNF+F+GQL ++ +C E G
Sbjct: 296 SPNFSFMGQLLQFESQVLAPHCSAEAG 322
>sp|Q99956|DUS9_HUMAN Dual specificity protein phosphatase 9 (Mitogen-activated protein
kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4)
Length = 384
Score = 113 bits (282), Expect = 8e-25
Identities = 67/156 (42%), Positives = 96/156 (61%), Gaps = 5/156 (3%)
Frame = +1
Query: 151 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVP--FYREDLFIYKRLSATDCNKQDM 324
+ILP L+LG+ DS ++E L + I +ILNVT N+P F + F YK++ +D Q++
Sbjct: 206 QILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNGDFHYKQIPISDHWSQNL 265
Query: 325 RAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRP 504
++ EAI+FIDEA SQN VLVHC AGVSRS T+ AYL++ L++ ++ K+
Sbjct: 266 SRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKKS 325
Query: 505 IVEPNFNFLGQLERYYCDLERGV---ESRSKEFSFG 603
+ PNFNF+GQL D ER + E S+E G
Sbjct: 326 NISPNFNFMGQL----LDFERSLRLEERHSQEQGSG 357
>sp|Q16829|DUS7_HUMAN Dual specificity protein phosphatase 7 (Dual specificity protein
phosphatase PYST2)
Length = 368
Score = 112 bits (281), Expect = 1e-24
Identities = 66/171 (38%), Positives = 98/171 (57%), Gaps = 2/171 (1%)
Frame = +1
Query: 151 EILPFLFLGNEMDSNDVEVLQEKKITHILNVTTNVP--FYREDLFIYKRLSATDCNKQDM 324
+ILP+L+LG DS +++VL + I +ILNVT N+P F F YK++ +D Q++
Sbjct: 196 QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNL 255
Query: 325 RAYYHEAIQFIDEAYSQNGKVLVHCWAGVSRSATIVAAYLLKHTKLNVLQTITFLQSKRP 504
++ EAI FIDEA S+ VLVHC AG+SRS T+ AYL++ L++ F++ K+
Sbjct: 256 SQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKS 315
Query: 505 IVEPNFNFLGQLERYYCDLERGVESRSKEFSFGQVEQIARKLASEHEKMKL 657
+ PNFNF+GQL D ER + S + EQ+ + H L
Sbjct: 316 NISPNFNFMGQL----LDFERTLGLSSPCDNHASSEQLYFSTPTNHNLFPL 362
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,250,307
Number of Sequences: 369166
Number of extensions: 1720734
Number of successful extensions: 4238
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4071
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4209
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8838279920
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)