Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_A23
(863 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P20488|SYPH_BOVIN Synaptophysin (Major synaptic vesicle ... 160 4e-39
sp|P08247|SYPH_HUMAN Synaptophysin (Major synaptic vesicle ... 157 5e-38
sp|P07825|SYPH_RAT Synaptophysin (Major synaptic vesicle pr... 153 7e-37
sp|Q62277|SYPH_MOUSE Synaptophysin (Major synaptic vesicle ... 153 7e-37
sp|Q8TBG9|SYNPR_HUMAN Synaptoporin 144 2e-34
sp|P22831|SYNPR_RAT Synaptoporin 144 2e-34
sp|Q8BGN8|SYNPR_MOUSE Synaptoporin 142 9e-34
sp|O09117|SYPL_MOUSE Synaptophysin-like protein (Pantophysin) 135 2e-31
sp|Q16563|SYPL_HUMAN Synaptophysin-like protein (Pantophysin) 129 1e-29
sp|Q5VXT5|SYPL2_HUMAN Synaptophysin-like protein 2 125 2e-28
>sp|P20488|SYPH_BOVIN Synaptophysin (Major synaptic vesicle protein p38)
Length = 313
Score = 160 bits (405), Expect = 4e-39
Identities = 80/201 (39%), Positives = 112/201 (55%), Gaps = 2/201 (0%)
Frame = +3
Query: 9 FIKILQIVLTIIAFALXXXXXXXXEISYQCINNTKHEI-LRVNYSYPFNINGSNKNIEIC 185
F+K+LQ V I AFA ++S C N TK ++ + V + YPF ++ C
Sbjct: 28 FVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTKSDLNIEVEFEYPFRLHEVYFEAPTC 87
Query: 186 SKANREAIVYGNYSSQSQFFVFVGVIAMLYCLAAIILYVFFSEMSFQNDRIPKIDFIITA 365
++ + GNYSS ++FFV V V A LY + A+ Y+F +N++ P +DF+ TA
Sbjct: 88 QGDPKKIFLVGNYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMLDFLATA 147
Query: 366 VIAILWFICSVAWADGVSKLKMYTDPAKIILGIEYCTSTGK-CKASLYGSYGGLNASLIA 542
V A +W + S AWA G+S +KM TDP II G+ C G CK GLN S++
Sbjct: 148 VFAFMWLVSSSAWAKGLSDVKMATDPENIIKGMHVCHQPGNTCKELRDPVTSGLNTSVVF 207
Query: 543 GFANIALWAANLWFLFKETLW 605
GF N+ LW NLWF+FKET W
Sbjct: 208 GFLNLVLWVGNLWFVFKETGW 228
>sp|P08247|SYPH_HUMAN Synaptophysin (Major synaptic vesicle protein p38)
Length = 313
Score = 157 bits (396), Expect = 5e-38
Identities = 78/201 (38%), Positives = 112/201 (55%), Gaps = 2/201 (0%)
Frame = +3
Query: 9 FIKILQIVLTIIAFALXXXXXXXXEISYQCINNTKHEI-LRVNYSYPFNINGSNKNIEIC 185
F+K+LQ V I AFA ++S C N T+ ++ + V + YPF ++ + C
Sbjct: 28 FVKVLQWVFAIFAFATCGSYSGELQLSVDCANKTESDLSIEVEFEYPFRLHQVYFDAPTC 87
Query: 186 SKANREAIVYGNYSSQSQFFVFVGVIAMLYCLAAIILYVFFSEMSFQNDRIPKIDFIITA 365
+ + G+YSS ++FFV V V A LY + A+ Y+F +N++ P +DF+ TA
Sbjct: 88 RGGTTKVFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMLDFLATA 147
Query: 366 VIAILWFICSVAWADGVSKLKMYTDPAKIILGIEYCTSTGK-CKASLYGSYGGLNASLIA 542
V A +W + S AWA G+S +KM TDP II + C TG CK GLN S++
Sbjct: 148 VFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPVCRQTGNTCKELRDPVTSGLNTSVVF 207
Query: 543 GFANIALWAANLWFLFKETLW 605
GF N+ LW NLWF+FKET W
Sbjct: 208 GFLNLVLWVGNLWFVFKETGW 228
>sp|P07825|SYPH_RAT Synaptophysin (Major synaptic vesicle protein p38)
Length = 307
Score = 153 bits (386), Expect = 7e-37
Identities = 80/202 (39%), Positives = 112/202 (55%), Gaps = 3/202 (1%)
Frame = +3
Query: 9 FIKILQIVLTIIAFALXXXXXXXXEISYQCINNTKHEI-LRVNYSYPFNINGSNKNIEIC 185
F+K+LQ V I AFA +S +C N T+ + + V + YPF ++ + C
Sbjct: 22 FVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVEFEYPFRLHQVYFDAPSC 81
Query: 186 SKANREAI-VYGNYSSQSQFFVFVGVIAMLYCLAAIILYVFFSEMSFQNDRIPKIDFIIT 362
K I + G+YSS ++FFV V V A LY + A+ Y+F +N++ P +DF+ T
Sbjct: 82 VKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLAT 141
Query: 363 AVIAILWFICSVAWADGVSKLKMYTDPAKIILGIEYCTSTGK-CKASLYGSYGGLNASLI 539
AV A +W + S AWA G+S +KM TDP II + C TG CK GLN S++
Sbjct: 142 AVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVV 201
Query: 540 AGFANIALWAANLWFLFKETLW 605
GF N+ LW NLWF+FKET W
Sbjct: 202 FGFLNLVLWVGNLWFVFKETGW 223
>sp|Q62277|SYPH_MOUSE Synaptophysin (Major synaptic vesicle protein p38) (BM89 antigen)
Length = 314
Score = 153 bits (386), Expect = 7e-37
Identities = 80/202 (39%), Positives = 112/202 (55%), Gaps = 3/202 (1%)
Frame = +3
Query: 9 FIKILQIVLTIIAFALXXXXXXXXEISYQCINNTKHEI-LRVNYSYPFNINGSNKNIEIC 185
F+K+LQ V I AFA +S +C N T+ + + V + YPF ++ + C
Sbjct: 28 FVKVLQWVFAIFAFATCGSYTGELRLSVECANKTESALNIEVEFEYPFRLHQVYFDAPSC 87
Query: 186 SKANREAI-VYGNYSSQSQFFVFVGVIAMLYCLAAIILYVFFSEMSFQNDRIPKIDFIIT 362
K I + G+YSS ++FFV V V A LY + A+ Y+F +N++ P +DF+ T
Sbjct: 88 VKGGTTKIFLVGDYSSSAEFFVTVAVFAFLYSMGALATYIFLQNKYRENNKGPMMDFLAT 147
Query: 363 AVIAILWFICSVAWADGVSKLKMYTDPAKIILGIEYCTSTGK-CKASLYGSYGGLNASLI 539
AV A +W + S AWA G+S +KM TDP II + C TG CK GLN S++
Sbjct: 148 AVFAFMWLVSSSAWAKGLSDVKMATDPENIIKEMPMCRQTGNTCKELRDPVTSGLNTSVV 207
Query: 540 AGFANIALWAANLWFLFKETLW 605
GF N+ LW NLWF+FKET W
Sbjct: 208 FGFLNLVLWVGNLWFVFKETGW 229
>sp|Q8TBG9|SYNPR_HUMAN Synaptoporin
Length = 265
Score = 144 bits (364), Expect = 2e-34
Identities = 73/196 (37%), Positives = 112/196 (57%), Gaps = 3/196 (1%)
Frame = +3
Query: 30 VLTIIAFALXXXXXXXXEISYQCINNTKHEI-LRVNYSYPFNINGSNKNIEICSKANREA 206
+ I AFA +S C+N T+ + + + ++YPF ++ + C R+
Sbjct: 9 LFAIFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQK 68
Query: 207 I-VYGNYSSQSQFFVFVGVIAMLYCLAAIILYVFFSEMSFQNDRIPKIDFIITAVIAILW 383
+ + G+ SS ++FFV V V A LY LAA ++Y+FF +N+R P IDFI+T V + LW
Sbjct: 69 LALIGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLW 128
Query: 384 FICSVAWADGVSKLKMYTDPAKIILGIEYCTS-TGKCKASLYGSYGGLNASLIAGFANIA 560
+ S AWA G+S +K+ TDP +++L + C + KC A LN S++ GF N
Sbjct: 129 LVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAIHSPVMSSLNTSVVFGFLNFI 188
Query: 561 LWAANLWFLFKETLWY 608
LWA N+WF+FKET W+
Sbjct: 189 LWAGNIWFVFKETGWH 204
>sp|P22831|SYNPR_RAT Synaptoporin
Length = 265
Score = 144 bits (364), Expect = 2e-34
Identities = 73/196 (37%), Positives = 112/196 (57%), Gaps = 3/196 (1%)
Frame = +3
Query: 30 VLTIIAFALXXXXXXXXEISYQCINNTKHEI-LRVNYSYPFNINGSNKNIEICSKANREA 206
+ I AFA +S C+N T+ + + + ++YPF ++ + C R+
Sbjct: 9 LFAIFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLHQVTFEVPTCEGKERQK 68
Query: 207 I-VYGNYSSQSQFFVFVGVIAMLYCLAAIILYVFFSEMSFQNDRIPKIDFIITAVIAILW 383
+ + G+ SS ++FFV V V A LY LAA ++Y+FF +N+R P IDFI+T V + LW
Sbjct: 69 LALVGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLW 128
Query: 384 FICSVAWADGVSKLKMYTDPAKIILGIEYCTS-TGKCKASLYGSYGGLNASLIAGFANIA 560
+ S AWA G+S +K+ TDP +++L + C + KC A LN S++ GF N
Sbjct: 129 LVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAVHSPVMSSLNTSVVFGFLNFI 188
Query: 561 LWAANLWFLFKETLWY 608
LWA N+WF+FKET W+
Sbjct: 189 LWAGNIWFVFKETGWH 204
>sp|Q8BGN8|SYNPR_MOUSE Synaptoporin
Length = 265
Score = 142 bits (359), Expect = 9e-34
Identities = 72/196 (36%), Positives = 111/196 (56%), Gaps = 3/196 (1%)
Frame = +3
Query: 30 VLTIIAFALXXXXXXXXEISYQCINNTKHEI-LRVNYSYPFNINGSNKNIEICS-KANRE 203
+ + AFA +S C+N T+ + + + ++YPF + + C K ++
Sbjct: 9 LFAMFAFATCGGYSGGLRLSVDCVNKTESNLSIDIAFAYPFRLQQVTFEVPTCEGKEQQK 68
Query: 204 AIVYGNYSSQSQFFVFVGVIAMLYCLAAIILYVFFSEMSFQNDRIPKIDFIITAVIAILW 383
+ G+ SS ++FFV V V A LY LAA ++Y+FF +N+R P IDFI+T V + LW
Sbjct: 69 LALVGDSSSSAEFFVTVAVFAFLYSLAATVVYIFFQNKYRENNRGPLIDFIVTVVFSFLW 128
Query: 384 FICSVAWADGVSKLKMYTDPAKIILGIEYCTS-TGKCKASLYGSYGGLNASLIAGFANIA 560
+ S AWA G+S +K+ TDP +++L + C + KC A LN S++ GF N
Sbjct: 129 LVGSSAWAKGLSDVKVATDPKEVLLLMSACKQPSNKCMAVHSPVMSSLNTSVVFGFLNFI 188
Query: 561 LWAANLWFLFKETLWY 608
LWA N+WF+FKET W+
Sbjct: 189 LWAGNIWFVFKETGWH 204
>sp|O09117|SYPL_MOUSE Synaptophysin-like protein (Pantophysin)
Length = 261
Score = 135 bits (339), Expect = 2e-31
Identities = 74/214 (34%), Positives = 115/214 (53%), Gaps = 8/214 (3%)
Frame = +3
Query: 9 FIKILQIVLTIIAFALXXXXXXXXEISYQC--INNTKHEILRVNYSYPFNINGSN----K 170
FIKIL+ +I AFA EI C + K++ + + YPF +N ++
Sbjct: 35 FIKILEWFASIFAFATCGGFKGKTEIQVNCPKVGVNKNQTVTATFGYPFRLNQASFHTPP 94
Query: 171 NIEICSKANREAIVYGNYSSQSQFFVFVGVIAMLYCLAAIILYVFFSEMSFQNDRIPKID 350
N+ +C + ++ G+YSS +QF+V V LYC+AA++LYV ++ + + ++P ID
Sbjct: 95 NVSVCDVNWEKHVLIGDYSSSAQFYVTFAVFVFLYCIAALLLYVGYTNLYRDSRKLPMID 154
Query: 351 FIITAVIAILWFICSVAWADGVSKLKMYTDPAKIILGIEYCT--STGKCKASLYGSYGGL 524
FI+T V LW + S AWA ++ +K+ T +I+ +E C S C S G L
Sbjct: 155 FIVTLVATFLWLVSSSAWAKALTDIKVATG-HRIVEELEICNPESGVSCYFVSVTSMGSL 213
Query: 525 NASLIAGFANIALWAANLWFLFKETLWYERRNPS 626
N S+I GF N+ LW N WF++KET + N S
Sbjct: 214 NVSVIFGFLNMILWGGNAWFVYKETSLHSPSNTS 247
>sp|Q16563|SYPL_HUMAN Synaptophysin-like protein (Pantophysin)
Length = 259
Score = 129 bits (323), Expect = 1e-29
Identities = 70/212 (33%), Positives = 113/212 (53%), Gaps = 6/212 (2%)
Frame = +3
Query: 9 FIKILQIVLTIIAFALXXXXXXXXEISYQCINN-TKHEILRVNYSYPFNINGSN----KN 173
FIK+L+ + +I AFA EI C T+++ + + YPF +N ++
Sbjct: 35 FIKVLEWIASIFAFATCGGFKGQTEIQVNCPPAVTENKTVTATFGYPFRLNEASFQPPPG 94
Query: 174 IEICSKANREAIVYGNYSSQSQFFVFVGVIAMLYCLAAIILYVFFSEMSFQNDRIPKIDF 353
+ IC ++ ++ G+YSS +QF+V V LYC+AA++LYV ++ + + ++P IDF
Sbjct: 95 VNICDVNWKDYVLIGDYSSSAQFYVTFAVFVFLYCIAALLLYVGYTSLYLDSRKLPMIDF 154
Query: 354 IITAVIAILWFICSVAWADGVSKLKMYTDPAKIILGIEYCTSTG-KCKASLYGSYGGLNA 530
++T V LW + + AWA ++ +K+ T II + C C S G LN
Sbjct: 155 VVTLVATFLWLVSTSAWAKALTDIKIATG-HNIIDELPPCKKKAVLCYFGSVTSMGSLNV 213
Query: 531 SLIAGFANIALWAANLWFLFKETLWYERRNPS 626
S+I GF N+ LW N WF++KET + N S
Sbjct: 214 SVIFGFLNMILWGGNAWFVYKETSLHSPSNTS 245
>sp|Q5VXT5|SYPL2_HUMAN Synaptophysin-like protein 2
Length = 272
Score = 125 bits (313), Expect = 2e-28
Identities = 63/212 (29%), Positives = 106/212 (50%), Gaps = 4/212 (1%)
Frame = +3
Query: 9 FIKILQIVLTIIAFALXXXXXXXXEISYQCINNTKH-EILRVNYSYPFNINGSNKNIEIC 185
FIK+LQ + I AF +C N K + V + YPF ++ + +C
Sbjct: 37 FIKVLQWLFAIFAFGSCGSYSGETGAMVRCNNEAKDVSSIIVAFGYPFRLHRIQYEMPLC 96
Query: 186 SKANREAIVY--GNYSSQSQFFVFVGVIAMLYCLAAIILYVFFSEMSFQNDRIPKIDFII 359
+ + ++ G++S+ ++FFV +G+ + Y +AA+++Y+ F + +N R P +DF +
Sbjct: 97 DEESSSKTMHLMGDFSAPAEFFVTLGIFSFFYTMAALVIYLRFHNLYTENKRFPLVDFCV 156
Query: 360 TAVIAILWFICSVAWADGVSKLKMYTDPAKIILGIEYC-TSTGKCKASLYGSYGGLNASL 536
T W + + AW G++ +K T P+ + + C C A S G N S+
Sbjct: 157 TVSFTFFWLVAAAAWGKGLTDVKGATRPSSLTAAMSVCHGEEAVCSAGATPSMGLANISV 216
Query: 537 IAGFANIALWAANLWFLFKETLWYERRNPSDQ 632
+ GF N LWA N WF+FKET W+ + DQ
Sbjct: 217 LFGFINFFLWAGNCWFVFKETPWHGQGQGQDQ 248
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,377,417
Number of Sequences: 369166
Number of extensions: 1995815
Number of successful extensions: 4566
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4420
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4544
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8582957970
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)