Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_013_A11
(713 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9D658|TP4A3_MOUSE Protein tyrosine phosphatase type IVA... 132 1e-30
sp|Q6P9X4|TP4A2_RAT Protein tyrosine phosphatase type IVA p... 131 2e-30
sp|O75365|TP4A3_HUMAN Protein tyrosine phosphatase type IVA... 128 2e-29
sp|Q63739|TP4A1_MOUSE Protein tyrosine phosphatase type IVA... 126 5e-29
sp|Q5R7J8|TP4A1_PONPY Protein tyrosine phosphatase type IVA... 125 9e-29
sp|O60729|CC14B_HUMAN Dual specificity protein phosphatase ... 50 8e-06
sp|P81299|CDC14_CAEEL Probable tyrosine-protein phosphatase... 49 1e-05
sp|Q9UNH5|C14A_HUMAN Dual specificity protein phosphatase C... 48 3e-05
sp|Q6GQT0|CC14A_MOUSE Dual specificity protein phosphatase ... 48 3e-05
sp|Q6PFY9|CC14B_MOUSE Dual specificity protein phosphatase ... 47 7e-05
>sp|Q9D658|TP4A3_MOUSE Protein tyrosine phosphatase type IVA protein 3 (Protein-tyrosine
phosphatase 4a3) (Protein-tyrosine phosphatase of
regenerating liver-3) (PRL-3)
Length = 173
Score = 132 bits (331), Expect = 1e-30
Identities = 65/139 (46%), Positives = 89/139 (64%), Gaps = 1/139 (0%)
Frame = +3
Query: 9 SPSQDNVHIFAEECKRLNVSDVVRVCESHYSEDAFKEVDINLWHWEFSDGSPPPADILEK 188
+PS + F E+ K+ + VVRVCE Y + ++ I + W F DG+PPP ++E
Sbjct: 24 NPSNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVED 83
Query: 189 WFQLLKDRF-NSPSHSNGPIAVHCIAGFGRAPVLVAVALMELGMHCEDAIEMIRSKRKGS 365
W LLK +F N P +AVHC+AG GRAPVLVA+AL+E GM EDAI+ IR KR+G+
Sbjct: 84 WLSLLKAKFYNDPGSC---VAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGA 140
Query: 366 FNERQISYLTHYRAKSRLK 422
N +Q++YL YR K RL+
Sbjct: 141 INSKQLTYLEKYRPKQRLR 159
>sp|Q6P9X4|TP4A2_RAT Protein tyrosine phosphatase type IVA protein 2 (Protein-tyrosine
phosphatase 4a2) (Protein-tyrosine phosphatase of
regenerating liver-2) (PRL-2)
sp|O70274|TP4A2_MOUSE Protein tyrosine phosphatase type IVA protein 2 (Protein-tyrosine
phosphatase 4a2) (Protein-tyrosine phosphatase of
regenerating liver-2) (PRL-2)
sp|Q12974|TP4A2_HUMAN Protein tyrosine phosphatase type IVA protein 2 (Protein-tyrosine
phosphatase 4a2) (Protein-tyrosine phosphatase of
regenerating liver-2) (PRL-2) (PTP(CAAXII)) (HU-PP-1)
(OV-1)
Length = 167
Score = 131 bits (329), Expect = 2e-30
Identities = 62/138 (44%), Positives = 91/138 (65%)
Frame = +3
Query: 9 SPSQDNVHIFAEECKRLNVSDVVRVCESHYSEDAFKEVDINLWHWEFSDGSPPPADILEK 188
+P+ ++ F EE K+ V+ +VRVC++ Y + ++ I++ W F DG+PPP I++
Sbjct: 21 NPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDD 80
Query: 189 WFQLLKDRFNSPSHSNGPIAVHCIAGFGRAPVLVAVALMELGMHCEDAIEMIRSKRKGSF 368
W LLK +F +AVHC+AG GRAPVLVA+AL+E GM EDA++ IR KR+G+F
Sbjct: 81 WLNLLKTKFRE--EPGCCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQFIRQKRRGAF 138
Query: 369 NERQISYLTHYRAKSRLK 422
N +Q+ YL YR K RL+
Sbjct: 139 NSKQLLYLEKYRPKMRLR 156
>sp|O75365|TP4A3_HUMAN Protein tyrosine phosphatase type IVA protein 3 (Protein-tyrosine
phosphatase 4a3) (Protein-tyrosine phosphatase of
regenerating liver-3) (PRL-3) (PRL-R)
Length = 173
Score = 128 bits (321), Expect = 2e-29
Identities = 62/138 (44%), Positives = 88/138 (63%)
Frame = +3
Query: 9 SPSQDNVHIFAEECKRLNVSDVVRVCESHYSEDAFKEVDINLWHWEFSDGSPPPADILEK 188
+P+ + F E+ K+ + VVRVCE Y + ++ I + W F DG+PPP ++E
Sbjct: 24 NPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVED 83
Query: 189 WFQLLKDRFNSPSHSNGPIAVHCIAGFGRAPVLVAVALMELGMHCEDAIEMIRSKRKGSF 368
W L+K +F S +AVHC+AG GRAPVLVA+AL+E GM EDAI+ IR KR+G+
Sbjct: 84 WLSLVKAKFCEAPGSC--VAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAI 141
Query: 369 NERQISYLTHYRAKSRLK 422
N +Q++YL YR K RL+
Sbjct: 142 NSKQLTYLEKYRPKQRLR 159
>sp|Q63739|TP4A1_MOUSE Protein tyrosine phosphatase type IVA protein 1 (Protein-tyrosine
phosphatase 4a1) (Protein-tyrosine phosphatase of
regenerating liver-1) (PRL-1)
sp|Q93096|TP4A1_HUMAN Protein tyrosine phosphatase type IVA protein 1 (Protein-tyrosine
phosphatase 4a1) (Protein-tyrosine phosphatase of
regenerating liver-1) (PRL-1) (PTP(CAAXI))
sp|Q78EG7|TP4A1_RAT Protein tyrosine phosphatase type IVA protein 1 (Protein-tyrosine
phosphatase 4a1) (Protein-tyrosine phosphatase of
regenerating liver-1) (PRL-1)
sp|Q9TSM6|TP4A1_MACFA Protein tyrosine phosphatase type IVA protein 1 (Protein-tyrosine
phosphatase 4a1) (Protein-tyrosine phosphatase of
regenerating liver-1) (PRL-1)
Length = 173
Score = 126 bits (317), Expect = 5e-29
Identities = 62/138 (44%), Positives = 89/138 (64%)
Frame = +3
Query: 9 SPSQDNVHIFAEECKRLNVSDVVRVCESHYSEDAFKEVDINLWHWEFSDGSPPPADILEK 188
+P+ ++ F EE K+ V+ +VRVCE+ Y ++ I++ W F DG+PP I++
Sbjct: 24 NPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDD 83
Query: 189 WFQLLKDRFNSPSHSNGPIAVHCIAGFGRAPVLVAVALMELGMHCEDAIEMIRSKRKGSF 368
W L+K +F IAVHC+AG GRAPVLVA+AL+E GM EDA++ IR KR+G+F
Sbjct: 84 WLSLVKIKFRE--EPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAF 141
Query: 369 NERQISYLTHYRAKSRLK 422
N +Q+ YL YR K RL+
Sbjct: 142 NSKQLLYLEKYRPKMRLR 159
>sp|Q5R7J8|TP4A1_PONPY Protein tyrosine phosphatase type IVA protein 1 (Protein-tyrosine
phosphatase 4a1) (Protein-tyrosine phosphatase of
regenerating liver-1) (PRL-1)
Length = 173
Score = 125 bits (315), Expect = 9e-29
Identities = 62/138 (44%), Positives = 89/138 (64%)
Frame = +3
Query: 9 SPSQDNVHIFAEECKRLNVSDVVRVCESHYSEDAFKEVDINLWHWEFSDGSPPPADILEK 188
+P+ ++ F EE K+ V+ +VRVCE+ Y ++ I++ W F DG+PP I++
Sbjct: 24 NPTNATLNKFIEELKKYGVTTIVRVCEATYDTALVEKEGIHVLDWPFDDGAPPSNQIVDG 83
Query: 189 WFQLLKDRFNSPSHSNGPIAVHCIAGFGRAPVLVAVALMELGMHCEDAIEMIRSKRKGSF 368
W L+K +F IAVHC+AG GRAPVLVA+AL+E GM EDA++ IR KR+G+F
Sbjct: 84 WLSLVKIKFRE--EPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAF 141
Query: 369 NERQISYLTHYRAKSRLK 422
N +Q+ YL YR K RL+
Sbjct: 142 NSKQLLYLEKYRPKMRLR 159
>sp|O60729|CC14B_HUMAN Dual specificity protein phosphatase CDC14B (CDC14 cell division
cycle 14 homolog B)
Length = 498
Score = 49.7 bits (117), Expect = 8e-06
Identities = 40/166 (24%), Positives = 73/166 (43%), Gaps = 1/166 (0%)
Frame = +3
Query: 18 QDNVHIFAEECKRLNVSDVVRVCESHYSEDAFKEVDINLWHWEFSDGSPPPADILEKWFQ 197
Q + + + K NV+ ++R+ + Y F + + F+DGS P I++++
Sbjct: 242 QHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLD 301
Query: 198 LLKDRFNSPSHSNGPIAVHCIAGFGRAPVLVAVALME-LGMHCEDAIEMIRSKRKGSFNE 374
+ ++ + G IAVHC AG GR L+A +M+ M + I +R R GS
Sbjct: 302 ICEN-------AEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIG 354
Query: 375 RQISYLTHYRAKSRLKQSHRCLML*PTENNQ*SQSNCRIIGTISSI 512
Q +L + L+ + L EN Q + +++ + I
Sbjct: 355 PQQQFLVMKQTNLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDI 400
>sp|P81299|CDC14_CAEEL Probable tyrosine-protein phosphatase cdc-14 (Cell division
cycle-related protein 14)
Length = 1063
Score = 49.3 bits (116), Expect = 1e-05
Identities = 34/121 (28%), Positives = 58/121 (47%), Gaps = 1/121 (0%)
Frame = +3
Query: 33 IFAEECKRLNVSDVVRVCESHYSEDAFKEVDINLWHWEFSDGSPPPADILEKWFQLLKDR 212
++ + + VS +VR+ +Y F + + F DGS P +I+ K+ +++
Sbjct: 228 VYFDYFRENKVSTIVRLNAKNYDASKFTKAGFDHVDLFFIDGSTPSDEIMLKFIKVV--- 284
Query: 213 FNSPSHSNGPIAVHCIAGFGRAPVLVAVALM-ELGMHCEDAIEMIRSKRKGSFNERQISY 389
++ G +AVHC AG GR L+A +M E G+ + + +R R GS Q Y
Sbjct: 285 ----DNTKGGVAVHCKAGLGRTGTLIACWMMKEYGLTAGECMGWLRVCRPGSVIGPQQPY 340
Query: 390 L 392
L
Sbjct: 341 L 341
Score = 30.4 bits (67), Expect = 4.9
Identities = 12/24 (50%), Positives = 14/24 (58%)
Frame = +3
Query: 33 IFAEECKRLNVSDVVRVCESHYSE 104
+F EEC R+ V C SHYSE
Sbjct: 791 LFVEECTRIYKQPAVYTCSSHYSE 814
>sp|Q9UNH5|C14A_HUMAN Dual specificity protein phosphatase CDC14A (CDC14 cell division
cycle 14 homolog A)
Length = 594
Score = 47.8 bits (112), Expect = 3e-05
Identities = 38/121 (31%), Positives = 57/121 (47%), Gaps = 2/121 (1%)
Frame = +3
Query: 51 KRLNVSDVVRVCESHYSEDAFKEVDINLWHWEFSDGSPPPADILEKWFQLLKDRFNSPSH 230
K+ NV+ VVR+ + Y F + + F DGS P +I+ ++ + ++
Sbjct: 217 KKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICEN------- 269
Query: 231 SNGPIAVHCIAGFGRAPVLVAVALME--LGMHCEDAIEMIRSKRKGSFNERQISYLTHYR 404
+ G IAVHC AG GR L+A +M+ H E I IR R GS Q +L +
Sbjct: 270 TEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAE-IIAWIRICRPGSIIGPQQHFLEEKQ 328
Query: 405 A 407
A
Sbjct: 329 A 329
>sp|Q6GQT0|CC14A_MOUSE Dual specificity protein phosphatase CDC14A (CDC14 cell division
cycle 14 homolog A)
Length = 603
Score = 47.8 bits (112), Expect = 3e-05
Identities = 37/121 (30%), Positives = 57/121 (47%), Gaps = 2/121 (1%)
Frame = +3
Query: 51 KRLNVSDVVRVCESHYSEDAFKEVDINLWHWEFSDGSPPPADILEKWFQLLKDRFNSPSH 230
K+ NV+ +VR+ + Y F + + F DGS P +I+ ++ + ++
Sbjct: 217 KKNNVTTIVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTPSDNIVRRFLNICEN------- 269
Query: 231 SNGPIAVHCIAGFGRAPVLVAVALME--LGMHCEDAIEMIRSKRKGSFNERQISYLTHYR 404
+ G IAVHC AG GR L+A +M+ H E I IR R GS Q +L +
Sbjct: 270 TEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAE-IIAWIRICRPGSIIGPQQHFLKEKQ 328
Query: 405 A 407
A
Sbjct: 329 A 329
>sp|Q6PFY9|CC14B_MOUSE Dual specificity protein phosphatase CDC14B (CDC14 cell division
cycle 14 homolog B)
Length = 485
Score = 46.6 bits (109), Expect = 7e-05
Identities = 33/115 (28%), Positives = 53/115 (46%), Gaps = 1/115 (0%)
Frame = +3
Query: 51 KRLNVSDVVRVCESHYSEDAFKEVDINLWHWEFSDGSPPPADILEKWFQLLKDRFNSPSH 230
K NV+ ++R+ + Y F + + F DGS P I++++ + ++
Sbjct: 253 KNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFPDGSTPAESIVQEFLDICEN------- 305
Query: 231 SNGPIAVHCIAGFGRAPVLVAVALME-LGMHCEDAIEMIRSKRKGSFNERQISYL 392
G IAVHC AG GR L+ LM+ M ++I +R R GS Q +L
Sbjct: 306 VKGAIAVHCKAGLGRTGTLIGCYLMKHYRMTAAESIAWLRICRPGSVIGPQQQFL 360
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,262,819
Number of Sequences: 369166
Number of extensions: 1620536
Number of successful extensions: 4090
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3929
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4075
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6316483550
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)