Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_P19
(608 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P54578|UBP14_HUMAN Ubiquitin carboxyl-terminal hydrolase... 222 5e-58
sp|P60051|UBP14_PANTR Ubiquitin carboxyl-terminal hydrolase... 222 5e-58
sp|Q9JMA1|UBP14_MOUSE Ubiquitin carboxyl-terminal hydrolase... 220 3e-57
sp|P40826|UBP14_RABIT Ubiquitin carboxyl-terminal hydrolase... 220 3e-57
sp|Q17361|UBP14_CAEEL Ubiquitin carboxyl-terminal hydrolase... 156 3e-38
sp|Q92353|UBP6_SCHPO Probable ubiquitin carboxyl-terminal h... 122 5e-28
sp|P43593|UBP6_YEAST Ubiquitin carboxyl-terminal hydrolase ... 96 9e-20
sp|P39967|UBP9_YEAST Ubiquitin carboxyl-terminal hydrolase ... 56 8e-08
sp|P53874|UBP10_YEAST Ubiquitin carboxyl-terminal hydrolase... 53 5e-07
sp|Q70EK9|UBP51_HUMAN Ubiquitin carboxyl-terminal hydrolase... 53 7e-07
>sp|P54578|UBP14_HUMAN Ubiquitin carboxyl-terminal hydrolase 14 (Ubiquitin thiolesterase
14) (Ubiquitin-specific processing protease 14)
(Deubiquitinating enzyme 14)
Length = 494
Score = 222 bits (566), Expect = 5e-58
Identities = 102/172 (59%), Positives = 130/172 (75%)
Frame = +2
Query: 2 PAYLSVQFVRFYYKEKERINAKVLKDIKFSIVLDMYEFCTDELKSKMQPMRDKYKIMEDR 181
PAYL++Q VRF+YKEKE +NAKVLKD+KF ++LDMYE CT EL+ KM R K+K +ED+
Sbjct: 321 PAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDK 380
Query: 182 KAEAERINKKGENLIDNTKLEESKPEHYPYWFSDDIGSNNCGIYELQAIVTHQGRSSSSG 361
K + N D + + ++ P+ F+DDIGSNNCG Y+LQA++THQGRSSSSG
Sbjct: 381 KVNQQ------PNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSG 434
Query: 362 HYVGWVRQSGDIWLKYDDDSVTQVTAEDILRLSGGGDWHCAYVLLYGPKSIE 517
HYV WV++ D W+K+DDD V+ VT EDILRLSGGGDWH AYVLLYGP+ +E
Sbjct: 435 HYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVE 486
>sp|P60051|UBP14_PANTR Ubiquitin carboxyl-terminal hydrolase 14 (Ubiquitin thiolesterase
14) (Ubiquitin-specific processing protease 14)
(Deubiquitinating enzyme 14)
Length = 493
Score = 222 bits (566), Expect = 5e-58
Identities = 102/172 (59%), Positives = 130/172 (75%)
Frame = +2
Query: 2 PAYLSVQFVRFYYKEKERINAKVLKDIKFSIVLDMYEFCTDELKSKMQPMRDKYKIMEDR 181
PAYL++Q VRF+YKEKE +NAKVLKD+KF ++LDMYE CT EL+ KM R K+K +ED+
Sbjct: 321 PAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDK 380
Query: 182 KAEAERINKKGENLIDNTKLEESKPEHYPYWFSDDIGSNNCGIYELQAIVTHQGRSSSSG 361
K + N D + + ++ P+ F+DDIGSNNCG Y+LQA++THQGRSSSSG
Sbjct: 381 KVNQQ------PNTSDKKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSG 434
Query: 362 HYVGWVRQSGDIWLKYDDDSVTQVTAEDILRLSGGGDWHCAYVLLYGPKSIE 517
HYV WV++ D W+K+DDD V+ VT EDILRLSGGGDWH AYVLLYGP+ +E
Sbjct: 435 HYVSWVKRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVE 486
>sp|Q9JMA1|UBP14_MOUSE Ubiquitin carboxyl-terminal hydrolase 14 (Ubiquitin thiolesterase
14) (Ubiquitin-specific processing protease 14)
(Deubiquitinating enzyme 14)
Length = 493
Score = 220 bits (560), Expect = 3e-57
Identities = 105/172 (61%), Positives = 133/172 (77%)
Frame = +2
Query: 2 PAYLSVQFVRFYYKEKERINAKVLKDIKFSIVLDMYEFCTDELKSKMQPMRDKYKIMEDR 181
PAYL++Q VRF+YKEKE +NAKVLKD+KF ++LD+YE CT EL+ KM R K+K +ED+
Sbjct: 321 PAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDVYELCTPELQEKMVSFRSKFKDLEDK 380
Query: 182 KAEAERINKKGENLIDNTKLEESKPEHYPYWFSDDIGSNNCGIYELQAIVTHQGRSSSSG 361
K +N++ N+ +E K E P+ F+DDIGSNNCG Y+LQA++THQGRSSSSG
Sbjct: 381 K-----VNQQPNANDKNSPPKEIKYE--PFSFADDIGSNNCGYYDLQAVLTHQGRSSSSG 433
Query: 362 HYVGWVRQSGDIWLKYDDDSVTQVTAEDILRLSGGGDWHCAYVLLYGPKSIE 517
HYV WVR+ D W+K+DDD V+ VT EDILRLSGGGDWH AYVLLYGP+ +E
Sbjct: 434 HYVSWVRRKQDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVE 485
>sp|P40826|UBP14_RABIT Ubiquitin carboxyl-terminal hydrolase 14 (Ubiquitin thiolesterase
14) (Ubiquitin-specific processing protease 14)
(Deubiquitinating enzyme 14)
Length = 493
Score = 220 bits (560), Expect = 3e-57
Identities = 101/172 (58%), Positives = 129/172 (75%)
Frame = +2
Query: 2 PAYLSVQFVRFYYKEKERINAKVLKDIKFSIVLDMYEFCTDELKSKMQPMRDKYKIMEDR 181
PAYL++Q VRF+YKEKE +NAKVLKD+KF ++LD+YE CT EL+ KM R K+K +ED+
Sbjct: 320 PAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDVYELCTPELQEKMVSFRSKFKDIEDK 379
Query: 182 KAEAERINKKGENLIDNTKLEESKPEHYPYWFSDDIGSNNCGIYELQAIVTHQGRSSSSG 361
K + N D + + + P+ F+DDIGSNNCG Y+LQA++THQGRSSSSG
Sbjct: 380 KVNQQ------PNASDKKSSPQKEVRYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSG 433
Query: 362 HYVGWVRQSGDIWLKYDDDSVTQVTAEDILRLSGGGDWHCAYVLLYGPKSIE 517
HYV WV++ D W+K+DDD V+ VT EDILRLSGGGDWH AYVLLYGP+ +E
Sbjct: 434 HYVSWVKRKHDEWIKFDDDKVSIVTPEDILRLSGGGDWHIAYVLLYGPRRVE 485
>sp|Q17361|UBP14_CAEEL Ubiquitin carboxyl-terminal hydrolase 14 (Ubiquitin thiolesterase
14) (Ubiquitin-specific processing protease 14)
(Deubiquitinating enzyme 14)
Length = 489
Score = 156 bits (395), Expect = 3e-38
Identities = 82/179 (45%), Positives = 108/179 (60%), Gaps = 6/179 (3%)
Frame = +2
Query: 2 PAYLSVQFVRFYYKEKERINAKVLKDIKFSIVLDMYEFCTDELKSKMQPMRDKYKIMEDR 181
P YL+V RF+YKE + NAK+LK ++F + LD Y+ C+ ELK K+ R K+ ED
Sbjct: 291 PKYLTVNINRFFYKESTKTNAKILKSVQFPMQLDTYDLCSQELKDKLVARRADIKLEEDA 350
Query: 182 KAEAERINK-----KGENLIDNTKLEESKPEHYPYWFSDDIGSNNCGIYELQAIVTHQGR 346
K E E K +G+ + D+ P F DD GSNN G Y+L+ I+TH+GR
Sbjct: 351 KLERELRKKVLDKEQGDKIFDDGVA-------LPTAFEDDAGSNNSGFYDLKGIITHKGR 403
Query: 347 SSSSGHYVGWVRQSGD-IWLKYDDDSVTQVTAEDILRLSGGGDWHCAYVLLYGPKSIEK 520
SS GHYV W+R S D W +DD+ VT V E IL+ SGGGDWH AYVLLY + I++
Sbjct: 404 SSQDGHYVAWMRSSEDGKWRLFDDEHVTVVDEEAILKTSGGGDWHSAYVLLYEARVIKQ 462
>sp|Q92353|UBP6_SCHPO Probable ubiquitin carboxyl-terminal hydrolase 6 (Ubiquitin
thiolesterase 6) (Ubiquitin-specific processing protease
6) (Deubiquitinating enzyme 6)
Length = 467
Score = 122 bits (307), Expect = 5e-28
Identities = 72/190 (37%), Positives = 101/190 (53%), Gaps = 19/190 (10%)
Frame = +2
Query: 2 PAYLSVQFVRFYYKEKERINAKVLKDIKFSIVLDMYEFCTDELKSKMQPMRDKYKIMEDR 181
P YL+V FVRFY+K AK+L+ +KF LD EFCT EL K+ P+RDK + +E
Sbjct: 284 PNYLTVNFVRFYWKASIGKKAKILRKVKFPFELDAVEFCTPELSQKLIPVRDKLREIEKN 343
Query: 182 KAEAERINKKGENLIDNTKLEESKPEH-----------------YPYWFSDDIGSNNCGI 310
E ER K+ K++ S+ E +DD G+N G+
Sbjct: 344 DEEHERAAKR-------IKIQPSEDEKEAEAECRLTQVATCQSLVDPELADDEGANPTGL 396
Query: 311 YELQAIVTHQGRSSSSGHYVGWVRQSGD--IWLKYDDDSVTQVTAEDILRLSGGGDWHCA 484
Y+L +++H G S+SSGHY W+R S + W +++D V+ V AE I L GGG+ A
Sbjct: 397 YDLVGVLSHAGASASSGHYQAWIRNSNNRAEWFRFNDAKVSIVPAEKIETLDGGGEADSA 456
Query: 485 YVLLYGPKSI 514
Y+LLY K I
Sbjct: 457 YILLYKAKDI 466
>sp|P43593|UBP6_YEAST Ubiquitin carboxyl-terminal hydrolase 6 (Ubiquitin thiolesterase 6)
(Ubiquitin-specific processing protease 6)
(Deubiquitinating enzyme 6)
Length = 499
Score = 95.5 bits (236), Expect = 9e-20
Identities = 61/188 (32%), Positives = 97/188 (51%), Gaps = 22/188 (11%)
Frame = +2
Query: 2 PAYLSVQFVRFYYKEKERINAKVLKDIKFSIVLDMYEFCTDELKSKMQPMRDKYKIMEDR 181
P +L+VQ+VRF++K +K+L+ + F LD+ + T E ++ +RD+ + +E
Sbjct: 307 PKFLTVQYVRFFWKRSTNKKSKILRKVVFPFQLDVADMLTPEYAAEKVKVRDELRKVEKE 366
Query: 182 KAEAERINKK-------GENLI-------DNTKLEESKP----EHYPYWFSDDI--GSNN 301
K E ER K+ EN++ L ES+ E Y F ++ G N
Sbjct: 367 KNEKEREIKRRKFDPSSSENVMTpreQYETQVALNESEKDQWLEEYKKHFPPNLEKGENP 426
Query: 302 CGIYELQAIVTHQGRSSSSGHYVGWVRQSGD--IWLKYDDDSVTQVTAEDILRLSGGGDW 475
+Y L ++THQG +S SGHY ++R D W K++DD V+ V E I L+GGG+
Sbjct: 427 SCVYNLIGVITHQGANSESGHYQAFIRDELDENKWYKFNDDKVSVVEKEKIESLAGGGES 486
Query: 476 HCAYVLLY 499
A +L+Y
Sbjct: 487 DSALILMY 494
>sp|P39967|UBP9_YEAST Ubiquitin carboxyl-terminal hydrolase 9 (Ubiquitin thiolesterase 9)
(Ubiquitin-specific processing protease 9)
(Deubiquitinating enzyme 9)
Length = 754
Score = 55.8 bits (133), Expect = 8e-08
Identities = 31/84 (36%), Positives = 40/84 (47%), Gaps = 1/84 (1%)
Frame = +2
Query: 311 YELQAIVTHQGRSSSSGHYVGWVRQSGDIWLKYDDDSVTQVTAEDILRLSG-GGDWHCAY 487
YEL +V H G GHYV R WL YDD++V + E +L+ +G GD AY
Sbjct: 601 YELSGVVIHMGSGPQHGHYVCICRNEKFGWLLYDDETVESIKEETVLQFTGHPGDQTTAY 660
Query: 488 VLLYGPKSIEKDAYKNNGDQAVSQ 559
VL Y +K +N SQ
Sbjct: 661 VLFYKETQADKTENQNENIDTSSQ 684
>sp|P53874|UBP10_YEAST Ubiquitin carboxyl-terminal hydrolase 10 (Ubiquitin thiolesterase
10) (Ubiquitin-specific processing protease 10)
(Deubiquitinating enzyme 10) (Disrupter of telomere
silencing protein 4)
Length = 792
Score = 53.1 bits (126), Expect = 5e-07
Identities = 27/71 (38%), Positives = 40/71 (56%), Gaps = 3/71 (4%)
Frame = +2
Query: 311 YELQAIVTHQGRSSSSGHYVGWVRQSGDIWLKYDDDSVTQVTAEDILRLSGGGDWHCAYV 490
Y+L ++V H+GRS SSGHY+ +Q W YDD+ + ++ D+L+ AY
Sbjct: 674 YQLLSVVVHEGRSLSSGHYIAHCKQPDGSWATYDDEYINIISERDVLKEPN------AYY 727
Query: 491 LLY---GPKSI 514
LLY PKS+
Sbjct: 728 LLYTRLTPKSV 738
>sp|Q70EK9|UBP51_HUMAN Ubiquitin carboxyl-terminal hydrolase 51 (Ubiquitin thiolesterase
51) (Ubiquitin-specific processing protease 51)
(Deubiquitinating enzyme 51)
Length = 711
Score = 52.8 bits (125), Expect = 7e-07
Identities = 27/71 (38%), Positives = 38/71 (53%)
Frame = +2
Query: 311 YELQAIVTHQGRSSSSGHYVGWVRQSGDIWLKYDDDSVTQVTAEDILRLSGGGDWHCAYV 490
Y L A++ H G + SGHY ++RQ D W DD +T+ T ED+L G Y+
Sbjct: 649 YSLFAVINHHG-TLESGHYTSFIRQQKDQWFSCDDAIITKATIEDLLYSEG-------YL 700
Query: 491 LLYGPKSIEKD 523
L Y + +EKD
Sbjct: 701 LFYHKQGLEKD 711
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,026,353
Number of Sequences: 369166
Number of extensions: 1289448
Number of successful extensions: 3871
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3730
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3847
length of database: 68,354,980
effective HSP length: 105
effective length of database: 48,957,805
effective search space used: 4748907085
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)