Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_P17-2
(573 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P31226|SAX_RANCA Saxiphilin precursor (SAX) 58 1e-08
sp|P06882|THYG_RAT Thyroglobulin precursor 58 2e-08
sp|O08710|THYG_MOUSE Thyroglobulin precursor 57 4e-08
sp|P01267|THYG_BOVIN Thyroglobulin precursor 55 1e-07
sp|P01266|THYG_HUMAN Thyroglobulin precursor 55 1e-07
sp|O88322|NID2_MOUSE Nidogen-2 precursor (NID-2) (Entactin-2) 52 8e-07
sp|Q14112|NID2_HUMAN Nidogen-2 precursor (NID-2) (Osteonido... 49 7e-06
sp|P81439|EQST_ACTEQ Equistatin 49 7e-06
sp|Q9BQ16|TICN3_HUMAN Testican-3 precursor (SPARC/osteonect... 43 5e-04
sp|Q8BKV0|TICN3_MOUSE Testican-3 precursor (SPARC/osteonect... 43 5e-04
>sp|P31226|SAX_RANCA Saxiphilin precursor (SAX)
Length = 844
Score = 58.2 bits (139), Expect = 1e-08
Identities = 44/148 (29%), Positives = 65/148 (43%), Gaps = 13/148 (8%)
Frame = +2
Query: 92 NNDQCNVGLICDEVCKEDNNAPNCFKRHLDARRLIKSGAVDVTFPFCEDTGMYKPVQCVG 271
+ D N+ I E + + C K A + + P C++ G Y+P QC G
Sbjct: 87 SKDPYNLKPIIAEPYSSNRDLQKCLKERQQA---LAKKMIGHYIPQCDEKGNYQPQQCHG 143
Query: 272 AA--CWCVEESGDEIEGYITGIEESYGKTCN------CAKDKLEY--SQRKIVGRTF-RC 418
+ CWCV G++I G T ++ TC C K++ K++GR +C
Sbjct: 144 STGHCWCVNAMGEKISGTNTPPGQTRA-TCERHELPKCLKERQVALGGDEKVLGRFVPQC 202
Query: 419 DHLGNYEKVQCHGSICY--CADLSGNKI 496
D GNYE Q HGS Y C + G +I
Sbjct: 203 DEKGNYEPQQFHGSTGYSWCVNAIGEEI 230
Score = 32.0 bits (71), Expect = 1.1
Identities = 21/64 (32%), Positives = 29/64 (45%), Gaps = 5/64 (7%)
Frame = +2
Query: 140 EDNNAPNCFKRHLDARRLIKSGAVDVT---FPFCEDTGMYKPVQCVGAA--CWCVEESGD 304
E + P C K R++ G V P C++ G Y+P Q G+ WCV G+
Sbjct: 173 ERHELPKCLKE----RQVALGGDEKVLGRFVPQCDEKGNYEPQQFHGSTGYSWCVNAIGE 228
Query: 305 EIEG 316
EI G
Sbjct: 229 EIAG 232
>sp|P06882|THYG_RAT Thyroglobulin precursor
Length = 2768
Score = 57.8 bits (138), Expect = 2e-08
Identities = 31/97 (31%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCVGAACWCVEESGDEIEG-YITGIEESYGKTCNCAKDKLE-YSQRKI 397
P C G Y+ +QC CWCV G E+EG ++G C + +++ + +
Sbjct: 618 PSCTAEGSYEDIQCYAGECWCVNSQGKEVEGSRVSGGHPRCPTKCEKQRAQMQNLAGAQP 677
Query: 398 VGRTF---RCDHLGNYEKVQCHGSICYCADLSGNKIP 499
G +F C G + VQC S CYC D G IP
Sbjct: 678 AGSSFFVPTCTSEGYFLPVQCFNSECYCVDAEGQVIP 714
Score = 48.1 bits (113), Expect = 2e-05
Identities = 30/108 (27%), Positives = 44/108 (40%), Gaps = 13/108 (12%)
Frame = +2
Query: 212 DVTFPFCEDTGMYKPVQCV--GAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYS 385
D P C + G ++ VQC G +CWCV+ G E+ G G+ C +
Sbjct: 47 DEYVPQCSEDGSFQTVQCQNDGQSCWCVDSDGTEVPG-----SRQLGRPTACLSFCQLHK 101
Query: 386 QRKIVGRTF---------RCDHLGNYEKVQC--HGSICYCADLSGNKI 496
QR ++ +C GNY VQC C+C D G ++
Sbjct: 102 QRILLSSYINSTDALYLPQCQDSGNYAPVQCDLQQVQCWCVDTEGMEV 149
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/102 (30%), Positives = 46/102 (45%), Gaps = 10/102 (9%)
Frame = +2
Query: 176 LDARRLIKSGAVDVT----FPFCEDTGMYKPVQC--VGAACWCVEESGDEIEGYITGIEE 337
L +R++ S ++ T P C+D+G Y PVQC CWCV+ G E+ G
Sbjct: 99 LHKQRILLSSYINSTDALYLPQCQDSGNYAPVQCDLQQVQCWCVDTEGMEVYG-----TR 153
Query: 338 SYGKTCNCAKDKLEYSQRKIVG----RTFRCDHLGNYEKVQC 451
G+ C + S+R + G +CD G + VQC
Sbjct: 154 QQGRPTRCPRSCEIRSRRLLHGVGDKSPPQCDADGEFMPVQC 195
Score = 45.1 bits (105), Expect = 1e-04
Identities = 33/103 (32%), Positives = 46/103 (44%), Gaps = 4/103 (3%)
Frame = +2
Query: 203 GAVDVTFPFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEY 382
G D+ P C TG Y Q G WCV+ S E T C+ K ++
Sbjct: 1100 GPGDLFTPVCLQTGEYVRQQTSGTGAWCVDPSSGEGVPTNTNSSAQCPGLCDALKSRV-L 1158
Query: 383 SQRKIVGRTFRCDHL-GNYEKVQC---HGSICYCADLSGNKIP 499
S++ +G T C+ L G + VQC GS C+C SG ++P
Sbjct: 1159 SRKVGLGYTPVCEALDGGFSPVQCDLAQGS-CWCVLASGEEVP 1200
Score = 38.9 bits (89), Expect = 0.009
Identities = 22/58 (37%), Positives = 29/58 (50%), Gaps = 1/58 (1%)
Frame = +2
Query: 224 PFCEDTGMYKPVQC-VGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRK 394
P C G Y+ VQC + CWCV+ G EI G G+ CAKD+ S+R+
Sbjct: 318 PSCHRDGHYQTVQCQMERMCWCVDAQGIEIPG-----TRQQGQPLFCAKDQSCASERQ 370
Score = 37.0 bits (84), Expect = 0.035
Identities = 31/110 (28%), Positives = 44/110 (40%), Gaps = 16/110 (14%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYI-----------TGIEESYGKTCNCA 364
P C G ++PVQC CWCV+ G+ I G + T E S A
Sbjct: 1030 PQCNTIGGWEPVQCHPGTGQCWCVDGWGELIPGSLMARSSQMPQCPTSCELSRANGLISA 1089
Query: 365 KDKLEYSQRKIVGRTFR--CDHLGNYEKVQCHGSICYCAD-LSGNKIPTS 505
+ + + G F C G Y + Q G+ +C D SG +PT+
Sbjct: 1090 WKQAGHQRNPGPGDLFTPVCLQTGEYVRQQTSGTGAWCVDPSSGEGVPTN 1139
Score = 36.2 bits (82), Expect = 0.060
Identities = 19/61 (31%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Frame = +2
Query: 161 CFKRHLDARRLIKSGAVDVTF--PFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGIE 334
C K+ + L + +F P C G + PVQC + C+CV+ G I G + I
Sbjct: 662 CEKQRAQMQNLAGAQPAGSSFFVPTCTSEGYFLPVQCFNSECYCVDAEGQVIPGTQSTIG 721
Query: 335 E 337
E
Sbjct: 722 E 722
Score = 33.9 bits (76), Expect = 0.30
Identities = 16/34 (47%), Positives = 20/34 (58%), Gaps = 3/34 (8%)
Frame = +2
Query: 224 PFCEDT-GMYKPVQC--VGAACWCVEESGDEIEG 316
P CE G + PVQC +CWCV SG+E+ G
Sbjct: 1168 PVCEALDGGFSPVQCDLAQGSCWCVLASGEEVPG 1201
Score = 30.8 bits (68), Expect = 2.5
Identities = 13/37 (35%), Positives = 20/37 (54%), Gaps = 2/37 (5%)
Frame = +2
Query: 401 GRTF--RCDHLGNYEKVQCHGSICYCADLSGNKIPTS 505
GR F C G+YE +QC+ C+C + G ++ S
Sbjct: 613 GRFFVPSCTAEGSYEDIQCYAGECWCVNSQGKEVEGS 649
Score = 28.9 bits (63), Expect = 9.5
Identities = 12/29 (41%), Positives = 17/29 (58%), Gaps = 1/29 (3%)
Frame = +2
Query: 416 CDHLGNYEKVQCHGS-ICYCADLSGNKIP 499
C G+Y+ VQC +C+C D G +IP
Sbjct: 320 CHRDGHYQTVQCQMERMCWCVDAQGIEIP 348
Score = 28.9 bits (63), Expect = 9.5
Identities = 8/14 (57%), Positives = 13/14 (92%)
Frame = +2
Query: 275 ACWCVEESGDEIEG 316
+CWCV+E+G E++G
Sbjct: 898 SCWCVDEAGQELDG 911
>sp|O08710|THYG_MOUSE Thyroglobulin precursor
Length = 2766
Score = 56.6 bits (135), Expect = 4e-08
Identities = 30/97 (30%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCVGAACWCVEESGDEIEG-YITGIEESYGKTCNCAKDKLE-YSQRKI 397
P C G Y+ +QC CWCV+ G E++G + G C + +++ + +
Sbjct: 618 PSCTAGGSYEDIQCYAGECWCVDSRGKELDGSRVRGGRPRCPTKCEKQRAQMQSLASAQP 677
Query: 398 VGRTF---RCDHLGNYEKVQCHGSICYCADLSGNKIP 499
G +F C G + VQC S CYC D G IP
Sbjct: 678 AGSSFFVPTCTREGYFLPVQCFNSECYCVDTEGQVIP 714
Score = 49.3 bits (116), Expect = 7e-06
Identities = 30/104 (28%), Positives = 44/104 (42%), Gaps = 13/104 (12%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCV--GAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRKI 397
P C + G ++ VQC G +CWCV+ G E+ G G+ C + QR +
Sbjct: 51 PQCSEDGSFQTVQCQNDGQSCWCVDSDGREVPG-----SRQLGRPTVCLSFCQLHKQRIL 105
Query: 398 VGRTF---------RCDHLGNYEKVQC--HGSICYCADLSGNKI 496
+G +C GNY VQC C+C D G ++
Sbjct: 106 LGSYINSTDALYLPQCQDSGNYAPVQCDLQRVQCWCVDTEGMEV 149
Score = 40.4 bits (93), Expect = 0.003
Identities = 26/82 (31%), Positives = 36/82 (43%), Gaps = 6/82 (7%)
Frame = +2
Query: 224 PFCEDTGMYKPVQC--VGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRKI 397
P C+D+G Y PVQC CWCV+ G E+ G G+ C + ++R +
Sbjct: 119 PQCQDSGNYAPVQCDLQRVQCWCVDTEGMEVYG-----TRQQGRPTRCPRSCEIRNRRLL 173
Query: 398 VGRTFR----CDHLGNYEKVQC 451
G R C G + VQC
Sbjct: 174 HGVGDRSPPQCTADGEFMPVQC 195
Score = 39.3 bits (90), Expect = 0.007
Identities = 31/103 (30%), Positives = 45/103 (43%), Gaps = 4/103 (3%)
Frame = +2
Query: 203 GAVDVTFPFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEY 382
G D+ P C TG Y Q G WCV+ + E T C+ K +
Sbjct: 1100 GPGDLFIPVCLQTGEYVRKQTSGTGTWCVDPASGEGMPVNTNGSAQCPGLCDVLKSR-AL 1158
Query: 383 SQRKIVGRTFRCDHL-GNYEKVQC---HGSICYCADLSGNKIP 499
S++ +G + C+ L G + VQC GS C+C SG ++P
Sbjct: 1159 SRKVGLGYSPVCEALDGAFSPVQCDLAQGS-CWCVLGSGEEVP 1200
Score = 36.6 bits (83), Expect = 0.046
Identities = 29/117 (24%), Positives = 47/117 (40%), Gaps = 18/117 (15%)
Frame = +2
Query: 161 CFKRHLDARRLIKSGAVDVTF--PFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGIE 334
C K+ + L + +F P C G + PVQC + C+CV+ G I G + +
Sbjct: 662 CEKQRAQMQSLASAQPAGSSFFVPTCTREGYFLPVQCFNSECYCVDTEGQVIPGTQSTVG 721
Query: 335 ESYGKTC-NCAKDKLEYSQRKIVGRTF---------------RCDHLGNYEKVQCHG 457
E+ K C + + + E + +VG +C G + VQC G
Sbjct: 722 EA--KQCPSVCQLQAEQAFLGVVGVLLSNSSMVPSISNVYIPQCSASGQWRHVQCDG 776
Score = 35.4 bits (80), Expect = 0.10
Identities = 18/51 (35%), Positives = 24/51 (47%), Gaps = 1/51 (1%)
Frame = +2
Query: 224 PFCEDTGMYKPVQC-VGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDK 373
P C G Y+ VQC CWCV+ G E+ G G+ +CA D+
Sbjct: 318 PRCHRDGHYQTVQCQTEGMCWCVDAQGREVPG-----TRQQGQPPSCAADQ 363
Score = 34.3 bits (77), Expect = 0.23
Identities = 16/34 (47%), Positives = 20/34 (58%), Gaps = 3/34 (8%)
Frame = +2
Query: 224 PFCEDT-GMYKPVQC--VGAACWCVEESGDEIEG 316
P CE G + PVQC +CWCV SG+E+ G
Sbjct: 1168 PVCEALDGAFSPVQCDLAQGSCWCVLGSGEEVPG 1201
Score = 32.7 bits (73), Expect = 0.66
Identities = 28/110 (25%), Positives = 41/110 (37%), Gaps = 16/110 (14%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYITGIEESYGK---TCNCAKDKLEYSQ 388
P C G ++PVQC CWCV+ G+ I G + + C ++ S
Sbjct: 1030 PQCNMIGGWEPVQCHAGTGQCWCVDGRGEFIPGSLMSRSSQMPQCPTNCELSRASGLISA 1089
Query: 389 RKIVGRTFR----------CDHLGNYEKVQCHGSICYCAD-LSGNKIPTS 505
K G C G Y + Q G+ +C D SG +P +
Sbjct: 1090 WKQAGPQRNPGPGDLFIPVCLQTGEYVRKQTSGTGTWCVDPASGEGMPVN 1139
Score = 32.0 bits (71), Expect = 1.1
Identities = 12/30 (40%), Positives = 18/30 (60%), Gaps = 1/30 (3%)
Frame = +2
Query: 413 RCDHLGNYEKVQCHGS-ICYCADLSGNKIP 499
RC G+Y+ VQC +C+C D G ++P
Sbjct: 319 RCHRDGHYQTVQCQTEGMCWCVDAQGREVP 348
Score = 31.2 bits (69), Expect = 1.9
Identities = 11/30 (36%), Positives = 17/30 (56%)
Frame = +2
Query: 416 CDHLGNYEKVQCHGSICYCADLSGNKIPTS 505
C G+YE +QC+ C+C D G ++ S
Sbjct: 620 CTAGGSYEDIQCYAGECWCVDSRGKELDGS 649
>sp|P01267|THYG_BOVIN Thyroglobulin precursor
Length = 2769
Score = 55.5 bits (132), Expect = 1e-07
Identities = 31/97 (31%), Positives = 41/97 (42%), Gaps = 5/97 (5%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCVGAACWCVEESGDEIEG-YITGIEESYGKTCNCAKDKLE--YSQRK 394
P C G Y+ VQC CWCV+ G E+ G + G C + +++ +
Sbjct: 617 PACTAEGSYEEVQCFAGDCWCVDAQGRELAGSRVRGGRPRCPTECEKQRARMQSLLGSQP 676
Query: 395 IVGRTF--RCDHLGNYEKVQCHGSICYCADLSGNKIP 499
F C GN+ VQC S CYC D G IP
Sbjct: 677 AGSSLFVPACTSKGNFLPVQCFNSECYCVDTEGQPIP 713
Score = 46.6 bits (109), Expect = 4e-05
Identities = 29/99 (29%), Positives = 43/99 (43%), Gaps = 8/99 (8%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCV--GAACWCVEESGDEIEG-YITGIEESYGKTCNCAKDKL---EYS 385
P C + G ++ VQC GA+CWCV+ G E+ G G + C K ++ Y
Sbjct: 50 PQCAEDGSFQTVQCGKDGASCWCVDADGREVPGSRQPGRPAACLSFCQLQKQQILLSSYI 109
Query: 386 QRKIVGRTFRCDHLGNYEKVQC--HGSICYCADLSGNKI 496
+C G+Y VQC C+C D G ++
Sbjct: 110 NSTATSYLPQCQDSGDYSPVQCDLRRRQCWCVDAEGMEV 148
Score = 40.8 bits (94), Expect = 0.002
Identities = 29/102 (28%), Positives = 45/102 (44%), Gaps = 10/102 (9%)
Frame = +2
Query: 176 LDARRLIKSGAVDVT----FPFCEDTGMYKPVQCV--GAACWCVEESGDEIEGYITGIEE 337
L ++++ S ++ T P C+D+G Y PVQC CWCV+ G E+ G
Sbjct: 98 LQKQQILLSSYINSTATSYLPQCQDSGDYSPVQCDLRRRQCWCVDAEGMEVYG-----TR 152
Query: 338 SYGKTCNCAKDKLEYSQRKIVGRTFR----CDHLGNYEKVQC 451
G+ C + ++R + G R C G + VQC
Sbjct: 153 QQGRPARCPRSCEIRNRRLLHGVGDRSPPQCSPDGAFRPVQC 194
Score = 40.0 bits (92), Expect = 0.004
Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 1/58 (1%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCV-GAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRK 394
P C G Y+ QC G CWCV+ G EI G G+ +CA+D+ S+R+
Sbjct: 317 PSCHPDGEYQAAQCQQGGPCWCVDSRGQEIPG-----TRQRGEPPSCAEDQSCPSERR 369
Score = 37.4 bits (85), Expect = 0.027
Identities = 25/96 (26%), Positives = 36/96 (37%), Gaps = 18/96 (18%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRKIVG 403
P C G + PVQC + C+CV+ G I G + G+ C ++R +G
Sbjct: 684 PACTSKGNFLPVQCFNSECYCVDTEGQP----IPGTRSALGEPKKCPSPCQLQAERAFLG 739
Query: 404 --RTF----------------RCDHLGNYEKVQCHG 457
RT +C G + VQC G
Sbjct: 740 TVRTLVSNPSTLPALSSIYIPQCSASGQWSPVQCDG 775
Score = 37.0 bits (84), Expect = 0.035
Identities = 15/33 (45%), Positives = 20/33 (60%), Gaps = 2/33 (6%)
Frame = +2
Query: 413 RCDHLGNYEKVQCHGSI--CYCADLSGNKIPTS 505
+CD G +E VQCH + C+C D G +PTS
Sbjct: 1030 QCDAFGGWEPVQCHAATGHCWCVDGKGEYVPTS 1062
Score = 35.4 bits (80), Expect = 0.10
Identities = 23/69 (33%), Positives = 33/69 (47%), Gaps = 3/69 (4%)
Frame = +2
Query: 224 PFCE-DTGMYKPVQCVGA--ACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRK 394
P C + G + PVQC A +CWCV SG+E+ G T + S C + L +S
Sbjct: 1167 PACRAEDGGFSPVQCDPAQGSCWCVLGSGEEVPG--TRVAGSQ-PACESPQCPLPFSVAD 1223
Query: 395 IVGRTFRCD 421
+ G C+
Sbjct: 1224 VAGGAILCE 1232
Score = 34.3 bits (77), Expect = 0.23
Identities = 28/100 (28%), Positives = 42/100 (42%), Gaps = 4/100 (4%)
Frame = +2
Query: 212 DVTFPFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQR 391
D+ P C +TG + +Q A WCV+ + E T C + + S+R
Sbjct: 1102 DLFIPTCLETGEFARLQASEAGTWCVDPASGEGVPPGTNSSAQCPSLCEVLQSGVP-SRR 1160
Query: 392 KIVGRTFRC-DHLGNYEKVQC---HGSICYCADLSGNKIP 499
G + C G + VQC GS C+C SG ++P
Sbjct: 1161 TSPGYSPACRAEDGGFSPVQCDPAQGS-CWCVLGSGEEVP 1199
Score = 33.1 bits (74), Expect = 0.51
Identities = 14/36 (38%), Positives = 21/36 (58%), Gaps = 2/36 (5%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYIT 325
P C+ G ++PVQC A CWCV+ G+ + +T
Sbjct: 1029 PQCDAFGGWEPVQCHAATGHCWCVDGKGEYVPTSLT 1064
Score = 32.3 bits (72), Expect = 0.86
Identities = 12/30 (40%), Positives = 17/30 (56%)
Frame = +2
Query: 416 CDHLGNYEKVQCHGSICYCADLSGNKIPTS 505
C G+YE+VQC C+C D G ++ S
Sbjct: 619 CTAEGSYEEVQCFAGDCWCVDAQGRELAGS 648
>sp|P01266|THYG_HUMAN Thyroglobulin precursor
Length = 2768
Score = 55.1 bits (131), Expect = 1e-07
Identities = 31/97 (31%), Positives = 42/97 (43%), Gaps = 5/97 (5%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCVGAACWCVEESGDEIEG-YITGIEESYGKTCNCAKDKLE-YSQRKI 397
P C G Y+ VQC CWCV G E+ G + G + C + +++ +
Sbjct: 618 PSCTTEGSYEDVQCFSGECWCVNSWGKELPGSRVRGGQPRCPTDCEKQRARMQSLMGSQP 677
Query: 398 VGRTF---RCDHLGNYEKVQCHGSICYCADLSGNKIP 499
G T C G++ VQC S CYC D G IP
Sbjct: 678 AGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIP 714
Score = 43.1 bits (100), Expect = 5e-04
Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 4/101 (3%)
Frame = +2
Query: 224 PFCE-DTGMYKPVQCVGA--ACWCVEESGDEIEG-YITGIEESYGKTCNCAKDKLEYSQR 391
P C + G + PVQC A +CWCV +SG+E+ G +TG + + C + L ++
Sbjct: 1167 PACRAEDGGFSPVQCDQAQGSCWCVMDSGEEVPGTRVTGGQPA----CESPRCPLPFNAS 1222
Query: 392 KIVGRTFRCDHLGNYEKVQCHGSICYCADLSGNKIPTSPYV 514
++VG T C+ + C S + P P +
Sbjct: 1223 EVVGGTILCETISGPTGSAMQQCQLLCRQGSWSVFPPGPLI 1263
Score = 42.0 bits (97), Expect = 0.001
Identities = 29/102 (28%), Positives = 46/102 (45%), Gaps = 10/102 (9%)
Frame = +2
Query: 176 LDARRLIKSGAVDVT----FPFCEDTGMYKPVQC--VGAACWCVEESGDEIEGYITGIEE 337
L ++++ SG ++ T P C+D+G Y PVQC CWCV+ G E+ G
Sbjct: 98 LQKQQILLSGYINSTDTSYLPQCQDSGDYAPVQCDVQQVQCWCVDAEGMEVYG-----TR 152
Query: 338 SYGKTCNCAKDKLEYSQRKIVG----RTFRCDHLGNYEKVQC 451
G+ C + ++R + G +C G + VQC
Sbjct: 153 QLGRPKRCPRSCEIRNRRLLHGVGDKSPPQCSAEGEFMPVQC 194
Score = 41.2 bits (95), Expect = 0.002
Identities = 38/131 (29%), Positives = 53/131 (40%), Gaps = 5/131 (3%)
Frame = +2
Query: 122 CDEVCKEDNNAPNCFKRHLDARRLIKSGAVDVTFPFCEDTGMYKPVQCVGAACWCVE-ES 298
C C E + AR D+ P C +TG Y +Q GA WCV+ S
Sbjct: 1073 CPTTC-EKSRTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVDPAS 1131
Query: 299 GDEIEGYITGIEESYGKTCNCAKDKLEYSQRKIVGRTFRC-DHLGNYEKVQC---HGSIC 466
G+E+ + + CN K + S+R G C G + VQC GS C
Sbjct: 1132 GEELRPGSSSSAQC-PSLCNVLKSGV-LSRRVSPGYVPACRAEDGGFSPVQCDQAQGS-C 1188
Query: 467 YCADLSGNKIP 499
+C SG ++P
Sbjct: 1189 WCVMDSGEEVP 1199
Score = 39.7 bits (91), Expect = 0.005
Identities = 32/114 (28%), Positives = 47/114 (41%), Gaps = 15/114 (13%)
Frame = +2
Query: 182 ARRLIKSGAVDVTFPFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYITGIEESYGK-- 349
A L++SG P C+ G ++PVQC CWCV+E G I G +T +
Sbjct: 1018 ASALLRSGPY---MPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCP 1074
Query: 350 -TCNCAKD-------KLEYSQRKIVGRTF---RCDHLGNYEKVQCHGSICYCAD 478
TC ++ K SQ + C G Y ++Q G+ +C D
Sbjct: 1075 TTCEKSRTSGLLSSWKQARSQENPSPKDLFVPACLETGEYARLQASGAGTWCVD 1128
Score = 37.0 bits (84), Expect = 0.035
Identities = 29/118 (24%), Positives = 48/118 (40%), Gaps = 18/118 (15%)
Frame = +2
Query: 158 NCFKRHLDARRLIKSGAVDVTF--PFCEDTGMYKPVQCVGAACWCVEESGDEIEGYITGI 331
+C K+ + L+ S T P C G + PVQC + C+CV+ G I G + I
Sbjct: 661 DCEKQRARMQSLMGSQPAGSTLFVPACTSEGHFLPVQCFNSECYCVDAEGQAIPGTRSAI 720
Query: 332 --------------EESYGKTCNCAKDKLEYSQRKIVGRTF--RCDHLGNYEKVQCHG 457
E+++ +T S + T+ +C G + +VQC+G
Sbjct: 721 GKPKKCPTPCQLQSEQAFLRTVQALLS--NSSMLPTLSDTYIPQCSTDGQWRQVQCNG 776
Score = 35.4 bits (80), Expect = 0.10
Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 1/58 (1%)
Frame = +2
Query: 224 PFCEDTGMYKPVQC-VGAACWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQRK 394
P C G Y+ VQC CWCV+ G E+ G G+ +CA+ + S+R+
Sbjct: 317 PSCRRNGDYQAVQCQTEGPCWCVDAQGKEMHG-----TRQQGEPPSCAEGQSCASERQ 369
Score = 34.7 bits (78), Expect = 0.17
Identities = 15/33 (45%), Positives = 19/33 (57%), Gaps = 2/33 (6%)
Frame = +2
Query: 413 RCDHLGNYEKVQCHGSI--CYCADLSGNKIPTS 505
+CD G++E VQCH C+C D G IP S
Sbjct: 1030 QCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGS 1062
Score = 31.6 bits (70), Expect = 1.5
Identities = 17/39 (43%), Positives = 23/39 (58%), Gaps = 2/39 (5%)
Frame = +2
Query: 278 CWCVEESGDEIEGYITGIEESYGKTC--NCAKDKLEYSQ 388
CWCV+E+G E+EG + E S TC +C + KL Q
Sbjct: 898 CWCVDEAGQELEGMRS--EPSKLPTCPGSCEEAKLRVLQ 934
Score = 31.2 bits (69), Expect = 1.9
Identities = 12/30 (40%), Positives = 17/30 (56%)
Frame = +2
Query: 416 CDHLGNYEKVQCHGSICYCADLSGNKIPTS 505
C G+YE VQC C+C + G ++P S
Sbjct: 620 CTTEGSYEDVQCFSGECWCVNSWGKELPGS 649
>sp|O88322|NID2_MOUSE Nidogen-2 precursor (NID-2) (Entactin-2)
Length = 1403
Score = 52.4 bits (124), Expect = 8e-07
Identities = 33/114 (28%), Positives = 51/114 (44%), Gaps = 20/114 (17%)
Frame = +2
Query: 215 VTFPFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYIT---------GIEESYGKTCNC 361
+ P C+D G + P+QC G+ CWCV+ +G E+ G T G +
Sbjct: 986 IHIPQCDDQGNFVPLQCHGSTGFCWCVDRNGHEVPGTQTPPGSTPPHCGPPPEPTQRPRT 1045
Query: 362 AKDKLEYSQRKIVGRTFR-------CDHLGNYEKVQCHG--SICYCADLSGNKI 496
++ S + G T R CD LG++ +QCHG C+C D G ++
Sbjct: 1046 VCERWRESLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREL 1099
Score = 40.0 bits (92), Expect = 0.004
Identities = 16/37 (43%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 212 DVTFPFCEDTGMYKPVQCVGAA--CWCVEESGDEIEG 316
D P C+D G + P+QC G + CWCV++ G E++G
Sbjct: 1065 DQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGRELQG 1101
Score = 38.5 bits (88), Expect = 0.012
Identities = 14/31 (45%), Positives = 22/31 (70%), Gaps = 2/31 (6%)
Frame = +2
Query: 413 RCDHLGNYEKVQCHGS--ICYCADLSGNKIP 499
+CD GN+ +QCHGS C+C D +G+++P
Sbjct: 990 QCDDQGNFVPLQCHGSTGFCWCVDRNGHEVP 1020
>sp|Q14112|NID2_HUMAN Nidogen-2 precursor (NID-2) (Osteonidogen)
Length = 1375
Score = 49.3 bits (116), Expect = 7e-06
Identities = 35/115 (30%), Positives = 50/115 (43%), Gaps = 24/115 (20%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYITGIEESYGKTCNCAKDKLEYSQR-- 391
P C++ G + P+QC G+ CWCV+ G E+ G T G T E +QR
Sbjct: 961 PQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQT----PPGSTPPHCGPSPEPTQRPP 1016
Query: 392 -----------KIVGRTFR-------CDHLGNYEKVQCHG--SICYCADLSGNKI 496
+ G T R CD LG++ +QCHG C+C D G ++
Sbjct: 1017 TICERWRENLLEHYGGTPRDDQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREV 1071
Score = 40.4 bits (93), Expect = 0.003
Identities = 16/37 (43%), Positives = 24/37 (64%), Gaps = 2/37 (5%)
Frame = +2
Query: 212 DVTFPFCEDTGMYKPVQCVGAA--CWCVEESGDEIEG 316
D P C+D G + P+QC G + CWCV++ G E++G
Sbjct: 1037 DQYVPQCDDLGHFIPLQCHGKSDFCWCVDKDGREVQG 1073
Score = 37.7 bits (86), Expect = 0.021
Identities = 14/31 (45%), Positives = 21/31 (67%), Gaps = 2/31 (6%)
Frame = +2
Query: 413 RCDHLGNYEKVQCHGS--ICYCADLSGNKIP 499
+CD GN+ +QCHGS C+C D G+++P
Sbjct: 962 QCDEQGNFLPLQCHGSTGFCWCVDPDGHEVP 992
>sp|P81439|EQST_ACTEQ Equistatin
Length = 199
Score = 49.3 bits (116), Expect = 7e-06
Identities = 38/111 (34%), Positives = 53/111 (47%), Gaps = 12/111 (10%)
Frame = +2
Query: 200 SGAVDVTFPFCEDTGMYKPVQCVGAA--CWCVEESGDEIEGYITGIEESYGKTCNCAKDK 373
SG + P C++TG ++ QC G+ CWCV+E G EI G T I S C+ K
Sbjct: 14 SGLIGAYVPQCKETGEFEEKQCWGSTGYCWCVDEDGKEILG--TKIRGS--PDCSRRKAA 69
Query: 374 L---EYSQRKIVG-----RTFRCDHLGNYEKVQCHGS--ICYCADLSGNKI 496
L + Q IV C G++++VQC S CYC D G ++
Sbjct: 70 LTLCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKEL 120
Score = 46.6 bits (109), Expect = 4e-05
Identities = 47/179 (26%), Positives = 78/179 (43%), Gaps = 18/179 (10%)
Frame = +2
Query: 23 GFVFLSLATCIFSSKLEEFDVCGNNDQCNVGLICDEVCKED-----NNAPNCFKRH--LD 181
G + + C + + EE G+ C DE KE +P+C +R L
Sbjct: 15 GLIGAYVPQCKETGEFEEKQCWGSTGYC---WCVDEDGKEILGTKIRGSPDCSRRKAALT 71
Query: 182 ARRLIKSGAVDVTF----PFCEDTGMYKPVQCVGA--ACWCVEESGDEIEGYITGIEESY 343
+++++ V+V P C+ G + VQC + C+CV++ G E+EG S
Sbjct: 72 LCQMMQAIIVNVPGWCGPPSCKADGSFDEVQCCASNGECYCVDKKGKELEGTRQKGRPSC 131
Query: 344 GKTCN-CAKDKLEYSQRKIVGRTF--RCDHLGNYEKVQCHGS--ICYCADLSGNKIPTS 505
+ + C + +L+ + F +C G+Y VQC S C+C D G K+P S
Sbjct: 132 ERHLSPCEEARLQAHSNSLRVGMFVPQCLEDGSYNPVQCWPSTGYCWCVDEGGVKVPGS 190
>sp|Q9BQ16|TICN3_HUMAN Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like
domains proteoglycan 3)
Length = 436
Score = 43.1 bits (100), Expect = 5e-04
Identities = 16/33 (48%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEG 316
P C++ G YKP QC G+ CWCV+ G+E+ G
Sbjct: 339 PLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMG 371
Score = 37.0 bits (84), Expect = 0.035
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 3/49 (6%)
Frame = +2
Query: 389 RKIVGRTFR-CDHLGNYEKVQCHGSI--CYCADLSGNKIPTSPYVDIAN 526
+K++G+ CD G Y+ QCHGS+ C+C D GN++ S +A+
Sbjct: 331 KKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVAD 379
>sp|Q8BKV0|TICN3_MOUSE Testican-3 precursor (SPARC/osteonectin, CWCV, and Kazal-like
domains proteoglycan 3)
Length = 436
Score = 43.1 bits (100), Expect = 5e-04
Identities = 16/33 (48%), Positives = 22/33 (66%), Gaps = 2/33 (6%)
Frame = +2
Query: 224 PFCEDTGMYKPVQCVGAA--CWCVEESGDEIEG 316
P C++ G YKP QC G+ CWCV+ G+E+ G
Sbjct: 339 PLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVVG 371
Score = 37.0 bits (84), Expect = 0.035
Identities = 18/49 (36%), Positives = 29/49 (59%), Gaps = 3/49 (6%)
Frame = +2
Query: 389 RKIVGRTFR-CDHLGNYEKVQCHGSI--CYCADLSGNKIPTSPYVDIAN 526
+K++G+ CD G Y+ QCHGS+ C+C D GN++ S +A+
Sbjct: 331 KKLLGQYIPLCDEDGYYKPTQCHGSVGQCWCVDRYGNEVVGSRINGVAD 379
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,038,662
Number of Sequences: 369166
Number of extensions: 1370704
Number of successful extensions: 3750
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3447
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3681
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4226258440
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)