Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_O12
(647 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 228 8e-60
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 227 2e-59
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 225 7e-59
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 224 1e-58
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 223 4e-58
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 221 2e-57
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 219 4e-57
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 219 4e-57
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 218 8e-57
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 213 3e-55
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 228 bits (582), Expect = 8e-60
Identities = 111/193 (57%), Positives = 135/193 (69%), Gaps = 2/193 (1%)
Frame = +3
Query: 6 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IES 182
W+FS+TG+LEGQ+FRK+ L+S SEQ LVDCS LMDNAFRYIKD G I++
Sbjct: 149 WAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDT 208
Query: 183 EGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 362
E YPY A D +C N + GFTDI +E +A AVATVGPVSVAIDA H SFQ
Sbjct: 209 EKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQ 268
Query: 363 LYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKN 539
Y G+YNE C LDHGVL VG+GT + G+ YW+VKNSW TWG+ G+IKM ++K+N
Sbjct: 269 FYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKEN 328
Query: 540 QCGIATMASYPLV 578
QCGIA+ +SYPLV
Sbjct: 329 QCGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 227 bits (579), Expect = 2e-59
Identities = 112/193 (58%), Positives = 132/193 (68%), Gaps = 2/193 (1%)
Frame = +3
Query: 6 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IES 182
W+FS+TG+LEGQ+FRK L+S SEQ LVDCS LMDNAFRYIKD G I++
Sbjct: 147 WAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDT 206
Query: 183 EGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 362
E YPY D +C N + I TGF DI +E + AVAT+GPVSVAIDA H SFQ
Sbjct: 207 EKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQ 266
Query: 363 LYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKN 539
LY G+YNE C LDHGVL VGYGT + G YW+VKNSW TWGE GYIKM++++ N
Sbjct: 267 LYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNN 326
Query: 540 QCGIATMASYPLV 578
QCGIAT +SYP V
Sbjct: 327 QCGIATASSYPTV 339
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 225 bits (574), Expect = 7e-59
Identities = 114/193 (59%), Positives = 132/193 (68%), Gaps = 2/193 (1%)
Frame = +3
Query: 6 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IES 182
W+FSATG+LEGQ FRK +L+S SEQ LVD S LMDNAF+YIK+ G ++S
Sbjct: 26 WAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQGNQGCNGGLMDNAFQYIKENGGLDS 85
Query: 183 EGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 362
E YPY ATD +C P K TGF DI Q E L AVATVGP+SVAIDAGH+SFQ
Sbjct: 86 EESYPYEATDTSCNYKPEYSAAKDTGFVDIP-QREKALMKAVATVGPISVAIDAGHSSFQ 144
Query: 363 LYKSGIYNEESCSTTQLDHGVLAVGYGTQ-IGKKYWIVKNSWDVTWGESGYIKMSKDKKN 539
YKSGIY + CS+ LDHGVL VGYG + K+WIVKNSW WG GY+KM+KD+ N
Sbjct: 145 FYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKFWIVKNSWGPEWGNKGYVKMAKDQNN 204
Query: 540 QCGIATMASYPLV 578
CGIAT ASYP V
Sbjct: 205 HCGIATAASYPTV 217
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 224 bits (571), Expect = 1e-58
Identities = 105/192 (54%), Positives = 138/192 (71%), Gaps = 1/192 (0%)
Frame = +3
Query: 6 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIK-DQGIES 182
W+FS TGSLEGQ+F K LIS +EQQLVDCS M++AF YIK + GI++
Sbjct: 132 WAFSTTGSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDT 191
Query: 183 EGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 362
E YPY A DG+C+ + + + C+G T+I S +ET L AV +GP+SV IDA H+SFQ
Sbjct: 192 EAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQ 251
Query: 363 LYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQ 542
Y SG+Y E SCS + LDH VLAVGYG++ G+ +W+VKNSW +WG++GYIKMS+++ N
Sbjct: 252 FYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNN 311
Query: 543 CGIATMASYPLV 578
CGIAT+ASYPLV
Sbjct: 312 CGIATVASYPLV 323
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 223 bits (567), Expect = 4e-58
Identities = 113/196 (57%), Positives = 132/196 (67%), Gaps = 5/196 (2%)
Frame = +3
Query: 6 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IES 182
W+FSATG+LEGQ FRK RLIS SEQ LVDCS LMD AF+Y++D G ++S
Sbjct: 139 WAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDS 198
Query: 183 EGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 362
E YPY AT+ +CK NP V TGF DI Q E L AVATVGP+SVAIDAGH SF
Sbjct: 199 EESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESFL 257
Query: 363 LYKSGIYNEESCSTTQLDHGVLAVGYGTQI----GKKYWIVKNSWDVTWGESGYIKMSKD 530
YK GIY E CS+ +DHGVL VGYG + KYW+VKNSW WG GY+KM+KD
Sbjct: 258 FYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKD 317
Query: 531 KKNQCGIATMASYPLV 578
++N CGIA+ ASYP V
Sbjct: 318 RRNHCGIASAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 221 bits (562), Expect = 2e-57
Identities = 115/197 (58%), Positives = 131/197 (66%), Gaps = 6/197 (3%)
Frame = +3
Query: 6 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IES 182
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+YIKD G ++S
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDS 198
Query: 183 EGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 359
E YPY ATD +C P TGF DI Q E L AVATVGP+SVAIDAGH SF
Sbjct: 199 EESYPYLATDTNSCNYKPECSAANDTGFVDIP-QREKALMKAVATVGPISVAIDAGHTSF 257
Query: 360 QLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGESGYIKMSK 527
Q YKSGIY + CS LDHGVL VGYG + K+WIVKNSW WG +GY+KM+K
Sbjct: 258 QFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAK 317
Query: 528 DKKNQCGIATMASYPLV 578
D+ N CGIAT ASYP V
Sbjct: 318 DQNNHCGIATAASYPTV 334
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 219 bits (559), Expect = 4e-57
Identities = 109/196 (55%), Positives = 128/196 (65%), Gaps = 5/196 (2%)
Frame = +3
Query: 6 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IES 182
W+FSATG+LEGQ FRK +L+S SEQ LVDCS M AF+Y+K+ G ++S
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDS 198
Query: 183 EGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 362
E YPY A D CK P V TGFT + E L AVATVGP+SVA+DAGH+SFQ
Sbjct: 199 EESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQ 258
Query: 363 LYKSGIYNEESCSTTQLDHGVLAVGYG----TQIGKKYWIVKNSWDVTWGESGYIKMSKD 530
YKSGIY E CS+ LDHGVL VGYG KYW+VKNSW WG +GY+K++KD
Sbjct: 259 FYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKD 318
Query: 531 KKNQCGIATMASYPLV 578
K N CGIAT ASYP V
Sbjct: 319 KNNHCGIATAASYPNV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 219 bits (559), Expect = 4e-57
Identities = 113/196 (57%), Positives = 130/196 (66%), Gaps = 5/196 (2%)
Frame = +3
Query: 6 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IES 182
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAFRY+KD G ++S
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDS 198
Query: 183 EGDYPYTATDG-TCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 359
E YPY D TC P TGF D+ Q E L AVAT+GP+SVAIDAGH SF
Sbjct: 199 EESYPYLGRDTETCNYKPECSAANDTGFVDLP-QREKALMKAVATLGPISVAIDAGHQSF 257
Query: 360 QLYKSGIYNEESCSTTQLDHGVLAVGY---GTQIGKKYWIVKNSWDVTWGESGYIKMSKD 530
Q YKSGIY + CS+ LDHGVL VGY GT K+WIVKNSW WG +GY+KM+KD
Sbjct: 258 QFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKD 317
Query: 531 KKNQCGIATMASYPLV 578
+ N CGIAT ASYP V
Sbjct: 318 QNNHCGIATAASYPTV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 218 bits (556), Expect = 8e-57
Identities = 107/192 (55%), Positives = 135/192 (70%), Gaps = 1/192 (0%)
Frame = +3
Query: 6 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IES 182
W+FSATG+LEGQ+F KN+ L+S SEQQLVDCS M +AF YIKD G I++
Sbjct: 131 WAFSATGALEGQHFLKNDELVSLSEQQLVDCSTDYGNDGCGGGWMTSAFDYIKDNGGIDT 190
Query: 183 EGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQ 362
E YPY A D +C+ + + I CTG ++Q E L AV+ VGP+SVAIDA H SFQ
Sbjct: 191 ESSYPYEAEDRSCRFDANSIGAICTGSVEVQHTEEA-LQEAVSGVGPISVAIDASHFSFQ 249
Query: 363 LYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQ 542
Y SG+Y E++CS T LDHGVLAVGYGT+ K YW+VKNSW +WG++GYIKMS+++ N
Sbjct: 250 FYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDYWLVKNSWGSSWGDAGYIKMSRNRDNN 309
Query: 543 CGIATMASYPLV 578
CGIA+ SYP V
Sbjct: 310 CGIASEPSYPTV 321
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 213 bits (543), Expect = 3e-55
Identities = 109/197 (55%), Positives = 131/197 (66%), Gaps = 6/197 (3%)
Frame = +3
Query: 6 WSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQG-IES 182
W+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+Y+KD G +++
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKDNGGLDT 198
Query: 183 EGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASF 359
E YPY + +C P TGF DI Q E L AVATVGP+SVAIDAGH+SF
Sbjct: 199 EESYPYLGRETNSCTYKPECSAANDTGFVDIP-QREKALMKAVATVGPISVAIDAGHSSF 257
Query: 360 QLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGESGYIKMSK 527
Q YKSGIY + CS+ LDHGVL VGYG + K+WIVKNSW WG +GY+KM+K
Sbjct: 258 QFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNSSKFWIVKNSWGPEWGWNGYVKMAK 317
Query: 528 DKKNQCGIATMASYPLV 578
D+ N CGI+T ASYP V
Sbjct: 318 DQNNHCGISTAASYPTV 334
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,944,612
Number of Sequences: 369166
Number of extensions: 1336459
Number of successful extensions: 4209
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3703
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3791
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5316264630
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)