Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_M20
(811 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 239 5e-63
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 235 1e-61
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 224 2e-58
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 223 5e-58
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 219 9e-57
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 219 9e-57
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 216 8e-56
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 215 1e-55
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 215 1e-55
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 214 2e-55
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 239 bits (611), Expect = 5e-63
Identities = 113/227 (49%), Positives = 157/227 (69%), Gaps = 2/227 (0%)
Frame = +3
Query: 69 FVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEE 248
F+ P L VDWR KG VT VK+Q C + WAF++TG+ EG++ ++GVL+S SE+
Sbjct: 116 FISPAHVTL-PKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQ 174
Query: 249 QLIDCSDAYGNSGCKGGSPDNSFNYYKPY-GMNNEETYPYFGIKDRCKYNNNSVIAHVVS 425
L+DCS YGN+GC GG DN+F Y K G++ E++YPY I D C +N +V A
Sbjct: 175 NLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRG 234
Query: 426 FIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGY 605
F D+ + +E ++A AV+ GP++ IDAS SFQFY EG+YN+P C + +H VL+VG+
Sbjct: 235 FTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGF 294
Query: 606 GESE-GEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 743
G E GEDYW+VKNSWG WGD G+IKM+R+ NQCGIAS++S+P++
Sbjct: 295 GTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 235 bits (599), Expect = 1e-61
Identities = 107/212 (50%), Positives = 149/212 (70%), Gaps = 2/212 (0%)
Frame = +3
Query: 108 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 287
VDWR+ G VT VK+Q C + WAF++TG+ EG++ + GVL+S SE+ L+DCS YGN+G
Sbjct: 126 VDWREHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNG 185
Query: 288 CKGGSPDNSFNYYKPY-GMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVA 464
C GG DN+F Y K G++ E++YPY GI D C +N ++ A F+D+ +E ++
Sbjct: 186 CNGGLMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMK 245
Query: 465 AAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESE-GEDYWIVK 641
AV+ GP++ IDAS SFQ Y EG+YN+P C + + +H VL+VGYG E G DYW+VK
Sbjct: 246 KAVATMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWLVK 305
Query: 642 NSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 737
NSWG WG+ GYIKM R+ NNQCGIA+++S+P
Sbjct: 306 NSWGTTWGEQGYIKMARNQNNQCGIATASSYP 337
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 224 bits (572), Expect = 2e-58
Identities = 109/237 (45%), Positives = 152/237 (64%), Gaps = 1/237 (0%)
Frame = +3
Query: 36 NLMSRSQINSKFVMPYKTKLNDDEVDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAM 215
N+ RS S F +T EVDWR KG VTPVK+Q C + WAF+ TGS EG++ +
Sbjct: 87 NIPRRSAPVSVFYPKKETGPQATEVDWRTKGAVTPVKDQGQCGSCWAFSTTGSLEGQHFL 146
Query: 216 QTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPY-GMNNEETYPYFGIKDRCKY 392
+TG L+S +E+QL+DCS YG GC GG +++F+Y K G++ E YPY C++
Sbjct: 147 KTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRF 206
Query: 393 NNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKT 572
++NSV A ++A +E + AV GP++ IDA+ SFQFY G+Y +P+CS +
Sbjct: 207 DSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPS 266
Query: 573 SPNHAVLIVGYGESEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 743
+HAVL VGYG G+D+W+VKNSW WGD GYIKM R+ NN CGIA+ S+P++
Sbjct: 267 YLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 223 bits (568), Expect = 5e-58
Identities = 105/247 (42%), Positives = 148/247 (59%), Gaps = 2/247 (0%)
Frame = +3
Query: 9 EVRSKYFSKNLMSRSQINSKFVMPYKT--KLNDDEVDWRKKGVVTPVKNQYGCNAGWAFA 182
E ++KY ++ MSR+ +PY+ + D++DWR+ G VT VK+Q C + WAF+
Sbjct: 79 EFKAKYLTE--MSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFS 136
Query: 183 ATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSGCKGGSPDNSFNYYKPYGMNNEETYP 362
TG+ EG+Y +SFSE+QL+DCS +GN+GC GG +N++ Y K +G+ E +YP
Sbjct: 137 TTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYP 196
Query: 363 YFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVAAAVSAEGPLTAIIDASLPSFQFYREG 542
Y ++ +C+YN +A V + V +E+++ V A P +D F YR G
Sbjct: 197 YTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVDVE-SDFMMYRSG 255
Query: 543 IYNDPTCSKTSPNHAVLIVGYGESEGEDYWIVKNSWGAMWGDHGYIKMIRDGNNQCGIAS 722
IY TCS NHAVL VGYG G DYWIVKNSWG WG+ GYI+M R+ N CGIAS
Sbjct: 256 IYQSQTCSPLRVNHAVLAVGYGTQGGTDYWIVKNSWGTYWGERGYIRMARNRGNMCGIAS 315
Query: 723 STSFPIL 743
S P++
Sbjct: 316 LASLPMV 322
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 219 bits (557), Expect = 9e-57
Identities = 105/215 (48%), Positives = 141/215 (65%), Gaps = 5/215 (2%)
Frame = +3
Query: 108 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 287
VDWR+KG VTPVKNQ C + WAF+ATG+ EG+ +TG L+S SE+ L+DCS GN G
Sbjct: 118 VDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEG 177
Query: 288 CKGGSPDNSFNYYKPY-GMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVA 464
C GG D +F Y + G+++EE+YPY ++ CKYN +A+ F+D+ + E +
Sbjct: 178 CNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALM 236
Query: 465 AAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYG----ESEGEDYW 632
AV+ GP++ IDA SF FY+EGIY +P CS +H VL+VGYG ES+ YW
Sbjct: 237 KAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYW 296
Query: 633 IVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 737
+VKNSWG WG GY+KM +D N CGIAS+ S+P
Sbjct: 297 LVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYP 331
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 219 bits (557), Expect = 9e-57
Identities = 103/215 (47%), Positives = 139/215 (64%), Gaps = 5/215 (2%)
Frame = +3
Query: 108 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 287
VDWRKKG VTPVKNQ C + WAF+ATG+ EG+ +TG L+S SE+ L+DCS GN G
Sbjct: 118 VDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQG 177
Query: 288 CKGGSPDNSFNYYKPY-GMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVA 464
C GG +F Y K G+++EE+YPY + + CKY + +A+ F VA E +
Sbjct: 178 CNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALM 237
Query: 465 AAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYG----ESEGEDYW 632
AV+ GP++ +DA SFQFY+ GIY +P CS + +H VL+VGYG S YW
Sbjct: 238 KAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYW 297
Query: 633 IVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 737
+VKNSWG WG +GY+K+ +D NN CGIA++ S+P
Sbjct: 298 LVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYP 332
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 216 bits (549), Expect = 8e-56
Identities = 109/216 (50%), Positives = 142/216 (65%), Gaps = 6/216 (2%)
Frame = +3
Query: 108 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 287
VDWR+KG VTPVKNQ C + WAF+ATG+ EG+ +TG L+S SE+ L+DCS A GN G
Sbjct: 118 VDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEG 177
Query: 288 CKGGSPDNSFNYYKPY-GMNNEETYPYFG-IKDRCKYNNNSVIAHVVSFIDVARNNEIQV 461
C GG DN+F Y K G+++EE+YPY G + C Y A+ F+D+ + E +
Sbjct: 178 CNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDLPQ-REKAL 236
Query: 462 AAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYGESEGED----Y 629
AV+ GP++ IDA SFQFY+ GIY DP CS +H VL+VGYG EG D +
Sbjct: 237 MKAVATLGPISVAIDAGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYG-FEGTDSNNKF 295
Query: 630 WIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 737
WIVKNSWG WG +GY+KM +D NN CGIA++ S+P
Sbjct: 296 WIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYP 331
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 215 bits (548), Expect = 1e-55
Identities = 102/217 (47%), Positives = 143/217 (65%), Gaps = 5/217 (2%)
Frame = +3
Query: 108 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 287
VDWR+KG VTPVKNQ C + WAF+A+G EG+ ++TG L+S SE+ L+DCS A GN G
Sbjct: 118 VDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQG 177
Query: 288 CKGGSPDNSFNYYKPY-GMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVA 464
C GG D +F Y K G+++EE+YPY CKY +A+ F+D+ + E +
Sbjct: 178 CNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALM 236
Query: 465 AAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYG----ESEGEDYW 632
AV+ GP++ +DAS PS QFY GIY +P CS + +H VL+VGYG +S YW
Sbjct: 237 KAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYW 296
Query: 633 IVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 743
+VKNSWG+ WG GYIK+ +D +N CG+A++ S+P++
Sbjct: 297 LVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 215 bits (547), Expect = 1e-55
Identities = 103/217 (47%), Positives = 141/217 (64%), Gaps = 5/217 (2%)
Frame = +3
Query: 108 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 287
VDWR+KG VTPVKNQ C + WAF+A+G EG+ ++TG L+S SE+ L+DCS GN G
Sbjct: 118 VDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQG 177
Query: 288 CKGGSPDNSFNYYKPY-GMNNEETYPYFGIKDRCKYNNNSVIAHVVSFIDVARNNEIQVA 464
C GG D +F Y K G+++EE+YPY CKY +A+ F+D+ + E +
Sbjct: 178 CNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQ-QEKALM 236
Query: 465 AAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYG----ESEGEDYW 632
AV+ GP++ +DAS PS QFY GIY +P CS +H VL+VGYG +S + YW
Sbjct: 237 KAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYW 296
Query: 633 IVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFPIL 743
+VKNSWG WG GYIK+ +D NN CG+A++ S+PI+
Sbjct: 297 LVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 214 bits (546), Expect = 2e-55
Identities = 106/216 (49%), Positives = 139/216 (64%), Gaps = 6/216 (2%)
Frame = +3
Query: 108 VDWRKKGVVTPVKNQYGCNAGWAFAATGSCEGRYAMQTGVLMSFSEEQLIDCSDAYGNSG 287
VDW KKG VTPVKNQ C + WAF+ATG+ EG+ +TG L+S SE+ L+DCS A GN G
Sbjct: 118 VDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQG 177
Query: 288 CKGGSPDNSFNYYKPY-GMNNEETYPYFGI-KDRCKYNNNSVIAHVVSFIDVARNNEIQV 461
C GG DN+F Y K G+++EE+YPY + C Y A+ F+D+ + E +
Sbjct: 178 CNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDIPQ-REKAL 236
Query: 462 AAAVSAEGPLTAIIDASLPSFQFYREGIYNDPTCSKTSPNHAVLIVGYG----ESEGEDY 629
AV+ GP++ IDA SFQFY+ GIY DP CS +H VL+VGYG +S +
Sbjct: 237 MKAVATVGPISVAIDAGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKF 296
Query: 630 WIVKNSWGAMWGDHGYIKMIRDGNNQCGIASSTSFP 737
WIVKNSWG WG +GY+KM +D NN CGIA++ S+P
Sbjct: 297 WIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAASYP 332
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,592,352
Number of Sequences: 369166
Number of extensions: 1657554
Number of successful extensions: 5051
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4479
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4629
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7715018400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)