Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_L24
(696 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q63524|TMED2_RAT Transmembrane emp24 domain trafficking ... 189 8e-48
sp|Q15363|TMED2_HUMAN Transmembrane emp24 domain traffickin... 189 8e-48
sp|P49020|TMED2_CRIGR Transmembrane emp24 domain traffickin... 189 8e-48
sp|Q9R0Q3|TMED2_MOUSE Transmembrane emp24 domain traffickin... 189 8e-48
sp|O17528|SEL9_CAEEL Suppressor/enhancer of lin-12 protein ... 183 3e-46
sp|Q9Y3B3|TMED7_HUMAN Transmembrane emp24 domain containing... 115 1e-25
sp|Q78IS1|TMED3_MOUSE Transmembrane emp24 domain containing... 104 3e-22
sp|Q6AY25|TMED3_RAT Transmembrane emp24 domain containing p... 102 1e-21
sp|Q9Y3Q3|TMED3_HUMAN Transmembrane emp24 domain containing... 100 4e-21
sp|Q9CXE7|TMED5_MOUSE Transmembrane emp24 domain containing... 91 2e-18
>sp|Q63524|TMED2_RAT Transmembrane emp24 domain trafficking protein 2 precursor
(Membrane protein p24A) (RNP21.4)
Length = 201
Score = 189 bits (479), Expect = 8e-48
Identities = 92/165 (55%), Positives = 121/165 (73%), Gaps = 3/165 (1%)
Frame = +1
Query: 79 NVEECFFDRIKPDTDMLLLYEVAEGGSLDIDAKITDPSGAVLYSAVKKSDDKFTFRTKAD 258
+ EECFF+R+ T M L++EVAEGG LDID +IT P +Y ++S K+TF D
Sbjct: 28 HAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMD 87
Query: 259 GIYKYCFSNTMSSVTNKILMFSLDTVSPPK--KVSSDSH-TKLEEMVNDLDKALTTVKHE 429
G YK+CFSN MS++T KI+MF++D PK + +++H KLEEM+N+L A+T VKHE
Sbjct: 88 GTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHE 147
Query: 430 QEYMETREKIHRKINENTNSRVLLWAIFEACVLVVMSAGQVYYLK 564
QEYME RE+IHR IN+NTNSRV+LW+ FEA VLV M+ GQ+YYLK
Sbjct: 148 QEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLK 192
>sp|Q15363|TMED2_HUMAN Transmembrane emp24 domain trafficking protein 2 precursor
(Membrane protein p24A)
Length = 201
Score = 189 bits (479), Expect = 8e-48
Identities = 92/165 (55%), Positives = 121/165 (73%), Gaps = 3/165 (1%)
Frame = +1
Query: 79 NVEECFFDRIKPDTDMLLLYEVAEGGSLDIDAKITDPSGAVLYSAVKKSDDKFTFRTKAD 258
+ EECFF+R+ T M L++EVAEGG LDID +IT P +Y ++S K+TF D
Sbjct: 28 HAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMD 87
Query: 259 GIYKYCFSNTMSSVTNKILMFSLDTVSPPK--KVSSDSH-TKLEEMVNDLDKALTTVKHE 429
G YK+CFSN MS++T KI+MF++D PK + +++H KLEEM+N+L A+T VKHE
Sbjct: 88 GTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHE 147
Query: 430 QEYMETREKIHRKINENTNSRVLLWAIFEACVLVVMSAGQVYYLK 564
QEYME RE+IHR IN+NTNSRV+LW+ FEA VLV M+ GQ+YYLK
Sbjct: 148 QEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLK 192
>sp|P49020|TMED2_CRIGR Transmembrane emp24 domain trafficking protein 2 precursor
(COPI-coated vesicle membrane protein p24)
Length = 196
Score = 189 bits (479), Expect = 8e-48
Identities = 92/165 (55%), Positives = 121/165 (73%), Gaps = 3/165 (1%)
Frame = +1
Query: 79 NVEECFFDRIKPDTDMLLLYEVAEGGSLDIDAKITDPSGAVLYSAVKKSDDKFTFRTKAD 258
+ EECFF+R+ T M L++EVAEGG LDID +IT P +Y ++S K+TF D
Sbjct: 23 HAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMD 82
Query: 259 GIYKYCFSNTMSSVTNKILMFSLDTVSPPK--KVSSDSH-TKLEEMVNDLDKALTTVKHE 429
G YK+CFSN MS++T KI+MF++D PK + +++H KLEEM+N+L A+T VKHE
Sbjct: 83 GTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHE 142
Query: 430 QEYMETREKIHRKINENTNSRVLLWAIFEACVLVVMSAGQVYYLK 564
QEYME RE+IHR IN+NTNSRV+LW+ FEA VLV M+ GQ+YYLK
Sbjct: 143 QEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLK 187
>sp|Q9R0Q3|TMED2_MOUSE Transmembrane emp24 domain trafficking protein 2 precursor
(Membrane protein p24A) (Sid 394)
Length = 201
Score = 189 bits (479), Expect = 8e-48
Identities = 92/165 (55%), Positives = 121/165 (73%), Gaps = 3/165 (1%)
Frame = +1
Query: 79 NVEECFFDRIKPDTDMLLLYEVAEGGSLDIDAKITDPSGAVLYSAVKKSDDKFTFRTKAD 258
+ EECFF+R+ T M L++EVAEGG LDID +IT P +Y ++S K+TF D
Sbjct: 28 HAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMD 87
Query: 259 GIYKYCFSNTMSSVTNKILMFSLDTVSPPK--KVSSDSH-TKLEEMVNDLDKALTTVKHE 429
G YK+CFSN MS++T KI+MF++D PK + +++H KLEEM+N+L A+T VKHE
Sbjct: 88 GTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHE 147
Query: 430 QEYMETREKIHRKINENTNSRVLLWAIFEACVLVVMSAGQVYYLK 564
QEYME RE+IHR IN+NTNSRV+LW+ FEA VLV M+ GQ+YYLK
Sbjct: 148 QEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLK 192
>sp|O17528|SEL9_CAEEL Suppressor/enhancer of lin-12 protein 9 precursor
Length = 203
Score = 183 bits (465), Expect = 3e-46
Identities = 89/169 (52%), Positives = 116/169 (68%), Gaps = 7/169 (4%)
Frame = +1
Query: 79 NVEECFFDRIKPDTDMLLLYEVAEGGSLDIDAKITDPSGAVLYSAVKKSDDKFTFRTKAD 258
N E+CFFDR+ T M L++EVAEGG LDID KIT P +Y ++S KFTF D
Sbjct: 26 NEEQCFFDRLTSGTKMGLMFEVAEGGFLDIDVKITGPDNKEIYKGERESSGKFTFAAHMD 85
Query: 259 GIYKYCFSNTMSSVTNKILMFSLDTVSPPKKV-------SSDSHTKLEEMVNDLDKALTT 417
G+Y YCF N MS++T K +MF+++ P ++ + + KLEEMV +L AL +
Sbjct: 86 GVYTYCFGNKMSTMTPKAVMFTVEITEPHQQAPGAAANQDAADNAKLEEMVRELSSALMS 145
Query: 418 VKHEQEYMETREKIHRKINENTNSRVLLWAIFEACVLVVMSAGQVYYLK 564
VKHEQEYME RE++HR INENTNSRV++WA FEA VLV M+ GQ++YLK
Sbjct: 146 VKHEQEYMEVRERVHRNINENTNSRVVMWAAFEAFVLVGMTVGQIFYLK 194
>sp|Q9Y3B3|TMED7_HUMAN Transmembrane emp24 domain containing protein 7 precursor
Length = 224
Score = 115 bits (288), Expect = 1e-25
Identities = 60/166 (36%), Positives = 91/166 (54%), Gaps = 4/166 (2%)
Frame = +1
Query: 79 NVEECFFDRIKPDTDMLLLYEVAEGGSLDIDAKITDPSGAVLYSAVKKSDDKFTFRTKAD 258
N ++CF++ I T L ++V GG D+D ++ DP G VLY +KK D FTF +
Sbjct: 44 NAKQCFYEDIAQGTKCTLEFQVITGGHYDVDCRLEDPDGKVLYKEMKKQYDSFTFTASKN 103
Query: 259 GIYKYCFSNTMSSVTNKILMFSLDTVSPPKKVSSDSH----TKLEEMVNDLDKALTTVKH 426
G YK+CFSN S+ T+K + F P S++ T++E + +AL +V
Sbjct: 104 GTYKFCFSNEFSTFTHKTVYFDFQVGEDPPLFPSENRVSALTQMESACVSIHEALKSVID 163
Query: 427 EQEYMETREKIHRKINENTNSRVLLWAIFEACVLVVMSAGQVYYLK 564
Q + RE R E+ N+RV W++ EA +L+V+S GQV+ LK
Sbjct: 164 YQTHFRLREAQGRSRAEDLNTRVAYWSVGEALILLVVSIGQVFLLK 209
>sp|Q78IS1|TMED3_MOUSE Transmembrane emp24 domain containing protein 3 precursor
Length = 221
Score = 104 bits (259), Expect = 3e-22
Identities = 56/167 (33%), Positives = 86/167 (51%), Gaps = 5/167 (2%)
Frame = +1
Query: 79 NVEECFFDRIKPDTDMLLLYEVAEGGSLDIDAKITDPSGAVLYSAVKKSDDKFTFRTKAD 258
N ++CF + ++ L Y+V GG D+D + DP G V+Y KK D FT++T+A
Sbjct: 40 NAKQCFHEEVEQGVKFSLDYQVITGGHYDVDCYVEDPRGNVIYRETKKQYDSFTYKTEAK 99
Query: 259 GIYKYCFSNTMSSVTNKILMFSLDTVSPPKKVSSDSH-----TKLEEMVNDLDKALTTVK 423
G+Y++CFSN S+ ++K + F P + + T++E + +AL TV
Sbjct: 100 GVYRFCFSNEFSTFSHKTVYFDFQVGDEPPILPDMGNRVTALTQMESACVTIHEALKTVI 159
Query: 424 HEQEYMETREKIHRKINENTNSRVLLWAIFEACVLVVMSAGQVYYLK 564
Q + RE R E+ NSRV W++ E L V+S QV LK
Sbjct: 160 DSQTHYRLREAQDRARAEDLNSRVSYWSVGETIALFVVSFSQVLLLK 206
>sp|Q6AY25|TMED3_RAT Transmembrane emp24 domain containing protein 3 precursor
Length = 221
Score = 102 bits (254), Expect = 1e-21
Identities = 54/167 (32%), Positives = 85/167 (50%), Gaps = 5/167 (2%)
Frame = +1
Query: 79 NVEECFFDRIKPDTDMLLLYEVAEGGSLDIDAKITDPSGAVLYSAVKKSDDKFTFRTKAD 258
N ++CF + ++ L Y+V GG D+D + DP G ++Y KK D FT++T+
Sbjct: 40 NAKQCFHEEVEQGVKFSLDYQVITGGHYDVDCYVEDPMGNIIYRETKKQYDSFTYKTEVK 99
Query: 259 GIYKYCFSNTMSSVTNKILMFSLDTVSPPKKVSSDSH-----TKLEEMVNDLDKALTTVK 423
G+Y++CFSN S+ ++K + F P + + T++E + +AL TV
Sbjct: 100 GVYRFCFSNEFSTFSHKTVYFDFQVGDEPPILPDMGNRVTALTQMESACVTIHEALKTVI 159
Query: 424 HEQEYMETREKIHRKINENTNSRVLLWAIFEACVLVVMSAGQVYYLK 564
Q + RE R E+ NSRV W++ E L V+S QV LK
Sbjct: 160 DSQTHYRLREAQDRARAEDLNSRVSYWSVGETIALFVVSFSQVLLLK 206
>sp|Q9Y3Q3|TMED3_HUMAN Transmembrane emp24 domain containing protein 3 precursor (Membrane
protein p24B)
Length = 217
Score = 100 bits (249), Expect = 4e-21
Identities = 54/167 (32%), Positives = 83/167 (49%), Gaps = 5/167 (2%)
Frame = +1
Query: 79 NVEECFFDRIKPDTDMLLLYEVAEGGSLDIDAKITDPSGAVLYSAVKKSDDKFTFRTKAD 258
N ++CF + ++ L Y+V GG D+D + DP G +Y KK D FT+R +
Sbjct: 36 NAKQCFHEEVEQGVKFSLDYQVITGGHYDVDCYVEDPQGNTIYRETKKQYDSFTYRAEVK 95
Query: 259 GIYKYCFSNTMSSVTNKILMFSLDTVSPPKKVSSDSH-----TKLEEMVNDLDKALTTVK 423
G+Y++CFSN S+ ++K + F P + + T++E + +AL TV
Sbjct: 96 GVYQFCFSNEFSTFSHKTVYFDFQVGDEPPILPDMGNRVTALTQMESACVTIHEALKTVI 155
Query: 424 HEQEYMETREKIHRKINENTNSRVLLWAIFEACVLVVMSAGQVYYLK 564
Q + RE R E+ NSRV W++ E L V+S QV LK
Sbjct: 156 DSQTHYRLREAQDRARAEDLNSRVSYWSVGETIALFVVSFSQVLLLK 202
>sp|Q9CXE7|TMED5_MOUSE Transmembrane emp24 domain containing protein 5 precursor
Length = 229
Score = 91.3 bits (225), Expect = 2e-18
Identities = 57/175 (32%), Positives = 85/175 (48%), Gaps = 15/175 (8%)
Frame = +1
Query: 85 EECFFDRIKPDTDMLLLYEVAEGGSLDIDAKITDPSGAVLYSAVKKSDDKFTFRTKADGI 264
+ECF+ + + + Y+V +GG LDID +T P G L +KSD T T+ DG
Sbjct: 45 KECFYQPMPLKASLEIEYQVLDGGELDIDFHLTSPEGRTLVFEQRKSDGVHTIETE-DGD 103
Query: 265 YKYCFSNTMSSVTNKILMFSLDTVSPPKKVSSDS------------HTKLE---EMVNDL 399
Y +CF NT S+++ K++ F L + ++V KLE E +N +
Sbjct: 104 YMFCFDNTFSTISEKVIFFELILDNMGEEVQGQEDWKKYITNTDVLEMKLEDILESINSI 163
Query: 400 DKALTTVKHEQEYMETREKIHRKINENTNSRVLLWAIFEACVLVVMSAGQVYYLK 564
L+ H Q + E R I E+ RV W++ V+VV+SA QVY LK
Sbjct: 164 KSRLSKSGHIQTLLRAFEARDRNIQESNFDRVNFWSVVNLMVMVVVSAIQVYTLK 218
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,388,666
Number of Sequences: 369166
Number of extensions: 1416750
Number of successful extensions: 4078
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3925
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4046
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6024953540
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)