Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_L22
(747 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitoc... 390 e-108
sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitocho... 389 e-108
sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitoc... 387 e-107
sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitoc... 367 e-101
sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytopl... 356 4e-98
sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytopl... 356 4e-98
sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplas... 355 7e-98
sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytopl... 353 3e-97
sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytopl... 345 6e-95
sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalo... 324 2e-88
>sp|P48735|IDHP_HUMAN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 452
Score = 390 bits (1003), Expect = e-108
Identities = 183/226 (80%), Positives = 201/226 (88%), Gaps = 1/226 (0%)
Frame = -1
Query: 747 TDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKI 568
TDESI GFAHSCFQYA+ KKWPLYMSTKNTILK YDGRFKDIFQEI+D+ YK +FDK KI
Sbjct: 224 TDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKI 283
Query: 567 WYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIE 388
WYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIE
Sbjct: 284 WYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIE 343
Query: 387 AEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACV 208
AEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLD NQ+LIR+ ++E+ CV
Sbjct: 344 AEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCV 403
Query: 207 DTVDSGKMTKDLAACIHGLKNVQPN-HYLVTMDFLDAIAENFESKL 73
+TV+SG MTKDLA CIHGL NV+ N H+L T DFLD I N + L
Sbjct: 404 ETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449
>sp|P33198|IDHP_PIG Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 421
Score = 389 bits (998), Expect = e-108
Identities = 182/226 (80%), Positives = 200/226 (88%), Gaps = 1/226 (0%)
Frame = -1
Query: 747 TDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKI 568
TDESI GFAHSCFQYA+ KKWPLYMSTKNTILK YDGRFKDIFQEI+++ YK +FDK KI
Sbjct: 193 TDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDFDKYKI 252
Query: 567 WYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIE 388
WYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIE
Sbjct: 253 WYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIE 312
Query: 387 AEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACV 208
AEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLD NQ+LIR+ +E+ CV
Sbjct: 313 AEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCV 372
Query: 207 DTVDSGKMTKDLAACIHGLKNVQPN-HYLVTMDFLDAIAENFESKL 73
+TV+SG MTKDLA CIHGL NV+ N H+L T DFLD I N + L
Sbjct: 373 ETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 418
>sp|Q04467|IDHP_BOVIN Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 452
Score = 387 bits (993), Expect = e-107
Identities = 182/226 (80%), Positives = 199/226 (88%), Gaps = 1/226 (0%)
Frame = -1
Query: 747 TDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKI 568
TDESI GFAHSCFQYA+ KKWPLYMSTKNTILK YDGRFKDIFQ I+++ YK EFDK KI
Sbjct: 224 TDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQAIFEKHYKTEFDKHKI 283
Query: 567 WYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIE 388
WYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+AQG+GSLGLMTSVL+CPDGKTIE
Sbjct: 284 WYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIE 343
Query: 387 AEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACV 208
AEAAHGTVTRHYREHQKG+PTSTNPIASIFAWTRGLEHRGKLD NQ+LIR+ +E+ CV
Sbjct: 344 AEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTLEKVCV 403
Query: 207 DTVDSGKMTKDLAACIHGLKNVQPN-HYLVTMDFLDAIAENFESKL 73
+TV+SG MTKDLA CIHGL NV+ N H+L T DFLD I N + L
Sbjct: 404 ETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRAL 449
>sp|P54071|IDHP_MOUSE Isocitrate dehydrogenase [NADP], mitochondrial precursor
(Oxalosuccinate decarboxylase) (IDH) (NADP(+)-specific
ICDH) (IDP) (ICD-M)
Length = 523
Score = 367 bits (942), Expect = e-101
Identities = 175/226 (77%), Positives = 193/226 (85%), Gaps = 1/226 (0%)
Frame = -1
Query: 747 TDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKI 568
TDESI GFAHSCFQY++ KKWPLY+STKNTILK YDGRFKDIFQEI+D+ YK +FD+ KI
Sbjct: 296 TDESISGFAHSCFQYSIQKKWPLYLSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDRNKI 355
Query: 567 WYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIE 388
WYEHRLIDDMVAQ LKSSGGFVW CKNYDGDVQSDI+A +GSLGLMTSVL+CPDGKTIE
Sbjct: 356 WYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILASRFGSLGLMTSVLVCPDGKTIE 415
Query: 387 AEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACV 208
AEAAHGTVTRHYREHQKG+PTST IASIFAWTRGLEHRGKLD NQ+LIR+ E+ CV
Sbjct: 416 AEAAHGTVTRHYREHQKGRPTSTKGIASIFAWTRGLEHRGKLDGNQDLIRFAQTREKVCV 475
Query: 207 DTVDSGKMTKDLAACIHGLKNVQPN-HYLVTMDFLDAIAENFESKL 73
TV+ G MTKDLA CIHGL NV+ N H+L T DFLD I N + L
Sbjct: 476 QTVE-GAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 520
>sp|Q9Z2K8|IDHC_MICOH Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 356 bits (913), Expect = 4e-98
Identities = 164/224 (73%), Positives = 193/224 (86%)
Frame = -1
Query: 744 DESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIW 565
D+SIE FAHS FQ AL+K WPLY+STKNTILK+YDGRFKDIFQEIYD+QYK++F+ KIW
Sbjct: 186 DKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIW 245
Query: 564 YEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEA 385
YEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EA
Sbjct: 246 YEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEA 305
Query: 384 EAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVD 205
EAAHGTVTRHYR HQKG+ TSTNPIASIFAW+RGL HR +LDNN EL + +E C++
Sbjct: 306 EAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALEEVCIE 365
Query: 204 TVDSGKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 73
T+++G MTKDLAACI GL NVQ + YL T +F+D + EN ++KL
Sbjct: 366 TIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|Q9Z2K9|IDHC_MICME Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 356 bits (913), Expect = 4e-98
Identities = 164/224 (73%), Positives = 193/224 (86%)
Frame = -1
Query: 744 DESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIW 565
D+SIE FAHS FQ AL+K WPLY+STKNTILK+YDGRFKDIFQEIYD+QYK++F+ KIW
Sbjct: 186 DKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIW 245
Query: 564 YEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEA 385
YEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EA
Sbjct: 246 YEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEA 305
Query: 384 EAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVD 205
EAAHGTVTRHYR HQKG+ TSTNPIASIFAW+RGL HR +LDNN EL + +E C++
Sbjct: 306 EAAHGTVTRHYRMHQKGQETSTNPIASIFAWSRGLAHRARLDNNTELSFFAKALEEVCIE 365
Query: 204 TVDSGKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 73
T+++G MTKDLAACI GL NVQ + YL T +F+D + EN ++KL
Sbjct: 366 TIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|P41562|IDHC_RAT Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 355 bits (911), Expect = 7e-98
Identities = 164/224 (73%), Positives = 194/224 (86%)
Frame = -1
Query: 744 DESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIW 565
D+SIE FAHS FQ AL+K WPLY+STKNTILK+YDGRFKDIFQEIYD+QYK++F+ KIW
Sbjct: 186 DKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSKFEAQKIW 245
Query: 564 YEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEA 385
YEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EA
Sbjct: 246 YEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEA 305
Query: 384 EAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVD 205
EAAHGTVTRHYR +QKG+ TSTNPIASIFAW+RGL HR KLDNN EL + + +E C++
Sbjct: 306 EAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFANALEEVCIE 365
Query: 204 TVDSGKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 73
T+++G MTKDLAACI GL NVQ + YL T +F+D + EN ++KL
Sbjct: 366 TIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|O75874|IDHC_HUMAN Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 353 bits (906), Expect = 3e-97
Identities = 164/224 (73%), Positives = 193/224 (86%)
Frame = -1
Query: 744 DESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIW 565
D+SIE FAHS FQ AL+K WPLY+STKNTILK+YDGRFKDIFQEIYD+QYK++F+ KIW
Sbjct: 186 DKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIW 245
Query: 564 YEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEA 385
YEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EA
Sbjct: 246 YEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEA 305
Query: 384 EAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVD 205
EAAHGTVTRHYR +QKG+ TSTNPIASIFAWTRGL HR KLDNN+EL + + +E ++
Sbjct: 306 EAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIE 365
Query: 204 TVDSGKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 73
T+++G MTKDLAACI GL NVQ + YL T +F+D + EN + KL
Sbjct: 366 TIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKL 409
>sp|O88844|IDHC_MOUSE Isocitrate dehydrogenase [NADP] cytoplasmic (Oxalosuccinate
decarboxylase) (IDH) (NADP(+)-specific ICDH) (IDP)
Length = 414
Score = 345 bits (886), Expect = 6e-95
Identities = 161/224 (71%), Positives = 191/224 (85%)
Frame = -1
Query: 744 DESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKIW 565
D+SIE FAHS FQ AL+K WPLY+STKNTILK+YDGRFKDIFQEIYD++YK++F+ I
Sbjct: 186 DKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEAQNIC 245
Query: 564 YEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIEA 385
YEHRLIDDMVAQA+KS GGF+W CKNYDGDVQSD VAQGYGSLG+MTSVL+CPDGKT+EA
Sbjct: 246 YEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEA 305
Query: 384 EAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACVD 205
EAAHGTVTRHYR +QKG+ TSTNPIASIFAW+RGL HR KLDNN EL + +E C++
Sbjct: 306 EAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIE 365
Query: 204 TVDSGKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 73
T+++G MTKDLAACI GL NVQ + YL T +F+D + EN ++KL
Sbjct: 366 TIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKL 409
>sp|P50218|IDHC_TOBAC Isocitrate dehydrogenase [NADP] (Oxalosuccinate decarboxylase)
(IDH) (NADP(+)-specific ICDH) (IDP)
Length = 415
Score = 324 bits (830), Expect = 2e-88
Identities = 151/225 (67%), Positives = 182/225 (80%)
Frame = -1
Query: 747 TDESIEGFAHSCFQYALNKKWPLYMSTKNTILKRYDGRFKDIFQEIYDRQYKAEFDKLKI 568
TDES+ FA + A KKWPLY+STKNTILK+YDGRFKDIFQE+Y+ +K+++++ I
Sbjct: 187 TDESVRSFAEASMNMAYQKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKSKYEEAGI 246
Query: 567 WYEHRLIDDMVAQALKSSGGFVWGCKNYDGDVQSDIVAQGYGSLGLMTSVLMCPDGKTIE 388
WYEHRLIDDM A ALKS GG+VW CKNYDGDVQSD +AQG+GSLGLMTSVL+CPDGKTIE
Sbjct: 247 WYEHRLIDDMAAYALKSEGGYVWACKNYDGDVQSDFLAQGFGSLGLMTSVLVCPDGKTIE 306
Query: 387 AEAAHGTVTRHYREHQKGKPTSTNPIASIFAWTRGLEHRGKLDNNQELIRYCHLMERACV 208
AEAAHGTVTRHYR HQKG TSTN IASIFAWTRGL HR LDNN+ L+ + +E AC+
Sbjct: 307 AEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDNNERLLDFTEKLEAACI 366
Query: 207 DTVDSGKMTKDLAACIHGLKNVQPNHYLVTMDFLDAIAENFESKL 73
V+SGKMTKDLA IHG K + +HYL T +F+DA+A+ +++L
Sbjct: 367 GAVESGKMTKDLALIIHGSK-LSRDHYLNTEEFIDAVADELKARL 410
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,346,439
Number of Sequences: 369166
Number of extensions: 1911495
Number of successful extensions: 5015
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4858
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4999
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6776504000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)