Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_L01
(702 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O60885|BRD4_HUMAN Bromodomain-containing protein 4 (HUNK... 122 1e-27
sp|P13709|FSH_DROME Female sterile homeotic protein (Fragil... 119 6e-27
sp|Q9ESU6|BRD4_MOUSE Bromodomain-containing protein 4 (Mito... 119 8e-27
sp|Q15059|BRD3_HUMAN Bromodomain-containing protein 3 (RING... 116 5e-26
sp|Q8K2F0|BRD3_MOUSE Bromodomain-containing protein 3 (Brom... 116 5e-26
sp|P25440|BRD2_HUMAN Bromodomain-containing protein 2 (RING... 113 4e-25
sp|Q5TJG6|BRD2_CANFA Bromodomain-containing protein 2 113 4e-25
sp|Q9FT54|GTE6_ARATH Transcription factor GTE6 (GENERAL TRA... 46 8e-05
sp|Q9HGP4|YK82_SCHPO Hypothetical bromodomain protein C631.02 39 0.017
sp|P28739|KLPA_EMENI Kinesin-like protein klpA 36 0.11
>sp|O60885|BRD4_HUMAN Bromodomain-containing protein 4 (HUNK1 protein)
Length = 1362
Score = 122 bits (305), Expect = 1e-27
Identities = 67/171 (39%), Positives = 108/171 (63%), Gaps = 9/171 (5%)
Frame = +3
Query: 189 TNVASSMPATLRMPCNESYQNTELPSAKSNRVTEDCKPMSYDDKRKLSMDINQLPGDKLG 368
+NV+ PA ++ +Y++ E + CKPMSY++KR+LS+DIN+LPG+KLG
Sbjct: 581 SNVSKKEPAPMKSKPPPTYESEE---------EDKCKPMSYEEKRQLSLDINKLPGEKLG 631
Query: 369 RIVQIIQEREPTLRDSNPDEIEIDFEVLHPVTLRELQKFVQSVLSRQKSSTNRK------ 530
R+V IIQ REP+L++SNPDEIEIDFE L P TLREL+++V S L +++ K
Sbjct: 632 RVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAG 691
Query: 531 SAKK---SSGQVSEGVVTSNTGADDTVTKIKEESRKDSLEGFQEIQTFNNH 674
S+K SS + +S++ ++D+ T++ +S+K G ++ + ++H
Sbjct: 692 SSKMKGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHH 742
>sp|P13709|FSH_DROME Female sterile homeotic protein (Fragile-chorion membrane protein)
Length = 2038
Score = 119 bits (299), Expect = 6e-27
Identities = 67/145 (46%), Positives = 87/145 (60%), Gaps = 7/145 (4%)
Frame = +3
Query: 288 EDCKPMSYDDKRKLSMDINQLPGDKLGRIVQIIQEREPTLRDSNPDEIEIDFEVLHPVTL 467
+ KPMSYD+KR+LS+DIN+LPGDKLGR+V IIQ REP+LRDSNPDEIEIDFE L P TL
Sbjct: 947 DTAKPMSYDEKRQLSLDINKLPGDKLGRVVHIIQNREPSLRDSNPDEIEIDFETLKPSTL 1006
Query: 468 RELQKFVQSVLSRQ-------KSSTNRKSAKKSSGQVSEGVVTSNTGADDTVTKIKEESR 626
REL+ +V S L ++ KS + + KK + VT GA K K+ES
Sbjct: 1007 RELESYVASCLRKKTHKKPSGKSKDEQMAEKKQELEKRLQDVTGQLGASKKTAK-KDESA 1065
Query: 627 KDSLEGFQEIQTFNNHPKGDTGAAS 701
+E Q ++ ++S
Sbjct: 1066 SSKVEAVQPANPVSSSSSSSDSSSS 1090
>sp|Q9ESU6|BRD4_MOUSE Bromodomain-containing protein 4 (Mitotic chromosome-associated
protein) (MCAP)
Length = 1400
Score = 119 bits (298), Expect = 8e-27
Identities = 64/150 (42%), Positives = 97/150 (64%), Gaps = 9/150 (6%)
Frame = +3
Query: 252 TELPSAKSNRVTEDCKPMSYDDKRKLSMDINQLPGDKLGRIVQIIQEREPTLRDSNPDEI 431
T+ P + + CKPMSY++KR+LS+DIN+LPG+KLGR+V IIQ REP+L++SNPDEI
Sbjct: 594 TKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEI 653
Query: 432 EIDFEVLHPVTLRELQKFVQSVLSRQKSSTNRK------SAKKSSGQVSEGVVT---SNT 584
EIDFE L P TLREL+++V S L +++ K S+K SE T S++
Sbjct: 654 EIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKMKGFSSSESESTSESSSS 713
Query: 585 GADDTVTKIKEESRKDSLEGFQEIQTFNNH 674
++D+ T++ +S+K G + + ++H
Sbjct: 714 DSEDSETEMAPKSKKKGHTGRDQKKHHHHH 743
>sp|Q15059|BRD3_HUMAN Bromodomain-containing protein 3 (RING3-like protein)
Length = 726
Score = 116 bits (291), Expect = 5e-26
Identities = 56/96 (58%), Positives = 78/96 (81%), Gaps = 4/96 (4%)
Frame = +3
Query: 288 EDCKPMSYDDKRKLSMDINQLPGDKLGRIVQIIQEREPTLRDSNPDEIEIDFEVLHPVTL 467
E+ PMSYD+KR+LS+DIN+LPG+KLGR+V IIQ REP+LRDSNPDEIEIDFE L P TL
Sbjct: 567 EEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTL 626
Query: 468 RELQKFVQSVLSRQK----SSTNRKSAKKSSGQVSE 563
REL+++V+S L +++ S++ +K A KS ++++
Sbjct: 627 RELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQ 662
>sp|Q8K2F0|BRD3_MOUSE Bromodomain-containing protein 3 (Bromodomain-containing FSH-like
protein FSRG2)
Length = 726
Score = 116 bits (291), Expect = 5e-26
Identities = 56/96 (58%), Positives = 78/96 (81%), Gaps = 4/96 (4%)
Frame = +3
Query: 288 EDCKPMSYDDKRKLSMDINQLPGDKLGRIVQIIQEREPTLRDSNPDEIEIDFEVLHPVTL 467
E+ PMSYD+KR+LS+DIN+LPG+KLGR+V IIQ REP+LRDSNPDEIEIDFE L P TL
Sbjct: 568 EEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTL 627
Query: 468 RELQKFVQSVLSRQK----SSTNRKSAKKSSGQVSE 563
REL+++V+S L +++ S++ +K A KS ++++
Sbjct: 628 RELERYVKSCLQKKQRKPLSTSGKKQAAKSKEELAQ 663
>sp|P25440|BRD2_HUMAN Bromodomain-containing protein 2 (RING3 protein) (O27.1.1)
Length = 801
Score = 113 bits (283), Expect = 4e-25
Identities = 57/102 (55%), Positives = 75/102 (73%)
Frame = +3
Query: 258 LPSAKSNRVTEDCKPMSYDDKRKLSMDINQLPGDKLGRIVQIIQEREPTLRDSNPDEIEI 437
LP+ + E+ +PMSYD+KR+LS+DIN+LPG+KLGR+V IIQ REP+LRDSNP+EIEI
Sbjct: 627 LPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEI 686
Query: 438 DFEVLHPVTLRELQKFVQSVLSRQKSSTNRKSAKKSSGQVSE 563
DFE L P TLREL+++V S L +K + KK G+ E
Sbjct: 687 DFETLKPSTLRELERYVLSCL--RKKPRKPYTIKKPVGKTKE 726
>sp|Q5TJG6|BRD2_CANFA Bromodomain-containing protein 2
Length = 803
Score = 113 bits (283), Expect = 4e-25
Identities = 57/102 (55%), Positives = 75/102 (73%)
Frame = +3
Query: 258 LPSAKSNRVTEDCKPMSYDDKRKLSMDINQLPGDKLGRIVQIIQEREPTLRDSNPDEIEI 437
LP+ + E+ +PMSYD+KR+LS+DIN+LPG+KLGR+V IIQ REP+LRDSNP+EIEI
Sbjct: 629 LPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEI 688
Query: 438 DFEVLHPVTLRELQKFVQSVLSRQKSSTNRKSAKKSSGQVSE 563
DFE L P TLREL+++V S L +K + KK G+ E
Sbjct: 689 DFETLKPSTLRELERYVLSCL--RKKPRKPYTIKKPVGKTKE 728
>sp|Q9FT54|GTE6_ARATH Transcription factor GTE6 (GENERAL TRANSCRIPTION FACTOR GROUP E6)
Length = 369
Score = 46.2 bits (108), Expect = 8e-05
Identities = 36/149 (24%), Positives = 68/149 (45%), Gaps = 3/149 (2%)
Frame = +3
Query: 198 ASSMPATLRMPCNESYQNTELPSAKSNRVTEDCKPMSYDDKRKLSMDINQLPGDKLGRIV 377
AS + T + + N EL +V E C+ ++ ++KR + + + +L D L +++
Sbjct: 226 ASHIKTTRELGNEICHANDELEKLM-RKVVERCRKITIEEKRNIGLALLKLSPDDLQKVL 284
Query: 378 QIIQEREPTLRDSNPDEIEIDFEVLHPVTLRELQKFVQSVLS---RQKSSTNRKSAKKSS 548
I+ + P+ + +E+ I+ ++L TL L+ FV+ L ++K K+ + S
Sbjct: 285 GIVAQANPSFQ-PRAEEVSIEMDILDEPTLWRLKFFVKDALDNAMKKKKEEETKTRELSG 343
Query: 549 GQVSEGVVTSNTGADDTVTKIKEESRKDS 635
Q E N TK+ E K S
Sbjct: 344 AQKKEVSKKRN-----ATTKLAERKTKRS 367
>sp|Q9HGP4|YK82_SCHPO Hypothetical bromodomain protein C631.02
Length = 727
Score = 38.5 bits (88), Expect = 0.017
Identities = 20/63 (31%), Positives = 35/63 (55%)
Frame = +3
Query: 300 PMSYDDKRKLSMDINQLPGDKLGRIVQIIQEREPTLRDSNPDEIEIDFEVLHPVTLRELQ 479
P++Y+ + +L+ N L D+L + +I++ P LR N DEIEID + P ++
Sbjct: 579 PITYEMQNELAEQCNYLSADQLSHVAEILRAALPHLR--NTDEIEIDVSAMPPDVFYKVY 636
Query: 480 KFV 488
+V
Sbjct: 637 YYV 639
>sp|P28739|KLPA_EMENI Kinesin-like protein klpA
Length = 770
Score = 35.8 bits (81), Expect = 0.11
Identities = 24/118 (20%), Positives = 49/118 (41%)
Frame = +3
Query: 345 QLPGDKLGRIVQIIQEREPTLRDSNPDEIEIDFEVLHPVTLRELQKFVQSVLSRQKSSTN 524
+L +K R+ ++ Q T D+ +IE+D + RE + +++ L R++ +TN
Sbjct: 280 ELEDEKCARVRELNQLHSKTALDAQLSQIELDKTIKELAATREDLQSLRTELDRERKNTN 339
Query: 525 RKSAKKSSGQVSEGVVTSNTGADDTVTKIKEESRKDSLEGFQEIQTFNNHPKGDTGAA 698
+ + + S A + E R++ E F+ + +T AA
Sbjct: 340 NLRQNLDTAASNSVTLESTISALKARIEFLESGREEQSEAFERLNQQMMDAMAETNAA 397
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,068,877
Number of Sequences: 369166
Number of extensions: 1253235
Number of successful extensions: 3735
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3641
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3727
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6122130210
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)