Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_K19
(641 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 337 2e-92
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 329 4e-90
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 326 3e-89
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 323 3e-88
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 310 2e-84
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 293 3e-79
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 284 2e-76
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 261 1e-69
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 258 1e-68
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 257 2e-68
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 337 bits (863), Expect = 2e-92
Identities = 147/213 (69%), Positives = 168/213 (78%)
Frame = +1
Query: 1 SCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDG 180
SCWAFGAVEAI+DR CIHSNG +SAED+LTCCG CGDGCNGGFPSGAW++W G
Sbjct: 107 SCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKG 166
Query: 181 LVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYG 360
LV+GG Y +H+GC+ Y+ P C HHV G P CTGE TPKC K C+ GYS +Y EDK +G
Sbjct: 167 LVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCNKTCEPGYSPSYKEDKHFG 226
Query: 361 KSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPSYKSGVYQHVSGGMLGGHAIKILGWG 540
SSYSV +N++ IM EI NGPVE AFSVY+DF YKSGVYQHVSG ++GGHAI+ILGWG
Sbjct: 227 CSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWG 286
Query: 541 VENNTPYWLVANSWNPTWGDNGYFKILRGSDEC 639
VEN TPYWLV NSWN WGDNG+FKILRG D C
Sbjct: 287 VENGTPYWLVGNSWNTDWGDNGFFKILRGQDHC 319
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 329 bits (843), Expect = 4e-90
Identities = 143/213 (67%), Positives = 168/213 (78%)
Frame = +1
Query: 1 SCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDG 180
SCWAFGAVEAI+DR CIH+N + +SAEDLLTCCG CGDGCNGG+P+ AW++W G
Sbjct: 107 SCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKG 166
Query: 181 LVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYG 360
LV+GG Y +H+GC+ Y+ P C HHV G P CTGE TPKC K C+ GYS TY +DK YG
Sbjct: 167 LVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYG 226
Query: 361 KSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPSYKSGVYQHVSGGMLGGHAIKILGWG 540
+SYSV ++++ IM EI NGPVE AFSVY+DF YKSGVYQHV+G M+GGHAI+ILGWG
Sbjct: 227 YNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWG 286
Query: 541 VENNTPYWLVANSWNPTWGDNGYFKILRGSDEC 639
VEN TPYWLVANSWN WGDNG+FKILRG D C
Sbjct: 287 VENGTPYWLVANSWNTDWGDNGFFKILRGQDHC 319
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 326 bits (836), Expect = 3e-89
Identities = 138/213 (64%), Positives = 167/213 (78%)
Frame = +1
Query: 1 SCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDG 180
SCWAFGAVEA++DR CIH+NG +SAEDLLTCCG +CGDGCNGG+PSGAW++W G
Sbjct: 107 SCWAFGAVEAMSDRICIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWNFWTRKG 166
Query: 181 LVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYG 360
LV+GG Y +H+GC Y P C HHV G P CTGE TPKC K C+AGYS +Y EDK YG
Sbjct: 167 LVSGGVYNSHIGCLPYTIPPCEHHVNGSRPPCTGEGDTPKCNKMCEAGYSTSYKEDKHYG 226
Query: 361 KSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPSYKSGVYQHVSGGMLGGHAIKILGWG 540
+SYSV +++ IM EI NGPVE AF+V++DF +YKSGVY+H +G ++GGHAI+ILGWG
Sbjct: 227 YTSYSVSDSEKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDVMGGHAIRILGWG 286
Query: 541 VENNTPYWLVANSWNPTWGDNGYFKILRGSDEC 639
+EN PYWLVANSWN WGDNG+FKILRG + C
Sbjct: 287 IENGVPYWLVANSWNVDWGDNGFFKILRGENHC 319
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 323 bits (827), Expect = 3e-88
Identities = 138/213 (64%), Positives = 166/213 (77%)
Frame = +1
Query: 1 SCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDG 180
SCWAFGAVEAI+DR CIH+NG +SAEDLLTCCG +CGDGCNGG+PSGAW +W G
Sbjct: 107 SCWAFGAVEAISDRTCIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWSFWTKKG 166
Query: 181 LVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYG 360
LV+GG Y +H+GC Y P C HHV G P CTGE TP+C K+C+AGYS +Y EDK +G
Sbjct: 167 LVSGGVYNSHVGCLPYTIPPCEHHVNGSRPPCTGEGDTPRCNKSCEAGYSPSYKEDKHFG 226
Query: 361 KSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPSYKSGVYQHVSGGMLGGHAIKILGWG 540
+SYSV ++ + IM EI NGPVE AF+V++DF +YKSGVY+H +G M+GGHAI+ILGWG
Sbjct: 227 YTSYSVSNSVKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDMMGGHAIRILGWG 286
Query: 541 VENNTPYWLVANSWNPTWGDNGYFKILRGSDEC 639
VEN PYWL ANSWN WGDNG+FKILRG + C
Sbjct: 287 VENGVPYWLAANSWNLDWGDNGFFKILRGENHC 319
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 310 bits (795), Expect = 2e-84
Identities = 137/214 (64%), Positives = 159/214 (74%), Gaps = 1/214 (0%)
Frame = +1
Query: 1 SCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDG 180
SCWAFGAVEAI+DR C+H+N + +SAEDLL+CCGF CG GCNGG+PSGAW YW G
Sbjct: 107 SCWAFGAVEAISDRICVHTNAKVSVEVSAEDLLSCCGFECGMGCNGGYPSGAWRYWTERG 166
Query: 181 LVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEF-PTPKCKKACQAGYSKTYAEDKQY 357
LV+GG Y +H+GC+ Y P C HHV G P CTGE TP+C + C+ GYS +Y EDK Y
Sbjct: 167 LVSGGLYDSHVGCRAYTIPPCEHHVNGSRPPCTGEGGETPRCSRHCEPGYSPSYKEDKHY 226
Query: 358 GKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPSYKSGVYQHVSGGMLGGHAIKILGW 537
G +SY V +++ IM EI NGPVE AF VY DF YKSGVYQHVSG +GGHAI+ILGW
Sbjct: 227 GITSYGVPRSEKEIMAEIYKNGPVEGAFIVYEDFLMYKSGVYQHVSGEQVGGHAIRILGW 286
Query: 538 GVENNTPYWLVANSWNPTWGDNGYFKILRGSDEC 639
GVEN TPYWL ANSWN WG G+FKILRG D C
Sbjct: 287 GVENGTPYWLAANSWNTDWGITGFFKILRGEDHC 320
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 293 bits (750), Expect = 3e-79
Identities = 127/214 (59%), Positives = 157/214 (73%), Gaps = 1/214 (0%)
Frame = +1
Query: 1 SCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDG 180
SCWAFGAVEA+TDR CI S G Q+ +SA DL++CC CGDGC GGFP AW YWV G
Sbjct: 117 SCWAFGAVEAMTDRICIQSGGGQSAELSALDLISCCK-DCGDGCQGGFPGVAWDYWVKRG 175
Query: 181 LVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNC-TGEFPTPKCKKACQAGYSKTYAEDKQY 357
+VTGG H GCQ Y FPKC HH G YP C T + TP+CK+ CQ GY Y +DK Y
Sbjct: 176 IVTGGSKENHTGCQPYPFPKCEHHTKGKYPACGTKIYKTPQCKQTCQKGYKTPYEQDKHY 235
Query: 358 GKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPSYKSGVYQHVSGGMLGGHAIKILGW 537
G SY+V +N++ I ++I+ GPVEAAF VY DF +YKSG+Y+HV+G ++GGHAI+I+GW
Sbjct: 236 GDESYNVQNNEKVIQRDIMMYGPVEAAFDVYEDFLNYKSGIYRHVTGSIVGGHAIRIIGW 295
Query: 538 GVENNTPYWLVANSWNPTWGDNGYFKILRGSDEC 639
GVE TPYWL+ANSWN WG+ G F+++RG DEC
Sbjct: 296 GVEKRTPYWLIANSWNEDWGEKGLFRMVRGRDEC 329
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 284 bits (726), Expect = 2e-76
Identities = 124/214 (57%), Positives = 156/214 (72%), Gaps = 1/214 (0%)
Frame = +1
Query: 1 SCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDG 180
SCW+FGAVEA++DR CI S G Q +SA DLLTCC CG GC GG AW YWV +G
Sbjct: 116 SCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCE-SCGLGCEGGILGPAWDYWVKEG 174
Query: 181 LVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGE-FPTPKCKKACQAGYSKTYAEDKQY 357
+VT H GC+ Y FPKC HH G YP C + + TP+CK+ CQ Y Y +DK
Sbjct: 175 IVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYTQDKHR 234
Query: 358 GKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPSYKSGVYQHVSGGMLGGHAIKILGW 537
GKSSY+V ++++AI +EI+ GPVEA+F+VY DF +YKSG+Y+H++G LGGHAI+I+GW
Sbjct: 235 GKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHITGEALGGHAIRIIGW 294
Query: 538 GVENNTPYWLVANSWNPTWGDNGYFKILRGSDEC 639
GVEN TPYWL+ANSWN WG+NGYF+I+RG DEC
Sbjct: 295 GVENKTPYWLIANSWNEDWGENGYFRIVRGRDEC 328
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 261 bits (666), Expect = 1e-69
Identities = 118/218 (54%), Positives = 154/218 (70%), Gaps = 5/218 (2%)
Frame = +1
Query: 1 SCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDG 180
SCWAFGAVEA++DR CI S+G +SA+DLL+CC CG GCNGG P AW YWV DG
Sbjct: 132 SCWAFGAVEAMSDRICIASHGELQVTLSADDLLSCCK-SCGFGCNGGDPLAAWRYWVKDG 190
Query: 181 LVTGGEYGAHLGCQDYAFPKCSHHV----IGPYPNCTGEFPTPKCKKACQAGYS-KTYAE 345
+VTG Y A+ GC+ Y FP C HH P P+ +PTPKC+K C + Y+ KTY+E
Sbjct: 191 IVTGSNYTANNGCKPYPFPPCEHHSKKTHFDPCPHDL--YPTPKCEKKCVSDYTDKTYSE 248
Query: 346 DKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPSYKSGVYQHVSGGMLGGHAIK 525
DK +G S+Y V + +AI +E++T+GP+E AF VY DF +Y GVY H G + GGHA+K
Sbjct: 249 DKFFGASAYGVKDDVEAIQKELMTHGPLEIAFEVYEDFLNYDGGVYVHTGGKLGGGHAVK 308
Query: 526 ILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDEC 639
++GWG+++ PYW VANSWN WG++G+F+ILRG DEC
Sbjct: 309 LIGWGIDDGIPYWTVANSWNTDWGEDGFFRILRGVDEC 346
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 258 bits (658), Expect = 1e-68
Identities = 118/219 (53%), Positives = 148/219 (67%), Gaps = 6/219 (2%)
Frame = +1
Query: 1 SCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCG--FRCGDGCNGGFPSGAWHYWVT 174
SCWAF A EAI+DR CI SNG +S+EDLL+CC F CG+GC GG+P AW +WV
Sbjct: 109 SCWAFAAAEAISDRTCIASNGAVNTLLSSEDLLSCCTGMFSCGNGCEGGYPIQAWKWWVK 168
Query: 175 DGLVTGGEYGAHLGCQDYAFPKCSHHVIG-PYPNCTGEF-PTPKCKKACQA--GYSKTYA 342
GLVTGG Y GC+ Y+ C V G +P C + PTPKC +C + Y+ Y
Sbjct: 169 HGLVTGGSYETQFGCKPYSIAPCGETVNGVKWPACPEDTEPTPKCVDSCTSKNNYATPYL 228
Query: 343 EDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPSYKSGVYQHVSGGMLGGHAI 522
+DK +G ++Y+V + I EILTNGP+E AF+VY DF Y +GVY H +G LGGHA+
Sbjct: 229 QDKHFGSTAYAVGKKVEQIQTEILTNGPIEVAFTVYEDFYQYTTGVYVHTAGASLGGHAV 288
Query: 523 KILGWGVENNTPYWLVANSWNPTWGDNGYFKILRGSDEC 639
KILGWGV+N TPYWLVANSWN WG+ GYF+I+RG +EC
Sbjct: 289 KILGWGVDNGTPYWLVANSWNVAWGEKGYFRIIRGLNEC 327
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 257 bits (656), Expect = 2e-68
Identities = 118/213 (55%), Positives = 146/213 (68%)
Frame = +1
Query: 1 SCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHYWVTDG 180
SCWAFGA E I+DR CI + G Q P IS +DLL+CCG CG+GC GG+P A +W + G
Sbjct: 112 SCWAFGAAEMISDRTCIETKGAQQPIISPDDLLSCCGSSCGNGCEGGYPIQALRWWDSKG 171
Query: 181 LVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGEFPTPKCKKACQAGYSKTYAEDKQYG 360
+VTGG+Y GC+ Y C+ NC E TP C +CQ+GYS YA+DK +G
Sbjct: 172 VVTGGDYHG-AGCKPYPIAPCTSG------NCP-ESKTPSCSMSCQSGYSTAYAKDKHFG 223
Query: 361 KSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPSYKSGVYQHVSGGMLGGHAIKILGWG 540
S+Y+V N +I EI NGPVEAAFSVY DF YKSGVY+H +G LGGHAIKI+GWG
Sbjct: 224 VSAYAVPKNAASIQAEIYANGPVEAAFSVYEDFYKYKSGVYKHTAGKYLGGHAIKIIGWG 283
Query: 541 VENNTPYWLVANSWNPTWGDNGYFKILRGSDEC 639
E+ +PYWLVANSW WG++G+FKI RG D+C
Sbjct: 284 TESGSPYWLVANSWGVNWGESGFFKIYRGDDQC 316
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 84,369,890
Number of Sequences: 369166
Number of extensions: 1997207
Number of successful extensions: 6276
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5748
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6139
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 5218718490
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)