Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_I19
(697 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q96TA2|YMEL1_HUMAN ATP-dependent metalloprotease YME1L1 ... 132 1e-30
sp|O88967|YMEL1_MOUSE ATP-dependent metalloprotease YME1L1 ... 130 3e-30
sp|P54813|YME1_CAEEL YME1 protein homolog 129 6e-30
sp|P46508|YME1_SCHMA YME1 protein homolog 128 2e-29
sp|Q925S8|YMEL1_RAT ATP-dependent metalloprotease YME1L1 (Y... 128 2e-29
sp|P0AAI3|FTSH_ECOLI Cell division protein ftsH >gi|7741682... 116 6e-26
sp|Q8X9L0|FTSH_ECO57 Cell division protease ftsH 116 6e-26
sp|P45219|FTSH2_HAEIN Cell division protein ftsH homolog 2 113 4e-25
sp|P32795|YME1_YEAST YME1 protein (TAT-binding homolog 11) ... 113 4e-25
sp|P71377|FTSH1_HAEIN Cell division protein ftsH homolog 1 113 4e-25
>sp|Q96TA2|YMEL1_HUMAN ATP-dependent metalloprotease YME1L1 (YME1-like protein 1)
(ATP-dependent metalloprotease FtsH1) (Meg-4)
(Presenilin-associated metalloprotease) (PAMP)
Length = 773
Score = 132 bits (331), Expect = 1e-30
Identities = 73/169 (43%), Positives = 110/169 (65%), Gaps = 1/169 (0%)
Frame = +1
Query: 4 AFLTPNSLAIHKVTIIPRTHSLGHTSFLRQKEL-HTTKAQLQARIDCNLGGKVAEELIYG 180
A+ T +++ I+K TI+PR +LGH S L + + + T+AQL A++D ++GG+VAEELI+G
Sbjct: 607 AYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFG 666
Query: 181 PDKVTAGAATDLKVATAIAQSMVMHYGMSKDSKYRSFSNSISDKESLSPEAKSKIDEEIN 360
D +T GA++D AT IA+ MV +GMS+ ++ SD LSPE +S I++EI
Sbjct: 667 TDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTY----SDTGKLSPETQSAIEQEIR 722
Query: 361 IILNDSYERVRKLLTDNTDKLKILAETLLKHETLDTVEVAELLSDNNLD 507
I+L DSYER + +L + + K LAE LL +ETLD E+ +L L+
Sbjct: 723 ILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLE 771
>sp|O88967|YMEL1_MOUSE ATP-dependent metalloprotease YME1L1 (YME1-like protein 1)
(ATP-dependent metalloprotease FtsH1)
Length = 715
Score = 130 bits (327), Expect = 3e-30
Identities = 72/169 (42%), Positives = 110/169 (65%), Gaps = 1/169 (0%)
Frame = +1
Query: 4 AFLTPNSLAIHKVTIIPRTHSLGHTSFLRQKEL-HTTKAQLQARIDCNLGGKVAEELIYG 180
A+ T +++ I+K TI+PR +LGH S L + + + T+AQL A++D ++GG+VAEELI+G
Sbjct: 549 AYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFG 608
Query: 181 PDKVTAGAATDLKVATAIAQSMVMHYGMSKDSKYRSFSNSISDKESLSPEAKSKIDEEIN 360
D +T GA++D AT IA+ MV +GMS+ ++ SD LSPE +S I++EI
Sbjct: 609 TDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTY----SDTGKLSPETQSAIEQEIR 664
Query: 361 IILNDSYERVRKLLTDNTDKLKILAETLLKHETLDTVEVAELLSDNNLD 507
I+L +SYER + +L + + K LAE LL +ETLD E+ +L L+
Sbjct: 665 ILLRESYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLE 713
>sp|P54813|YME1_CAEEL YME1 protein homolog
Length = 676
Score = 129 bits (325), Expect = 6e-30
Identities = 73/170 (42%), Positives = 106/170 (62%), Gaps = 6/170 (3%)
Frame = +1
Query: 13 TPNSLAIHKVTIIPRTHSLGHTSFLRQKELHT-TKAQLQARIDCNLGGKVAEELIYGPDK 189
T ++ +HKVTIIPR SLGHT+ L +K+ + TKAQ+ A +D +GG+VAEELI+G DK
Sbjct: 473 TKDATPLHKVTIIPRGQSLGHTAMLPEKDSYQLTKAQMLATLDVMMGGRVAEELIFGDDK 532
Query: 190 VTAGAATDLKVATAIAQSMVMHYGMSKDSKYRSFS-----NSISDKESLSPEAKSKIDEE 354
VT GAA DL AT +A MV +GMS R F+ +++ L+P+ ID E
Sbjct: 533 VTTGAADDLSKATQLAVQMVKVFGMSDKVGLRDFTAQDNESALVKVSDLAPQTAELIDAE 592
Query: 355 INIILNDSYERVRKLLTDNTDKLKILAETLLKHETLDTVEVAELLSDNNL 504
IN +L +SY+R + +L + ++LAE LL++ETL EV ++S +
Sbjct: 593 INRVLQESYKRAKVILETKKKEHQLLAEALLEYETLSADEVKRVISGQKI 642
>sp|P46508|YME1_SCHMA YME1 protein homolog
Length = 662
Score = 128 bits (321), Expect = 2e-29
Identities = 74/164 (45%), Positives = 106/164 (64%), Gaps = 1/164 (0%)
Frame = +1
Query: 4 AFLTPNSLAIHKVTIIPRTHSLGHTSFLRQKELH-TTKAQLQARIDCNLGGKVAEELIYG 180
A LT +S+ +HKVTIIPR + G TSFL++K++ T+AQL A++D +GG+V EEL++G
Sbjct: 433 ALLTADSIPLHKVTIIPRGEAGGLTSFLQEKDISFMTRAQLLAQLDVLMGGRVGEELVFG 492
Query: 181 PDKVTAGAATDLKVATAIAQSMVMHYGMSKDSKYRSFSNSISDKESLSPEAKSKIDEEIN 360
DKVT GAA D + AT +AQ+MV +G S R + + E L + ID+E++
Sbjct: 493 ADKVTNGAADDFRKATILAQNMVKRFGFSSKIGPRVIPD--TQDEQLGEATRDLIDKEVD 550
Query: 361 IILNDSYERVRKLLTDNTDKLKILAETLLKHETLDTVEVAELLS 492
+LNDS RVR LL+ + + K+LAE LL ETL EV +L+
Sbjct: 551 QLLNDSLTRVRTLLSSQSKQHKLLAEALLHFETLTKDEVLAVLA 594
>sp|Q925S8|YMEL1_RAT ATP-dependent metalloprotease YME1L1 (YME1-like protein 1)
(ATP-dependent metalloprotease FtsH1) (Meg-4)
Length = 715
Score = 128 bits (321), Expect = 2e-29
Identities = 71/169 (42%), Positives = 109/169 (64%), Gaps = 1/169 (0%)
Frame = +1
Query: 4 AFLTPNSLAIHKVTIIPRTHSLGHTSFLRQKEL-HTTKAQLQARIDCNLGGKVAEELIYG 180
A+ T +++ I+K TI+PR +LGH S L + + + +AQL A++D ++GG+VAEELI+G
Sbjct: 549 AYYTKDAMPINKATIMPRGPTLGHVSLLPENDRWNEIRAQLLAQMDVSMGGRVAEELIFG 608
Query: 181 PDKVTAGAATDLKVATAIAQSMVMHYGMSKDSKYRSFSNSISDKESLSPEAKSKIDEEIN 360
D +T GA++D AT IA+ MV +GMS+ ++ SD LSPE +S I++EI
Sbjct: 609 TDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTY----SDTGKLSPETQSAIEQEIR 664
Query: 361 IILNDSYERVRKLLTDNTDKLKILAETLLKHETLDTVEVAELLSDNNLD 507
I+L +SYER + +L + + K LAE LL +ETLD E+ +L L+
Sbjct: 665 ILLRESYERAKHILKTHAKEHKNLAEALLTYETLDAKEIQIVLEGKKLE 713
>sp|P0AAI3|FTSH_ECOLI Cell division protein ftsH
sp|P0AAI4|FTSH_SHIFL Cell division protein ftsH
Length = 644
Score = 116 bits (290), Expect = 6e-26
Identities = 61/171 (35%), Positives = 105/171 (61%), Gaps = 10/171 (5%)
Frame = +1
Query: 10 LTPNSLAIHKVTIIPRTHSLGHTSFLRQKE-LHTTKAQLQARIDCNLGGKVAEELIYGPD 186
L P +HKVTIIPR +LG T FL + + + ++ +L+++I GG++AEE+IYGP+
Sbjct: 424 LVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIYGPE 483
Query: 187 KVTAGAATDLKVATAIAQSMVMHYGMS---------KDSKYRSFSNSISDKESLSPEAKS 339
V+ GA+ D+KVAT +A++MV +G S ++ S++ + +S E
Sbjct: 484 HVSTGASNDIKVATNLARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDETAR 543
Query: 340 KIDEEINIILNDSYERVRKLLTDNTDKLKILAETLLKHETLDTVEVAELLS 492
ID+E+ ++ +Y R R+LLTDN D L + + L+K+ET+D ++ +L++
Sbjct: 544 IIDQEVKALIERNYNRARQLLTDNMDILHAMKDALMKYETIDAPQIDDLMA 594
>sp|Q8X9L0|FTSH_ECO57 Cell division protease ftsH
Length = 644
Score = 116 bits (290), Expect = 6e-26
Identities = 61/171 (35%), Positives = 105/171 (61%), Gaps = 10/171 (5%)
Frame = +1
Query: 10 LTPNSLAIHKVTIIPRTHSLGHTSFLRQKE-LHTTKAQLQARIDCNLGGKVAEELIYGPD 186
L P +HKVTIIPR +LG T FL + + + ++ +L+++I GG++AEE+IYGP+
Sbjct: 424 LVPEHDPVHKVTIIPRGRALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIYGPE 483
Query: 187 KVTAGAATDLKVATAIAQSMVMHYGMS---------KDSKYRSFSNSISDKESLSPEAKS 339
V+ GA+ D+KVAT +A++MV +G S ++ S++ + +S E
Sbjct: 484 HVSTGASNDIKVATNLARNMVTQWGFSEKLGPLLYAEEEGEVFLGRSVAKAKHMSDETAR 543
Query: 340 KIDEEINIILNDSYERVRKLLTDNTDKLKILAETLLKHETLDTVEVAELLS 492
ID+E+ ++ +Y R R+LLTDN D L + + L+K+ET+D ++ +L++
Sbjct: 544 IIDQEVKALIERNYNRARQLLTDNMDILHAMKDALMKYETIDAPQIDDLMA 594
>sp|P45219|FTSH2_HAEIN Cell division protein ftsH homolog 2
Length = 381
Score = 113 bits (283), Expect = 4e-25
Identities = 60/172 (34%), Positives = 104/172 (60%), Gaps = 10/172 (5%)
Frame = +1
Query: 7 FLTPNSLAIHKVTIIPRTHSLGHTSFLRQ-KELHTTKAQLQARIDCNLGGKVAEELIYGP 183
+L P +HKVTIIPR +LG T FL + ++ ++ QL++++ G++AE+LIYG
Sbjct: 168 YLVPEHDPVHKVTIIPRGRALGVTFFLPEGDQISISQKQLESKLSTLYAGRLAEDLIYGE 227
Query: 184 DKVTAGAATDLKVATAIAQSMVMHYGMS---------KDSKYRSFSNSISDKESLSPEAK 336
+ ++ GA+ D+KVAT IA++MV +G S +D S++ + +S E
Sbjct: 228 ENISTGASNDIKVATNIARNMVTQWGFSEKLGPILYTEDEGEVFLGRSMAKAKHMSDETA 287
Query: 337 SKIDEEINIILNDSYERVRKLLTDNTDKLKILAETLLKHETLDTVEVAELLS 492
IDEE+ I+N +Y R R++L DN D L + + L+K+ET++ ++ +L++
Sbjct: 288 HSIDEEVRAIVNRNYARAREILIDNMDILHAMKDALVKYETIEEEQIKQLMN 339
>sp|P32795|YME1_YEAST YME1 protein (TAT-binding homolog 11) (OSD1 protein)
Length = 747
Score = 113 bits (283), Expect = 4e-25
Identities = 68/169 (40%), Positives = 100/169 (59%), Gaps = 1/169 (0%)
Frame = +1
Query: 13 TPNSLAIHKVTIIPRTHSLGHTSFLRQKE-LHTTKAQLQARIDCNLGGKVAEELIYGPDK 189
T + ++K TI+PR +LG T L + + + TK + QAR+D +GGK+AEELIYG D
Sbjct: 551 TNGATPLYKATILPRGRALGITFQLPEMDKVDITKRECQARLDVCMGGKIAEELIYGKDN 610
Query: 190 VTAGAATDLKVATAIAQSMVMHYGMSKDSKYRSFSNSISDKESLSPEAKSKIDEEINIIL 369
T+G +DL+ AT A++MV YGMS D + S + ES S + + D E+ +L
Sbjct: 611 TTSGCGSDLQSATGTARAMVTQYGMSDDVGPVNLS---ENWESWSNKIRDIADNEVIELL 667
Query: 370 NDSYERVRKLLTDNTDKLKILAETLLKHETLDTVEVAELLSDNNLDSSK 516
DS ER R+LLT +L LA+ L+++ETLD E+ ++ LD K
Sbjct: 668 KDSEERARRLLTKKNVELHRLAQGLIEYETLDAHEIEQVCKGEKLDKLK 716
>sp|P71377|FTSH1_HAEIN Cell division protein ftsH homolog 1
Length = 635
Score = 113 bits (283), Expect = 4e-25
Identities = 60/172 (34%), Positives = 104/172 (60%), Gaps = 10/172 (5%)
Frame = +1
Query: 7 FLTPNSLAIHKVTIIPRTHSLGHTSFLRQ-KELHTTKAQLQARIDCNLGGKVAEELIYGP 183
+L P +HKVTIIPR +LG T FL + ++ ++ QL++++ G++AE+LIYG
Sbjct: 422 YLVPEHDPVHKVTIIPRGRALGVTFFLPEGDQISISQKQLESKLSTLYAGRLAEDLIYGE 481
Query: 184 DKVTAGAATDLKVATAIAQSMVMHYGMS---------KDSKYRSFSNSISDKESLSPEAK 336
+ ++ GA+ D+KVAT IA++MV +G S +D S++ + +S E
Sbjct: 482 ENISTGASNDIKVATNIARNMVTQWGFSEKLGPILYTEDEGEVFLGRSMAKAKHMSDETA 541
Query: 337 SKIDEEINIILNDSYERVRKLLTDNTDKLKILAETLLKHETLDTVEVAELLS 492
IDEE+ I+N +Y R R++L DN D L + + L+K+ET++ ++ +L++
Sbjct: 542 HSIDEEVRAIVNRNYARAREILIDNMDILHAMKDALVKYETIEEEQIKQLMN 593
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,519,347
Number of Sequences: 369166
Number of extensions: 1256930
Number of successful extensions: 3939
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3741
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3855
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6024953540
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)