Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_H10
(840 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8VHI6|WASF3_MOUSE Wiskott-Aldrich syndrome protein fami... 70 9e-12
sp|Q9UPY6|WASF3_HUMAN Wiskott-Aldrich syndrome protein fami... 69 1e-11
sp|Q9Y6W5|WASF2_HUMAN Wiskott-Aldrich syndrome protein fami... 57 5e-08
sp|Q92558|WASF1_HUMAN Wiskott-Aldrich syndrome protein fami... 57 6e-08
sp|Q8R5H6|WASF1_MOUSE Wiskott-Aldrich syndrome protein fami... 57 6e-08
sp|Q8IV90|WASF4_HUMAN Wiskott-Aldrich syndrome protein fami... 56 1e-07
sp|Q8BH43|WASF2_MOUSE Wiskott-Aldrich syndrome protein fami... 55 2e-07
sp|O42184|REST_CHICK Restin (Cytoplasmic linker protein 170... 30 6.4
sp|Q9UJV3|TRIM1_HUMAN Midline-2 (Midline defect 2) (Tripart... 30 8.3
sp|P31804|FLIA_ECOLI RNA polymerase sigma factor for flagel... 30 8.3
>sp|Q8VHI6|WASF3_MOUSE Wiskott-Aldrich syndrome protein family member 3 (WASP-family
protein member 3) (WAVE-3 protein)
Length = 501
Score = 69.7 bits (169), Expect = 9e-12
Identities = 37/132 (28%), Positives = 73/132 (55%), Gaps = 2/132 (1%)
Frame = +3
Query: 24 LIKQISCLTVKAKDIFDELAVSLTNIVDRSLILENKIDQLTEQIKMNDSSVLQPLVNQ-- 197
+I+Q+S L+ A+DIF EL N R+ L+++ID+L ++ DS+V + +
Sbjct: 37 IIRQLSSLSKHAEDIFGELFNEANNFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDIN 96
Query: 198 QTEVYKIHLSRDDERFVQMEMPDCIREIFDKAEPPPDLFKFDEFRKEEGDSLKYYTDPEF 377
+ +K +D + + +P+ + +I+++++ PP L +R ++ D LK+YTDP +
Sbjct: 97 MKKAFKSSTIQDQQVVSKNSIPNPVADIYNQSDKPPPLSILTPYRDDKKDGLKFYTDPSY 156
Query: 378 FLREWLKNVRVD 413
F W + + D
Sbjct: 157 FFDLWKEKMLQD 168
>sp|Q9UPY6|WASF3_HUMAN Wiskott-Aldrich syndrome protein family member 3 (WASP-family
protein member 3) (WAVE-3 protein) (Verprolin homology
domain-containing protein 3)
Length = 502
Score = 69.3 bits (168), Expect = 1e-11
Identities = 37/132 (28%), Positives = 73/132 (55%), Gaps = 2/132 (1%)
Frame = +3
Query: 24 LIKQISCLTVKAKDIFDELAVSLTNIVDRSLILENKIDQLTEQIKMNDSSVLQPLVNQ-- 197
+I+Q+S L+ A+DIF EL N R+ L+++ID+L ++ DS+V + +
Sbjct: 37 IIRQLSSLSKHAEDIFGELFNEANNFYIRANSLQDRIDRLAVKVTQLDSTVEEVSLQDIN 96
Query: 198 QTEVYKIHLSRDDERFVQMEMPDCIREIFDKAEPPPDLFKFDEFRKEEGDSLKYYTDPEF 377
+ +K +D + + +P+ + +I+++++ PP L +R ++ D LK+YTDP +
Sbjct: 97 MKKAFKSSTVQDQQVVSKNSIPNPVADIYNQSDKPPPLNILTPYRDDKKDGLKFYTDPSY 156
Query: 378 FLREWLKNVRVD 413
F W + + D
Sbjct: 157 FFDLWKEKMLQD 168
>sp|Q9Y6W5|WASF2_HUMAN Wiskott-Aldrich syndrome protein family member 2 (WASP-family
protein member 2) (WAVE-2 protein) (Verprolin homology
domain-containing protein 2)
Length = 498
Score = 57.4 bits (137), Expect = 5e-08
Identities = 34/134 (25%), Positives = 65/134 (48%), Gaps = 4/134 (2%)
Frame = +3
Query: 24 LIKQISCLTVKAKDIFDELAVSLTNIVDRSLILENKIDQLTEQIKMNDSSVLQPLVNQQ- 200
+I+Q+ L+ A+DIF EL R L ++D+L Q+K+ + V+ Q
Sbjct: 36 VIRQLGSLSKYAEDIFGELFTQANTFASRVSSLAERVDRL--QVKVTQLDPKEEEVSLQG 93
Query: 201 ---TEVYKIHLSRDDERFVQMEMPDCIREIFDKAEPPPDLFKFDEFRKEEGDSLKYYTDP 371
+ ++ +D + F + +P + E ++ + PP L +R + ++LK+YTDP
Sbjct: 94 INTRKAFRSSTIQDQKLFDRNSLPVPVLETYNTCDTPPPLNNLTPYRDDGKEALKFYTDP 153
Query: 372 EFFLREWLKNVRVD 413
+F W + + D
Sbjct: 154 SYFFDLWKEKMLQD 167
>sp|Q92558|WASF1_HUMAN Wiskott-Aldrich syndrome protein family member 1 (WASP-family
protein member 1) (WAVE-1 protein) (Verprolin homology
domain-containing protein 1)
Length = 559
Score = 57.0 bits (136), Expect = 6e-08
Identities = 34/132 (25%), Positives = 66/132 (50%), Gaps = 2/132 (1%)
Frame = +3
Query: 24 LIKQISCLTVKAKDIFDELAVSLTNIVDRSLILENKIDQLTEQIKMNDSSVLQPLVNQQT 203
+I+Q+S L+ A+DIF EL + R L+ ++D+L+ + D + + T
Sbjct: 37 IIRQLSSLSKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDIT 96
Query: 204 --EVYKIHLSRDDERFVQMEMPDCIREIFDKAEPPPDLFKFDEFRKEEGDSLKYYTDPEF 377
+ ++ +D + F + +P ++E +D E PP L +R + + LK+YT+P +
Sbjct: 97 MRKAFRSSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSY 156
Query: 378 FLREWLKNVRVD 413
F W + + D
Sbjct: 157 FFDLWKEKMLQD 168
>sp|Q8R5H6|WASF1_MOUSE Wiskott-Aldrich syndrome protein family member 1 (WASP-family
protein member 1) (WAVE-1 protein)
Length = 559
Score = 57.0 bits (136), Expect = 6e-08
Identities = 34/132 (25%), Positives = 66/132 (50%), Gaps = 2/132 (1%)
Frame = +3
Query: 24 LIKQISCLTVKAKDIFDELAVSLTNIVDRSLILENKIDQLTEQIKMNDSSVLQPLVNQQT 203
+I+Q+S L+ A+DIF EL + R L+ ++D+L+ + D + + T
Sbjct: 37 IIRQLSSLSKYAEDIFGELFNEAHSFSFRVNSLQERVDRLSVSVTQLDPKEEELSLQDIT 96
Query: 204 --EVYKIHLSRDDERFVQMEMPDCIREIFDKAEPPPDLFKFDEFRKEEGDSLKYYTDPEF 377
+ ++ +D + F + +P ++E +D E PP L +R + + LK+YT+P +
Sbjct: 97 MRKAFRSSTIQDQQLFDRKTLPIPLQETYDVCEQPPPLNILTPYRDDGKEGLKFYTNPSY 156
Query: 378 FLREWLKNVRVD 413
F W + + D
Sbjct: 157 FFDLWKEKMLQD 168
>sp|Q8IV90|WASF4_HUMAN Wiskott-Aldrich syndrome protein family member 4 (WASP-family
protein member 4)
Length = 625
Score = 56.2 bits (134), Expect = 1e-07
Identities = 33/133 (24%), Positives = 63/133 (47%), Gaps = 3/133 (2%)
Frame = +3
Query: 24 LIKQISCLTVKAKDIFDELAVSLTNIVDRSLILENKIDQL---TEQIKMNDSSVLQPLVN 194
+I+Q+ L+ A+DIF EL L ++D L Q+ + V ++N
Sbjct: 164 VIRQLGSLSKYAEDIFGELFTQANTFASPVSSLAERVDGLQVKVTQLDPKEEEVSLQVIN 223
Query: 195 QQTEVYKIHLSRDDERFVQMEMPDCIREIFDKAEPPPDLFKFDEFRKEEGDSLKYYTDPE 374
+ + ++ +D + F + +P + E ++ + PP L +R + ++LK+YTDP
Sbjct: 224 TR-KAFRSSTIQDQKLFDRNSLPVPVLETYNTCDTPPPLNNLTPYRDDGTEALKFYTDPS 282
Query: 375 FFLREWLKNVRVD 413
+F W K + D
Sbjct: 283 YFFDLWKKKMLQD 295
>sp|Q8BH43|WASF2_MOUSE Wiskott-Aldrich syndrome protein family member 2 (WASP-family
protein member 2) (WAVE-2 protein)
Length = 497
Score = 55.5 bits (132), Expect = 2e-07
Identities = 31/134 (23%), Positives = 67/134 (50%), Gaps = 4/134 (2%)
Frame = +3
Query: 24 LIKQISCLTVKAKDIFDELAVSLTNIVDRSLILENKIDQLTEQIKMNDSSVLQPLVNQQ- 200
+I+Q+ L+ A+DIF E+ + R L ++D++ Q+K+ + V+ Q
Sbjct: 36 VIRQLGSLSKYAEDIFGEICTQASAFASRVNSLAERVDRV--QVKVTQLDPKEEEVSLQG 93
Query: 201 ---TEVYKIHLSRDDERFVQMEMPDCIREIFDKAEPPPDLFKFDEFRKEEGDSLKYYTDP 371
+ ++ ++D + F + +P + E ++ + PP L +R + ++LK+YT+P
Sbjct: 94 INTRKAFRSSTTQDQKLFDRNSLPVPVLETYNSCDAPPPLNNLSPYRDDGKEALKFYTNP 153
Query: 372 EFFLREWLKNVRVD 413
+F W + + D
Sbjct: 154 SYFFDLWKEKMLQD 167
>sp|O42184|REST_CHICK Restin (Cytoplasmic linker protein 170) (CLIP-170)
Length = 1433
Score = 30.4 bits (67), Expect = 6.4
Identities = 20/70 (28%), Positives = 40/70 (57%), Gaps = 9/70 (12%)
Frame = +3
Query: 27 IKQISCLTVKAKDIFDE-------LAVSLTNIVDRSLI-LENKIDQLTE-QIKMNDSSVL 179
+K+I L K ++ +E L L ++ D+ L+ +E+ +++L E +IK+ + VL
Sbjct: 679 LKEIEALKAKLLEVTEEKEQTLENLKAKLESVEDQHLVEMEDTLNKLQEAEIKVKELDVL 738
Query: 180 QPLVNQQTEV 209
Q N+QT++
Sbjct: 739 QAKCNEQTKL 748
>sp|Q9UJV3|TRIM1_HUMAN Midline-2 (Midline defect 2) (Tripartite motif protein 1) (Midin-2)
(RING finger protein 60)
Length = 715
Score = 30.0 bits (66), Expect = 8.3
Identities = 18/65 (27%), Positives = 38/65 (58%), Gaps = 3/65 (4%)
Frame = +3
Query: 33 QISCLTVKAKDIFDELAVSLTNIVDRSLILEN---KIDQLTEQIKMNDSSVLQPLVNQQT 203
Q++ L + + + L ++LTN+V R+ LEN K+ Q+ +Q+++N + L+ +
Sbjct: 208 QVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECD 267
Query: 204 EVYKI 218
E+ +I
Sbjct: 268 ELVEI 272
>sp|P31804|FLIA_ECOLI RNA polymerase sigma factor for flagellar operon (Sigma-F factor)
(Sigma-27) (Sigma-28)
Length = 239
Score = 30.0 bits (66), Expect = 8.3
Identities = 18/78 (23%), Positives = 37/78 (47%)
Frame = +3
Query: 135 DQLTEQIKMNDSSVLQPLVNQQTEVYKIHLSRDDERFVQMEMPDCIREIFDKAEPPPDLF 314
D + ++ N V Q + + E+ + + + +++ D + + D LF
Sbjct: 87 DWVPRSVRRNAREVAQAIGQLEQELGRNATETEVAERLGIDIADYRQMLLDTNNS--QLF 144
Query: 315 KFDEFRKEEGDSLKYYTD 368
+DE+R+E GDS++ TD
Sbjct: 145 SYDEWREEHGDSIELVTD 162
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 69,758,187
Number of Sequences: 369166
Number of extensions: 1119180
Number of successful extensions: 2997
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2921
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2995
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8197207050
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)