Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_F20
(865 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P10746|HEM4_HUMAN Uroporphyrinogen-III synthase (UROS) (... 125 2e-28
sp|P51163|HEM4_MOUSE Uroporphyrinogen-III synthase (UROS) (... 117 5e-26
sp|P06174|HEM4_YEAST Uroporphyrinogen-III synthase (UROS) (... 82 3e-15
sp|P87214|HEM4_SCHPO Uroporphyrinogen-III synthase (UROS) (... 69 2e-11
sp|Q10234|RT05_SCHPO Probable mitochondrial 40S ribosomal p... 34 0.46
sp|Q8TYR8|Y224_METKA Hypothetical UPF0284 protein MK0224 34 0.60
sp|P18963|IRA1_YEAST Inhibitory regulator protein IRA1 32 1.8
sp|P64192|G6PI_MYCTU Glucose-6-phosphate isomerase (GPI) (P... 32 2.3
sp|P96803|G6PI_MYCSM Glucose-6-phosphate isomerase (GPI) (P... 32 2.3
sp|Q12873|CHD3_HUMAN Chromodomain helicase-DNA-binding prot... 32 3.0
>sp|P10746|HEM4_HUMAN Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III
cosynthetase) (Hydroxymethylbilane hydrolyase
[cyclizing]) (UROIIIS)
Length = 265
Score = 125 bits (314), Expect = 2e-28
Identities = 71/206 (34%), Positives = 113/206 (54%), Gaps = 13/206 (6%)
Frame = +1
Query: 103 ENFSAIIFTSPRAVQAFQMSGLPASKNVV-------------CFVVGNATKALAESLGFE 243
E++ +IFTSPRAV+A ++ +K V +VVGNAT +L +G +
Sbjct: 54 EDYGGLIFTSPRAVEAAELCLEQNNKTEVWERSLKEKWNAKSVYVVGNATASLVSKIGLD 113
Query: 244 TAGAESGNADVLLDTIVNYDRNALTKPVLFPCGKMHRPVLPKKLEENGIQIKSVFVYSTK 423
T G GNA+ L + I + + +AL P+LFPCG + R +LPK L++ GI ++S+ VY T
Sbjct: 114 TEGETCGNAEKLAEYICSRESSAL--PLLFPCGNLKREILPKALKDKGIAMESITVYQTV 171
Query: 424 ESVELSEKLKQLFTNSQNIPDLLVFFSPSGIAFSEKVLKDEIVSKHSHLKFGSMGPATSA 603
+ L ++ Q +P + FFSPSG+ +S K +++ +KF ++GP T+
Sbjct: 172 AHPGIQGNLNSYYSQ-QGVPASITFFSPSGLTYSLKHIQELSGDNIDQIKFAAIGPTTAR 230
Query: 604 QLTSSGFSVELESRSPKPEALLKAIK 681
L + G V + SP P+AL I+
Sbjct: 231 ALAAQGLPVSCTAESPTPQALATGIR 256
>sp|P51163|HEM4_MOUSE Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III
cosynthetase) (Hydroxymethylbilane hydrolyase
[cyclizing]) (UROIIIS)
Length = 265
Score = 117 bits (292), Expect = 5e-26
Identities = 70/209 (33%), Positives = 112/209 (53%), Gaps = 13/209 (6%)
Frame = +1
Query: 103 ENFSAIIFTSPRAVQAFQMSGLPASKNVV-------------CFVVGNATKALAESLGFE 243
E F +IFTSPRAV+A ++ +K +VVG+AT +L +G +
Sbjct: 54 EGFGGLIFTSPRAVEAVKLCLEKDNKTEAWEKSLKDRWNAKSVYVVGSATASLVNKIGLD 113
Query: 244 TAGAESGNADVLLDTIVNYDRNALTKPVLFPCGKMHRPVLPKKLEENGIQIKSVFVYSTK 423
GA SGNA+ L + I + + L P+LFPCG + LPK L++ GI ++S+ VY T
Sbjct: 114 AEGAGSGNAEKLAEYICSKPSSEL--PLLFPCGTIKGDTLPKMLKDKGIPMESMHVYQTV 171
Query: 424 ESVELSEKLKQLFTNSQNIPDLLVFFSPSGIAFSEKVLKDEIVSKHSHLKFGSMGPATSA 603
+ LK + + Q IP + FFSPSG+ +S + ++ S +KF ++GP+T+
Sbjct: 172 PHPGIQGSLKSYYED-QGIPASITFFSPSGLKYSLEYIQALSGSSFDQIKFIAIGPSTTR 230
Query: 604 QLTSSGFSVELESRSPKPEALLKAIKGLI 690
+ + G V + SP P+AL I+ ++
Sbjct: 231 AMAAKGLPVSCTAESPTPQALAAGIRNVL 259
>sp|P06174|HEM4_YEAST Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III
cosynthetase) (Hydroxymethylbilane hydrolyase
[cyclizing]) (UROIIIS)
Length = 275
Score = 81.6 bits (200), Expect = 3e-15
Identities = 63/229 (27%), Positives = 104/229 (45%), Gaps = 22/229 (9%)
Frame = +1
Query: 61 EELKSICSNYTQWYENFSAIIFTSPRAVQAFQMSGLPA----------SKNVVCFVVGNA 210
++ +++ + + + II TS R V++ + +P SK V + VG A
Sbjct: 46 QDFRNVLNTIPNYLNTINYIIITSQRTVESLNEAIIPTLTSEQKAALLSKTV--YTVGPA 103
Query: 211 TKALAESLGF------ETAGAESGNADVLLDTIVNYDRNALTKPVLFPCGKMHRPVLPKK 372
T GF E AG S AD+++D + + +LF G++ R ++PKK
Sbjct: 104 TANFIRRSGFINVKGGEDAGNGSILADIIIDDLSTDIKACPPSELLFLVGEIRRDIIPKK 163
Query: 373 LEENGIQIKSVFVYSTKESVELSEKLKQLF------TNSQNIPDLLVFFSPSGIAFSEKV 534
L GI+++ V Y T+ ELS+ K+ + D +V FSP G +
Sbjct: 164 LHSKGIKVREVVTYKTE---ELSDGFKRFIHAMKECDEDEVFSDWVVVFSPQGTKEITQY 220
Query: 535 LKDEIVSKHSHLKFGSMGPATSAQLTSSGFSVELESRSPKPEALLKAIK 681
L D SHL+ S+GP T L + + ++ S P P++LL AI+
Sbjct: 221 LGDSNRLPGSHLRVASIGPTTKKYLDDNDVTSDVVSPKPDPKSLLDAIE 269
>sp|P87214|HEM4_SCHPO Uroporphyrinogen-III synthase (UROS) (Uroporphyrinogen-III
cosynthetase) (Hydroxymethylbilane hydrolyase
[cyclizing]) (UROIIIS)
Length = 251
Score = 68.6 bits (166), Expect = 2e-11
Identities = 61/218 (27%), Positives = 96/218 (44%), Gaps = 10/218 (4%)
Frame = +1
Query: 55 HPEELKSICSNYTQWYENFSAIIFTSPRAVQ----AFQMSGLPASKNVVC----FVVGNA 210
H E+L+ N + Y +I TS R + A + + ++ F VG A
Sbjct: 40 HEEQLRDKLKNVRKTY---CGLIVTSQRVSETLDEALKQEDETERQKILMETPIFTVGPA 96
Query: 211 TKALAESLGFE-TAGAESGNADVLLDTIVN-YDRNALTKPVLFPCGKMHRPVLPKKLEEN 384
T LGF+ T G + G +VL D I Y KP+LF G+ HR ++ +KL ++
Sbjct: 97 TDDSIRRLGFQQTHGKDCGRGEVLADLIEEWYTTTKQHKPLLFLVGEKHRDIIQRKLGDD 156
Query: 385 GIQIKSVFVYSTKESVELSEKLKQLFTNSQNIPDLLVFFSPSGIAFSEKVLKDEIVSKHS 564
++ S+ VY+T+E ++K I D +V FSP+ I +
Sbjct: 157 --RVDSLIVYATQELENTETQIKDTIRKHPTI-DWIVAFSPTSICSLLNTFE-------- 205
Query: 565 HLKFGSMGPATSAQLTSSGFSVELESRSPKPEALLKAI 678
LK ++GP T L G + S +P PE+L +I
Sbjct: 206 -LKIATIGPTTGDYLKKLGTQPNVVSPAPNPESLASSI 242
>sp|Q10234|RT05_SCHPO Probable mitochondrial 40S ribosomal protein S5
Length = 387
Score = 34.3 bits (77), Expect = 0.46
Identities = 21/72 (29%), Positives = 33/72 (45%)
Frame = +1
Query: 61 EELKSICSNYTQWYENFSAIIFTSPRAVQAFQMSGLPASKNVVCFVVGNATKALAESLGF 240
EELKS ++ +YEN+ I P A++A Q S P + V K + G+
Sbjct: 106 EELKSRFKDHLPFYENY---IRNHPLAIEALQKSTAPRQTGLKLNYVSKLDKYVTPLDGY 162
Query: 241 ETAGAESGNADV 276
G+E N ++
Sbjct: 163 SHLGSEESNGEI 174
>sp|Q8TYR8|Y224_METKA Hypothetical UPF0284 protein MK0224
Length = 378
Score = 33.9 bits (76), Expect = 0.60
Identities = 37/142 (26%), Positives = 62/142 (43%), Gaps = 13/142 (9%)
Frame = +1
Query: 235 GFETAGAESGNADV----------LLDTIVNYDRNALTKPVLFPCGKMHRPVLPKKLEEN 384
G E G E G+ D ++ +V + T PVL G P+L EE
Sbjct: 221 GLEAQGVEPGDLDAHEAIRRFGDPMMPAVVGIIYGSRT-PVLLAGGTQMAPILAYLAEEG 279
Query: 385 GIQIKSVFVYSTKESVELSEK-LKQLFTNSQNIPDLLVFFSPSGIAFSEKVLKDEIVSKH 561
+ + VFV +TK VE + ++ LF + + D ++F + G FSE + + +
Sbjct: 280 QLDPERVFVGTTKYVVEDEDSDIESLF---RQVGDYVLFSADPG--FSESKFRGFRLYEE 334
Query: 562 SHLK--FGSMGPATSAQLTSSG 621
++K G+ G +A L + G
Sbjct: 335 GYVKEGVGAGGAQVAAALKTKG 356
>sp|P18963|IRA1_YEAST Inhibitory regulator protein IRA1
Length = 3092
Score = 32.3 bits (72), Expect = 1.8
Identities = 49/184 (26%), Positives = 73/184 (39%), Gaps = 15/184 (8%)
Frame = +1
Query: 1 FDGNNFNVSLIETLDFVFHPEELKSICSN--YTQWYENFSAIIFTSPRAVQAFQMSGLPA 174
F G N + TL F PE+ S C Y ++F +S + ++ +P
Sbjct: 2102 FYGGKANFQKLTTLFFSLIPEQASSNCMGCYYFNVNKSFMDQWASSYTVENPYLVTTIPR 2161
Query: 175 SKNVVCFVVGNATKALAESLGFETAGAE-SGNADVLLDTIVNYDRNALT-KPVLFPCGK- 345
CF+ N ++L +SLG E + V L I YD+ PV G
Sbjct: 2162 -----CFINSNTDQSLIKSLGLSGRSLEVLKDVRVTLHDITLYDKEKKKFCPVSLKIGNK 2216
Query: 346 ----MHR-PVLPKKLEEN---GIQIKSVFVYSTKESVELSEK--LKQLFTNSQNIPDLLV 495
+H P L K N I+ +V+ S SV++S + FT S + + LV
Sbjct: 2217 YFQVLHEIPQLYKVTVSNRTFSIKFNNVYKISNLISVDVSNTTGVSSEFTLSLDNEEKLV 2276
Query: 496 FFSP 507
F SP
Sbjct: 2277 FCSP 2280
>sp|P64192|G6PI_MYCTU Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase)
(PGI) (Phosphohexose isomerase) (PHI)
sp|P64193|G6PI_MYCBO Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase)
(PGI) (Phosphohexose isomerase) (PHI)
Length = 553
Score = 32.0 bits (71), Expect = 2.3
Identities = 16/50 (32%), Positives = 25/50 (50%)
Frame = -3
Query: 377 SNFFGSTGRCILPQGNNTGLVKAFLS*FTIVSNKTSALPLSAPAVSNPND 228
SNFFG+ R +LP N+ A+L T+ SN S +P ++ +
Sbjct: 327 SNFFGAQSRTVLPYSNDLSRFPAYLQQLTMESNGKSTRADGSPVSADTGE 376
>sp|P96803|G6PI_MYCSM Glucose-6-phosphate isomerase (GPI) (Phosphoglucose isomerase)
(PGI) (Phosphohexose isomerase) (PHI)
Length = 442
Score = 32.0 bits (71), Expect = 2.3
Identities = 16/50 (32%), Positives = 24/50 (48%)
Frame = -3
Query: 377 SNFFGSTGRCILPQGNNTGLVKAFLS*FTIVSNKTSALPLSAPAVSNPND 228
SNFFG+ R +LP N+ A+L T+ SN S P ++ +
Sbjct: 216 SNFFGAQSRAVLPYSNDLSRFAAYLQQLTMESNGKSVRADGTPVSTDTGE 265
>sp|Q12873|CHD3_HUMAN Chromodomain helicase-DNA-binding protein 3 (CHD-3) (Mi-2 autoantigen
240 kDa protein) (Mi2-alpha)
Length = 1944
Score = 31.6 bits (70), Expect = 3.0
Identities = 19/55 (34%), Positives = 22/55 (40%)
Frame = +1
Query: 238 FETAGAESGNADVLLDTIVNYDRNALTKPVLFPCGKMHRPVLPKKLEENGIQIKS 402
FE + G V L I+ + P LFP M P LP E G IKS
Sbjct: 1004 FEALNSRGGGNQVSLLNIMMDLKKCCNHPYLFPVAAMESPKLPSGAYEGGALIKS 1058
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,606,500
Number of Sequences: 369166
Number of extensions: 1826533
Number of successful extensions: 4812
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4668
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4803
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8582957970
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)