Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_E17
(808 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q64428|ECHA_RAT Trifunctional enzyme alpha subunit, mito... 254 3e-67
sp|Q29554|ECHA_PIG Trifunctional enzyme alpha subunit, mito... 253 6e-67
sp|P40939|ECHA_HUMAN Trifunctional enzyme alpha subunit, mi... 250 4e-66
sp|P77399|FADJ_ECOLI Fatty acid oxidation complex alpha sub... 157 3e-38
sp|P21177|FADB_ECOLI Fatty oxidation complex alpha subunit ... 129 9e-30
sp|Q8X8I2|FADB_ECO57 Fatty oxidation complex alpha subunit ... 128 2e-29
sp|Q8ZAN0|FADB_YERPE Fatty oxidation complex alpha subunit ... 127 4e-29
sp|Q9L6L5|FADB_SALTY Fatty oxidation complex alpha subunit ... 126 6e-29
sp|P28793|FAOB_PSEFR Fatty oxidation complex alpha subunit ... 125 1e-28
sp|Q8Z3C6|FADB_SALTI Fatty oxidation complex alpha subunit ... 124 2e-28
>sp|Q64428|ECHA_RAT Trifunctional enzyme alpha subunit, mitochondrial precursor
(TP-alpha) [Includes: Long-chain enoyl-CoA hydratase ;
Long chain 3-hydroxyacyl-CoA dehydrogenase ]
Length = 763
Score = 254 bits (648), Expect = 3e-67
Identities = 143/268 (53%), Positives = 178/268 (66%), Gaps = 3/268 (1%)
Frame = +1
Query: 13 TSFEADKIFSKLHSTTDYKELKNTDIVIEAVFEDLDLKHKIIKEVESCLPENVVFATNTS 192
TSFE D IFS L DYK + D+VIEAVFEDL +KHK++KEVES PE+ +FA+NTS
Sbjct: 418 TSFERDSIFSNLIGQLDYKGFEKADMVIEAVFEDLAVKHKVLKEVESVTPEHCIFASNTS 477
Query: 193 ALPIHKIAEASKRPNKVIGMHYFSPVEKMPLLXXXXXXXXXXXXXAVAVDVGLRQGKVVI 372
ALPI++IA S+RP KVIGMHYFSPV+KM LL A AV VGL+QGKV+I
Sbjct: 478 ALPINQIAAVSQRPEKVIGMHYFSPVDKMQLLEIITTDKTSKDTTASAVAVGLKQGKVII 537
Query: 373 VVADGPGFYTTRILSTMMTEAIRLLQEGVTPSELDKVTRDFGWPVGSASLADEVGIDVAF 552
VV DGPGFYTTR L+ MM+E IR+LQEGV P +LD +T FG+PVG+A+LADEVGIDVA
Sbjct: 538 VVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDALTTGFGFPVGAATLADEVGIDVAQ 597
Query: 553 HVGQELELALGNRMKGGNVDILKDMVAAXXXXXXXXXXXXXXXXXXXIE--NTECLDILK 726
HV ++L A G R GG+V++LK MV+ + N+E +IL
Sbjct: 598 HVAEDLGKAFGERFGGGSVELLKLMVSKGFLGRKSGKGFYIYQSGSKNKNLNSEIDNILV 657
Query: 727 KYYV-KPPTDNFAERIQYRLFSRFVNEA 807
+ P + E IQYR+ +RFVNEA
Sbjct: 658 NLRLPAKPEVSSDEDIQYRVITRFVNEA 685
>sp|Q29554|ECHA_PIG Trifunctional enzyme alpha subunit, mitochondrial precursor
(TP-alpha) (78 kDa gastrin-binding protein) [Includes:
Long-chain enoyl-CoA hydratase ; Long chain
3-hydroxyacyl-CoA dehydrogenase ]
Length = 763
Score = 253 bits (645), Expect = 6e-67
Identities = 138/269 (51%), Positives = 174/269 (64%), Gaps = 4/269 (1%)
Frame = +1
Query: 13 TSFEADKIFSKLHSTTDYKELKNTDIVIEAVFEDLDLKHKIIKEVESCLPENVVFATNTS 192
TSFE D +FS L DY+ + D+VIEAVFE+L LKHK++KEVE+ +P++ VFA+NTS
Sbjct: 418 TSFERDSLFSNLTGQLDYQGFEKADMVIEAVFEELSLKHKVLKEVEAVIPDHCVFASNTS 477
Query: 193 ALPIHKIAEASKRPNKVIGMHYFSPVEKMPLLXXXXXXXXXXXXXAVAVDVGLRQGKVVI 372
ALPI +IA SKRP KVIGMHYFSPV+KM LL A AV+VGL+QGKV+I
Sbjct: 478 ALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDSTASAVEVGLKQGKVII 537
Query: 373 VVADGPGFYTTRILSTMMTEAIRLLQEGVTPSELDKVTRDFGWPVGSASLADEVGIDVAF 552
VV DGPGFYTTR L+ MM+E +R+LQEGV P +LD +T FG+PVG+A+L DEVG+DVA
Sbjct: 538 VVKDGPGFYTTRCLAPMMSEVLRILQEGVGPKKLDSLTTSFGFPVGAATLMDEVGMDVAK 597
Query: 553 HVGQELELALGNRMKGGNVDILKDMVAAXXXXXXXXXXXXXXXXXXXIEN----TECLDI 720
HV + L G R GGN+D+LK M++ N TE +
Sbjct: 598 HVAENLGKIFGERFAGGNLDVLKQMISKGFLGRKSGKGFYVYQEGVKNRNVNSDTESILA 657
Query: 721 LKKYYVKPPTDNFAERIQYRLFSRFVNEA 807
K +P + E IQYRL +RFVNEA
Sbjct: 658 SLKIPSRPDISS-DEDIQYRLVTRFVNEA 685
>sp|P40939|ECHA_HUMAN Trifunctional enzyme alpha subunit, mitochondrial precursor
(TP-alpha) (78 kDa gastrin-binding protein) [Includes:
Long-chain enoyl-CoA hydratase ; Long chain
3-hydroxyacyl-CoA dehydrogenase ]
Length = 763
Score = 250 bits (638), Expect = 4e-66
Identities = 136/268 (50%), Positives = 175/268 (65%), Gaps = 3/268 (1%)
Frame = +1
Query: 13 TSFEADKIFSKLHSTTDYKELKNTDIVIEAVFEDLDLKHKIIKEVESCLPENVVFATNTS 192
TSFE D IFS L DY+ + D+VIEAVFEDL LKH+++KEVE+ +P++ +FA+NTS
Sbjct: 418 TSFERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLSLKHRVLKEVEAVIPDHCIFASNTS 477
Query: 193 ALPIHKIAEASKRPNKVIGMHYFSPVEKMPLLXXXXXXXXXXXXXAVAVDVGLRQGKVVI 372
ALPI +IA SKRP KVIGMHYFSPV+KM LL A AV VGL+QGKV+I
Sbjct: 478 ALPISEIAAVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTSASAVAVGLKQGKVII 537
Query: 373 VVADGPGFYTTRILSTMMTEAIRLLQEGVTPSELDKVTRDFGWPVGSASLADEVGIDVAF 552
VV DGPGFYTTR L+ MM+E IR+LQEGV P +LD +T FG+PVG+A+L DEVG+DVA
Sbjct: 538 VVKDGPGFYTTRCLAPMMSEVIRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAK 597
Query: 553 HVGQELELALGNRMKGGNVDILKDMVAAXXXXXXXXXXXXXXXXXXXIE--NTECLDILK 726
HV ++L G R GGN ++L MV+ + N++ IL
Sbjct: 598 HVAEDLGKVFGERFGGGNPELLTQMVSKGFLGRKSGKGFYIYQEGVKRKDLNSDMDSILA 657
Query: 727 KYYVKPPTD-NFAERIQYRLFSRFVNEA 807
+ P ++ + E IQ+RL +RFVNEA
Sbjct: 658 SLKLPPKSEVSSDEDIQFRLVTRFVNEA 685
>sp|P77399|FADJ_ECOLI Fatty acid oxidation complex alpha subunit [Includes: Enoyl-CoA
hydratase ; 3-hydroxyacyl-CoA dehydrogenase ;
3-hydroxybutyryl-CoA epimerase ]
Length = 714
Score = 157 bits (397), Expect = 3e-38
Identities = 84/190 (44%), Positives = 113/190 (59%)
Frame = +1
Query: 22 EADKIFSKLHSTTDYKELKNTDIVIEAVFEDLDLKHKIIKEVESCLPENVVFATNTSALP 201
E DK + + TTDY+ + D++IEAVFE+L+LK +++ EVE + +FA+NTS+LP
Sbjct: 369 ERDKQLALISGTTDYRGFAHRDLIIEAVFENLELKQQMVAEVEQNCAAHTIFASNTSSLP 428
Query: 202 IHKIAEASKRPNKVIGMHYFSPVEKMPLLXXXXXXXXXXXXXAVAVDVGLRQGKVVIVVA 381
I IA + RP +VIG+H+FSPVEKMPL+ A V + +QGK IVV
Sbjct: 429 IGDIAAHATRPEQVIGLHFFSPVEKMPLVEIIPHAGTSAQTIATTVKLAKKQGKTPIVVR 488
Query: 382 DGPGFYTTRILSTMMTEAIRLLQEGVTPSELDKVTRDFGWPVGSASLADEVGIDVAFHVG 561
D GFY RIL+ + EAIR+L +G +D FG+PVG L DEVGID +
Sbjct: 489 DKAGFYVNRILAPYINEAIRMLTQGERVEHIDAALVKFGFPVGPIQLLDEVGIDTGTKII 548
Query: 562 QELELALGNR 591
LE A G R
Sbjct: 549 PVLEAAYGER 558
>sp|P21177|FADB_ECOLI Fatty oxidation complex alpha subunit [Includes: Enoyl-CoA
hydratase ; Delta(3)-cis-delta(2)-trans-enoyl-CoA
isomerase ; 3-hydroxyacyl-CoA dehydrogenase ;
3-hydroxybutyryl-CoA epimerase ]
Length = 729
Score = 129 bits (324), Expect = 9e-30
Identities = 70/189 (37%), Positives = 101/189 (53%), Gaps = 1/189 (0%)
Frame = +1
Query: 34 IFSKLHSTTDYKELKNTDIVIEAVFEDLDLKHKIIKEVESCLPENVVFATNTSALPIHKI 213
+ S +H T DY DIV+EAV E+ +K ++ E E + ++ V A+NTS +PI ++
Sbjct: 377 VISTIHPTLDYAGFDRVDIVVEAVVENPKVKKAVLAETEQKVRQDTVLASNTSTIPISEL 436
Query: 214 AEASKRPNKVIGMHYFSPVEKMPLLXXXXXXXXXXXXXAVAVDVGLRQGKVVIVVADGPG 393
A A +RP GMH+F+PV +MPL+ A V + GK IVV D PG
Sbjct: 437 ANALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPG 496
Query: 394 FYTTRILSTMMTEAIRLLQEGVTPSELDKV-TRDFGWPVGSASLADEVGIDVAFHVGQEL 570
F+ R+L +LL++G ++DKV + FGWP+G A L D VGID A H +
Sbjct: 497 FFVNRVLFPYFAGFSQLLRDGADFRKIDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVM 556
Query: 571 ELALGNRMK 597
RM+
Sbjct: 557 AAGFPQRMQ 565
>sp|Q8X8I2|FADB_ECO57 Fatty oxidation complex alpha subunit [Includes: Enoyl-CoA
hydratase ; Delta(3)-cis-delta(2)-trans-enoyl-CoA
isomerase ; 3-hydroxyacyl-CoA dehydrogenase ;
3-hydroxybutyryl-CoA epimerase ]
Length = 729
Score = 128 bits (321), Expect = 2e-29
Identities = 68/189 (35%), Positives = 101/189 (53%), Gaps = 1/189 (0%)
Frame = +1
Query: 34 IFSKLHSTTDYKELKNTDIVIEAVFEDLDLKHKIIKEVESCLPENVVFATNTSALPIHKI 213
+ S +H T DY + D+V+EA+ E+ +K ++ E E + + V A+NTS +PI ++
Sbjct: 377 VISTIHPTLDYAGFERVDVVVEAIVENPKVKKAVLAETEQKVRPDTVLASNTSTIPISEL 436
Query: 214 AEASKRPNKVIGMHYFSPVEKMPLLXXXXXXXXXXXXXAVAVDVGLRQGKVVIVVADGPG 393
A A +RP GMH+F+PV +MPL+ A V + GK IVV D PG
Sbjct: 437 ANALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPG 496
Query: 394 FYTTRILSTMMTEAIRLLQEGVTPSELDKV-TRDFGWPVGSASLADEVGIDVAFHVGQEL 570
F+ R+L +LL++G ++DKV + FGWP+G A L D VGID A H +
Sbjct: 497 FFVNRVLFPYFAGFSQLLRDGADFRKIDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVM 556
Query: 571 ELALGNRMK 597
RM+
Sbjct: 557 AAGFPQRMQ 565
>sp|Q8ZAN0|FADB_YERPE Fatty oxidation complex alpha subunit [Includes: Enoyl-CoA
hydratase ; Delta(3)-cis-delta(2)-trans-enoyl-CoA
isomerase ; 3-hydroxyacyl-CoA dehydrogenase ;
3-hydroxybutyryl-CoA epimerase ]
Length = 729
Score = 127 bits (319), Expect = 4e-29
Identities = 68/197 (34%), Positives = 105/197 (53%), Gaps = 1/197 (0%)
Frame = +1
Query: 7 KYTSFEADKIFSKLHSTTDYKELKNTDIVIEAVFEDLDLKHKIIKEVESCLPENVVFATN 186
K + I + + T DY ++ +++EAV E+ +K ++ EVE+ + E+ V A+N
Sbjct: 368 KVDGLKMASILATIRPTLDYAGIERAQVIVEAVVENPKVKAAVLAEVEALIGEDTVLASN 427
Query: 187 TSALPIHKIAEASKRPNKVIGMHYFSPVEKMPLLXXXXXXXXXXXXXAVAVDVGLRQGKV 366
TS +PI ++A++ KRP GMH+F+PV +MPL+ A V + GK
Sbjct: 428 TSTIPIDQLAKSLKRPENFCGMHFFNPVHRMPLVEIIRGAKTSDKTLAAVVAYATQMGKT 487
Query: 367 VIVVADGPGFYTTRILSTMMTEAIRLLQEGVTPSELDKV-TRDFGWPVGSASLADEVGID 543
IVV D PGF+ R+L + L+++G ++DKV + FGWP+G A L D VGID
Sbjct: 488 PIVVNDCPGFFVNRVLFPYLAGFGMLVRDGGDFHQIDKVMEKQFGWPMGPAYLLDVVGID 547
Query: 544 VAFHVGQELELALGNRM 594
A H + RM
Sbjct: 548 TAHHAQAVMAAGFPERM 564
>sp|Q9L6L5|FADB_SALTY Fatty oxidation complex alpha subunit [Includes: Enoyl-CoA
hydratase ; Delta(3)-cis-delta(2)-trans-enoyl-CoA
isomerase ; 3-hydroxyacyl-CoA dehydrogenase ;
3-hydroxybutyryl-CoA epimerase ]
Length = 729
Score = 126 bits (317), Expect = 6e-29
Identities = 69/189 (36%), Positives = 99/189 (52%), Gaps = 1/189 (0%)
Frame = +1
Query: 34 IFSKLHSTTDYKELKNTDIVIEAVFEDLDLKHKIIKEVESCLPENVVFATNTSALPIHKI 213
+ S +H T DY D+V+EAV E+ +K ++ E E + V A+NTS +PI ++
Sbjct: 377 VISTIHPTLDYAGFDRVDVVVEAVVENPKVKKAVLAETEQKVRPETVLASNTSTIPIGEL 436
Query: 214 AEASKRPNKVIGMHYFSPVEKMPLLXXXXXXXXXXXXXAVAVDVGLRQGKVVIVVADGPG 393
A A +RP GMH+F+PV +MPL+ A V + GK IVV D PG
Sbjct: 437 ASALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNDCPG 496
Query: 394 FYTTRILSTMMTEAIRLLQEGVTPSELDKV-TRDFGWPVGSASLADEVGIDVAFHVGQEL 570
F+ R+L +LL++G ++DKV + FGWP+G A L D VGID A H +
Sbjct: 497 FFVNRVLFPYFAGFSQLLRDGADFRKVDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVM 556
Query: 571 ELALGNRMK 597
RM+
Sbjct: 557 AAGFPQRMQ 565
>sp|P28793|FAOB_PSEFR Fatty oxidation complex alpha subunit [Includes: Enoyl-CoA
hydratase ; Delta(3)-cis-delta(2)-trans-enoyl-CoA
isomerase ; 3-hydroxyacyl-CoA dehydrogenase ;
3-hydroxybutyryl-CoA epimerase ]
Length = 715
Score = 125 bits (315), Expect = 1e-28
Identities = 69/197 (35%), Positives = 102/197 (51%)
Frame = +1
Query: 7 KYTSFEADKIFSKLHSTTDYKELKNTDIVIEAVFEDLDLKHKIIKEVESCLPENVVFATN 186
+ T + ++ + + T Y + N D+V+EAV E+ +K ++ EVE+ + E+ + A+N
Sbjct: 369 RMTPAKMAEVLNGIRPTLSYGDFGNVDLVVEAVVENPKVKQAVLAEVENHVREDAILASN 428
Query: 187 TSALPIHKIAEASKRPNKVIGMHYFSPVEKMPLLXXXXXXXXXXXXXAVAVDVGLRQGKV 366
TS + I +A+A KRP +GMH+F+PV MPL+ A V + GK
Sbjct: 429 TSTISISLLAKALKRPENFVGMHFFNPVHMMPLVEVIRGEKSSDLAVATTVAYAKKMGKN 488
Query: 367 VIVVADGPGFYTTRILSTMMTEAIRLLQEGVTPSELDKVTRDFGWPVGSASLADEVGIDV 546
IVV D PGF R+L +L+ GV +DKV FGWP+G A L D VGID
Sbjct: 489 PIVVNDCPGFLVNRVLFPYFGGFAKLVSAGVDFVRIDKVMEKFGWPMGPAYLMDVVGIDT 548
Query: 547 AFHVGQELELALGNRMK 597
H + +RMK
Sbjct: 549 GHHGRDVMAEGFPDRMK 565
>sp|Q8Z3C6|FADB_SALTI Fatty oxidation complex alpha subunit [Includes: Enoyl-CoA
hydratase ; Delta(3)-cis-delta(2)-trans-enoyl-CoA
isomerase ; 3-hydroxyacyl-CoA dehydrogenase ;
3-hydroxybutyryl-CoA epimerase ]
Length = 729
Score = 124 bits (312), Expect = 2e-28
Identities = 68/189 (35%), Positives = 99/189 (52%), Gaps = 1/189 (0%)
Frame = +1
Query: 34 IFSKLHSTTDYKELKNTDIVIEAVFEDLDLKHKIIKEVESCLPENVVFATNTSALPIHKI 213
+ S +H T DY D+V+EAV E+ +K ++ E E + V A+NTS +PI ++
Sbjct: 377 VISTIHPTLDYAGFDRVDVVVEAVVENPKVKKAVLAETEQKVRPETVLASNTSTIPIGEL 436
Query: 214 AEASKRPNKVIGMHYFSPVEKMPLLXXXXXXXXXXXXXAVAVDVGLRQGKVVIVVADGPG 393
A A +RP GMH+F+PV +MPL+ A V + GK IVV + PG
Sbjct: 437 ASALERPENFCGMHFFNPVHRMPLVEIIRGEKSSDETIAKVVAWASKMGKTPIVVNNCPG 496
Query: 394 FYTTRILSTMMTEAIRLLQEGVTPSELDKV-TRDFGWPVGSASLADEVGIDVAFHVGQEL 570
F+ R+L +LL++G ++DKV + FGWP+G A L D VGID A H +
Sbjct: 497 FFVNRVLFPYFAGFSQLLRDGADFRKVDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVM 556
Query: 571 ELALGNRMK 597
RM+
Sbjct: 557 AAGFPQRMQ 565
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 78,641,198
Number of Sequences: 369166
Number of extensions: 1375314
Number of successful extensions: 3707
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3589
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3671
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7666799535
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)