Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_D23
(340 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q00963|SPTCB_DROME Spectrin beta chain 101 5e-22
sp|Q01082|SPTB2_HUMAN Spectrin beta chain, brain 1 (Spectri... 97 1e-20
sp|Q62261|SPTB2_MOUSE Spectrin beta chain, brain 1 (Spectri... 97 1e-20
sp|P11277|SPTB1_HUMAN Spectrin beta chain, erythrocyte (Bet... 88 7e-18
sp|P15508|SPTB1_MOUSE Spectrin beta chain, erythrocyte (Bet... 86 2e-17
sp|O15020|SPTN2_HUMAN Spectrin beta chain, brain 2 (Spectri... 77 9e-15
sp|Q9QWN8|SPTN2_RAT Spectrin beta chain, brain 2 (Spectrin,... 77 2e-14
sp|Q13813|SPTA2_HUMAN Spectrin alpha chain, brain (Spectrin... 62 3e-10
sp|P16086|SPTA2_RAT Spectrin alpha chain, brain (Spectrin, ... 62 5e-10
sp|P16546|SPTA2_MOUSE Spectrin alpha chain, brain (Spectrin... 62 5e-10
>sp|Q00963|SPTCB_DROME Spectrin beta chain
Length = 2291
Score = 101 bits (252), Expect = 5e-22
Identities = 46/113 (40%), Positives = 71/113 (62%)
Frame = +1
Query: 1 MQLQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIML 180
M LQRRL + RD+ AI+AK+ L ++ +++ E P + II + I + +WE+L ML
Sbjct: 989 MTLQRRLSGMDRDLAAIQAKLSSLEREANSIEDEHPEEAKIIRERIAQIELIWEQLTQML 1048
Query: 181 QDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
++RD++L + +L +F +DLD F WL K Q VA++D P LPEAE+ H
Sbjct: 1049 KERDSKLEEAGDLHRFLRDLDHFQTWLTKTQTDVASEDTPTSLPEAEKLLNQH 1101
Score = 47.8 bits (112), Expect = 8e-06
Identities = 25/111 (22%), Positives = 53/111 (47%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L+++ SL ++ E ++ + N L E D + I+ + + W+ELK +++
Sbjct: 1525 LKKKNQSLATEIDNHEPRINAICNNGRKLIDEGHEDAKKFEALISDLTQKWQELKDAIEN 1584
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R L S ++Q++F D + W+ + ++ + +D KD A+ H
Sbjct: 1585 RRKHLLESEKVQQYFFDAQEAESWMSEQELYMMVEDRGKDEISAQNLMKKH 1635
Score = 43.5 bits (101), Expect = 2e-04
Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 1/78 (1%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEA-KVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQ 183
L R RD +A+ +V +N ++NL + SD I + ++NE W++L +++
Sbjct: 1737 LSERFNEFARDTEAVGGERVAKVNGIADNLIQAGHSDSATIAEWKDNLNESWQDLLELIE 1796
Query: 184 DRDTRLNSSNELQKFFKD 237
R L +S EL KFF D
Sbjct: 1797 TRTQMLAASRELHKFFHD 1814
Score = 42.4 bits (98), Expect = 3e-04
Identities = 28/115 (24%), Positives = 57/115 (49%), Gaps = 4/115 (3%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITS----VNELWEELKI 174
LQR+ + +D+ + ++V+ + +S L+ D+ +EIT+ V W+ L+
Sbjct: 1843 LQRKHYNFLQDLITLYSQVQQIQEESAKLQDAYAGDKA---KEITNREQEVLHAWDNLQA 1899
Query: 175 MLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
M R +L + +L +FF + +W++ + Q+ T + P+D+ E NH
Sbjct: 1900 MCDARKQKLADTGDLFRFFNMVRILMIWMEDLVRQMNTSEKPRDVSGVELLMNNH 1954
Score = 36.6 bits (83), Expect = 0.019
Identities = 20/84 (23%), Positives = 45/84 (53%)
Frame = +1
Query: 70 LNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSF 249
L+ Q+E+LK + +++ +D+ + +++ ++EL + + R RL + L K + D
Sbjct: 800 LHKQAESLKLNE-AEKANVDKRLEAIDNRYKELTELAKLRKQRLLDALSLYKLMSEADGV 858
Query: 250 DVWLKKVQIQVATQDIPKDLPEAE 321
+ W+K+ + T KD+ + E
Sbjct: 859 EQWIKEKTKMLDTMTPGKDIEDVE 882
Score = 33.5 bits (75), Expect = 0.16
Identities = 17/100 (17%), Positives = 49/100 (49%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L ++ +L++ V+ ++ L + + S + + + +++L+ LK + +
Sbjct: 1631 LMKKHENLEQSVEDYANTIRQLGEVARQFSGDDISSGDAVAVKQSQLDKLYAGLKDLAGE 1690
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
R RLN + +L +++D + W+ ++ +Q++ +D
Sbjct: 1691 RRARLNEALQLFMLSREVDDLEQWITDREVVAGSQELGQD 1730
Score = 31.6 bits (70), Expect = 0.60
Identities = 16/72 (22%), Positives = 31/72 (43%)
Frame = +1
Query: 124 IDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPK 303
I + + W+ L + + R RL ++ E + F D D D W+ V+++D+ +
Sbjct: 712 IKDRLKEILNKWDHLLDLTKYRRQRLENAVEYFQLFADADDVDNWMLDTLRIVSSEDVGR 771
Query: 304 DLPEAEEYCVNH 339
D + H
Sbjct: 772 DEANVQSLLKKH 783
>sp|Q01082|SPTB2_HUMAN Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1)
(Beta-II spectrin) (Fodrin beta chain)
Length = 2364
Score = 97.1 bits (240), Expect = 1e-20
Identities = 43/113 (38%), Positives = 71/113 (62%)
Frame = +1
Query: 1 MQLQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIML 180
M LQR+L ++RD+ AIEAK+ L ++E L+ E P I + ++++WEE+K L
Sbjct: 992 MALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTL 1051
Query: 181 QDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
++R+ L +++LQ+F +DLD F WL + Q +A++D+P L EAE+ H
Sbjct: 1052 KNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQH 1104
Score = 47.4 bits (111), Expect = 1e-05
Identities = 21/80 (26%), Positives = 42/80 (52%)
Frame = +1
Query: 70 LNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSF 249
+ + L EKP E ++ +++T ++++WE L+ Q + RL +N+ + F +
Sbjct: 1333 IEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADL 1392
Query: 250 DVWLKKVQIQVATQDIPKDL 309
D WL ++ Q+ + D K L
Sbjct: 1393 DKWLHGLESQIQSDDYGKHL 1412
Score = 47.0 bits (110), Expect = 1e-05
Identities = 29/112 (25%), Positives = 52/112 (46%), Gaps = 1/112 (0%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYI-IDQEITSVNELWEELKIMLQ 183
LQR + + D+QA+ +V+ L + L+ D+ I + V E W+ L +
Sbjct: 1842 LQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACE 1901
Query: 184 DRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R RL + + +FF + +W++ V Q+ Q+ P+D+ E NH
Sbjct: 1902 SRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNH 1953
Score = 45.1 bits (105), Expect = 5e-05
Identities = 29/105 (27%), Positives = 52/105 (49%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLN 204
+++ D+ A E +V+ + + L+ E D I +V LWE L +L+ R RL
Sbjct: 466 AIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLE 525
Query: 205 SSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
+ LQK F+++ W+ ++++ V +QD K L E+ H
Sbjct: 526 MNLGLQKIFQEMLYIMDWMDEMKVLVLSQDYGKHLLGVEDLLQKH 570
Score = 40.4 bits (93), Expect = 0.001
Identities = 21/106 (19%), Positives = 51/106 (48%), Gaps = 1/106 (0%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPS-DEYIIDQEITSVNELWEELKIMLQDRDTRL 201
+LQ+++Q + ++ + +S+N+ + S I Q + + +LW L + R RL
Sbjct: 1529 TLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGLLIEETEKRHRRL 1588
Query: 202 NSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
++ Q+++ D + W+ + ++ + +++ KD A H
Sbjct: 1589 EEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKDEQSAVSMLKKH 1634
Score = 39.7 bits (91), Expect = 0.002
Identities = 23/108 (21%), Positives = 49/108 (45%), Gaps = 4/108 (3%)
Frame = +1
Query: 28 LQRDVQAIEAKVKYLNNQSENLKKE----KPSDEYIIDQEITSVNELWEELKIMLQDRDT 195
++ D+ +V+ +N ++ + KP D +I + + ++EL + +R
Sbjct: 573 VEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRA 632
Query: 196 RLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
RL S L KFF ++ + W+++ + +++ D KDL H
Sbjct: 633 RLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKH 680
Score = 37.4 bits (85), Expect = 0.011
Identities = 20/100 (20%), Positives = 50/100 (50%), Gaps = 1/100 (1%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYI-IDQEITSVNELWEELKIMLQDRDTRL 201
+++ ++ E + + + E + + + +Y+ + Q + +++ W EL M ++R L
Sbjct: 1106 NIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLL 1165
Query: 202 NSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAE 321
+ S+ Q+F +D + +L + +A ++P L AE
Sbjct: 1166 SQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAE 1205
Score = 36.6 bits (83), Expect = 0.019
Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 1/104 (0%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAI-EAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQ 183
LQ R RD I + +V +N+ ++ L SD I + +NE W +L ++
Sbjct: 1736 LQERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELID 1795
Query: 184 DRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPE 315
R L +S EL KF+ D +I QD K LPE
Sbjct: 1796 TRTQILAASYELHKFYHDAK---------EIFGRIQDKHKKLPE 1830
Score = 35.0 bits (79), Expect = 0.054
Identities = 19/76 (25%), Positives = 35/76 (46%)
Frame = +1
Query: 79 QSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVW 258
+ E++ E+ I + I + E W L+ + R RL ++ L +F D D D W
Sbjct: 700 EGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDIDAW 759
Query: 259 LKKVQIQVATQDIPKD 306
+ + V++ D+ D
Sbjct: 760 MLDILKIVSSSDVGHD 775
Score = 35.0 bits (79), Expect = 0.054
Identities = 21/102 (20%), Positives = 47/102 (46%), Gaps = 1/102 (0%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
+Q R SL+ ++ ++V +N + L E I + +N W + + ++
Sbjct: 887 IQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVDR 946
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLK-KVQIQVATQDIPKDL 309
+ L S+ +Q + + + W++ K ++ +TQD+ DL
Sbjct: 947 KKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDL 988
Score = 30.0 bits (66), Expect = 1.7
Identities = 17/84 (20%), Positives = 42/84 (50%)
Frame = +1
Query: 70 LNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSF 249
L+ Q+ L +E ++ + ++ + E ++E+ + + R L + L K F + D+
Sbjct: 803 LHEQASALPQEH-AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADAC 861
Query: 250 DVWLKKVQIQVATQDIPKDLPEAE 321
++W+ + + + IP+ L + E
Sbjct: 862 ELWIDEKEQWLNNMQIPEKLEDLE 885
Score = 28.5 bits (62), Expect = 5.1
Identities = 17/89 (19%), Positives = 39/89 (43%)
Frame = +1
Query: 40 VQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNEL 219
+ A E K+ + L + + I +++ S+++ + + + RL + +L
Sbjct: 1218 MDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDL 1277
Query: 220 QKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
QKF +D +W+ + + QD+ D
Sbjct: 1278 QKFLQDCQELSLWINEKML--TAQDMSYD 1304
>sp|Q62261|SPTB2_MOUSE Spectrin beta chain, brain 1 (Spectrin, non-erythroid beta chain 1)
(Beta-II spectrin) (Fodrin beta chain)
Length = 2363
Score = 97.1 bits (240), Expect = 1e-20
Identities = 43/113 (38%), Positives = 71/113 (62%)
Frame = +1
Query: 1 MQLQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIML 180
M LQR+L ++RD+ AIEAK+ L ++E L+ E P I + ++++WEE+K L
Sbjct: 992 MALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTL 1051
Query: 181 QDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
++R+ L +++LQ+F +DLD F WL + Q +A++D+P L EAE+ H
Sbjct: 1052 KNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQH 1104
Score = 46.2 bits (108), Expect = 2e-05
Identities = 29/112 (25%), Positives = 52/112 (46%), Gaps = 1/112 (0%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYI-IDQEITSVNELWEELKIMLQ 183
LQR + + D+QA+ +V+ L + L+ D+ I + V E W+ L +
Sbjct: 1842 LQRMHTTFEHDIQALGTQVRQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLGACE 1901
Query: 184 DRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R RL + + +FF + +W++ V Q+ Q+ P+D+ E NH
Sbjct: 1902 GRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNH 1953
Score = 43.9 bits (102), Expect = 1e-04
Identities = 28/105 (26%), Positives = 52/105 (49%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLN 204
+++ D+ A E +V+ + + L+ E D I +V LWE L +L+ R RL
Sbjct: 466 AIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLE 525
Query: 205 SSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
+ LQK F+++ W+ ++++ + +QD K L E+ H
Sbjct: 526 MNLGLQKIFQEMLYIMDWMDEMKVLLLSQDYGKHLLGVEDLLQKH 570
Score = 42.7 bits (99), Expect = 3e-04
Identities = 21/85 (24%), Positives = 44/85 (51%), Gaps = 1/85 (1%)
Frame = +1
Query: 70 LNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSF 249
+ + L EKP E ++ +++T ++++WE L+ Q + RL +N+ + F +
Sbjct: 1333 IEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADL 1392
Query: 250 DVWLKKVQIQ-VATQDIPKDLPEAE 321
D WL ++ + D KDL +++
Sbjct: 1393 DKWLHGLEKPGFQSDDYGKDLTQSQ 1417
Score = 40.0 bits (92), Expect = 0.002
Identities = 23/108 (21%), Positives = 49/108 (45%), Gaps = 4/108 (3%)
Frame = +1
Query: 28 LQRDVQAIEAKVKYLNNQSENLKKE----KPSDEYIIDQEITSVNELWEELKIMLQDRDT 195
++ D+ +V+ +N ++ + KP D +I + + ++EL + +R
Sbjct: 573 VEADIAIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAERRA 632
Query: 196 RLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
RL S L KFF ++ + W+++ + +++ D KDL H
Sbjct: 633 RLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKH 680
Score = 39.3 bits (90), Expect = 0.003
Identities = 32/104 (30%), Positives = 45/104 (43%), Gaps = 1/104 (0%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAI-EAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQ 183
LQ R RD I + +V +NN ++ L SD I + +NE W +L ++
Sbjct: 1736 LQERFREFARDTGNIGQERVDTVNNMADELINSGHSDAATIAEWKDGLNEAWADLLELID 1795
Query: 184 DRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPE 315
R L +S EL KF+ D +I QD K LPE
Sbjct: 1796 TRTQILAASYELHKFYHDAK---------EIFGRIQDKHKKLPE 1830
Score = 38.5 bits (88), Expect = 0.005
Identities = 18/94 (19%), Positives = 50/94 (53%), Gaps = 1/94 (1%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPS-DEYIIDQEITSVNELWEELKIMLQDRDTRL 201
+LQ+++Q + ++ + +S+N+ + S + I Q + + +LW L + R RL
Sbjct: 1529 TLQKEIQGHQPRIDDIFERSQNIITDSSSLNAEAIRQRLADLKQLWGLLIEETEKRHRRL 1588
Query: 202 NSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPK 303
+++ Q+++ D + W+ + ++ + ++ P+
Sbjct: 1589 EEAHKAQQYYFDAAEAEAWMSEQELYMMSEKRPR 1622
Score = 37.4 bits (85), Expect = 0.011
Identities = 20/100 (20%), Positives = 50/100 (50%), Gaps = 1/100 (1%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYI-IDQEITSVNELWEELKIMLQDRDTRL 201
+++ ++ E + + + E + + + +Y+ + Q + +++ W EL M ++R L
Sbjct: 1106 NIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLL 1165
Query: 202 NSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAE 321
+ S+ Q+F +D + +L + +A ++P L AE
Sbjct: 1166 SQSHAYQQFLRDTKQAEAFLNNQEYVLAHTEMPTTLEGAE 1205
Score = 34.7 bits (78), Expect = 0.070
Identities = 21/102 (20%), Positives = 47/102 (46%), Gaps = 1/102 (0%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
+Q R SL+ ++ ++V +N + L E I + +N W + + ++
Sbjct: 887 IQHRFESLEPEMNNQASRVAVVNQIARQLMHNGHPSEKEIRAQQDKLNTRWSQFRELVDR 946
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLK-KVQIQVATQDIPKDL 309
+ L S+ +Q + + + W++ K ++ +TQD+ DL
Sbjct: 947 KKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDL 988
Score = 34.3 bits (77), Expect = 0.092
Identities = 19/76 (25%), Positives = 35/76 (46%)
Frame = +1
Query: 79 QSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVW 258
+ E++ E+ I + I + E W L+ + R RL ++ L +F D D D W
Sbjct: 700 EGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRIKRLEEASLLHQFQADADDIDAW 759
Query: 259 LKKVQIQVATQDIPKD 306
+ + V++ D+ D
Sbjct: 760 MLDILKIVSSNDVGHD 775
Score = 28.5 bits (62), Expect = 5.1
Identities = 17/89 (19%), Positives = 39/89 (43%)
Frame = +1
Query: 40 VQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNEL 219
+ A E K+ + L + + I +++ S+++ + + + RL + +L
Sbjct: 1218 MDANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNREAASELLMRLKDNRDL 1277
Query: 220 QKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
QKF +D +W+ + + QD+ D
Sbjct: 1278 QKFLQDCQELSLWINEKML--TAQDMSYD 1304
Score = 28.1 bits (61), Expect = 6.6
Identities = 13/62 (20%), Positives = 30/62 (48%)
Frame = +1
Query: 136 ITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPE 315
+ + E +E+ + + R L + L K F + D+ ++W+ + + + IP+ L +
Sbjct: 824 LAGIEERCKEMAELTRLRKQALRDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLED 883
Query: 316 AE 321
E
Sbjct: 884 LE 885
>sp|P11277|SPTB1_HUMAN Spectrin beta chain, erythrocyte (Beta-I spectrin)
Length = 2137
Score = 87.8 bits (216), Expect = 7e-18
Identities = 44/111 (39%), Positives = 65/111 (58%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
+QR+L L+RDV AI+A+V L +S+ L P + I Q + ELW+ L+ LQ
Sbjct: 993 IQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKENIGQRQKHLEELWQGLQQSLQG 1052
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
++ L ++LQ F +DLD F WL Q VA++D+P+ LPEAE+ H
Sbjct: 1053 QEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQH 1103
Score = 54.3 bits (129), Expect = 9e-08
Identities = 29/105 (27%), Positives = 55/105 (52%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLN 204
+++ D A E +V+ L + ++ L+KE D+ I ++ LW L+ +LQ R RL
Sbjct: 466 AIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLE 525
Query: 205 SSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
++ LQK F+D+ W+ +++ + + + K L E E+ H
Sbjct: 526 TTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKH 570
Score = 45.8 bits (107), Expect = 3e-05
Identities = 21/94 (22%), Positives = 48/94 (51%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLN 204
+LQ ++ +V+ + + + L + D +++ + + W+ L+ R RL
Sbjct: 1522 TLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLR 1581
Query: 205 SSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
+NE Q+++ D D + W+ + ++ V + +IPKD
Sbjct: 1582 DANEAQQYYLDADEAEAWIGEQELYVISDEIPKD 1615
Score = 43.5 bits (101), Expect = 2e-04
Identities = 22/72 (30%), Positives = 38/72 (52%)
Frame = +1
Query: 94 KKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQ 273
K +P D +I ++ + + +EEL M T+L S L KFF ++D + W+K+ +
Sbjct: 598 KGYQPCDPQVIQDRMSHLEQCFEELSNMAAGARTQLEQSKRLWKFFWEMDEAESWIKEKE 657
Query: 274 IQVATQDIPKDL 309
++ D KDL
Sbjct: 658 QIYSSLDYGKDL 669
Score = 38.9 bits (89), Expect = 0.004
Identities = 17/86 (19%), Positives = 45/86 (52%)
Frame = +1
Query: 52 EAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFF 231
E ++ ++ + + L EKP ++ Q++ +++ LW+EL+ +++ L+++
Sbjct: 1326 EGWLENIDAEGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRL 1385
Query: 232 KDLDSFDVWLKKVQIQVATQDIPKDL 309
+ + W+ ++ Q+ + D KDL
Sbjct: 1386 QTHADLNKWISAMEDQLRSDDPGKDL 1411
Score = 34.7 bits (78), Expect = 0.070
Identities = 18/100 (18%), Positives = 45/100 (45%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
LQR+ + + +++ ++A ++ + ++ + I+ I V+ W++LK +
Sbjct: 675 LQRKHKAFEDELRGLDAHLEQIFQEAHGMVARNEFGHPQIEARIKEVSAQWDQLKDLAAF 734
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
L + +F D D WL+ ++ +D+ +D
Sbjct: 735 CKKNLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQD 774
Score = 30.8 bits (68), Expect = 1.0
Identities = 19/100 (19%), Positives = 45/100 (45%), Gaps = 1/100 (1%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEY-IIDQEITSVNELWEELKIMLQDRDTRL 201
+ +R++ + +V+ + + L+ ++ I + V+ W+ L R T+L
Sbjct: 1840 AFERELHLLGVQVQQFQDVATRLQTAYAGEKAEAIQNKEQEVSAAWQALLDACAGRRTQL 1899
Query: 202 NSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAE 321
+ + +FF W++ + Q+ TQ+ P+D+ E
Sbjct: 1900 VDTADKFRFFSMARDLLSWMESIIRQIETQERPRDVSSVE 1939
Score = 28.9 bits (63), Expect = 3.9
Identities = 17/102 (16%), Positives = 47/102 (46%), Gaps = 1/102 (0%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
+Q R L ++++ + ++ +N + +L + + Q +N W+ + ++ +
Sbjct: 886 VQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSE 945
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWL-KKVQIQVATQDIPKDL 309
R ++S+ + D + W+ K ++ +T+D +DL
Sbjct: 946 RREAVDSALRVHTLCVDCEETSKWITDKTKVVESTKDPGRDL 987
Score = 28.9 bits (63), Expect = 3.9
Identities = 21/107 (19%), Positives = 45/107 (42%), Gaps = 1/107 (0%)
Frame = +1
Query: 4 QLQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYII-DQEITSVNELWEELKIML 180
QL ++ ++ ++ + + + E + + + EY++ Q + ++ W+ L M
Sbjct: 1098 QLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWDALGRMW 1157
Query: 181 QDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAE 321
+ R L Q+F KD + L + +A + P L AE
Sbjct: 1158 ESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAE 1204
>sp|P15508|SPTB1_MOUSE Spectrin beta chain, erythrocyte (Beta-I spectrin)
Length = 2128
Score = 86.3 bits (212), Expect = 2e-17
Identities = 43/111 (38%), Positives = 65/111 (58%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
+QR+L L+RDV AI +V L +S+ L + P + I Q V +LW+ L+ LQ
Sbjct: 985 IQRKLSGLERDVLAIRDRVSALERESQYLMESHPEQKEDIGQRQADVEKLWKGLQDALQG 1044
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
++ L +++LQ F +DLD F WL Q VA++D+P+ LPEAE+ H
Sbjct: 1045 QELSLGEASKLQAFLQDLDDFKAWLSMAQKAVASEDMPESLPEAEQLLQQH 1095
Score = 53.9 bits (128), Expect = 1e-07
Identities = 29/105 (27%), Positives = 55/105 (52%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLN 204
+++ D A E +VK L + ++ L+KE D+ I ++ LW L+ +L+ R RL
Sbjct: 458 AIETDTAAYEERVKALEDLAQELEKENYHDQKRIIARKDNILRLWSYLQELLRSRRQRLE 517
Query: 205 SSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
++ LQK F+D+ W+ +++ + + + K L E E+ H
Sbjct: 518 ATLALQKLFQDMLHSIDWMDEIKAHILSAEFGKHLLEVEDLLQKH 562
Score = 43.1 bits (100), Expect = 2e-04
Identities = 21/72 (29%), Positives = 37/72 (51%)
Frame = +1
Query: 94 KKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQ 273
K +P D +I ++ + + + EL M R +L S L KFF ++D + W+K+ +
Sbjct: 590 KGYQPCDPQVIQDRVSHLEQCFSELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKE 649
Query: 274 IQVATQDIPKDL 309
++ D KDL
Sbjct: 650 QIYSSLDYGKDL 661
Score = 41.2 bits (95), Expect = 8e-04
Identities = 20/100 (20%), Positives = 49/100 (49%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
LQR+ + + +++ ++A +K + +++++ +K I+ + V+ W+ LK +
Sbjct: 667 LQRKHKAFEDELRGLDAHLKQIFQEADDMVAQKQFGHPQIETRVKEVSAQWDHLKELAAF 726
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
R L + +F D D WL+ ++ +D+ +D
Sbjct: 727 RKKDLQDAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQD 766
Score = 40.8 bits (94), Expect = 0.001
Identities = 20/94 (21%), Positives = 46/94 (48%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLN 204
+LQ ++ +V+ + + + L K D I++ + + W+ L+ R RL
Sbjct: 1514 TLQNEILGHAPRVEDVLRRGQELVKAAEIDCQDIEERLGHLQSSWDTLREAAAGRLQRLR 1573
Query: 205 SSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
++E Q+++ D + W+ + ++ V + + PKD
Sbjct: 1574 DAHEAQQYYLDAGEAEAWISEQELYVFSDEPPKD 1607
Score = 37.7 bits (86), Expect = 0.008
Identities = 16/80 (20%), Positives = 43/80 (53%)
Frame = +1
Query: 70 LNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSF 249
++ + L EKP + ++ + + ++++LWEEL+ + + +L+++ +
Sbjct: 1324 IDAEGRQLMAEKPQFKDVVSERLEALHKLWEELQSTAKAKAEQLSAARSSDLRLQTHADL 1383
Query: 250 DVWLKKVQIQVATQDIPKDL 309
+ W+ ++ Q+ + D+ KDL
Sbjct: 1384 NKWIGAMEDQLRSDDLGKDL 1403
Score = 33.9 bits (76), Expect = 0.12
Identities = 18/102 (17%), Positives = 51/102 (50%), Gaps = 1/102 (0%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
+Q R L ++++ + A++ +N + NL + + Q +N+ W+ + ++ +
Sbjct: 878 VQHRFDILDQEMKTLMAQIDGVNLAANNLVESGHPRSGEVKQYQDRLNKRWQAFQAVVSE 937
Query: 187 RDTRLNSSNELQKFFKDLDSFDVW-LKKVQIQVATQDIPKDL 309
+ ++S+ + + D + W + K ++ +T+D+ +DL
Sbjct: 938 QREAVDSALRVNNYCVDCEETSKWIMDKTKVVESTKDLGQDL 979
Score = 30.4 bits (67), Expect = 1.3
Identities = 21/107 (19%), Positives = 46/107 (42%), Gaps = 1/107 (0%)
Frame = +1
Query: 4 QLQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEY-IIDQEITSVNELWEELKIML 180
QL ++ +++ ++ A + E + + + +Y ++ Q + ++ W+ L+ M
Sbjct: 1090 QLLQQHAAIKEEIDAHRDDYHRVKASGEKVIEGQTDPDYQLLGQRLEGLDTDWDALRRMW 1149
Query: 181 QDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAE 321
+ R L Q+F KD + L + +A + P L AE
Sbjct: 1150 ESRGNTLTQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLAAAE 1196
Score = 29.6 bits (65), Expect = 2.3
Identities = 16/87 (18%), Positives = 44/87 (50%)
Frame = +1
Query: 61 VKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDL 240
+++L +Q++ +E D + + ++ +L++++ + R +L + +L F +
Sbjct: 791 MEHLEHQAQGFPEEF-RDSPDVTNRLQALRKLYQQVLTQAELRGHKLQEALDLYTVFGES 849
Query: 241 DSFDVWLKKVQIQVATQDIPKDLPEAE 321
D+ ++W+ + + DIP L + E
Sbjct: 850 DACELWMTEKGKWLDQMDIPNTLEDLE 876
Score = 29.6 bits (65), Expect = 2.3
Identities = 18/100 (18%), Positives = 45/100 (45%), Gaps = 1/100 (1%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEY-IIDQEITSVNELWEELKIMLQDRDTRL 201
+ +R++ + +V+ + + L+ ++ I + V+ W+ L R +L
Sbjct: 1831 AFERELHLLGVQVQQFQDVATRLQTAYAGEKADAIQSKEQEVSAAWQALLDACAGRRAQL 1890
Query: 202 NSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAE 321
+ + +FF + W++ + Q+ TQ+ P+D+ E
Sbjct: 1891 VDTADKFRFFSMVRDLLSWMESIIRQIETQERPRDVSSVE 1930
Score = 28.5 bits (62), Expect = 5.1
Identities = 20/81 (24%), Positives = 33/81 (40%)
Frame = +1
Query: 79 QSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVW 258
++ N K P D ++ + +N WE L+ R+ L S Q+F + + W
Sbjct: 374 RANNQKVYTPHDGKLV----SDINRAWESLEEAEYQRELALRSELIRQEFDRKAAMRETW 429
Query: 259 LKKVQIQVATQDIPKDLPEAE 321
L + Q V + DL E
Sbjct: 430 LNENQRLVTQDNFGYDLAAVE 450
>sp|O15020|SPTN2_HUMAN Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2)
(Beta-III spectrin)
Length = 2390
Score = 77.4 bits (189), Expect = 9e-15
Identities = 38/113 (33%), Positives = 60/113 (53%)
Frame = +1
Query: 1 MQLQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIML 180
+ LQR+L +RD++AI A+V L ++ L P+ I+ + V WE+L+ +
Sbjct: 995 LALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWEDLRATM 1054
Query: 181 QDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
+ R+ L + LQ F + LD F WL + Q VA+++ P LPEAE H
Sbjct: 1055 RRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQH 1107
Score = 49.3 bits (116), Expect = 3e-06
Identities = 28/106 (26%), Positives = 56/106 (52%), Gaps = 1/106 (0%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYI-IDQEITSVNELWEELKIMLQ 183
LQRR + + D+QA+ +V+ + + L+K D+ I + + +V E W +L+
Sbjct: 1838 LQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSA 1897
Query: 184 DRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAE 321
R L + + +FFK + +W+ +V +Q+ Q+ P+D+ A+
Sbjct: 1898 ARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSAD 1943
Score = 44.7 bits (104), Expect = 7e-05
Identities = 29/109 (26%), Positives = 57/109 (52%)
Frame = +1
Query: 13 RRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRD 192
R+ +++ D+ A +V+ ++ + L E+ D I +V LW+ L+ M+ R
Sbjct: 465 RKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARR 524
Query: 193 TRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
RL + ELQK F+DL W+++++ ++ +QD+ + L E+ H
Sbjct: 525 ERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQDLGRHLAGVEDLLQLH 573
Score = 43.1 bits (100), Expect = 2e-04
Identities = 19/80 (23%), Positives = 42/80 (52%)
Frame = +1
Query: 70 LNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSF 249
++ + L EKP + ++ +++ ++ W+EL+ Q + L +N + F + +
Sbjct: 1336 VDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCAL 1395
Query: 250 DVWLKKVQIQVATQDIPKDL 309
+ WL+ +Q Q+ + D KDL
Sbjct: 1396 ESWLESLQAQLHSDDYGKDL 1415
Score = 40.8 bits (94), Expect = 0.001
Identities = 21/102 (20%), Positives = 50/102 (49%), Gaps = 1/102 (0%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
+Q+R +L+ ++ + A++ +N+ +E L K P + I +N W++ + +
Sbjct: 890 VQQRFETLEPEMNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADG 949
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLK-KVQIQVATQDIPKDL 309
+ L S+ +Q + + W++ K ++ +TQ + DL
Sbjct: 950 KKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLGNDL 991
Score = 40.4 bits (93), Expect = 0.001
Identities = 24/111 (21%), Positives = 50/111 (45%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L ++ +LQ+++Q E ++ L + L E + + E+W+ L L+
Sbjct: 1526 LMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPE------LAELQEMWKRLGHELEL 1579
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R RL + Q+F++D + W+ + ++ + Q+ KD A+ H
Sbjct: 1580 RGKRLEDALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKH 1630
Score = 38.5 bits (88), Expect = 0.005
Identities = 18/75 (24%), Positives = 38/75 (50%)
Frame = +1
Query: 94 KKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQ 273
K+ +P D ++ + + + + +E L + R RL S L +F ++ + W+++ Q
Sbjct: 602 KEYRPCDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQ 661
Query: 274 IQVATQDIPKDLPEA 318
+A+ D +DL A
Sbjct: 662 HLLASADTGRDLTGA 676
Score = 37.0 bits (84), Expect = 0.014
Identities = 22/105 (20%), Positives = 53/105 (50%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L+ + +++V+AI+A+ K L + + + +++ +V E + L +++
Sbjct: 1428 LEWEMAVREKEVEAIQAQAKALAQEDQGAGE--------VERTSRAVEEKFRALCQPMRE 1479
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAE 321
R RL +S E +F +D++ +W+ + ++ + KDLP +
Sbjct: 1480 RCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQ 1524
Score = 31.2 bits (69), Expect = 0.78
Identities = 21/104 (20%), Positives = 50/104 (48%), Gaps = 10/104 (9%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEI----------TSVNELWEELKI 174
S Q +V+ + + L + ++ + + S + +ID E V++L+ LK
Sbjct: 1622 SAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKE 1681
Query: 175 MLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
+ +R RL L + ++LD + W+++ ++ A+ ++ +D
Sbjct: 1682 LAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQD 1725
Score = 29.3 bits (64), Expect = 3.0
Identities = 13/50 (26%), Positives = 25/50 (50%)
Frame = +1
Query: 157 WEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
WE L+ + ++R RL + L +F D + + WL V++ ++ D
Sbjct: 729 WERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHD 778
>sp|Q9QWN8|SPTN2_RAT Spectrin beta chain, brain 2 (Spectrin, non-erythroid beta chain 2)
(Beta-III spectrin) (SPNB-3) (Beta SpIII sigma 1)
(Spectrin-like protein GTRAP41)
Length = 2388
Score = 76.6 bits (187), Expect = 2e-14
Identities = 38/113 (33%), Positives = 60/113 (53%)
Frame = +1
Query: 1 MQLQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIML 180
+ LQR+L +RD++AI A+V L ++ L P+ I+ + V WE+L+ +
Sbjct: 995 LALQRKLAGTERDLEAISARVGELTQEANALAAGHPAQAPAINTRLGEVQTGWEDLRATM 1054
Query: 181 QDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
+ R+ L + LQ F + LD F WL + Q VA+++ P LPEAE H
Sbjct: 1055 RRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVASEEGPATLPEAEALLAQH 1107
Score = 47.0 bits (110), Expect = 1e-05
Identities = 27/106 (25%), Positives = 55/106 (51%), Gaps = 1/106 (0%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYI-IDQEITSVNELWEELKIMLQ 183
LQRR + + D+QA+ +V+ + + L+K D+ I + + +V E W +L+
Sbjct: 1838 LQRRHCAYEHDIQALSTQVQQVQDDGLRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSA 1897
Query: 184 DRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAE 321
R L + + +FFK + +W+ + +Q+ Q+ P+D+ A+
Sbjct: 1898 ARRQLLLDTTDKFRFFKAVRELMLWMDGINLQMDAQERPRDVSSAD 1943
Score = 44.7 bits (104), Expect = 7e-05
Identities = 30/109 (27%), Positives = 55/109 (50%)
Frame = +1
Query: 13 RRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRD 192
R+ +++ D+ A +V+ ++ + L E D I +V LW+ L+ M+ R
Sbjct: 465 RKHEAIETDIVAYSGRVQAVDAVAAELAAEHYHDIKRIAARQNNVARLWDFLREMVAARR 524
Query: 193 TRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
RL + ELQK F+DL W+ +++ ++ +QD+ K L E+ H
Sbjct: 525 ERLLLNLELQKVFQDLLYLMDWMAEMKGRLQSQDLGKHLAGVEDLLQLH 573
Score = 44.7 bits (104), Expect = 7e-05
Identities = 26/104 (25%), Positives = 55/104 (52%), Gaps = 3/104 (2%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKP--SDEYIIDQEITSVNELWEELKIML 180
+Q+R +L+ ++ A+ A+V +++ +E L K P D I QE +N+ W++ + +
Sbjct: 890 VQQRFETLEPEMNALAARVTAVSDIAEQLLKASPPGKDRIIGTQE--QLNQRWQQFRSLA 947
Query: 181 QDRDTRLNSSNELQKFFKDLDSFDVWLK-KVQIQVATQDIPKDL 309
+ L S+ +Q + + W++ K ++ +TQD+ DL
Sbjct: 948 DGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQDLGNDL 991
Score = 44.7 bits (104), Expect = 7e-05
Identities = 19/80 (23%), Positives = 42/80 (52%)
Frame = +1
Query: 70 LNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSF 249
++ + L EKP + ++ +++ ++ W+EL+ Q + L +N + F + +
Sbjct: 1336 VDKEGRELTLEKPELKVLVSEKLEDLHRRWDELETTTQAKARSLFDANRAELFAQSCSAL 1395
Query: 250 DVWLKKVQIQVATQDIPKDL 309
+ WL+ +Q Q+ + D KDL
Sbjct: 1396 ESWLESLQAQLHSDDYGKDL 1415
Score = 42.0 bits (97), Expect = 4e-04
Identities = 24/111 (21%), Positives = 50/111 (45%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L ++ +LQ+++Q E ++ L + L E + + E+W+ L L+
Sbjct: 1526 LMKKNQTLQKEIQGHEPRIADLKERQRTLGTAAAGPE------LAELQEMWKRLSHELEL 1579
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R RL + Q+F++D + W+ + ++ + Q+ KD A+ H
Sbjct: 1580 RGKRLEEALRAQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKH 1630
Score = 41.2 bits (95), Expect = 8e-04
Identities = 24/105 (22%), Positives = 55/105 (52%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L+R + +++V+AI+A+ K L + ++ + +++ +V E + L ++D
Sbjct: 1428 LEREMAVREKEVEAIQAQAKALAQEDQSAGE--------VERTSRAVEEKFRALCQPMKD 1479
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAE 321
R RL +S E +F +D++ +W+ + ++ + KDLP +
Sbjct: 1480 RCRRLQASREQHQFHRDVEDEILWVTERLPMASSLEHGKDLPSVQ 1524
Score = 37.4 bits (85), Expect = 0.011
Identities = 16/72 (22%), Positives = 38/72 (52%)
Frame = +1
Query: 94 KKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQ 273
K+ +P D ++ + + ++ + +E L + R RL S L +F ++ + W+++ Q
Sbjct: 602 KEYRPCDPQLVSERVATLEQSYEALCELAATRRARLEESRRLWRFLWEVGEAEAWVREQQ 661
Query: 274 IQVATQDIPKDL 309
+A+ + +DL
Sbjct: 662 HLLASAETGRDL 673
Score = 33.5 bits (75), Expect = 0.16
Identities = 22/104 (21%), Positives = 51/104 (49%), Gaps = 10/104 (9%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEI----------TSVNELWEELKI 174
S Q +V+ + + L + ++ +K+ S + +ID E V++L+ LK
Sbjct: 1622 SAQAEVKKHQVLEQALADYAQTIKQLAASSQDMIDHEHPESTRLTIRQAQVDKLYAGLKE 1681
Query: 175 MLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
+ +R RL L + ++LD + W+++ ++ A+ ++ +D
Sbjct: 1682 LAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQD 1725
Score = 29.6 bits (65), Expect = 2.3
Identities = 13/50 (26%), Positives = 25/50 (50%)
Frame = +1
Query: 157 WEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
WE L+ + ++R RL + L +F D + + WL V++ ++ D
Sbjct: 729 WERLEALAEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPEVGHD 778
>sp|Q13813|SPTA2_HUMAN Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 2472
Score = 62.4 bits (150), Expect = 3e-10
Identities = 29/104 (27%), Positives = 59/104 (56%)
Frame = +1
Query: 28 LQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNS 207
L+ D+ A E ++K LN+Q+++L D + + ++N ++++K M R +LN
Sbjct: 1703 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNE 1762
Query: 208 SNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
S+ L +FF+D+D + W+K+ ++ V ++D +DL + H
Sbjct: 1763 SHRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKH 1806
Score = 59.7 bits (143), Expect = 2e-09
Identities = 30/111 (27%), Positives = 53/111 (47%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
LQR+ +RD+ A+ KV L +E L + P + ++ T +N+ W L
Sbjct: 1271 LQRKHEGFERDLAALGDKVNSLGETAERLTQSHPESAEDLQEKCTELNQAWSSLGKRADQ 1330
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R +L S++LQ+F D W+ ++ V++ ++ KD+ AE H
Sbjct: 1331 RKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERH 1381
Score = 57.8 bits (138), Expect = 8e-09
Identities = 31/111 (27%), Positives = 57/111 (51%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
LQ++ Q D+ A E +V +N + L +E+ +E +I + VN W+ LK +
Sbjct: 187 LQKKFEEFQTDMAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQDEVNAAWQRLKGLALQ 246
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R +L + E+Q+F +D+D W+K+ + +A+ D +DL + H
Sbjct: 247 RQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLASVQALLRKH 297
Score = 56.2 bits (134), Expect = 2e-08
Identities = 30/111 (27%), Positives = 55/111 (49%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L R+ L+RD+ A+E KVK L +++ L++ P I + + WE+++ + +
Sbjct: 293 LLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAAE 352
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R RLN S LQ+F D W+ +++ + ++ D+ AE H
Sbjct: 353 RHARLNDSYRLQRFLADFRDLTSWVTEMKALINADELASDVAGAEALLDRH 403
Score = 45.1 bits (105), Expect = 5e-05
Identities = 25/111 (22%), Positives = 51/111 (45%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L ++ +LQ ++ E ++K + + + +E + ++ +N+ WE LK
Sbjct: 822 LLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHELNQKWEALKAKASQ 881
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R L S + Q++F D + + W+++ + V + D KD AE H
Sbjct: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKH 932
Score = 44.7 bits (104), Expect = 7e-05
Identities = 31/141 (21%), Positives = 59/141 (41%), Gaps = 36/141 (25%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKE------------------KPSDE----- 117
LQ++ Q+D++A E+++K +N +E+L+ E P DE
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDETDSKT 1188
Query: 118 -------------YIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVW 258
I +NE W L+ + ++R L S++E+Q+F +D D W
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 1248
Query: 259 LKKVQIQVATQDIPKDLPEAE 321
+++ + T + DL +
Sbjct: 1249 IEEKNQALNTDNYGHDLASVQ 1269
Score = 42.7 bits (99), Expect = 3e-04
Identities = 28/113 (24%), Positives = 58/113 (51%), Gaps = 7/113 (6%)
Frame = +1
Query: 22 GSLQRDVQAIEAKVKYLNNQSENLKKEKPS----DEYIIDQEITSVNE---LWEELKIML 180
G +Q+ QA EA++ ++ + L+K + Y D+ +NE LW++L
Sbjct: 609 GKVQKH-QAFEAELSANQSRIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEAT 667
Query: 181 QDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
+ + +L +N+ Q+F ++++ ++WL +V+ +A+ D KDL + H
Sbjct: 668 ELKGIKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Score = 42.0 bits (97), Expect = 4e-04
Identities = 23/96 (23%), Positives = 48/96 (50%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L+++ L+ ++ A E ++ + + + L + + I Q + E W+ELK +
Sbjct: 1802 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAA 1861
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQD 294
R RL S E Q+F +++ + W+ + VA++D
Sbjct: 1862 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASED 1897
Score = 39.3 bits (90), Expect = 0.003
Identities = 18/75 (24%), Positives = 35/75 (46%)
Frame = +1
Query: 115 EYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQD 294
E + + ++ + W+ L ++ +L +N+ Q F + FD WL +V+ +A++D
Sbjct: 1626 EDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASED 1685
Query: 295 IPKDLPEAEEYCVNH 339
KDL H
Sbjct: 1686 YGKDLASVNNLLKKH 1700
Score = 38.1 bits (87), Expect = 0.006
Identities = 25/111 (22%), Positives = 53/111 (47%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
LQ++ L+ DV A + ++ + Q+ + D I ++ ++ +E LK +
Sbjct: 716 LQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVA 775
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R +L S LQ+ F+D++ + W+++ + A+ + KDL + H
Sbjct: 776 RKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKH 826
Score = 37.7 bits (86), Expect = 0.008
Identities = 17/61 (27%), Positives = 33/61 (54%)
Frame = +1
Query: 124 IDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPK 303
I V + W LK + ++ ++L S LQ+F +D+D + W+ + ++Q A+ + K
Sbjct: 1522 ISSRRNEVLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE-KLQTASDESYK 1580
Query: 304 D 306
D
Sbjct: 1581 D 1581
Score = 30.4 bits (67), Expect = 1.3
Identities = 24/112 (21%), Positives = 48/112 (42%)
Frame = +1
Query: 4 QLQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQ 183
++ R G+ Q Q + + + + S +K++ I+DQE + + W + ++ML
Sbjct: 1387 EIDARAGTFQAFEQFGQQLLAHGHYASPEIKQKLD----ILDQERADLEKAWVQRRMML- 1441
Query: 184 DRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
+ ELQ F +D + + W+ + + T+D L E H
Sbjct: 1442 ------DQCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 1487
Score = 29.6 bits (65), Expect = 2.3
Identities = 16/99 (16%), Positives = 44/99 (44%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLN 204
+ + +VQA + L+ + E I + ++ WE L ++++ +L
Sbjct: 87 AFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLL 146
Query: 205 SSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAE 321
+ +L ++ ++ + W+ + V ++++ +DL E
Sbjct: 147 QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVE 185
Score = 27.7 bits (60), Expect = 8.6
Identities = 14/40 (35%), Positives = 23/40 (57%)
Frame = +1
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
R +L S LQ+FF+D D W+ + +++ AT + KD
Sbjct: 565 RRAQLADSFHLQQFFRDSDELKSWVNE-KMKTATDEAYKD 603
>sp|P16086|SPTA2_RAT Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 2472
Score = 61.6 bits (148), Expect = 5e-10
Identities = 28/104 (26%), Positives = 61/104 (58%)
Frame = +1
Query: 28 LQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNS 207
L+ D+ A E ++K LN+Q+++L D + ++ ++N ++++K M R +L+
Sbjct: 1703 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSE 1762
Query: 208 SNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
S+ L +FF+D+D + W+K+ ++ V+++D +DL + H
Sbjct: 1763 SHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKH 1806
Score = 57.4 bits (137), Expect = 1e-08
Identities = 31/111 (27%), Positives = 57/111 (51%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
LQ++ Q D+ A E +V +N + L +E+ +E +I + VN W+ LK +
Sbjct: 187 LQKKFEEFQTDLAAHEERVNEVNQFAAKLIQEQHPEEELIKTKQEEVNAAWQRLKGLALQ 246
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R +L + E+Q+F +D+D W+K+ + +A+ D +DL + H
Sbjct: 247 RQGKLFGAAEVQRFNRDVDETIGWIKEKEQLMASDDFGRDLASVQALLRKH 297
Score = 57.0 bits (136), Expect = 1e-08
Identities = 29/111 (26%), Positives = 53/111 (47%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
LQR+ +RD+ A+ KV L ++ L + P + ++ T +N+ W L
Sbjct: 1271 LQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDLKEKCTELNQAWTSLGKRADQ 1330
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R +L S++LQ+F D W+ ++ V++ ++ KD+ AE H
Sbjct: 1331 RKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERH 1381
Score = 54.3 bits (129), Expect = 9e-08
Identities = 29/111 (26%), Positives = 55/111 (49%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L R+ L+RD+ A+E KVK L +++ L++ P I + + WE+++ + +
Sbjct: 293 LLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSANQIQVKREELITNWEQIRTLAAE 352
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R RL+ S LQ+F D W+ +++ + ++ D+ AE H
Sbjct: 353 RHARLDDSYRLQRFLADFRDLTSWVTEMKALINADELANDVAGAEALLDRH 403
Score = 46.2 bits (108), Expect = 2e-05
Identities = 25/111 (22%), Positives = 52/111 (46%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L ++ +LQ ++ E ++K + + + +E + +++ +N+ WE LK
Sbjct: 822 LLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLSELNQKWEALKAKASQ 881
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R L S + Q++F D + + W+++ + V + D KD AE H
Sbjct: 882 RRQDLEDSLQAQQYFADANEAESWMREKEPIVGSTDYGKDEDSAEALLKKH 932
Score = 44.7 bits (104), Expect = 7e-05
Identities = 31/141 (21%), Positives = 59/141 (41%), Gaps = 36/141 (25%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKE------------------KPSDE----- 117
LQ++ Q+D++A E+++K +N +E+L+ E P DE
Sbjct: 1129 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGMMPRDEADSKT 1188
Query: 118 -------------YIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVW 258
I +NE W L+ + ++R L S++E+Q+F +D D W
Sbjct: 1189 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 1248
Query: 259 LKKVQIQVATQDIPKDLPEAE 321
+++ + T + DL +
Sbjct: 1249 IEEKNQALNTDNYGHDLASVQ 1269
Score = 42.4 bits (98), Expect = 3e-04
Identities = 23/96 (23%), Positives = 48/96 (50%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L+++ L+ ++ A E ++ + + + L + + I Q + E W+ELK +
Sbjct: 1802 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAA 1861
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQD 294
R RL S E Q+F +++ + W+ + VA++D
Sbjct: 1862 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASED 1897
Score = 41.6 bits (96), Expect = 6e-04
Identities = 27/113 (23%), Positives = 58/113 (51%), Gaps = 7/113 (6%)
Frame = +1
Query: 22 GSLQRDVQAIEAKVKYLNNQSENLKKEKPS----DEYIIDQEITSVNE---LWEELKIML 180
G +Q+ QA EA++ ++ + L+K + Y ++ +NE LW++L
Sbjct: 609 GKVQKH-QAFEAELSANQSRIDALEKAGQKLIDVNHYAKEEVAARMNEVISLWKKLLEAT 667
Query: 181 QDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
+ + +L +N+ Q+F ++++ ++WL +V+ +A+ D KDL + H
Sbjct: 668 ELKGVKLREANQQQQFNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKH 720
Score = 39.3 bits (90), Expect = 0.003
Identities = 18/75 (24%), Positives = 35/75 (46%)
Frame = +1
Query: 115 EYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQD 294
E + + ++ + W+ L ++ +L +N+ Q F + FD WL +V+ +A++D
Sbjct: 1626 EDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASED 1685
Query: 295 IPKDLPEAEEYCVNH 339
KDL H
Sbjct: 1686 YGKDLASVNNLLKKH 1700
Score = 38.1 bits (87), Expect = 0.006
Identities = 25/111 (22%), Positives = 53/111 (47%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
LQ++ L+ DV A + ++ + Q+ + D I ++ ++ +E LK +
Sbjct: 716 LQKKHALLEADVAAHQDRIDGITIQARQFQDAGHFDAENIKKKQEALVARYEALKEPMVA 775
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R +L S LQ+ F+D++ + W+++ + A+ + KDL + H
Sbjct: 776 RKQKLADSLRLQQLFRDVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKH 826
Score = 37.4 bits (85), Expect = 0.011
Identities = 16/54 (29%), Positives = 32/54 (59%)
Frame = +1
Query: 145 VNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
V + W LK + ++ ++L S LQ+F +D+D + W+ + ++Q A+ + KD
Sbjct: 1529 VLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE-KLQTASDESYKD 1581
Score = 32.0 bits (71), Expect = 0.46
Identities = 25/112 (22%), Positives = 49/112 (43%)
Frame = +1
Query: 4 QLQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQ 183
++ R G+ Q Q + + + + S +K++ I+DQE T + + W + ++ML
Sbjct: 1387 EIDARAGTFQAFEQFGQQLLAHGHYASPEIKEKLD----ILDQERTDLEKAWVQRRMML- 1441
Query: 184 DRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
+ ELQ F +D + + W+ + + T+D L E H
Sbjct: 1442 ------DHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 1487
Score = 29.6 bits (65), Expect = 2.3
Identities = 16/99 (16%), Positives = 44/99 (44%)
Frame = +1
Query: 25 SLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLN 204
+ + +VQA + L+ + E I + ++ WE L ++++ +L
Sbjct: 87 AFEAEVQANSGAIVKLDETGNLMISEGHFASETIRTRLMELHRQWELLLEKMREKGIKLL 146
Query: 205 SSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAE 321
+ +L ++ ++ + W+ + V ++++ +DL E
Sbjct: 147 QAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVE 185
Score = 27.7 bits (60), Expect = 8.6
Identities = 14/40 (35%), Positives = 23/40 (57%)
Frame = +1
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
R +L S LQ+FF+D D W+ + +++ AT + KD
Sbjct: 565 RRAQLADSFHLQQFFRDSDELKSWVNE-KMKTATDEAYKD 603
>sp|P16546|SPTA2_MOUSE Spectrin alpha chain, brain (Spectrin, non-erythroid alpha chain)
(Alpha-II spectrin) (Fodrin alpha chain)
Length = 1458
Score = 61.6 bits (148), Expect = 5e-10
Identities = 28/104 (26%), Positives = 61/104 (58%)
Frame = +1
Query: 28 LQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQDRDTRLNS 207
L+ D+ A E ++K LN+Q+++L D + ++ ++N ++++K M R +L+
Sbjct: 689 LEADISAHEDRLKDLNSQADSLMTSSAFDTSQVKEKRDTINGRFQKIKSMATSRRAKLSE 748
Query: 208 SNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
S+ L +FF+D+D + W+K+ ++ V+++D +DL + H
Sbjct: 749 SHRLHQFFRDMDDEESWIKEKKLLVSSEDYGRDLTGVQNLRKKH 792
Score = 57.0 bits (136), Expect = 1e-08
Identities = 29/111 (26%), Positives = 53/111 (47%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
LQR+ +RD+ A+ KV L ++ L + P + ++ T +N+ W L
Sbjct: 257 LQRKHEGFERDLAALGDKVNSLGETAQRLIQSHPESAEDLKEKCTELNQAWTSLGKRADQ 316
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
R +L S++LQ+F D W+ ++ V++ ++ KD+ AE H
Sbjct: 317 RKAKLGDSHDLQRFLSDFRDLMSWINGIRGLVSSDELAKDVTGAEALLERH 367
Score = 44.7 bits (104), Expect = 7e-05
Identities = 31/141 (21%), Positives = 59/141 (41%), Gaps = 36/141 (25%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKE------------------KPSDE----- 117
LQ++ Q+D++A E+++K +N +E+L+ E P DE
Sbjct: 115 LQKKFDDFQKDLKANESRLKDINKVAEDLESEGLMAEEVQAVQQQEVYGAMPRDEADSKT 174
Query: 118 -------------YIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVW 258
I +NE W L+ + ++R L S++E+Q+F +D D W
Sbjct: 175 ASPWKSARLMVHTVATFNSIKELNERWRSLQQLAEERSQLLGSAHEVQRFHRDADETKEW 234
Query: 259 LKKVQIQVATQDIPKDLPEAE 321
+++ + T + DL +
Sbjct: 235 IEEKNQALNTDNYGHDLASVQ 255
Score = 42.4 bits (98), Expect = 3e-04
Identities = 23/96 (23%), Positives = 48/96 (50%)
Frame = +1
Query: 7 LQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQD 186
L+++ L+ ++ A E ++ + + + L + + I Q + E W+ELK +
Sbjct: 788 LRKKHKRLEAELAAHEPAIQGVLDTGKKLSDDNTIGQEEIQQRLAQFVEHWKELKQLAAA 847
Query: 187 RDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQD 294
R RL S E Q+F +++ + W+ + VA++D
Sbjct: 848 RGQRLEESLEYQQFVANVEEEEAWINEKMTLVASED 883
Score = 39.3 bits (90), Expect = 0.003
Identities = 18/75 (24%), Positives = 35/75 (46%)
Frame = +1
Query: 115 EYIIDQEITSVNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQD 294
E + + ++ + W+ L ++ +L +N+ Q F + FD WL +V+ +A++D
Sbjct: 612 EDAVKARLAALADQWQFLVQKSAEKSQKLKEANKQQNFNTGIKDFDFWLSEVEALLASED 671
Query: 295 IPKDLPEAEEYCVNH 339
KDL H
Sbjct: 672 YGKDLASVNNLLKKH 686
Score = 37.4 bits (85), Expect = 0.011
Identities = 16/54 (29%), Positives = 32/54 (59%)
Frame = +1
Query: 145 VNELWEELKIMLQDRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKD 306
V + W LK + ++ ++L S LQ+F +D+D + W+ + ++Q A+ + KD
Sbjct: 515 VLDRWRRLKAQMIEKRSKLGESQTLQQFSRDVDEIEAWISE-KLQTASDESYKD 567
Score = 32.0 bits (71), Expect = 0.46
Identities = 25/112 (22%), Positives = 49/112 (43%)
Frame = +1
Query: 4 QLQRRLGSLQRDVQAIEAKVKYLNNQSENLKKEKPSDEYIIDQEITSVNELWEELKIMLQ 183
++ R G+ Q Q + + + + S +K++ I+DQE T + + W + ++ML
Sbjct: 373 EIDARAGTFQAFEQFGQQLLAHGHYASPEIKEKLD----ILDQERTDLEKAWVQRRMML- 427
Query: 184 DRDTRLNSSNELQKFFKDLDSFDVWLKKVQIQVATQDIPKDLPEAEEYCVNH 339
+ ELQ F +D + + W+ + + T+D L E H
Sbjct: 428 ------DHCLELQLFHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKH 473
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.313 0.130 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,738,043
Number of Sequences: 369166
Number of extensions: 437234
Number of successful extensions: 1885
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 1628
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 1877
length of database: 68,354,980
effective HSP length: 80
effective length of database: 53,576,180
effective search space used: 1714437760
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)