Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_C03
(438 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 159 2e-39
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 154 8e-38
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 152 2e-37
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 152 3e-37
sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precu... 152 4e-37
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 151 5e-37
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 147 7e-36
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 147 7e-36
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 147 1e-35
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 145 5e-35
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 159 bits (403), Expect = 2e-39
Identities = 69/123 (56%), Positives = 94/123 (76%)
Frame = +1
Query: 1 DGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNE 180
DG+C+ + + + C+G T+I S +ET L AV +GP+SV IDA H+SFQ Y SG+Y E
Sbjct: 201 DGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYE 260
Query: 181 ESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASY 360
SCS + LDH VLAVGYG++ G+ +W+VKNSW +WG++GYIKMS+++ N CGIAT+ASY
Sbjct: 261 PSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASY 320
Query: 361 PLV 369
PLV
Sbjct: 321 PLV 323
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 154 bits (389), Expect = 8e-38
Identities = 73/124 (58%), Positives = 86/124 (69%), Gaps = 1/124 (0%)
Frame = +1
Query: 1 DGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNE 180
D +C N + I TGF DI +E + AVAT+GPVSVAIDA H SFQLY G+YNE
Sbjct: 216 DDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAIDASHESFQLYSEGVYNE 275
Query: 181 ESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMAS 357
C LDHGVL VGYGT + G YW+VKNSW TWGE GYIKM++++ NQCGIAT +S
Sbjct: 276 PECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYIKMARNQNNQCGIATASS 335
Query: 358 YPLV 369
YP V
Sbjct: 336 YPTV 339
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 152 bits (385), Expect = 2e-37
Identities = 71/124 (57%), Positives = 87/124 (70%), Gaps = 1/124 (0%)
Frame = +1
Query: 1 DGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNE 180
D +C N + GFTDI +E +A AVATVGPVSVAIDA H SFQ Y G+YNE
Sbjct: 218 DDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNE 277
Query: 181 ESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMAS 357
C LDHGVL VG+GT + G+ YW+VKNSW TWG+ G+IKM ++K+NQCGIA+ +S
Sbjct: 278 PQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASS 337
Query: 358 YPLV 369
YPLV
Sbjct: 338 YPLV 341
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 152 bits (384), Expect = 3e-37
Identities = 75/124 (60%), Positives = 85/124 (68%), Gaps = 1/124 (0%)
Frame = +1
Query: 1 DGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNE 180
D +C P K TGF DI Q E L AVATVGP+SVAIDAGH+SFQ YKSGIY +
Sbjct: 95 DTSCNYKPEYSAAKDTGFVDIP-QREKALMKAVATVGPISVAIDAGHSSFQFYKSGIYYD 153
Query: 181 ESCSTTQLDHGVLAVGYGTQ-IGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMAS 357
CS+ LDHGVL VGYG + K+WIVKNSW WG GY+KM+KD+ N CGIAT AS
Sbjct: 154 PDCSSKDLDHGVLVVGYGFEGTNNKFWIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAAS 213
Query: 358 YPLV 369
YP V
Sbjct: 214 YPTV 217
>sp|P13277|CYSP1_HOMAM Digestive cysteine proteinase 1 precursor
Length = 322
Score = 152 bits (383), Expect = 4e-37
Identities = 68/123 (55%), Positives = 89/123 (72%)
Frame = +1
Query: 1 DGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNE 180
D TC+ N + I CTG+ I +E+ L A +GP+SVAIDA H SFQ Y +G+Y E
Sbjct: 200 DNTCRFNSNTIGATCTGYVGIAQGSESALKTATRDIGPISVAIDASHRSFQSYYTGVYYE 259
Query: 181 ESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASY 360
SCS++QLDH VLAVGYG++ G+ +W+VKNSW +WGESGYIKM++++ N CGIAT A Y
Sbjct: 260 PSCSSSQLDHAVLAVGYGSEGGQDFWLVKNSWATSWGESGYIKMARNRNNNCGIATDACY 319
Query: 361 PLV 369
P V
Sbjct: 320 PTV 322
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 151 bits (382), Expect = 5e-37
Identities = 74/127 (58%), Positives = 84/127 (66%), Gaps = 4/127 (3%)
Frame = +1
Query: 1 DGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNE 180
D CK P V TGFT + E L AVATVGP+SVA+DAGH+SFQ YKSGIY E
Sbjct: 208 DEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFE 267
Query: 181 ESCSTTQLDHGVLAVGYG----TQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIAT 348
CS+ LDHGVL VGYG KYW+VKNSW WG +GY+K++KDK N CGIAT
Sbjct: 268 PDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIAT 327
Query: 349 MASYPLV 369
ASYP V
Sbjct: 328 AASYPNV 334
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 147 bits (372), Expect = 7e-36
Identities = 73/125 (58%), Positives = 84/125 (67%), Gaps = 4/125 (3%)
Frame = +1
Query: 7 TCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEES 186
+CK NP V TGF DI Q E L AVATVGP+SVAIDAGH SF YK GIY E
Sbjct: 210 SCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPD 268
Query: 187 CSTTQLDHGVLAVGYGTQI----GKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMA 354
CS+ +DHGVL VGYG + KYW+VKNSW WG GY+KM+KD++N CGIA+ A
Sbjct: 269 CSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAA 328
Query: 355 SYPLV 369
SYP V
Sbjct: 329 SYPTV 333
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 147 bits (372), Expect = 7e-36
Identities = 69/123 (56%), Positives = 89/123 (72%)
Frame = +1
Query: 1 DGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNE 180
D +C+ + + I CTG ++Q E L AV+ VGP+SVAIDA H SFQ Y SG+Y E
Sbjct: 200 DRSCRFDANSIGAICTGSVEVQHTEEA-LQEAVSGVGPISVAIDASHFSFQFYSSGVYYE 258
Query: 181 ESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASY 360
++CS T LDHGVLAVGYGT+ K YW+VKNSW +WG++GYIKMS+++ N CGIA+ SY
Sbjct: 259 QNCSPTFLDHGVLAVGYGTESTKDYWLVKNSWGSSWGDAGYIKMSRNRDNNCGIASEPSY 318
Query: 361 PLV 369
P V
Sbjct: 319 PTV 321
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 147 bits (370), Expect = 1e-35
Identities = 73/124 (58%), Positives = 83/124 (66%), Gaps = 3/124 (2%)
Frame = +1
Query: 7 TCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEES 186
TC P TGF D+ Q E L AVAT+GP+SVAIDAGH SFQ YKSGIY +
Sbjct: 211 TCNYKPECSAANDTGFVDLP-QREKALMKAVATLGPISVAIDAGHQSFQFYKSGIYFDPD 269
Query: 187 CSTTQLDHGVLAVGY---GTQIGKKYWIVKNSWDVTWGESGYIKMSKDKKNQCGIATMAS 357
CS+ LDHGVL VGY GT K+WIVKNSW WG +GY+KM+KD+ N CGIAT AS
Sbjct: 270 CSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKDQNNHCGIATAAS 329
Query: 358 YPLV 369
YP V
Sbjct: 330 YPTV 333
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 145 bits (365), Expect = 5e-35
Identities = 74/127 (58%), Positives = 85/127 (66%), Gaps = 4/127 (3%)
Frame = +1
Query: 1 DGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYKSGIYNE 180
DG+CK V TGF DI Q E L AVATVGP+SVA+DA H S Q Y SGIY E
Sbjct: 208 DGSCKYRAEYAVANDTGFVDIPQQ-EKALMKAVATVGPISVAMDASHPSLQFYSSGIYYE 266
Query: 181 ESCSTTQLDHGVLAVGY---GTQIGK-KYWIVKNSWDVTWGESGYIKMSKDKKNQCGIAT 348
+CS+ LDHGVL VGY GT K KYW+VKNSW WG GYIK++KD+ N CG+AT
Sbjct: 267 PNCSSKDLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLAT 326
Query: 349 MASYPLV 369
ASYP+V
Sbjct: 327 AASYPIV 333
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,921,028
Number of Sequences: 369166
Number of extensions: 1015937
Number of successful extensions: 3128
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2855
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2919
length of database: 68,354,980
effective HSP length: 100
effective length of database: 49,881,480
effective search space used: 2244666600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)