Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_B24
(737 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q14145|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (... 244 2e-64
sp|Q9Z2X8|KEAP1_MOUSE Kelch-like ECH-associated protein 1 (... 238 2e-62
sp|P57790|KEAP1_RAT Kelch-like ECH-associated protein 1 (Cy... 228 2e-59
sp|Q9NR64|KLHL1_HUMAN Kelch-like protein 1 172 1e-42
sp|Q9JI74|KLHL1_MOUSE Kelch-like protein 1 169 9e-42
sp|Q8VCK5|KLH20_MOUSE Kelch-like protein 20 (Kelch-like ECT... 162 1e-39
sp|Q9Y2M5|KLH20_HUMAN Kelch-like protein 20 (Kelch-like ECT... 162 1e-39
sp|Q6TDP4|KLH17_HUMAN Kelch-like protein 17 (Actinfilin) 156 5e-38
sp|Q96PQ7|KLHL5_HUMAN Kelch-like protein 5 156 6e-38
sp|Q9NXS3|BTBD5_HUMAN BTB/POZ domain containing protein 5 156 6e-38
>sp|Q14145|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2)
(Kelch-like protein 19)
Length = 624
Score = 244 bits (622), Expect = 2e-64
Identities = 119/216 (55%), Positives = 149/216 (68%)
Frame = +2
Query: 5 CAPMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASM 184
CAPMS+PR+R+ VG++D IYAVGGS +HHNS E+++P+ +W VA M
Sbjct: 406 CAPMSVPRNRIGVGVIDGHIYAVGGSH---------GCIHHNSVERYEPERDEWHLVAPM 456
Query: 185 NNCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALD 364
RIG+GVA +NRLLYAVGGFDG NRL SAE Y P+ + W + ++N RSGAGV L
Sbjct: 457 LTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLH 516
Query: 365 QHIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNE 544
IYA GGYD QL SVERYD + W FVAPM RSALG TV++G+I+V GGYDG+
Sbjct: 517 NCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHT 576
Query: 545 FLTSVEVYDPSTNIWTEVTKMDAGKSGHAVLLGREP 652
FL SVE YDP T+ W+EVT+M +G+SG V + EP
Sbjct: 577 FLDSVECYDPDTDTWSEVTRMTSGRSGVGVAVTMEP 612
Score = 119 bits (298), Expect = 8e-27
Identities = 63/170 (37%), Positives = 89/170 (52%), Gaps = 4/170 (2%)
Frame = +2
Query: 137 EKFDPDSGQWTPVASMNNCRIGLGVATVNRLLYAVGGF----DGENRLGSAERYNPDEDN 304
E ++P +G W +A + R GL V LLYAVGG DG + + YNP +
Sbjct: 343 EAYNPSNGTWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQ 402
Query: 305 WEFVASLNRTRSGAGVVALDQHIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSA 484
W A ++ R+ GV +D HIYA+GG SVERY+P++++W VAPM+ R
Sbjct: 403 WSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIG 462
Query: 485 LGATVYEGKIWVFGGYDGNEFLTSVEVYDPSTNIWTEVTKMDAGKSGHAV 634
+G V ++ GG+DG L S E Y P N W +T M+ +SG V
Sbjct: 463 VGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGV 512
>sp|Q9Z2X8|KEAP1_MOUSE Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2)
Length = 624
Score = 238 bits (606), Expect = 2e-62
Identities = 117/216 (54%), Positives = 147/216 (68%)
Frame = +2
Query: 5 CAPMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASM 184
CA MS+PR+R+ VG++D IYAVGGS +HH+S E+++P+ +W VA M
Sbjct: 406 CASMSVPRNRIGVGVIDGHIYAVGGSH---------GCIHHSSVERYEPERDEWHLVAPM 456
Query: 185 NNCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALD 364
RIG+GVA +NRLLYAVGGFDG NRL SAE Y P+ + W + +N RSGAGV L
Sbjct: 457 LTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLH 516
Query: 365 QHIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNE 544
IYA GGYD QL SVERYD + W FVAPM RSALG TV++GKI+V GGYDG+
Sbjct: 517 NCIYAAGGYDGQDQLNSVERYDVETETWTFVAPMRHHRSALGITVHQGKIYVLGGYDGHT 576
Query: 545 FLTSVEVYDPSTNIWTEVTKMDAGKSGHAVLLGREP 652
FL SVE YDP ++ W+EVT+M +G+SG V + EP
Sbjct: 577 FLDSVECYDPDSDTWSEVTRMTSGRSGVGVAVTMEP 612
Score = 121 bits (303), Expect = 2e-27
Identities = 64/170 (37%), Positives = 90/170 (52%), Gaps = 4/170 (2%)
Frame = +2
Query: 137 EKFDPDSGQWTPVASMNNCRIGLGVATVNRLLYAVGGF----DGENRLGSAERYNPDEDN 304
E ++P +G W +A + R GL V LLYAVGG DG + + YNP +
Sbjct: 343 EAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQ 402
Query: 305 WEFVASLNRTRSGAGVVALDQHIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSA 484
W AS++ R+ GV +D HIYA+GG SVERY+P++++W VAPM+ R
Sbjct: 403 WSPCASMSVPRNRIGVGVIDGHIYAVGGSHGCIHHSSVERYEPERDEWHLVAPMLTRRIG 462
Query: 485 LGATVYEGKIWVFGGYDGNEFLTSVEVYDPSTNIWTEVTKMDAGKSGHAV 634
+G V ++ GG+DG L S E Y P N W +T M+ +SG V
Sbjct: 463 VGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGV 512
>sp|P57790|KEAP1_RAT Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2)
(INrf2)
Length = 624
Score = 228 bits (580), Expect = 2e-59
Identities = 113/216 (52%), Positives = 143/216 (66%)
Frame = +2
Query: 5 CAPMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASM 184
CA +S+PR+R G++D IYAVGGS +HH+S E+++PD +W VA M
Sbjct: 406 CASLSVPRNRSGGGVIDGHIYAVGGSH---------GCIHHSSVERYEPDRDEWHLVAPM 456
Query: 185 NNCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALD 364
RIG+GVA +NRLLYAVGGFDG NRL SAE Y P+ + W + +N RSGAGV L
Sbjct: 457 LTRRIGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGVCVLH 516
Query: 365 QHIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNE 544
IYA GGYD QL SVERYD + W FVA M RSALG V++G+I+V GGYDG+
Sbjct: 517 SCIYAAGGYDGQDQLNSVERYDVETETWTFVASMKHRRSALGIAVHQGRIYVLGGYDGHT 576
Query: 545 FLTSVEVYDPSTNIWTEVTKMDAGKSGHAVLLGREP 652
FL SVE YDP T+ W+EVT++ +G+SG V + EP
Sbjct: 577 FLDSVECYDPDTDTWSEVTRLTSGRSGVGVAVTMEP 612
Score = 123 bits (308), Expect = 6e-28
Identities = 69/172 (40%), Positives = 92/172 (53%), Gaps = 6/172 (3%)
Frame = +2
Query: 137 EKFDPDSGQWTPVASMNNCRIGLGVATVNRLLYAVGGF----DGENRLGSAERYNPDEDN 304
E ++P +G W +A + R GL V LLYAVGG DG + + YNP +
Sbjct: 343 EAYNPSNGSWLRLADLQVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQ 402
Query: 305 WEFVASLN--RTRSGAGVVALDQHIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPR 478
W ASL+ R RSG GV+ D HIYA+GG SVERY+PD+++W VAPM+ R
Sbjct: 403 WSPCASLSVPRNRSGGGVI--DGHIYAVGGSHGCIHHSSVERYEPDRDEWHLVAPMLTRR 460
Query: 479 SALGATVYEGKIWVFGGYDGNEFLTSVEVYDPSTNIWTEVTKMDAGKSGHAV 634
+G V ++ GG+DG L S E Y P N W +T M+ +SG V
Sbjct: 461 IGVGVAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITPMNTIRSGAGV 512
>sp|Q9NR64|KLHL1_HUMAN Kelch-like protein 1
Length = 748
Score = 172 bits (435), Expect = 1e-42
Identities = 87/220 (39%), Positives = 128/220 (58%), Gaps = 6/220 (2%)
Frame = +2
Query: 11 PMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMNN 190
PMS RH + V +++ IYAVGG H + N+ E++DP S QWT VASM+
Sbjct: 538 PMSTHRHGLGVTVLEGPIYAVGG---------HDGWSYLNTVERWDPQSQQWTFVASMSI 588
Query: 191 CRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQH 370
R +GVA +N LY+VGG DG + L S E Y+P + W A + + R G GV D
Sbjct: 589 ARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGF 648
Query: 371 IYAIGGYDSACQ------LRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGY 532
+YA+GG+D+ L VERYDP + W VAP+ PR A+G + +++ GGY
Sbjct: 649 LYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGY 708
Query: 533 DGNEFLTSVEVYDPSTNIWTEVTKMDAGKSGHAVLLGREP 652
DG +L ++E YDP TN WT++ ++ G++G V++ ++P
Sbjct: 709 DGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP 748
Score = 132 bits (332), Expect = 1e-30
Identities = 71/191 (37%), Positives = 96/191 (50%)
Frame = +2
Query: 62 IYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMNNCRIGLGVATVNRLLYAV 241
+YAVGG +T EK+D + W MN R+ GVA ++ L+ +
Sbjct: 461 LYAVGGMDNNKGATT---------IEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVI 511
Query: 242 GGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQHIYAIGGYDSACQLRSVE 421
GG DG L + E YNP W + ++ R G GV L+ IYA+GG+D L +VE
Sbjct: 512 GGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVE 571
Query: 422 RYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEFLTSVEVYDPSTNIWTEVT 601
R+DP QW FVA M RS +G GK++ GG DG+ L+S+E YDP TN W
Sbjct: 572 RWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCA 631
Query: 602 KMDAGKSGHAV 634
M + G V
Sbjct: 632 PMCKRRGGVGV 642
Score = 103 bits (257), Expect = 5e-22
Identities = 61/159 (38%), Positives = 79/159 (49%), Gaps = 6/159 (3%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMN 187
A MSI R V V ++ +Y+VGG S S S E +DP + +W A M
Sbjct: 584 ASMSIARSTVGVAALNGKLYSVGGRDGSSCLS---------SMEYYDPHTNKWNMCAPMC 634
Query: 188 NCRIGLGVATVNRLLYAVGGFDG------ENRLGSAERYNPDEDNWEFVASLNRTRSGAG 349
R G+GVAT + LYAVGG D L ERY+P D W VA L+ R G
Sbjct: 635 KRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVG 694
Query: 350 VVALDQHIYAIGGYDSACQLRSVERYDPDKNQWVFVAPM 466
V L +YA+GGYD L ++E YDP N+W +A +
Sbjct: 695 VCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASL 733
Score = 83.6 bits (205), Expect = 5e-16
Identities = 49/121 (40%), Positives = 68/121 (56%)
Frame = +2
Query: 5 CAPMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASM 184
CAPM R V V D +YAVGG + S H S + + E++DP + WT VA +
Sbjct: 630 CAPMCKRRGGVGVATCDGFLYAVGGHD--APASNHCSRL-LDYVERYDPKTDTWTMVAPL 686
Query: 185 NNCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALD 364
+ R +GV + LYAVGG+DG+ L + E Y+P + W +ASLN R+GA VV +
Sbjct: 687 SMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIK 746
Query: 365 Q 367
Q
Sbjct: 747 Q 747
Score = 63.5 bits (153), Expect = 5e-10
Identities = 32/94 (34%), Positives = 48/94 (51%)
Frame = +2
Query: 371 IYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEFL 550
+YA+GG D+ ++E+YD N W+ M R G V + K++V GG DG + L
Sbjct: 461 LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTL 520
Query: 551 TSVEVYDPSTNIWTEVTKMDAGKSGHAVLLGREP 652
+VE Y+P T WT + M + G V + P
Sbjct: 521 NTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGP 554
Score = 38.9 bits (89), Expect = 0.014
Identities = 27/112 (24%), Positives = 52/112 (46%), Gaps = 3/112 (2%)
Frame = +2
Query: 353 VALDQHIYAIGGYDSACQ---LRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVF 523
+ D +A+ D CQ L +++ + + + + +P +PR + T+Y
Sbjct: 410 ILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLY-----AV 464
Query: 524 GGYDGNEFLTSVEVYDPSTNIWTEVTKMDAGKSGHAVLLGREPRFED*LFIV 679
GG D N+ T++E YD TN+W + M+ + V + +D LF++
Sbjct: 465 GGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAV-----IDDKLFVI 511
>sp|Q9JI74|KLHL1_MOUSE Kelch-like protein 1
Length = 751
Score = 169 bits (427), Expect = 9e-42
Identities = 85/220 (38%), Positives = 127/220 (57%), Gaps = 6/220 (2%)
Frame = +2
Query: 11 PMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMNN 190
PMS RH + V +++ IYAVGG H + N+ E++DP S QWT VASM+
Sbjct: 541 PMSTHRHGLGVTVLEGPIYAVGG---------HDGWSYLNTVERWDPQSQQWTYVASMSI 591
Query: 191 CRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQH 370
R +GVA +N LY+VGG DG + L S E Y+P + W + + R G GV D
Sbjct: 592 ARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWSMCPPMCKKRGGVGVATCDGF 651
Query: 371 IYAIGGYDSACQ------LRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGY 532
+YA+GG+D+ L VERY+P + W VAP+ PR A+G + +++ GGY
Sbjct: 652 LYAVGGHDAPASNHCSRLLDYVERYEPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGY 711
Query: 533 DGNEFLTSVEVYDPSTNIWTEVTKMDAGKSGHAVLLGREP 652
DG +L ++E YDP TN WT++ ++ G++G V++ ++P
Sbjct: 712 DGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIKQP 751
Score = 131 bits (329), Expect = 2e-30
Identities = 70/191 (36%), Positives = 97/191 (50%)
Frame = +2
Query: 62 IYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMNNCRIGLGVATVNRLLYAV 241
+YAVGG +T EK+D + W MN R+ GVA ++ L+ +
Sbjct: 464 LYAVGGMDNNKGATT---------IEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVI 514
Query: 242 GGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQHIYAIGGYDSACQLRSVE 421
GG DG L + E YNP W + ++ R G GV L+ IYA+GG+D L +VE
Sbjct: 515 GGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVE 574
Query: 422 RYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEFLTSVEVYDPSTNIWTEVT 601
R+DP QW +VA M RS +G GK++ GG DG+ L+S+E YDP TN W+
Sbjct: 575 RWDPQSQQWTYVASMSIARSTVGVAALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWSMCP 634
Query: 602 KMDAGKSGHAV 634
M + G V
Sbjct: 635 PMCKKRGGVGV 645
Score = 101 bits (252), Expect = 2e-21
Identities = 60/159 (37%), Positives = 78/159 (49%), Gaps = 6/159 (3%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMN 187
A MSI R V V ++ +Y+VGG S S S E +DP + +W+ M
Sbjct: 587 ASMSIARSTVGVAALNGKLYSVGGRDGSSCLS---------SMEYYDPHTNKWSMCPPMC 637
Query: 188 NCRIGLGVATVNRLLYAVGGFDG------ENRLGSAERYNPDEDNWEFVASLNRTRSGAG 349
R G+GVAT + LYAVGG D L ERY P D W VA L+ R G
Sbjct: 638 KKRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYEPKTDTWTMVAPLSMPRDAVG 697
Query: 350 VVALDQHIYAIGGYDSACQLRSVERYDPDKNQWVFVAPM 466
V L +YA+GGYD L ++E YDP N+W +A +
Sbjct: 698 VCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASL 736
Score = 80.5 bits (197), Expect = 4e-15
Identities = 47/121 (38%), Positives = 67/121 (55%)
Frame = +2
Query: 5 CAPMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASM 184
C PM R V V D +YAVGG + S H S + + E+++P + WT VA +
Sbjct: 633 CPPMCKKRGGVGVATCDGFLYAVGGHD--APASNHCSRL-LDYVERYEPKTDTWTMVAPL 689
Query: 185 NNCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALD 364
+ R +GV + LYAVGG+DG+ L + E Y+P + W +ASLN R+GA VV +
Sbjct: 690 SMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVIK 749
Query: 365 Q 367
Q
Sbjct: 750 Q 750
Score = 63.5 bits (153), Expect = 5e-10
Identities = 32/94 (34%), Positives = 48/94 (51%)
Frame = +2
Query: 371 IYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEFL 550
+YA+GG D+ ++E+YD N W+ M R G V + K++V GG DG + L
Sbjct: 464 LYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTL 523
Query: 551 TSVEVYDPSTNIWTEVTKMDAGKSGHAVLLGREP 652
+VE Y+P T WT + M + G V + P
Sbjct: 524 NTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGP 557
Score = 38.9 bits (89), Expect = 0.014
Identities = 27/112 (24%), Positives = 52/112 (46%), Gaps = 3/112 (2%)
Frame = +2
Query: 353 VALDQHIYAIGGYDSACQ---LRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVF 523
+ D +A+ D CQ L +++ + + + + +P +PR + T+Y
Sbjct: 413 ILADLENHALFKNDLECQKLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLY-----AV 467
Query: 524 GGYDGNEFLTSVEVYDPSTNIWTEVTKMDAGKSGHAVLLGREPRFED*LFIV 679
GG D N+ T++E YD TN+W + M+ + V + +D LF++
Sbjct: 468 GGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQFGVAV-----IDDKLFVI 514
>sp|Q8VCK5|KLH20_MOUSE Kelch-like protein 20 (Kelch-like ECT2 interacting protein)
Length = 604
Score = 162 bits (409), Expect = 1e-39
Identities = 87/207 (42%), Positives = 118/207 (57%), Gaps = 1/207 (0%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTP-VASM 184
A MS R V V ++DD++YAVGG H + NS E++DP + QW+ VA
Sbjct: 344 ASMSKRRCGVGVSVLDDLLYAVGG---------HDGSSYLNSVERYDPKTNQWSSDVAPT 394
Query: 185 NNCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALD 364
+ CR +GVA + LYAVGG DG + L ERY+P E+ W VAS++ R G V L
Sbjct: 395 STCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLG 454
Query: 365 QHIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNE 544
+YA+GG D L +VERY+P +N+W +APM R LG VY+ I+ GG D
Sbjct: 455 GFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTT 514
Query: 545 FLTSVEVYDPSTNIWTEVTKMDAGKSG 625
L+S E Y+P TN W+ V M + +SG
Sbjct: 515 ELSSAERYNPRTNQWSPVVAMTSRRSG 541
Score = 155 bits (392), Expect = 1e-37
Identities = 81/209 (38%), Positives = 110/209 (52%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMN 187
AP S R V V ++ +YAVGG +S N E++DP +WT VASM+
Sbjct: 392 APTSTCRTSVGVAVLGGFLYAVGGQDGVSCL---------NIVERYDPKENKWTRVASMS 442
Query: 188 NCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQ 367
R+G+ VA + LYAVGG DG + L + ERYNP E+ W +A + R G
Sbjct: 443 TRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQD 502
Query: 368 HIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEF 547
IYA+GG D +L S ERY+P NQW V M RS +G V G++ GG+DG +
Sbjct: 503 MIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTY 562
Query: 548 LTSVEVYDPSTNIWTEVTKMDAGKSGHAV 634
L ++EV+DP N W M+ + G V
Sbjct: 563 LKTIEVFDPDANTWRLYGGMNYRRLGGGV 591
Score = 135 bits (340), Expect = 1e-31
Identities = 76/200 (38%), Positives = 107/200 (53%), Gaps = 1/200 (0%)
Frame = +2
Query: 11 PMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMNN 190
P + PR + G ++++AVGG + S S E++DP + +W VASM+
Sbjct: 301 PRTRPRKPIRCG---EVLFAVGGWCSGDAIS---------SVERYDPQTNEWRMVASMSK 348
Query: 191 CRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEF-VASLNRTRSGAGVVALDQ 367
R G+GV+ ++ LLYAVGG DG + L S ERY+P + W VA + R+ GV L
Sbjct: 349 RRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGG 408
Query: 368 HIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEF 547
+YA+GG D L VERYDP +N+W VA M R + V G ++ GG DG
Sbjct: 409 FLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP 468
Query: 548 LTSVEVYDPSTNIWTEVTKM 607
L +VE Y+P N W + M
Sbjct: 469 LNTVERYNPQENRWHTIAPM 488
Score = 119 bits (299), Expect = 6e-27
Identities = 61/137 (44%), Positives = 81/137 (59%), Gaps = 1/137 (0%)
Frame = +2
Query: 227 LLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQHIYAIGGYDSACQ 406
+L+AVGG+ + + S ERY+P + W VAS+++ R G GV LD +YA+GG+D +
Sbjct: 314 VLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSY 373
Query: 407 LRSVERYDPDKNQWVF-VAPMIRPRSALGATVYEGKIWVFGGYDGNEFLTSVEVYDPSTN 583
L SVERYDP NQW VAP R+++G V G ++ GG DG L VE YDP N
Sbjct: 374 LNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKEN 433
Query: 584 IWTEVTKMDAGKSGHAV 634
WT V M + G AV
Sbjct: 434 KWTRVASMSTRRLGVAV 450
Score = 87.4 bits (215), Expect = 4e-17
Identities = 46/117 (39%), Positives = 64/117 (54%)
Frame = +2
Query: 2 TCAPMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVAS 181
T APM R + + D+IYAVGG + S SAE+++P + QW+PV +
Sbjct: 484 TIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELS---------SAERYNPRTNQWSPVVA 534
Query: 182 MNNCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGV 352
M + R G+G+A VN L AVGGFDG L + E ++PD + W +N R G GV
Sbjct: 535 MTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLGGGV 591
Score = 32.3 bits (72), Expect = 1.4
Identities = 20/69 (28%), Positives = 30/69 (43%)
Frame = +2
Query: 14 MSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMNNC 193
M+ R V + +V+ + AVGG + + E FDPD+ W MN
Sbjct: 535 MTSRRSGVGLAVVNGQLMAVGG---------FDGTTYLKTIEVFDPDANTWRLYGGMNYR 585
Query: 194 RIGLGVATV 220
R+G GV +
Sbjct: 586 RLGGGVGVI 594
>sp|Q9Y2M5|KLH20_HUMAN Kelch-like protein 20 (Kelch-like ECT2 interacting protein)
(Kelch-like protein X)
Length = 604
Score = 162 bits (409), Expect = 1e-39
Identities = 87/207 (42%), Positives = 118/207 (57%), Gaps = 1/207 (0%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTP-VASM 184
A MS R V V ++DD++YAVGG H + NS E++DP + QW+ VA
Sbjct: 344 ASMSKRRCGVGVSVLDDLLYAVGG---------HDGSSYLNSVERYDPKTNQWSSDVAPT 394
Query: 185 NNCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALD 364
+ CR +GVA + LYAVGG DG + L ERY+P E+ W VAS++ R G V L
Sbjct: 395 STCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLG 454
Query: 365 QHIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNE 544
+YA+GG D L +VERY+P +N+W +APM R LG VY+ I+ GG D
Sbjct: 455 GFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTT 514
Query: 545 FLTSVEVYDPSTNIWTEVTKMDAGKSG 625
L+S E Y+P TN W+ V M + +SG
Sbjct: 515 ELSSAERYNPRTNQWSPVVAMTSRRSG 541
Score = 155 bits (391), Expect = 1e-37
Identities = 78/194 (40%), Positives = 105/194 (54%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMN 187
AP S R V V ++ +YAVGG +S N E++DP +WT VASM+
Sbjct: 392 APTSTCRTSVGVAVLGGFLYAVGGQDGVSCL---------NIVERYDPKENKWTRVASMS 442
Query: 188 NCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQ 367
R+G+ VA + LYAVGG DG + L + ERYNP E+ W +A + R G
Sbjct: 443 TRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQD 502
Query: 368 HIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEF 547
IYA+GG D +L S ERY+P NQW V M RS +G V G++ GG+DG +
Sbjct: 503 MIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTY 562
Query: 548 LTSVEVYDPSTNIW 589
L ++EV+DP N W
Sbjct: 563 LKTIEVFDPDANTW 576
Score = 135 bits (340), Expect = 1e-31
Identities = 76/200 (38%), Positives = 107/200 (53%), Gaps = 1/200 (0%)
Frame = +2
Query: 11 PMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMNN 190
P + PR + G ++++AVGG + S S E++DP + +W VASM+
Sbjct: 301 PRTRPRKPIRCG---EVLFAVGGWCSGDAIS---------SVERYDPQTNEWRMVASMSK 348
Query: 191 CRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEF-VASLNRTRSGAGVVALDQ 367
R G+GV+ ++ LLYAVGG DG + L S ERY+P + W VA + R+ GV L
Sbjct: 349 RRCGVGVSVLDDLLYAVGGHDGSSYLNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGG 408
Query: 368 HIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEF 547
+YA+GG D L VERYDP +N+W VA M R + V G ++ GG DG
Sbjct: 409 FLYAVGGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSP 468
Query: 548 LTSVEVYDPSTNIWTEVTKM 607
L +VE Y+P N W + M
Sbjct: 469 LNTVERYNPQENRWHTIAPM 488
Score = 119 bits (299), Expect = 6e-27
Identities = 61/137 (44%), Positives = 81/137 (59%), Gaps = 1/137 (0%)
Frame = +2
Query: 227 LLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQHIYAIGGYDSACQ 406
+L+AVGG+ + + S ERY+P + W VAS+++ R G GV LD +YA+GG+D +
Sbjct: 314 VLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSY 373
Query: 407 LRSVERYDPDKNQWVF-VAPMIRPRSALGATVYEGKIWVFGGYDGNEFLTSVEVYDPSTN 583
L SVERYDP NQW VAP R+++G V G ++ GG DG L VE YDP N
Sbjct: 374 LNSVERYDPKTNQWSSDVAPTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKEN 433
Query: 584 IWTEVTKMDAGKSGHAV 634
WT V M + G AV
Sbjct: 434 KWTRVASMSTRRLGVAV 450
Score = 85.5 bits (210), Expect = 1e-16
Identities = 48/130 (36%), Positives = 70/130 (53%), Gaps = 5/130 (3%)
Frame = +2
Query: 2 TCAPMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVAS 181
T APM R + + D+IYAVGG + S SAE+++P + QW+PV +
Sbjct: 484 TIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELS---------SAERYNPRTNQWSPVVA 534
Query: 182 MNNCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTR--SGAGVV 355
M + R G+G+A VN L AVGGFDG L + E ++PD + W +N R G GV+
Sbjct: 535 MTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTWRLYGGMNYRRLWGGVGVI 594
Query: 356 AL---DQHIY 376
+ + HI+
Sbjct: 595 KMTHCESHIW 604
>sp|Q6TDP4|KLH17_HUMAN Kelch-like protein 17 (Actinfilin)
Length = 642
Score = 156 bits (395), Expect = 5e-38
Identities = 87/207 (42%), Positives = 114/207 (55%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMN 187
A MS R RV V V + +YAVGG S +T E +DP + W P SM
Sbjct: 373 ASMSTRRARVGVAAVGNRLYAVGGYDGTSDLAT---------VESYDPVTNTWQPEVSMG 423
Query: 188 NCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQ 367
R LGVA ++ LLY+ GG+DG + L SAERY+P W VA+++ R V LD
Sbjct: 424 TRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDG 483
Query: 368 HIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEF 547
++YA+GGYDS+ L +VE+Y+P N W VA M+ RS+ G V EG ++V GG DG
Sbjct: 484 NLYAVGGYDSSSHLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSC 543
Query: 548 LTSVEVYDPSTNIWTEVTKMDAGKSGH 628
L SVE Y P W V M+ +S H
Sbjct: 544 LNSVERYSPKAGAWESVAPMNIRRSTH 570
Score = 136 bits (342), Expect = 7e-32
Identities = 75/197 (38%), Positives = 105/197 (53%), Gaps = 2/197 (1%)
Frame = +2
Query: 59 IIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMNNCRIGLGVATVNRLLYA 238
+++AVGG + + H E +D + +W VASM+ R +GVA V LYA
Sbjct: 343 VLFAVGGGSLFAI---------HGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYA 393
Query: 239 VGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQHIYAIGGYDSACQLRSV 418
VGG+DG + L + E Y+P + W+ S+ RS GV AL +Y+ GGYD A L S
Sbjct: 394 VGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYSAGGYDGASCLNSA 453
Query: 419 ERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEFLTSVEVYDPSTNIWTEV 598
ERYDP W VA M R + +G ++ GGYD + L +VE Y+P N+W+ V
Sbjct: 454 ERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPV 513
Query: 599 TKMDAGKS--GHAVLLG 643
M + +S G AVL G
Sbjct: 514 ASMLSRRSSAGVAVLEG 530
Score = 122 bits (305), Expect = 1e-27
Identities = 68/166 (40%), Positives = 92/166 (55%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMN 187
A MS R V V +D +YAVGG + S H + EK++P W+PVASM
Sbjct: 467 AAMSTRRRYVRVATLDGNLYAVGG---------YDSSSHLATVEKYEPQVNVWSPVASML 517
Query: 188 NCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQ 367
+ R GVA + LY GG DG + L S ERY+P WE VA +N RS +VA+D
Sbjct: 518 SRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVAMDG 577
Query: 368 HIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYE 505
+YA+GG D + L S+E+Y+P N+WV + M RS++G V E
Sbjct: 578 WLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCMFTRRSSVGVAVLE 623
Score = 37.0 bits (84), Expect = 0.055
Identities = 24/74 (32%), Positives = 37/74 (50%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMN 187
APM+I R + +D +YAVGG+ S+ NS EK++P + +W + M
Sbjct: 561 APMNIRRSTHDLVAMDGWLYAVGGNDGSSSL---------NSIEKYNPRTNKWVAASCMF 611
Query: 188 NCRIGLGVATVNRL 229
R +GVA + L
Sbjct: 612 TRRSSVGVAVLELL 625
>sp|Q96PQ7|KLHL5_HUMAN Kelch-like protein 5
Length = 755
Score = 156 bits (394), Expect = 6e-38
Identities = 85/215 (39%), Positives = 123/215 (57%), Gaps = 6/215 (2%)
Frame = +2
Query: 11 PMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMNN 190
PMS RH + V +++ +YAVGG H + N+ E++DP + QW VA+M+
Sbjct: 546 PMSTHRHGLGVAVLEGPMYAVGG---------HDGWSYLNTVERWDPQARQWNFVATMST 596
Query: 191 CRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQH 370
R +GVA ++ LYAVGG DG + L S E ++P + W A +++ R G GV +
Sbjct: 597 PRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGL 656
Query: 371 IYAIGGYDS-ACQLRS-----VERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGY 532
+YAIGG+D+ A L S VERYDP + W VA M R A+G + K++ GGY
Sbjct: 657 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDKLYAVGGY 716
Query: 533 DGNEFLTSVEVYDPSTNIWTEVTKMDAGKSGHAVL 637
DG +L +VE YDP TN WT+V + G++G V+
Sbjct: 717 DGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVV 751
Score = 149 bits (377), Expect = 6e-36
Identities = 79/191 (41%), Positives = 104/191 (54%)
Frame = +2
Query: 62 IYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMNNCRIGLGVATVNRLLYAV 241
++AVGG S S EK+D + WTPVA+MN R+ GVA ++ LY V
Sbjct: 469 LFAVGGM---------DSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVV 519
Query: 242 GGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQHIYAIGGYDSACQLRSVE 421
GG DG L + E YNP W + ++ R G GV L+ +YA+GG+D L +VE
Sbjct: 520 GGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVE 579
Query: 422 RYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEFLTSVEVYDPSTNIWTEVT 601
R+DP QW FVA M PRS +G V GK++ GG DG+ L SVE +DP TN WT
Sbjct: 580 RWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCA 639
Query: 602 KMDAGKSGHAV 634
+M + G V
Sbjct: 640 QMSKRRGGVGV 650
Score = 140 bits (353), Expect = 4e-33
Identities = 77/217 (35%), Positives = 114/217 (52%), Gaps = 6/217 (2%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMN 187
A M+ R + V ++DD +Y VGG L T N+ E ++P + W+ + M+
Sbjct: 498 ANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL---------NTVECYNPKTKTWSVMPPMS 548
Query: 188 NCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQ 367
R GLGVA + +YAVGG DG + L + ER++P W FVA+++ RS GV L
Sbjct: 549 THRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSG 608
Query: 368 HIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDG--- 538
+YA+GG D + L+SVE +DP N+W A M + R +G T + G ++ GG+D
Sbjct: 609 KLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPAS 668
Query: 539 ---NEFLTSVEVYDPSTNIWTEVTKMDAGKSGHAVLL 640
+ VE YDP T++WT V M + V L
Sbjct: 669 NLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCL 705
Score = 77.8 bits (190), Expect = 3e-14
Identities = 47/120 (39%), Positives = 67/120 (55%), Gaps = 1/120 (0%)
Frame = +2
Query: 5 CAPMSIPRHRVAVGIVDDIIYAVGG-SATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVAS 181
CA MS R V V + ++YA+GG A S ++ S + E++DP + WT VAS
Sbjct: 638 CAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLS----DCVERYDPKTDMWTAVAS 693
Query: 182 MNNCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVAL 361
M+ R +GV + LYAVGG+DG+ L + E Y+P + W VA L R+GA VV +
Sbjct: 694 MSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLGRAGACVVTV 753
Score = 66.6 bits (161), Expect = 6e-11
Identities = 34/96 (35%), Positives = 50/96 (52%)
Frame = +2
Query: 371 IYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEFL 550
++A+GG DS S+E+YD N W VA M R G V + K++V GG DG + L
Sbjct: 469 LFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTL 528
Query: 551 TSVEVYDPSTNIWTEVTKMDAGKSGHAVLLGREPRF 658
+VE Y+P T W+ + M + G V + P +
Sbjct: 529 NTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMY 564
Score = 37.7 bits (86), Expect = 0.032
Identities = 24/74 (32%), Positives = 38/74 (51%)
Frame = +2
Query: 458 APMIRPRSALGATVYEGKIWVFGGYDGNEFLTSVEVYDPSTNIWTEVTKMDAGKSGHAVL 637
+P +PR + TV G ++ GG D + TS+E YD TN+WT V M+ + V
Sbjct: 456 SPRTKPRKS---TV--GTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVA 510
Query: 638 LGREPRFED*LFIV 679
+ +D L++V
Sbjct: 511 V-----LDDKLYVV 519
>sp|Q9NXS3|BTBD5_HUMAN BTB/POZ domain containing protein 5
Length = 571
Score = 156 bits (394), Expect = 6e-38
Identities = 87/209 (41%), Positives = 117/209 (55%), Gaps = 3/209 (1%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVM---HHNSAEKFDPDSGQWTPVA 178
AP++IPR+ + ++D +Y +GG AT + P V H NS E ++PD+ WT +
Sbjct: 315 APLNIPRYEFGICVLDQKVYVIGGIAT----NVRPGVTIRKHENSVECWNPDTNTWTSLE 370
Query: 179 SMNNCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVA 358
MN R LGV + LYA+GG+DG++ L S E+Y P W+ VA + TRS
Sbjct: 371 RMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAV 430
Query: 359 LDQHIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDG 538
LD IYAIGGY A + SVERYDP K+ W VA M R G V G I+V GG++G
Sbjct: 431 LDGMIYAIGGYGPA-HMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNG 489
Query: 539 NEFLTSVEVYDPSTNIWTEVTKMDAGKSG 625
L+S+E YDP N WT M ++G
Sbjct: 490 VSHLSSIERYDPHQNQWTVCRPMKEPRTG 518
Score = 112 bits (281), Expect = 8e-25
Identities = 56/163 (34%), Positives = 85/163 (52%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMN 187
APM+ R A ++D +IYA+GG H NS E++DP W VASM
Sbjct: 417 APMTTTRSCFAAAVLDGMIYAIGGYGPA----------HMNSVERYDPSKDSWEMVASMA 466
Query: 188 NCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQ 367
+ RI GV + ++ VGG +G + L S ERY+P ++ W + R+G G +D
Sbjct: 467 DKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVGAAVIDN 526
Query: 368 HIYAIGGYDSACQLRSVERYDPDKNQWVFVAPMIRPRSALGAT 496
++Y +GG+ + L +V++YDP + W+ A MI R G T
Sbjct: 527 YLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLT 569
Score = 89.0 bits (219), Expect = 1e-17
Identities = 54/142 (38%), Positives = 70/142 (49%), Gaps = 9/142 (6%)
Frame = +2
Query: 224 RLLYAVGGFDGENR-LGSAERYNPDEDNWEFVASLNRTRSGAGVVALDQHIYAIGGYDSA 400
++L AVGG G L S E Y P D+W +A LN R G+ LDQ +Y IGG +
Sbjct: 283 KVLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATN 342
Query: 401 CQ--------LRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGNEFLTS 556
+ SVE ++PD N W + M RS LG V G+++ GGYDG +L S
Sbjct: 343 VRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQS 402
Query: 557 VEVYDPSTNIWTEVTKMDAGKS 622
VE Y P W V M +S
Sbjct: 403 VEKYIPKIRKWQPVAPMTTTRS 424
Score = 73.2 bits (178), Expect = 7e-13
Identities = 40/118 (33%), Positives = 57/118 (48%)
Frame = +2
Query: 8 APMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASMN 187
A M+ R VG++ I+ VGG H V H +S E++DP QWT M
Sbjct: 463 ASMADKRIHFGVGVMLGFIFVVGG---------HNGVSHLSSIERYDPHQNQWTVCRPMK 513
Query: 188 NCRIGLGVATVNRLLYAVGGFDGENRLGSAERYNPDEDNWEFVASLNRTRSGAGVVAL 361
R G+G A ++ LY VGG G + L + ++Y+P D W A + R G+ AL
Sbjct: 514 EPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDSAGMIYCRCNFGLTAL 571
Score = 56.6 bits (135), Expect = 7e-08
Identities = 37/101 (36%), Positives = 52/101 (51%), Gaps = 12/101 (11%)
Frame = +2
Query: 377 AIGGYDS--ACQLRSVERYDPDKNQWVFVAPMIRPRSALGATVYEGKIWVFGGYDGN--- 541
A+GG AC L SVE Y P + W+ +AP+ PR G V + K++V GG N
Sbjct: 287 AVGGKSGLFAC-LDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRP 345
Query: 542 -----EFLTSVEVYDPSTNIWTEVTKMDAGKS--GHAVLLG 643
+ SVE ++P TN WT + +M+ +S G VL G
Sbjct: 346 GVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGVVVLAG 386
Score = 47.0 bits (110), Expect = 5e-05
Identities = 23/72 (31%), Positives = 33/72 (45%)
Frame = +2
Query: 5 CAPMSIPRHRVAVGIVDDIIYAVGGSATLSTQSTHPSVMHHNSAEKFDPDSGQWTPVASM 184
C PM PR V ++D+ +Y VGG H + N+ +K+DP S W A M
Sbjct: 509 CRPMKEPRTGVGAAVIDNYLYVVGG---------HSGSSYLNTVQKYDPISDTWLDSAGM 559
Query: 185 NNCRIGLGVATV 220
CR G+ +
Sbjct: 560 IYCRCNFGLTAL 571
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,028,080
Number of Sequences: 369166
Number of extensions: 1978055
Number of successful extensions: 5901
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4909
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5393
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6631293200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)