Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_B12
(822 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9JI92|SDCB1_RAT Syntenin-1 (Syndecan binding protein 1) 276 4e-74
sp|O00560|SDCB1_HUMAN Syntenin-1 (Syndecan binding protein ... 276 5e-74
sp|O08992|SDCB1_MOUSE Syntenin-1 (Syndecan binding protein ... 276 5e-74
sp|Q99JZ0|SDCB2_MOUSE Syntenin-2 (Syndecan binding protein 2) 245 9e-65
sp|Q9H190|SDCB2_HUMAN Syntenin-2 (Syndecan binding protein 2) 240 3e-63
sp|O35430|APBA1_RAT Amyloid beta A4 precursor protein-bindi... 61 3e-09
sp|Q02410|APBA1_HUMAN Amyloid beta A4 precursor protein-bin... 60 6e-09
sp|Q99767|APBA2_HUMAN Amyloid beta A4 precursor protein-bin... 55 2e-07
sp|Q5RD33|APBA2_PONPY Amyloid beta A4 precursor protein-bin... 55 2e-07
sp|P98084|APBA2_MOUSE Amyloid beta A4 precursor protein-bin... 55 2e-07
>sp|Q9JI92|SDCB1_RAT Syntenin-1 (Syndecan binding protein 1)
Length = 300
Score = 276 bits (707), Expect = 4e-74
Identities = 140/268 (52%), Positives = 189/268 (70%), Gaps = 7/268 (2%)
Frame = +3
Query: 9 NFINTVVNEPTGS-QGSLYPALDDYLGLDMRAAQ---NQMVQSYGNSVVGYGWRQNTSV- 173
N +++ P G+ LYP L Y+GL + A+ N V S G G + +SV
Sbjct: 34 NVVDSAAFPPGGNLYPKLYPELSQYMGLSLSEAEICENMPVVS-GAPTQGQLVARPSSVN 92
Query: 174 --VAPVTKNDVGISRAEIKQGLRRAVLCKDSKGIIGLRVQAVNKGIFVSFVNENSPASMA 347
VAPVT ND GI RAEIKQG+R +LCKD G IGLR+++V+ GIFV V NSPAS+
Sbjct: 93 YMVAPVTGNDAGIRRAEIKQGIREVILCKDQDGKIGLRLKSVDNGIFVQLVQANSPASLV 152
Query: 348 GLRFGDQILEVNNQVVAGWTTEKVHKFFKAAGSNNITVALRDRPFERTITMNKDSNGYIG 527
GLRFGDQ+L++N + AGW+++K HK K A IT+ +RDRPFERT+TM+KDS+G++G
Sbjct: 153 GLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTVTMHKDSSGHVG 212
Query: 528 FVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKEIQKIIDKTPNIVTVTIM 707
F+FK+G IT +VKDSSAARNGLL DH + EINGQNVIGLKD +I I+ +VT+TIM
Sbjct: 213 FIFKSGKITSIVKDSSAARNGLLTDHHICEINGQNVIGLKDAQIADILSTAGTVVTITIM 272
Query: 708 PMFVYEHMVKTLSSDLLKNHMDHSIPEI 791
P F++EH++K ++ ++K+ MDH+IPE+
Sbjct: 273 PAFIFEHIIKRMAPSIMKSLMDHTIPEV 300
>sp|O00560|SDCB1_HUMAN Syntenin-1 (Syndecan binding protein 1) (Melanoma
differentiation-associated protein 9) (MDA-9) (Scaffold
protein Pbp1) (Pro-TGF-alpha cytoplasmic
domain-interacting protein 18) (TACIP18)
Length = 298
Score = 276 bits (706), Expect = 5e-74
Identities = 136/251 (54%), Positives = 183/251 (72%), Gaps = 6/251 (2%)
Frame = +3
Query: 57 LYPALDDYLGLDMRAAQ---NQMVQSYGNSVVGYGWRQNTSV---VAPVTKNDVGISRAE 218
LYP L Y+GL + + N V S G + G + +S+ VAPVT NDVGI RAE
Sbjct: 49 LYPELSQYMGLSLNEEEIRANVAVVS-GAPLQGQLVARPSSINYMVAPVTGNDVGIRRAE 107
Query: 219 IKQGLRRAVLCKDSKGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVA 398
IKQG+R +LCKD G IGLR+++++ GIFV V NSPAS+ GLRFGDQ+L++N + A
Sbjct: 108 IKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCA 167
Query: 399 GWTTEKVHKFFKAAGSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSA 578
GW+++K HK K A IT+ +RDRPFERTITM+KDS G++GF+FKNG IT +VKDSSA
Sbjct: 168 GWSSDKAHKVLKQAFGEKITMTIRDRPFERTITMHKDSTGHVGFIFKNGKITSIVKDSSA 227
Query: 579 ARNGLLIDHKLIEINGQNVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSDLL 758
ARNGLL +H + EINGQNVIGLKD +I I+ + +VT+TIMP F++EH++K ++ ++
Sbjct: 228 ARNGLLTEHNICEINGQNVIGLKDSQIADILSTSGTVVTITIMPAFIFEHIIKRMAPSIM 287
Query: 759 KNHMDHSIPEI 791
K+ MDH+IPE+
Sbjct: 288 KSLMDHTIPEV 298
>sp|O08992|SDCB1_MOUSE Syntenin-1 (Syndecan binding protein 1) (Scaffold protein Pbp1)
Length = 299
Score = 276 bits (706), Expect = 5e-74
Identities = 134/250 (53%), Positives = 180/250 (72%), Gaps = 5/250 (2%)
Frame = +3
Query: 57 LYPALDDYLGLDMRAAQ--NQMVQSYGNSVVGYGWRQNTSV---VAPVTKNDVGISRAEI 221
LYP L Y+GL + A+ M G G + +SV VAPVT ND GI RAEI
Sbjct: 50 LYPELSQYMGLSLNEAEICESMPMVSGAPAQGQLVARPSSVNYMVAPVTGNDAGIRRAEI 109
Query: 222 KQGLRRAVLCKDSKGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQVVAG 401
KQG+R +LCKD G IGLR+++++ GIFV V NSPAS+ GLRFGDQ+L++N + AG
Sbjct: 110 KQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAG 169
Query: 402 WTTEKVHKFFKAAGSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAA 581
W+++K HK K A IT+ +RDRPFERT+TM+KDS+G++GF+FK+G IT +VKDSSAA
Sbjct: 170 WSSDKAHKVLKQAFGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAA 229
Query: 582 RNGLLIDHKLIEINGQNVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSDLLK 761
RNGLL DH + EINGQNVIGLKD +I I+ +VT+TIMP F++EH++K ++ ++K
Sbjct: 230 RNGLLTDHHICEINGQNVIGLKDAQIADILSTAGTVVTITIMPTFIFEHIIKRMAPSIMK 289
Query: 762 NHMDHSIPEI 791
+ MDH+IPE+
Sbjct: 290 SLMDHTIPEV 299
>sp|Q99JZ0|SDCB2_MOUSE Syntenin-2 (Syndecan binding protein 2)
Length = 292
Score = 245 bits (626), Expect = 9e-65
Identities = 129/254 (50%), Positives = 173/254 (68%), Gaps = 10/254 (3%)
Frame = +3
Query: 57 LYP---ALDDYLGLDMRAAQNQ----MVQSYGNSVV---GYGWRQNTSVVAPVTKNDVGI 206
LYP L+ Y+GL + + + Q + N VV G G VVAPV+ N++GI
Sbjct: 43 LYPNLAELESYMGLSLSSQEVQKNLTQIPDSDNMVVTSPGPG-----QVVAPVSGNNLGI 97
Query: 207 SRAEIKQGLRRAVLCKDSKGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNN 386
RAEIK G+R LCKD +G GLR+QAV+KG+FV V N+PAS+ GLRFGDQIL+++
Sbjct: 98 LRAEIKPGVREIHLCKDERGKTGLRLQAVDKGLFVQLVQANTPASLVGLRFGDQILQIDG 157
Query: 387 QVVAGWTTEKVHKFFKAAGSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVK 566
AGW T K HK K A + I + +RDRPF+RT+TM+KDS+G +GF K G I +VK
Sbjct: 158 CDCAGWNTHKAHKVLKKASAEKIVMVIRDRPFQRTVTMHKDSSGQVGFSIKKGKIVSVVK 217
Query: 567 DSSAARNGLLIDHKLIEINGQNVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLS 746
SSAARNGLL +H + E+NGQNVIGLKDK++ +I+ +++T+TI+P +YEHM+K LS
Sbjct: 218 GSSAARNGLLTNHYVCEVNGQNVIGLKDKKVTEILTTAGDVITLTIIPTVIYEHMIKRLS 277
Query: 747 SDLLKNHMDHSIPE 788
LL + MDHSIP+
Sbjct: 278 PLLLHHTMDHSIPD 291
>sp|Q9H190|SDCB2_HUMAN Syntenin-2 (Syndecan binding protein 2)
Length = 292
Score = 240 bits (613), Expect = 3e-63
Identities = 125/252 (49%), Positives = 174/252 (69%), Gaps = 8/252 (3%)
Frame = +3
Query: 57 LYP---ALDDYLGLDMRAAQNQ-----MVQSYGNSVVGYGWRQNTSVVAPVTKNDVGISR 212
LYP L++Y+GL + + + Q + + +V G G Q +VAPVT +G+ R
Sbjct: 43 LYPNLAELENYMGLSLSSQEVQESLLQIPEGDSTAVSGPGPGQ---MVAPVTGYSLGVRR 99
Query: 213 AEIKQGLRRAVLCKDSKGIIGLRVQAVNKGIFVSFVNENSPASMAGLRFGDQILEVNNQV 392
AEIK G+R LCKD +G GLR++ V++G+FV V N+PAS+ GLRFGDQ+L+++ +
Sbjct: 100 AEIKPGVREIHLCKDERGKTGLRLRKVDQGLFVQLVQANTPASLVGLRFGDQLLQIDGRD 159
Query: 393 VAGWTTEKVHKFFKAAGSNNITVALRDRPFERTITMNKDSNGYIGFVFKNGTITHLVKDS 572
AGW++ K H+ K A + I V +RDRPF+RT+TM+KDS G++GFV K G I LVK S
Sbjct: 160 CAGWSSHKAHQVVKKASGDKIVVVVRDRPFQRTVTMHKDSMGHVGFVIKKGKIVSLVKGS 219
Query: 573 SAARNGLLIDHKLIEINGQNVIGLKDKEIQKIIDKTPNIVTVTIMPMFVYEHMVKTLSSD 752
SAARNGLL +H + E++GQNVIGLKDK+I +I+ N+VT+TI+P +YEHMVK L
Sbjct: 220 SAARNGLLTNHYVCEVDGQNVIGLKDKKIMEILATAGNVVTLTIIPSVIYEHMVKKLPPV 279
Query: 753 LLKNHMDHSIPE 788
LL + MDHSIP+
Sbjct: 280 LLHHTMDHSIPD 291
>sp|O35430|APBA1_RAT Amyloid beta A4 precursor protein-binding family A member 1
(Neuron-specific X11 protein) (Neuronal
Munc18-1-interacting protein 1) (Mint-1) (Adapter protein
X11alpha)
Length = 839
Score = 61.2 bits (147), Expect = 3e-09
Identities = 38/144 (26%), Positives = 68/144 (47%), Gaps = 4/144 (2%)
Frame = +3
Query: 303 IFVSFVNENSPASMAG-LRFGDQILEVNNQVVAGW---TTEKVHKFFKAAGSNNITVALR 470
+ ++ + PA +G L GDQI+ +N + G T + + K K + + +R
Sbjct: 685 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNI-VR 743
Query: 471 DRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKD 650
P + D +GF +NG I L++ A R G+ + H++IEINGQ+V+
Sbjct: 744 CPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPH 803
Query: 651 KEIQKIIDKTPNIVTVTIMPMFVY 722
++I I+ + + MP +Y
Sbjct: 804 EKIVHILSNAVGEIHMKTMPAAMY 827
>sp|Q02410|APBA1_HUMAN Amyloid beta A4 precursor protein-binding family A member 1
(Neuron-specific X11 protein) (Neuronal
Munc18-1-interacting protein 1) (Mint-1) (Adapter protein
X11alpha)
Length = 837
Score = 60.5 bits (145), Expect = 6e-09
Identities = 39/144 (27%), Positives = 64/144 (44%), Gaps = 4/144 (2%)
Frame = +3
Query: 303 IFVSFVNENSPASMAG-LRFGDQILEVNNQVVAGWTTEKVHKFFKAAGSNNITVAL---R 470
+ ++ + PA +G L GDQI+ +N + G K N V L R
Sbjct: 683 VIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGL-ENQSRVKLNIVR 741
Query: 471 DRPFERTITMNKDSNGYIGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKD 650
P + D +GF +NG I L++ A R G+ + H++IEINGQ+V+
Sbjct: 742 CPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATPH 801
Query: 651 KEIQKIIDKTPNIVTVTIMPMFVY 722
++I I+ + + MP +Y
Sbjct: 802 EKIVHILSNAVGEIHMKTMPAAMY 825
>sp|Q99767|APBA2_HUMAN Amyloid beta A4 precursor protein-binding family A member 2
(Neuron-specific X11L protein) (Neuronal
Munc18-1-interacting protein 2) (Mint-2) (Adapter protein
X11beta)
Length = 749
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 2/142 (1%)
Frame = +3
Query: 303 IFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA-GSNNITVALRDRP 479
I + +N A L GDQI+ +N + G K + + + P
Sbjct: 596 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 655
Query: 480 FERTITMNKDSNGY-IGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKE 656
T+ + + Y +GF +NG I L++ A R G+ + H++IEINGQ+V+ ++
Sbjct: 656 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 715
Query: 657 IQKIIDKTPNIVTVTIMPMFVY 722
I + + + + + MP ++
Sbjct: 716 IVQALSNSVGEIHMKTMPAAMF 737
>sp|Q5RD33|APBA2_PONPY Amyloid beta A4 precursor protein-binding family A member 2
Length = 749
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 2/142 (1%)
Frame = +3
Query: 303 IFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA-GSNNITVALRDRP 479
I + +N A L GDQI+ +N + G K + + + P
Sbjct: 596 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 655
Query: 480 FERTITMNKDSNGY-IGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKE 656
T+ + + Y +GF +NG I L++ A R G+ + H++IEINGQ+V+ ++
Sbjct: 656 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 715
Query: 657 IQKIIDKTPNIVTVTIMPMFVY 722
I + + + + + MP ++
Sbjct: 716 IVQALSNSVGEIHMKTMPAAMF 737
>sp|P98084|APBA2_MOUSE Amyloid beta A4 precursor protein-binding family A member 2
(Neuron-specific X11L protein) (Neuronal
Munc18-1-interacting protein 2) (Mint-2) (Adapter protein
X11beta)
Length = 750
Score = 55.5 bits (132), Expect = 2e-07
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 2/142 (1%)
Frame = +3
Query: 303 IFVSFVNENSPASMAGLRFGDQILEVNNQVVAGWTTEKVHKFFKAA-GSNNITVALRDRP 479
I + +N A L GDQI+ +N + G K + + + P
Sbjct: 597 ILANMMNGGPAARSGKLSIGDQIMSINGTSLVGLPLATCQGIIKGLKNQTQVKLNIVSCP 656
Query: 480 FERTITMNKDSNGY-IGFVFKNGTITHLVKDSSAARNGLLIDHKLIEINGQNVIGLKDKE 656
T+ + + Y +GF +NG I L++ A R G+ + H++IEINGQ+V+ ++
Sbjct: 657 PVTTVLIKRPDLKYQLGFSVQNGIICSLMRGGIAERGGVRVGHRIIEINGQSVVATAHEK 716
Query: 657 IQKIIDKTPNIVTVTIMPMFVY 722
I + + + + + MP ++
Sbjct: 717 IVQALSNSVGEIHMKTMPAAMF 738
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 95,185,520
Number of Sequences: 369166
Number of extensions: 1946570
Number of successful extensions: 5447
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5100
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5415
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7907893860
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)