Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_B08
(677 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P40123|CAP2_HUMAN Adenylyl cyclase-associated protein 2 ... 183 4e-46
sp|Q9CYT6|CAP2_MOUSE Adenylyl cyclase-associated protein 2 ... 176 5e-44
sp|Q01518|CAP1_HUMAN Adenylyl cyclase-associated protein 1 ... 176 7e-44
sp|P52481|CAP2_RAT Adenylyl cyclase-associated protein 2 (C... 175 9e-44
sp|P40124|CAP1_MOUSE Adenylyl cyclase-associated protein 1 ... 174 2e-43
sp|Q08163|CAP1_RAT Adenylyl cyclase-associated protein 1 (C... 173 3e-43
sp|P40122|CAP_CHLVR Adenylyl cyclase-associated protein (CAP) 166 7e-41
sp|P36621|CAP_SCHPO Adenylyl cyclase-associated protein (CAP) 146 4e-35
sp|P54654|CAP_DICDI Adenylyl cyclase-associated protein (CAP) 142 6e-34
sp|P17555|CAP_YEAST Adenylyl cyclase-associated protein (CAP) 133 4e-31
>sp|P40123|CAP2_HUMAN Adenylyl cyclase-associated protein 2 (CAP 2)
Length = 477
Score = 183 bits (464), Expect = 4e-46
Identities = 96/240 (40%), Positives = 140/240 (58%), Gaps = 19/240 (7%)
Frame = +2
Query: 2 FAAQLEYLKESTSSGKPTDAVLDTLLKPMSDAIASITDYREKNRRSEYFNHLSAVSEGIP 181
F AQ +L ++ +P + + LLKP+S+ I I +RE+NR S FNHLSAVSE IP
Sbjct: 82 FQAQRAFLLMASQYQQPHENDVAALLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIP 141
Query: 182 VLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKK 361
LGW+ VSP P P++KEM DA+ FYTNRV+KDYK + HVDW K+++ +++ELQ+++K+
Sbjct: 142 ALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVKSYLNIWSELQAYIKE 201
Query: 362 HYTTGLTWSSQCAAPVATTC------------------VXXXXXXXXXXKSTADDGAADK 487
H+TTGLTWS PVA+T + + ++
Sbjct: 202 HHTTGLTWSK--TGPVASTVSAFSVLSSGPGLPPPPPPLPPPGPPPLFENEGKKEESSPS 259
Query: 488 HLALFSEINKGSEVTSGLKKVTDDMKTHKNPNLRA-GSTVPAKVKPEVAAKPGHGTKPAQ 664
ALF+++N+G +T GL+ VTDD KT+KNP+LRA G + K + + P+Q
Sbjct: 260 RSALFAQLNQGEAITKGLRHVTDDQKTYKNPSLRAQGGQTQSPTKSHTPSPTSPKSYPSQ 319
>sp|Q9CYT6|CAP2_MOUSE Adenylyl cyclase-associated protein 2 (CAP 2)
Length = 476
Score = 176 bits (446), Expect = 5e-44
Identities = 90/224 (40%), Positives = 131/224 (58%), Gaps = 18/224 (8%)
Frame = +2
Query: 2 FAAQLEYLKESTSSGKPTDAVLDTLLKPMSDAIASITDYREKNRRSEYFNHLSAVSEGIP 181
F AQ +L + +P + + LLKP+S+ I I +RE+NR S FNHLSAVSE I
Sbjct: 82 FQAQRAFLLMVSQYQQPQENEVAVLLKPISEKIQEIQTFRERNRGSNMFNHLSAVSESIA 141
Query: 182 VLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKK 361
LGW+ VSP P P++KEM DA+ FYTNRV+KDYK + HVDW ++++ +++ELQ+++++
Sbjct: 142 ALGWIAVSPKPGPYVKEMNDAATFYTNRVLKDYKHSDLRHVDWVRSYLNIWSELQAYIRE 201
Query: 362 HYTTGLTWSSQCAAPVATTC------------------VXXXXXXXXXXKSTADDGAADK 487
H+TTGLTWS PVA+T + +
Sbjct: 202 HHTTGLTWSK--TGPVASTASAFSILSSGPGLPPPPPPPPPPGPPPPFENEDKKEEPSPS 259
Query: 488 HLALFSEINKGSEVTSGLKKVTDDMKTHKNPNLRAGSTVPAKVK 619
ALF+++N+G +T GL+ VTDD KT+KNP+LRA + + K
Sbjct: 260 RSALFAQLNQGEAITKGLRHVTDDKKTYKNPSLRAQGQIRSPTK 303
>sp|Q01518|CAP1_HUMAN Adenylyl cyclase-associated protein 1 (CAP 1)
Length = 475
Score = 176 bits (445), Expect = 7e-44
Identities = 96/220 (43%), Positives = 132/220 (60%), Gaps = 16/220 (7%)
Frame = +2
Query: 47 KPTDAVLDTLLKPMSDAIASITDYREKNRRSEYFNHLSAVSEGIPVLGWVRVSPAPCPFI 226
+P + L LL P+S+ I + +REKNR S+ FNHLSAVSE I LGWV ++P P P++
Sbjct: 95 QPAENKLSDLLAPISEQIKEVITFREKNRGSKLFNHLSAVSESIQALGWVAMAPKPGPYV 154
Query: 227 KEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYTTGLTWSSQCAAP 406
KEM DA+ FYTNRV+K+YK+ + HVDW KA+++++TELQ+++K+ +TTGL WS P
Sbjct: 155 KEMNDAAMFYTNRVLKEYKDVDKKHVDWVKAYLSIWTELQAYIKEFHTTGLAWSK--TGP 212
Query: 407 VATTC---------------VXXXXXXXXXXKSTADDGAADKHLALFSEINKGSEVTSGL 541
VA S+ D +A + ALF++IN+G +T L
Sbjct: 213 VAKELSGLPSGPSAGSGPPPPPPGPPPPPVSTSSGSDESASRS-ALFAQINQGESITHAL 271
Query: 542 KKVTDDMKTHKNPNLRAGS-TVPAKVKPEVAAKPGHGTKP 658
K V+DDMKTHKNP L+A S V + KP A KP P
Sbjct: 272 KHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSP 311
>sp|P52481|CAP2_RAT Adenylyl cyclase-associated protein 2 (CAP 2)
Length = 477
Score = 175 bits (444), Expect = 9e-44
Identities = 89/224 (39%), Positives = 131/224 (58%), Gaps = 18/224 (8%)
Frame = +2
Query: 2 FAAQLEYLKESTSSGKPTDAVLDTLLKPMSDAIASITDYREKNRRSEYFNHLSAVSEGIP 181
F AQ +L + +P + + LLKP+S+ I I +RE+NR S+ FNHLSAVSE I
Sbjct: 83 FQAQRAFLLMVSQHQQPQENEVAVLLKPISEKIQEIQTFRERNRGSDMFNHLSAVSESIA 142
Query: 182 VLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKK 361
LGW+ VSP P P++KEM DA+ FYTNRV++DYK + HVDW ++++ +++ELQ+++K+
Sbjct: 143 ALGWIAVSPKPGPYVKEMNDAATFYTNRVLRDYKHSDLRHVDWVRSYLKIWSELQAYIKE 202
Query: 362 HYTTGLTWSSQCAAPVATTC------------------VXXXXXXXXXXKSTADDGAADK 487
H+TTGLTWS PVA+T + +
Sbjct: 203 HHTTGLTWSK--TGPVASTASAFSILSSGPGLPPPPPPPPPPGPPPPFENEGGKEEPSPS 260
Query: 488 HLALFSEINKGSEVTSGLKKVTDDMKTHKNPNLRAGSTVPAKVK 619
ALF+++N+G +T GL+ VTDD K +KNP+LRA + + K
Sbjct: 261 RSALFAQLNQGEAITKGLRHVTDDKKIYKNPSLRAQGQIRSPTK 304
>sp|P40124|CAP1_MOUSE Adenylyl cyclase-associated protein 1 (CAP 1)
Length = 474
Score = 174 bits (440), Expect = 2e-43
Identities = 99/235 (42%), Positives = 137/235 (58%), Gaps = 17/235 (7%)
Frame = +2
Query: 23 LKESTSSGKPTDAVLDTLLKPMSDAIASITDYREKNRRSEYFNHLSAVSEGIPVLGWVRV 202
L ++ +P L LL P+S+ I + +REKNR S++FNHLSAVSE I LGWV +
Sbjct: 86 LATASQCQQPAGNKLSDLLAPISEQIQEVITFREKNRGSKFFNHLSAVSESIQALGWVAL 145
Query: 203 SPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYTTGLT 382
+ P PF+KEM DA+ FYTNRV+K+Y++ + HVDW +A+++++TELQ+++K+ +TTGL
Sbjct: 146 AAKPGPFVKEMNDAAMFYTNRVLKEYRDVDKKHVDWVRAYLSIWTELQAYIKEFHTTGLA 205
Query: 383 WSSQCAAPVATTC----------------VXXXXXXXXXXKSTADDGAADKHLALFSEIN 514
WS PVA S +DD A+ ALF++IN
Sbjct: 206 WSK--TGPVAKELSGLPSGPSVGSGPPPPPPGPPPPPIPTSSGSDDSAS--RSALFAQIN 261
Query: 515 KGSEVTSGLKKVTDDMKTHKNPNLRAGS-TVPAKVKPEVAAKPGHGTKPAQVKPA 676
+G +T LK V+DDMKTHKNP L+A S V + KP A KP P KPA
Sbjct: 262 QGESITHALKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSP---KPA 313
>sp|Q08163|CAP1_RAT Adenylyl cyclase-associated protein 1 (CAP 1)
Length = 474
Score = 173 bits (439), Expect = 3e-43
Identities = 98/227 (43%), Positives = 134/227 (59%), Gaps = 17/227 (7%)
Frame = +2
Query: 47 KPTDAVLDTLLKPMSDAIASITDYREKNRRSEYFNHLSAVSEGIPVLGWVRVSPAPCPFI 226
+P L LL P+S+ I + +REKNR S++FNHLSAVSE I LGWV ++ P PF+
Sbjct: 94 QPAGNKLSDLLAPISEQIQEVITFREKNRGSKFFNHLSAVSESIQALGWVALAAKPGPFV 153
Query: 227 KEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYTTGLTWSSQCAAP 406
KEM DA+ FYTNRV+K+Y++ + HVDW +A+++++TELQ+++K+ +TTGL WS P
Sbjct: 154 KEMNDAAMFYTNRVLKEYRDVDKKHVDWVRAYLSIWTELQAYIKEFHTTGLAWSK--TGP 211
Query: 407 VATTC----------------VXXXXXXXXXXKSTADDGAADKHLALFSEINKGSEVTSG 538
VA S +DD A+ ALF++IN+G +T
Sbjct: 212 VAKELSGLPSGPSVGSGPPPPPPGPPPPPVPTSSGSDDSAS--RSALFAQINQGESITHA 269
Query: 539 LKKVTDDMKTHKNPNLRAGS-TVPAKVKPEVAAKPGHGTKPAQVKPA 676
LK V+DDMKTHKNP L+A S V + KP A KP P KPA
Sbjct: 270 LKHVSDDMKTHKNPALKAQSGPVRSGPKPFSAPKPQTSPSP---KPA 313
>sp|P40122|CAP_CHLVR Adenylyl cyclase-associated protein (CAP)
Length = 481
Score = 166 bits (419), Expect = 7e-41
Identities = 83/216 (38%), Positives = 128/216 (59%), Gaps = 20/216 (9%)
Frame = +2
Query: 2 FAAQLEYLKESTSSGKPTDAVLDTLLKPMSDAIASITDYREKNRRSEYFNHLSAVSEGIP 181
F L ++ + +P+ L+ LLKP+S+AI+ + D+REKNR S+ FNHLSA+SEG+P
Sbjct: 74 FHCHLVLMEVAARHNRPSQTDLEGLLKPLSEAISKVQDFREKNRSSKQFNHLSAISEGLP 133
Query: 182 VLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKK 361
LGWV V+P P +I++M++++QFYTN+++K+++E + +W +++ + ++VK
Sbjct: 134 FLGWVGVAPKPVLYIQQMEESAQFYTNKLLKEFRESDPKQANWATSFIQLLKGFAAYVKD 193
Query: 362 HYTTGLTWSSQ-CAAPVATTCVXXXXXXXXXXKS-------------------TADDGAA 481
H+ GL W+ + AA A V S T +
Sbjct: 194 HHQAGLMWNKEKSAATPAALAVSAHKPPVPPPPSGFAPPPPPPIQAPTVTHAVTGSHSSE 253
Query: 482 DKHLALFSEINKGSEVTSGLKKVTDDMKTHKNPNLR 589
D LF++++KGSEVT+GLKKVTDDMKTHKNP LR
Sbjct: 254 DSRSQLFAQLSKGSEVTAGLKKVTDDMKTHKNPELR 289
>sp|P36621|CAP_SCHPO Adenylyl cyclase-associated protein (CAP)
Length = 551
Score = 146 bits (369), Expect = 4e-35
Identities = 82/228 (35%), Positives = 119/228 (52%), Gaps = 29/228 (12%)
Frame = +2
Query: 77 LKPMSDAIASITDYREKNRRSEYFNHLSAVSEGIPVLGWVRVSPAPCPFIKEMQDASQFY 256
LKP+ + +IT+ R+++R + FN LS V GI +LGWV V P P F+ EM+D+SQFY
Sbjct: 169 LKPIQSELLTITNIRDEHRTAPEFNQLSTVMSGISILGWVTVEPTPLSFMSEMKDSSQFY 228
Query: 257 TNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHYTTGLTWSSQCAAPVATTCVXXXX 436
NRV+K++K K+ ++W ++++ + TEL ++VK H+ TGLTWS++ A T +
Sbjct: 229 ANRVMKEFKGKDDLQIEWVRSYLTLLTELITYVKTHFKTGLTWSTKQDAVPLKTALANLS 288
Query: 437 XXXXXXKSTAD-----------------------------DGAADKHLALFSEINKGSEV 529
S+ D D D A+F+EINKG +
Sbjct: 289 ASKTQAPSSGDSANGGLPPPPPPPPPSNDFWKDSNEPAPADNKGDMG-AVFAEINKGEGI 347
Query: 530 TSGLKKVTDDMKTHKNPNLRAGSTVPAKVKPEVAAKPGHGTKPAQVKP 673
TSGL+KV THKNPNLR P P+ K +KPA+ P
Sbjct: 348 TSGLRKVDKSEMTHKNPNLRKTGPTPG---PKPKIKSSAPSKPAETAP 392
>sp|P54654|CAP_DICDI Adenylyl cyclase-associated protein (CAP)
Length = 464
Score = 142 bits (359), Expect = 6e-34
Identities = 79/226 (34%), Positives = 127/226 (56%), Gaps = 13/226 (5%)
Frame = +2
Query: 8 AQLEYLKESTSSGKPTDAVLDTLLKPMSDAIASITDYREKNRRSEYFNHLSAVSEGIPVL 187
A+ + ++ S KP+ L L+KP+++ A + R+ NR S++FN+LSA+SE I L
Sbjct: 90 AEKALINTASQSKKPSQETLLELIKPLNNFAAEVGKIRDSNRSSKFFNNLSAISESIGFL 149
Query: 188 GWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFVKKHY 367
WV V P P P + EM+ +++FYTNR++K++K N VDW ++ +L+ ++K+++
Sbjct: 150 SWVVVEPTPGPHVAEMRGSAEFYTNRILKEFKGVNQDQVDWVSNYVNFLKDLEKYIKQYH 209
Query: 368 TTGLTWS-----SQCAAPVATTCVXXXXXXXXXXKSTADDGAADKHLALFSEINKGSEVT 532
TTGLTW+ ++ A P + + + A+F E++KG VT
Sbjct: 210 TTGLTWNPKGGDAKSATPAPASSAPAAPVAPAVSSTPVESKKGPGLGAVFGELSKGDGVT 269
Query: 533 SGLKKVTDDMK----THKNPNLRAGSTVPAKV----KPEVAAKPGH 646
SGLKKVT+DMK T K+ ++A T AKV +P V A G+
Sbjct: 270 SGLKKVTNDMKSKNFTDKSSVVKAADTKVAKVDAPSRPAVFALQGN 315
>sp|P17555|CAP_YEAST Adenylyl cyclase-associated protein (CAP)
Length = 526
Score = 133 bits (335), Expect = 4e-31
Identities = 77/255 (30%), Positives = 131/255 (51%), Gaps = 32/255 (12%)
Frame = +2
Query: 2 FAAQLEYLKESTSSGKP--TDAVLDTLLKPMSDAIASITDYREKNRRSEYFNHLSAVSEG 175
F +QL +L+ + S KP + L+P+++ I + +E NR+S+YF +LSA+SEG
Sbjct: 114 FQSQLTFLRAAVRSRKPDYSSQTFADSLRPINENIIKLGQLKESNRQSKYFAYLSALSEG 173
Query: 176 IPVLGWVRVSPAPCPFIKEMQDASQFYTNRVIKDYKEKNAAHVDWTKAWMAVFTELQSFV 355
P+ WV V P + + +DA+QF+TNR++K+Y+E + V+W K ++A F L++++
Sbjct: 174 APLFSWVAVD-TPVSMVTDFKDAAQFWTNRILKEYRESDPNAVEWVKKFLASFDNLKAYI 232
Query: 356 KKHYTTGLTW-------------------SSQCAAPVATTCV-----------XXXXXXX 445
K+++TTG++W ++ +P + T
Sbjct: 233 KEYHTTGVSWKKDGMDFADAMAQSTKNTGATSSPSPASATAAPAPPPPPPAPPASVFEIS 292
Query: 446 XXXKSTADDGAADKHLALFSEINKGSEVTSGLKKVTDDMKTHKNPNLRAGSTVPAKVKPE 625
+T+ D A+F+E+N+G +T GLKKV +THKNP LR STV +
Sbjct: 293 NDTPATSSDANKGGIGAVFAELNQGENITKGLKKVDKSQQTHKNPELRQSSTVSS--TGS 350
Query: 626 VAAKPGHGTKPAQVK 670
+ P KP+ +K
Sbjct: 351 KSGPPPRPKKPSTLK 365
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 70,186,896
Number of Sequences: 369166
Number of extensions: 1300522
Number of successful extensions: 4105
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3951
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4098
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5733423530
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)