Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_B01
(759 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O35244|PRDX6_RAT Peroxiredoxin 6 (Antioxidant protein 2)... 205 9e-53
sp|P52570|TSA_ONCVO Putative peroxiredoxin (Thioredoxin per... 205 9e-53
sp|O17433|1CPX_DIRIM 1-Cys peroxiredoxin (Thioredoxin perox... 204 2e-52
sp|P30041|PRDX6_HUMAN Peroxiredoxin 6 (Antioxidant protein ... 202 6e-52
sp|O77834|PRDX6_BOVIN Peroxiredoxin 6 (Antioxidant protein ... 202 6e-52
sp|O08709|PRDX6_MOUSE Peroxiredoxin 6 (Antioxidant protein ... 198 1e-50
sp|P52573|REHY_ORYSA Probable peroxiredoxin (Thioredoxin pe... 181 2e-45
sp|P34227|PRX1_YEAST Mitochondrial peroxiredoxin PRX1 (Thio... 175 1e-43
sp|P52572|REHY_HORVU Probable peroxiredoxin (Thioredoxin pe... 175 1e-43
sp|P52571|REHY_BROSE Probable peroxiredoxin (Thioredoxin pe... 165 1e-40
>sp|O35244|PRDX6_RAT Peroxiredoxin 6 (Antioxidant protein 2) (1-Cys peroxiredoxin)
(1-Cys PRX) (Acidic calcium-independent phospholipase
A2) (aiPLA2) (Non-selenium glutathione peroxidase)
(NSGPx) (Thiol-specific antioxidant protein)
Length = 224
Score = 205 bits (522), Expect = 9e-53
Identities = 101/225 (44%), Positives = 143/225 (63%), Gaps = 1/225 (0%)
Frame = +1
Query: 4 LKLGATFTTYKVKSTAGDLIIPNYFGESWGLICTHPADFTPVCTTEFAETVKIYPEFTKR 183
L LG ++ +T G + ++ G+SWG++ +HP DFTPVCTTE K+ PEF KR
Sbjct: 5 LLLGDEAPNFEANTTIGHIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKR 64
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKLDLPFPIIADTDRKLVTELGMIDE 363
NVK++ +S D++++H AW+ DI ++K LPFPII D DR L LGM+D
Sbjct: 65 NVKLIALSIDSVEDHFAWSKDINAYNGAAPTEK-----LPFPIIDDKDRDLAILLGMLDP 119
Query: 364 SARTSAGIPLPARAVYFLDPKRIVRASILYPASCGRNFDEIIRVIDSLQKNTETGLVTPV 543
+ + G+P+ AR V+ P + ++ SILYPA+ GRNFDEI+RV+DSLQ + TPV
Sbjct: 120 AEKDEKGMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTASNPVATPV 179
Query: 544 NWKVGENLIVPPTMSTEDAKKKF-GDVKVISLPSKKEYLRYAKQP 675
+WK GE+++V PT+ E+AK+ F V LPS K+YLRY QP
Sbjct: 180 DWKKGESVMVLPTLPEEEAKQLFPKGVFTKELPSGKKYLRYTPQP 224
>sp|P52570|TSA_ONCVO Putative peroxiredoxin (Thioredoxin peroxidase) (Thiol-specific
antioxidant)
Length = 232
Score = 205 bits (522), Expect = 9e-53
Identities = 103/203 (50%), Positives = 134/203 (66%), Gaps = 5/203 (2%)
Frame = +1
Query: 82 ESWGLICTHPADFTPVCTTEFAETVKIYPEFTKRNVKIVGISCDTIDNHKAWAADIQCLA 261
+SW ++ +HP DFTPVCTTE A V++ PEF KRNVK++G+SCD+ D+H WA DI L
Sbjct: 33 DSWAILFSHPRDFTPVCTTELARLVQLAPEFKKRNVKLIGLSCDSADSHSKWADDILALY 92
Query: 262 KT----CDSDKSEKLDLPFPIIADTDRKLVTELGMIDESARTSAGIPLPARAVYFLDPKR 429
K CDS+K LP+PIIAD DR L TELGM+D R G L AR V+ + +
Sbjct: 93 KMKCVGCDSEKK----LPYPIIADEDRSLATELGMMDPDERDEKGNTLTARCVFIIGSDK 148
Query: 430 IVRASILYPASCGRNFDEIIRVIDSLQKNTETGLVTPVNWKVGENLIVPPTMSTEDAKKK 609
++ SILYPA+ GRNFDEI+RV+DSLQ + TPV+WK G++ +V PT+ +AKK
Sbjct: 149 TLKLSILYPATTGRNFDEILRVVDSLQLTAVKLVATPVDWKDGDDCVVLPTIDDNEAKKL 208
Query: 610 FGD-VKVISLPSKKEYLRYAKQP 675
FG+ + I LPS K YLR P
Sbjct: 209 FGEKIHTIDLPSGKHYLRMVPHP 231
>sp|O17433|1CPX_DIRIM 1-Cys peroxiredoxin (Thioredoxin peroxidase) (1-CysPxn)
Length = 235
Score = 204 bits (520), Expect = 2e-52
Identities = 106/234 (45%), Positives = 147/234 (62%), Gaps = 12/234 (5%)
Frame = +1
Query: 10 LGATFTTYKVKSTAGDLIIPNYFG----ESWGLICTHPADFTPVCTTEFAETVKIYPEFT 177
LG F ++ ++ G IP+++ +SW ++ +HP DFTPVCTTE A V++ PEF
Sbjct: 7 LGDKFPDFRAETNEG--FIPSFYDWIGKDSWAILFSHPRDFTPVCTTELARLVQLAPEFN 64
Query: 178 KRNVKIVGISCDTIDNHKAWAADIQCLAK-------TCDSDKSEKLDLPFPIIADTDRKL 336
KRNVK++G+SCD+ ++H+ W DI + K TC S LPFPIIAD +R L
Sbjct: 65 KRNVKLIGLSCDSAESHRKWVDDIMAVCKMKCNDGDTCCSGNK----LPFPIIADENRFL 120
Query: 337 VTELGMIDESARTSAGIPLPARAVYFLDPKRIVRASILYPASCGRNFDEIIRVIDSLQKN 516
TELGM+D R G L AR V+ + P++ ++ SILYPA+ GRNFDEI+RV+DSLQ
Sbjct: 121 ATELGMMDPDERDENGNALTARCVFIIGPEKTLKLSILYPATTGRNFDEILRVVDSLQLT 180
Query: 517 TETGLVTPVNWKVGENLIVPPTMSTEDAKKKFGD-VKVISLPSKKEYLRYAKQP 675
+ TPV+WK G++ +V PT+ +AKK FG+ + I LPS K YLR P
Sbjct: 181 AVKLVATPVDWKDGDDCVVLPTIDDTEAKKLFGEKINTIELPSGKHYLRMVAHP 234
>sp|P30041|PRDX6_HUMAN Peroxiredoxin 6 (Antioxidant protein 2) (1-Cys peroxiredoxin)
(1-Cys PRX) (Acidic calcium-independent phospholipase
A2) (aiPLA2) (Non-selenium glutathione peroxidase)
(NSGPx) (24 kDa protein) (Liver 2D page spot 40) (Red
blood cells page spot 12)
Length = 224
Score = 202 bits (515), Expect = 6e-52
Identities = 103/225 (45%), Positives = 148/225 (65%), Gaps = 1/225 (0%)
Frame = +1
Query: 4 LKLGATFTTYKVKSTAGDLIIPNYFGESWGLICTHPADFTPVCTTEFAETVKIYPEFTKR 183
L LG ++ +T G + ++ G+SWG++ +HP DFTPVCTTE K+ PEF KR
Sbjct: 5 LLLGDVAPNFEANTTVGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKR 64
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKLDLPFPIIADTDRKLVTELGMIDE 363
NVK++ +S D++++H AW+ DI A C+ + +EKL PFPII D +R+L LGM+D
Sbjct: 65 NVKLIALSIDSVEDHLAWSKDIN--AYNCE-EPTEKL--PFPIIDDRNRELAILLGMLDP 119
Query: 364 SARTSAGIPLPARAVYFLDPKRIVRASILYPASCGRNFDEIIRVIDSLQKNTETGLVTPV 543
+ + G+P+ AR V+ P + ++ SILYPA+ GRNFDEI+RV+ SLQ E + TPV
Sbjct: 120 AEKDEKGMPVTARVVFVFGPDKKLKLSILYPATTGRNFDEILRVVISLQLTAEKRVATPV 179
Query: 544 NWKVGENLIVPPTMSTEDAKKKF-GDVKVISLPSKKEYLRYAKQP 675
+WK G++++V PT+ E+AKK F V LPS K+YLRY QP
Sbjct: 180 DWKDGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP 224
>sp|O77834|PRDX6_BOVIN Peroxiredoxin 6 (Antioxidant protein 2) (1-Cys peroxiredoxin)
(1-Cys PRX) (Acidic calcium-independent phospholipase
A2) (aiPLA2) (Non-selenium glutathione peroxidase)
(NSGPx) (PHGPx) (Ciliary body glutathione peroxidase)
Length = 224
Score = 202 bits (515), Expect = 6e-52
Identities = 102/225 (45%), Positives = 144/225 (64%), Gaps = 1/225 (0%)
Frame = +1
Query: 4 LKLGATFTTYKVKSTAGDLIIPNYFGESWGLICTHPADFTPVCTTEFAETVKIYPEFTKR 183
L LG ++ +T G + +Y G+SWG++ +HP DFTPVCTTE K+ PEF KR
Sbjct: 5 LLLGDEAPNFEANTTIGRIRFHDYLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKR 64
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKLDLPFPIIADTDRKLVTELGMIDE 363
NVK++ +S D++++H AW+ DI ++K LPFPII D +R L +LGM+D
Sbjct: 65 NVKMIALSIDSVEDHLAWSKDINAYNGEEPTEK-----LPFPIIDDKNRDLAIQLGMLDP 119
Query: 364 SARTSAGIPLPARAVYFLDPKRIVRASILYPASCGRNFDEIIRVIDSLQKNTETGLVTPV 543
+ + G+P+ AR V+ P + ++ SILYPA+ GRNFDEI+RVI SLQ E + TPV
Sbjct: 120 AEKDEKGMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVIISLQLTAEKRVATPV 179
Query: 544 NWKVGENLIVPPTMSTEDAKKKF-GDVKVISLPSKKEYLRYAKQP 675
+WK G++++V PT+ E+AKK F V LPS K+YLRY QP
Sbjct: 180 DWKNGDSVMVLPTIPEEEAKKLFPKGVFTKELPSGKKYLRYTPQP 224
>sp|O08709|PRDX6_MOUSE Peroxiredoxin 6 (Antioxidant protein 2) (1-Cys peroxiredoxin)
(1-Cys PRX) (Acidic calcium-independent phospholipase
A2) (aiPLA2) (Non-selenium glutathione peroxidase)
(NSGPx)
Length = 224
Score = 198 bits (504), Expect = 1e-50
Identities = 100/225 (44%), Positives = 141/225 (62%), Gaps = 1/225 (0%)
Frame = +1
Query: 4 LKLGATFTTYKVKSTAGDLIIPNYFGESWGLICTHPADFTPVCTTEFAETVKIYPEFTKR 183
L LG ++ +T G + ++ G+SWG++ +HP DFTPVCTTE K+ PEF KR
Sbjct: 5 LLLGDEAPNFEANTTIGRIRFHDFLGDSWGILFSHPRDFTPVCTTELGRAAKLAPEFAKR 64
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKLDLPFPIIADTDRKLVTELGMIDE 363
NVK++ +S D++++H AW+ DI ++K LPFPII D R L LGM+D
Sbjct: 65 NVKLIALSIDSVEDHLAWSKDINAYNGETPTEK-----LPFPIIDDKGRDLAILLGMLDP 119
Query: 364 SARTSAGIPLPARAVYFLDPKRIVRASILYPASCGRNFDEIIRVIDSLQKNTETGLVTPV 543
+ +P+ AR V+ P + ++ SILYPA+ GRNFDEI+RV+DSLQ + TPV
Sbjct: 120 VEKDDNNMPVTARVVFIFGPDKKLKLSILYPATTGRNFDEILRVVDSLQLTGTKPVATPV 179
Query: 544 NWKVGENLIVPPTMSTEDAKKKF-GDVKVISLPSKKEYLRYAKQP 675
+WK GE+++V PT+S E+AK+ F V LPS K+YLRY QP
Sbjct: 180 DWKKGESVMVVPTLSEEEAKQCFPKGVFTKELPSGKKYLRYTPQP 224
>sp|P52573|REHY_ORYSA Probable peroxiredoxin (Thioredoxin peroxidase) (RAB24 protein)
Length = 220
Score = 181 bits (458), Expect = 2e-45
Identities = 91/223 (40%), Positives = 134/223 (60%), Gaps = 1/223 (0%)
Frame = +1
Query: 4 LKLGATFTTYKVKSTAGDLIIPNYFGESWGLICTHPADFTPVCTTEFAETVKIYPEFTKR 183
L +G T ++ ST G + I ++ G+++ ++ +HP DFTPVCTTE A EF KR
Sbjct: 4 LTIGDTVPNLELDSTHGKIRIHDFVGDTYVILFSHPGDFTPVCTTELAAMAAYAKEFDKR 63
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKLDLPFPIIADTDRKLVTELGMIDE 363
VK++GISCD + +HK W DI+ + +PI+AD R+ + +L M+D
Sbjct: 64 GVKLLGISCDDVQSHKDWFKDIEAY--------KPGNRVTYPIMADPSREAIKQLNMVDP 115
Query: 364 SARTSAGIPLPARAVYFLDPKRIVRASILYPASCGRNFDEIIRVIDSLQKNTETGLVTPV 543
+ S G LP+RA++ + P + V+ S LYPA GRN DE++R +D+LQ +T L TPV
Sbjct: 116 DEKDSNGGHLPSRALHIVGPDKKVKLSFLYPACVGRNMDEVVRAVDALQTAAKTRLATPV 175
Query: 544 NWKVGENLIVPPTMSTEDAKKKFGD-VKVISLPSKKEYLRYAK 669
NWK GE ++PP +S ++AK+KF LPS K YLR+ K
Sbjct: 176 NWKPGEPFVIPPGVSDDEAKEKFPQGFDTADLPSGKGYLRFTK 218
>sp|P34227|PRX1_YEAST Mitochondrial peroxiredoxin PRX1 (Thioredoxin reductase) (1-Cys
Prx) (Mitochondrial thiol peroxidase) (mTPx)
Length = 261
Score = 175 bits (444), Expect = 1e-43
Identities = 86/224 (38%), Positives = 137/224 (61%), Gaps = 2/224 (0%)
Frame = +1
Query: 4 LKLGATFTTYKVKSTAGDLIIPNYFGESWGLICTHPADFTPVCTTEFAETVKIYPEFTKR 183
L++ + + +T G + +Y G+SWG++ +HPADFTPVCTTE + K+ PEF KR
Sbjct: 49 LRINSDAPNFDADTTVGKINFYDYLGDSWGVLFSHPADFTPVCTTEVSAFAKLKPEFDKR 108
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKLDLPFPIIADTDRKLVTELGMIDE 363
NVK++G+S + +++H+ W DI+ +AK ++ FPII DT R + M+D
Sbjct: 109 NVKLIGLSVEDVESHEKWIQDIKEIAKV--------KNVGFPIIGDTFRNVAFLYDMVDA 160
Query: 364 SA--RTSAGIPLPARAVYFLDPKRIVRASILYPASCGRNFDEIIRVIDSLQKNTETGLVT 537
+ G R+V+ +DPK+ +R YP++ GRN E++RVID+LQ + G+VT
Sbjct: 161 EGFKNINDGSLKTVRSVFVIDPKKKIRLIFTYPSTVGRNTSEVLRVIDALQLTDKEGVVT 220
Query: 538 PVNWKVGENLIVPPTMSTEDAKKKFGDVKVISLPSKKEYLRYAK 669
P+NW+ +++I+PP++S ++AK KFG I K YLR+ K
Sbjct: 221 PINWQPADDVIIPPSVSNDEAKAKFGQFNEI-----KPYLRFTK 259
>sp|P52572|REHY_HORVU Probable peroxiredoxin (Thioredoxin peroxidase) (Rehydrin homolog)
(B15C)
Length = 218
Score = 175 bits (444), Expect = 1e-43
Identities = 88/223 (39%), Positives = 130/223 (58%), Gaps = 1/223 (0%)
Frame = +1
Query: 4 LKLGATFTTYKVKSTAGDLIIPNYFGESWGLICTHPADFTPVCTTEFAETVKIYPEFTKR 183
L +G T ++ ST G + I +Y G + ++ +HP DFTPVCTTE A EF KR
Sbjct: 4 LTIGDTVPNLELDSTHGKIRIHDYVGNGYVILFSHPGDFTPVCTTELAAMANYAKEFEKR 63
Query: 184 NVKIVGISCDTIDNHKAWAADIQCLAKTCDSDKSEKLDLPFPIIADTDRKLVTELGMIDE 363
VK++GISCD + +HK W DI+ + +PI+AD DR + +L M+D
Sbjct: 64 GVKLLGISCDDVQSHKEWTKDIEAY--------KPGSKVTYPIMADPDRSAIKQLNMVDP 115
Query: 364 SARTSAGIPLPARAVYFLDPKRIVRASILYPASCGRNFDEIIRVIDSLQKNTETGLVTPV 543
+ + G LP+R ++ + P ++V+ S LYP+ GRN DE++R +DSL + + TP
Sbjct: 116 DEKDAQG-QLPSRTLHIVGPDKVVKLSFLYPSCTGRNMDEVVRAVDSLLTAAKHKVATPA 174
Query: 544 NWKVGENLIVPPTMSTEDAKKKFGD-VKVISLPSKKEYLRYAK 669
NWK GE +++ P +S E+AKK F + LPSKK YLR+ K
Sbjct: 175 NWKPGECVVIAPGVSDEEAKKMFPQGFETADLPSKKGYLRFTK 217
>sp|P52571|REHY_BROSE Probable peroxiredoxin (Thioredoxin peroxidase) (Rehydrin homolog)
(Dormancy-associated protein PBS128)
Length = 202
Score = 165 bits (417), Expect = 1e-40
Identities = 84/210 (40%), Positives = 122/210 (58%), Gaps = 1/210 (0%)
Frame = +1
Query: 43 STAGDLIIPNYFGESWGLICTHPADFTPVCTTEFAETVKIYPEFTKRNVKIVGISCDTID 222
ST G + I +Y + ++ +HP DFTPVCTTE A EF KR VK++GISCD +
Sbjct: 1 STHGKIRIHDYVANGYVILFSHPGDFTPVCTTELAAMANYAKEFEKRGVKLLGISCDDVQ 60
Query: 223 NHKAWAADIQCLAKTCDSDKSEKLDLPFPIIADTDRKLVTELGMIDESARTSAGIPLPAR 402
+HK W DI+ + +PI+AD DR + +L M+D + + G LP+R
Sbjct: 61 SHKEWTKDIEAY--------KPGSKVTYPIMADPDRSAIKQLNMVDPDEKDAEG-QLPSR 111
Query: 403 AVYFLDPKRIVRASILYPASCGRNFDEIIRVIDSLQKNTETGLVTPVNWKVGENLIVPPT 582
++ + P + V+ S LYP+ GRN DE++R +DSL + + TP NWK GE +++ P
Sbjct: 112 TLHIVGPDKKVKLSFLYPSCTGRNMDEVVRAVDSLLTAAKHKVATPANWKPGECVVIAPG 171
Query: 583 MSTEDAKKKFGD-VKVISLPSKKEYLRYAK 669
+S E+AKK F + LPSKK YLR+ K
Sbjct: 172 VSDEEAKKLFPQGFETKDLPSKKGYLRFTK 201
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 83,949,817
Number of Sequences: 369166
Number of extensions: 1705886
Number of successful extensions: 4860
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4592
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4723
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 6970118400
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)