Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_012_A21
(682 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 232 8e-61
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 229 5e-60
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 226 4e-59
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 225 7e-59
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 220 2e-57
sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor 215 1e-55
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 212 8e-55
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 211 2e-54
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 208 9e-54
sp|P61277|CATK_MACMU Cathepsin K precursor >gi|47117667|sp|... 207 2e-53
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 232 bits (591), Expect = 8e-61
Identities = 120/216 (55%), Positives = 144/216 (66%), Gaps = 1/216 (0%)
Frame = +1
Query: 37 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 216
RR +WE+N+K I+ HN EY GKH++++ +N F DMT+EEF+ G KP +G +
Sbjct: 48 RRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPR-KGKVF 106
Query: 217 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQ 396
P P SVDWR+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK RLIS SEQ
Sbjct: 107 QEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQN 165
Query: 397 LVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTRCTGF 573
LVDCS LMD AF+Y++D G++SE YPY AT+ +CK NP V TGF
Sbjct: 166 LVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGF 225
Query: 574 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYK 681
DI Q E L AVATVGP+SVAIDAGH SF YK
Sbjct: 226 VDIPKQ-EKALMKAVATVGPISVAIDAGHESFLFYK 260
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 229 bits (584), Expect = 5e-60
Identities = 113/216 (52%), Positives = 144/216 (66%), Gaps = 1/216 (0%)
Frame = +1
Query: 37 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 216
RR +WE+N+K I+ HN EY GKH +++ +N F DMTNEEF+ + +G + + +G +
Sbjct: 48 RRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVF 106
Query: 217 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQ 396
P + LP SVDWR+KGYVTPVKNQ+QCGSCW+FSATG+LEGQ FRK +L+S SEQ
Sbjct: 107 REPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQN 165
Query: 397 LVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTRCTGF 573
LVDCS M AF+Y+K+ G++SE YPY A D CK P V TGF
Sbjct: 166 LVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGF 225
Query: 574 TDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYK 681
T + E L AVATVGP+SVA+DAGH+SFQ YK
Sbjct: 226 TVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYK 261
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 226 bits (576), Expect = 4e-59
Identities = 117/217 (53%), Positives = 140/217 (64%), Gaps = 2/217 (0%)
Frame = +1
Query: 37 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 216
RR +WE+N+K I+ HN EY GKH +++ +N F DMTNEEF+ G K +G +
Sbjct: 48 RRAVWEKNMKMIELHNREYSQGKHGFTMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKMF 106
Query: 217 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQ 396
P +P SVDWR+KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ
Sbjct: 107 QEPL-FAEIPKSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQN 165
Query: 397 LVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTRCTG 570
LVDCS LMDNAFRY+KD G++SE YPY D TC P TG
Sbjct: 166 LVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDSEESYPYLGRDTETCNYKPECSAANDTG 225
Query: 571 FTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYK 681
F D+ Q E L AVAT+GP+SVAIDAGH SFQ YK
Sbjct: 226 FVDL-PQREKALMKAVATLGPISVAIDAGHQSFQFYK 261
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 225 bits (574), Expect = 7e-59
Identities = 120/217 (55%), Positives = 139/217 (64%), Gaps = 2/217 (0%)
Frame = +1
Query: 37 RRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTY 216
RR +WE+N K I HN EY GKH + + +N F DMTNEEF+ G K +G +
Sbjct: 48 RRAVWEKNKKIIDLHNQEYSEGKHAFRMAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKLF 106
Query: 217 MAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQ 396
P + V P SVDW +KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ
Sbjct: 107 HEPLLVDV-PKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQN 165
Query: 397 LVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKRNPSKIVTRCTG 570
LVDCS LMDNAF+YIKD G++SE YPY ATD +C P TG
Sbjct: 166 LVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDSEESYPYLATDTNSCNYKPECSAANDTG 225
Query: 571 FTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYK 681
F DI Q E L AVATVGP+SVAIDAGH SFQ YK
Sbjct: 226 FVDI-PQREKALMKAVATVGPISVAIDAGHTSFQFYK 261
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 220 bits (561), Expect = 2e-57
Identities = 118/228 (51%), Positives = 144/228 (63%), Gaps = 2/228 (0%)
Frame = +1
Query: 4 GRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIM 183
GR Y + RR +WE+N+K I+ HN EY GKH +S+ +N F DMTNEEF+ G
Sbjct: 37 GRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHGFSMAMNAFGDMTNEEFRQVMNGFQ 96
Query: 184 KTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRK 363
K +G + + V P SVDWR+KGYVT VKNQ QCGSCW+FSATG+LEGQ FRK
Sbjct: 97 NQKHK-KGKVFHESLVLEV-PKSVDWREKGYVTAVKNQGQCGSCWAFSATGALEGQMFRK 154
Query: 364 NNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATD-GTCKR 537
+L+S SEQ LVDCS LMDNAF+Y+KD G+++E YPY + +C
Sbjct: 155 TGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKDNGGLDTEESYPYLGRETNSCTY 214
Query: 538 NPSKIVTRCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYK 681
P TGF DI Q E L AVATVGP+SVAIDAGH+SFQ YK
Sbjct: 215 KPECSAANDTGFVDI-PQREKALMKAVATVGPISVAIDAGHSSFQFYK 261
>sp|Q24940|CATLP_FASHE Cathepsin L-like proteinase precursor
Length = 326
Score = 215 bits (547), Expect = 1e-55
Identities = 105/227 (46%), Positives = 142/227 (62%)
Frame = +1
Query: 1 FGRKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGI 180
+ ++Y+ D RR IWE+N+K+IQ+HNL +DLG TY+LGLNQF DMT EEFKAKYL
Sbjct: 28 YNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEFKAKYLTE 87
Query: 181 MKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFR 360
M + N +P +DWR+ GYVT VK+Q CGSCW+FS TG++EGQY +
Sbjct: 88 MSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTMEGQYMK 147
Query: 361 KNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQGIESEGDYPYTATDGTCKRN 540
ISFSEQQLVDCS LM+NA++Y+K G+E+E YPYTA +G C+ N
Sbjct: 148 NERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYN 207
Query: 541 PSKIVTRCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLYK 681
V + TG+ + S +E +L N V P +VA+D + F +Y+
Sbjct: 208 KQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVDV-ESDFMMYR 253
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 212 bits (539), Expect = 8e-55
Identities = 116/225 (51%), Positives = 140/225 (62%), Gaps = 1/225 (0%)
Frame = +1
Query: 7 RKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMK 186
R Y + RR IWE+N++ IQ HN EY G+H +S+ +N F DMTNEEF+ G
Sbjct: 38 RLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRH 97
Query: 187 TKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKN 366
K +G + P + + P SVDWR+KG VTPVKNQ QCGSCW+FSA+G LEGQ F K
Sbjct: 98 QKHK-KGRLFQEPLMLKI-PKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKT 155
Query: 367 NRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNP 543
+LIS SEQ LVDCS LMD AF+YIK+ G++SE YPY A DG+CK
Sbjct: 156 GKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRA 215
Query: 544 SKIVTRCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLY 678
V TGF DI Q E L AVATVGP+SVA+DA H S Q Y
Sbjct: 216 EFAVANDTGFVDI-PQQEKALMKAVATVGPISVAMDASHPSLQFY 259
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 211 bits (536), Expect = 2e-54
Identities = 114/225 (50%), Positives = 140/225 (62%), Gaps = 1/225 (0%)
Frame = +1
Query: 7 RKYDELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGIMK 186
R Y + RR +WE+N++ IQ HN EY GKH +++ +N F DMTNEEF+ G
Sbjct: 38 RLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRH 97
Query: 187 TKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKN 366
K +G + P + + P +VDWR+KG VTPVKNQ QCGSCW+FSA+G LEGQ F K
Sbjct: 98 QKHK-KGRLFQEPLMLQI-PKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKT 155
Query: 367 NRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNP 543
+LIS SEQ LVDCS LMD AF+YIK+ G++SE YPY A DG+CK
Sbjct: 156 GKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRA 215
Query: 544 SKIVTRCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLY 678
V TGF DI Q E L AVATVGP+SVA+DA H S Q Y
Sbjct: 216 EYAVANDTGFVDI-PQQEKALMKAVATVGPISVAMDASHPSLQFY 259
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 208 bits (530), Expect = 9e-54
Identities = 109/228 (47%), Positives = 147/228 (64%), Gaps = 2/228 (0%)
Frame = +1
Query: 1 FGRKY-DELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLG 177
+GR+Y D D RR+I+EQN KYI++ N +Y+ G+ T++L +N+F DMT EEF A G
Sbjct: 27 YGRQYVDAEEDSYRRVIFEQNQKYIEEFNKKYENGEVTFNLAMNKFGDMTLEEFNAVMKG 86
Query: 178 IMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYF 357
+ + + S + + G VDWR KG VTPVK+Q QCGSCW+FS TGSLEGQ+F
Sbjct: 87 NIPRR-SAPVSVFYPKKETGPQATEVDWRTKGAVTPVKDQGQCGSCWAFSTTGSLEGQHF 145
Query: 358 RKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIK-DQGIESEGDYPYTATDGTCK 534
K LIS +EQQLVDCS M++AF YIK + GI++E YPY A DG+C+
Sbjct: 146 LKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCR 205
Query: 535 RNPSKIVTRCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLY 678
+ + + C+G T+I S +ET L AV +GP+SV IDA H+SFQ Y
Sbjct: 206 FDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFY 253
>sp|P61277|CATK_MACMU Cathepsin K precursor
sp|P61276|CATK_MACFA Cathepsin K precursor
Length = 329
Score = 207 bits (527), Expect = 2e-53
Identities = 109/222 (49%), Positives = 139/222 (62%), Gaps = 2/222 (0%)
Frame = +1
Query: 19 ELTDITRRLIWEQNLKYIQKHNLEYDLGKHTYSLGLNQFADMTNEEFKAKYLGI-MKTKP 195
++ +I+RRLIWE+NLKYI HNLE LG HTY L +N DMTNEE K G+ +
Sbjct: 40 KVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTNEEVVQKMTGLKVPASH 99
Query: 196 TLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRL 375
+ T P+ G P SVD+R+KGYVTPVKNQ QCGSCW+FS+ G+LEGQ +K +L
Sbjct: 100 SRSNDTLYIPDWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKL 159
Query: 376 ISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYI-KDQGIESEGDYPYTATDGTCKRNPSKI 552
++ S Q LVDC M NAF+Y+ K++GI+SE YPY + +C NP+
Sbjct: 160 LNLSPQNLVDC--VSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGK 217
Query: 553 VTRCTGFTDIQSQNETDLANAVATVGPVSVAIDAGHASFQLY 678
+C G+ +I NE L AVA VGPVSVAIDA SFQ Y
Sbjct: 218 AAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFY 259
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.316 0.132 0.398
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,791,092
Number of Sequences: 369166
Number of extensions: 1422471
Number of successful extensions: 4127
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3690
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3795
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5782011865
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)