Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_P14
(881 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P22922|A1AT_BOMMO Antitrypsin precursor (AT) 74 4e-13
sp|P80034|ACH2_BOMMO Antichymotrypsin-2 (Antichymotrypsin I... 74 4e-13
sp|O75830|SPI2_HUMAN Serpin I2 precursor (Myoepithelium-der... 66 1e-10
sp|P48594|SCCA2_HUMAN Squamous cell carcinoma antigen 2 (SC... 66 1e-10
sp|Q80X76|SPA3F_MOUSE Serine protease inhibitor A3F (Serpin... 66 1e-10
sp|P29508|SCCA1_HUMAN Squamous cell carcinoma antigen 1 (SC... 65 2e-10
sp|P07758|A1AT1_MOUSE Alpha-1-antitrypsin 1-1 precursor (Se... 64 6e-10
sp|P22599|A1AT2_MOUSE Alpha-1-antitrypsin 1-2 precursor (Se... 64 6e-10
sp|P81105|A1AT6_MOUSE Alpha-1-antitrypsin 1-6 precursor (Se... 63 9e-10
sp|Q00898|A1AT5_MOUSE Alpha-1-antitrypsin 1-5 precursor (Se... 63 1e-09
>sp|P22922|A1AT_BOMMO Antitrypsin precursor (AT)
Length = 392
Score = 74.3 bits (181), Expect = 4e-13
Identities = 41/133 (30%), Positives = 73/133 (54%), Gaps = 1/133 (0%)
Frame = +3
Query: 321 KNIKFCKDDGAIKSVNEEVEKLTNHKVKDFLNSHN-KPKTGITLFNFIQLKAPFCNIFRP 497
+NI F K+ A KS+N+ VE+ TN+++KD +N + T L N I K + + F
Sbjct: 137 QNIDFSKNTVAAKSINDWVEENTNNRIKDLVNPDSLSSATAAVLVNAIYFKGAWSSKFDE 196
Query: 498 DSTEIGEFHVNSSKTIKIPMLKSGGMVMYNEDKEIGARVMYHSFLGCNFSILAIVPSKKF 677
T +F+V+ KTIK+PM+ G Y E + A+++ + G S++ ++P K
Sbjct: 197 RLTSDRDFYVSKDKTIKVPMMYKRGDYKYGESAVLNAQLIEIPYKGDQSSLIVVLPKDKD 256
Query: 678 GLSEMEKKLTAEK 716
G++++++ L K
Sbjct: 257 GITQLQEALKDPK 269
>sp|P80034|ACH2_BOMMO Antichymotrypsin-2 (Antichymotrypsin II) (ACHY-II)
Length = 375
Score = 74.3 bits (181), Expect = 4e-13
Identities = 41/133 (30%), Positives = 73/133 (54%), Gaps = 1/133 (0%)
Frame = +3
Query: 321 KNIKFCKDDGAIKSVNEEVEKLTNHKVKDFLNSHN-KPKTGITLFNFIQLKAPFCNIFRP 497
+NI F K+ A KS+N+ VE+ TN+++KD +N + T L N I K + + F
Sbjct: 121 QNIDFSKNTVAAKSINDWVEENTNNRIKDLVNPDSLSSATAAVLVNAIYFKGAWSSKFDE 180
Query: 498 DSTEIGEFHVNSSKTIKIPMLKSGGMVMYNEDKEIGARVMYHSFLGCNFSILAIVPSKKF 677
T +F+V+ KTIK+PM+ G Y E + A+++ + G S++ ++P K
Sbjct: 181 RLTSDRDFYVSKDKTIKVPMMYKRGDYKYGESAVLNAQLIEIPYKGDQSSLIVVLPKDKD 240
Query: 678 GLSEMEKKLTAEK 716
G++++++ L K
Sbjct: 241 GITQLQEALKDPK 253
>sp|O75830|SPI2_HUMAN Serpin I2 precursor (Myoepithelium-derived serine protease
inhibitor) (Pancpin) (Protease inhibitor 14) (TSA2004)
Length = 405
Score = 66.2 bits (160), Expect = 1e-10
Identities = 41/157 (26%), Positives = 78/157 (49%), Gaps = 3/157 (1%)
Frame = +3
Query: 312 TAFKNIKFCKDDGAIKSVNEEVEKLTNHKVKDFLNSHN-KPKTGITLFNFIQLKAPFCNI 488
+A K + F + ++ VE+ T+ K+KD + P T + L N I K +
Sbjct: 133 SAIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQK 192
Query: 489 FRPDSTEIGEFHVNSSKTIKIPMLKSGGMVMYN--EDKEIGARVMYHSFLGCNFSILAIV 662
FR + T++ F + T+KIPM+K+ Y + + +V+ S+ G FS++ I+
Sbjct: 193 FRKEDTQLINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELSYKGDEFSLIIIL 252
Query: 663 PSKKFGLSEMEKKLTAEKYSHLTGNMRSVLGSLSIPK 773
P++ + E+EK +TA++ M+ +S+P+
Sbjct: 253 PAEGMDIEEVEKLITAQQILKWLSEMQEEEVEISLPR 289
>sp|P48594|SCCA2_HUMAN Squamous cell carcinoma antigen 2 (SCCA-2) (Leupin)
Length = 390
Score = 65.9 bits (159), Expect = 1e-10
Identities = 66/271 (24%), Positives = 118/271 (43%), Gaps = 28/271 (10%)
Frame = +3
Query: 45 NKDEPVCISPLAILGNLNLVLQSTTSQNVIQQIDQVLHFN----------AXXXXXXXXX 194
+K+ + SP++I L +VL N QQI +VLHF+ A
Sbjct: 22 SKENNIFYSPISITSALGMVLLGA-KDNTAQQISKVLHFDQVTENTTEKAATYHVDRSGN 80
Query: 195 XXXMISDLITHIEN--------------GDKEFVQFHQENGACFPSGMALENLTAFKNIK 332
L+T G+K + QF QE + + T+ ++
Sbjct: 81 VHHQFQKLLTEFNKSTDAYELKIANKLFGEKTY-QFLQE----YLDAIKKFYQTSVESTD 135
Query: 333 FCK-DDGAIKSVNEEVEKLTNHKVKD-FLNSHNKPKTGITLFNFIQLKAPFCNIFRPDST 506
F + + K +N VE TN K+K+ F + T + L N I K + N F+ ++T
Sbjct: 136 FANAPEESRKKINSWVESQTNEKIKNLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKENT 195
Query: 507 EIGEFHVNSSKTIKIPMLKSGGMVMYNEDKEIGARVMYHSFLGCNFSILAIVPSKKFGLS 686
+ +F N + + M++ + +++ A+V+ + G + S++ ++P++ GL
Sbjct: 196 KEEKFWPNKNTYKSVQMMRQYNSFNFALLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQ 255
Query: 687 EMEKKLTAEKYSHLTG--NMRSVLGSLSIPK 773
++E+KLTAEK T NMR L +P+
Sbjct: 256 KLEEKLTAEKLMEWTSLQNMRETCVDLHLPR 286
>sp|Q80X76|SPA3F_MOUSE Serine protease inhibitor A3F (Serpin A3F)
Length = 445
Score = 65.9 bits (159), Expect = 1e-10
Identities = 67/260 (25%), Positives = 120/260 (46%), Gaps = 10/260 (3%)
Frame = +3
Query: 24 FRLLHASNKDEPVCISPLAILGNLNLVLQSTTSQNVIQQIDQVLHFN-AXXXXXXXXXXX 200
++ L N DE V SP +I L L+ S N +++I + L FN
Sbjct: 49 YKELVLKNPDENVVFSPFSICTALTLLSLGAKS-NTLKEILEGLKFNLTETPEPDIHQGF 107
Query: 201 XMISDLITH------IENGDKEFVQFHQENGACFPS-GMALENLTAFKNIKFCKDDGAIK 359
+ DL++ I G F++ H + A F AL AF F + A K
Sbjct: 108 RYLLDLLSQPGNQVQISTGSALFIEKHLQILAEFKEKARALYQAEAF-TADFQQPLEATK 166
Query: 360 SVNEEVEKLTNHKVKDFLNSHNKPKTGITLFNFIQLKAPFCNIFRPDSTEIGEFHVNSSK 539
+N+ V T K+K+ ++ +K +T + L N+I K + F PD T EF+++ ++
Sbjct: 167 LINDYVSNQTQGKIKELISDLDK-RTLMVLVNYIYFKGKWEMPFDPDDTCKSEFYLDENR 225
Query: 540 TIKIPMLKSGGMVM-YNEDKEIGARVMYHSFLGCNFSILAIVPSKKFGLSEMEKKLTAEK 716
++K+PM+K + Y D+E+ V+ + G N S + I+P + + ++E L E
Sbjct: 226 SVKVPMMKINNLTTPYFRDEELSCTVVELKYTG-NASAMFILPDQG-KMQQVEASLQPET 283
Query: 717 YSHLTGNMR-SVLGSLSIPK 773
+ +++ ++ L +PK
Sbjct: 284 LRNWKDSLKPRLIDELCLPK 303
>sp|P29508|SCCA1_HUMAN Squamous cell carcinoma antigen 1 (SCCA-1) (Protein T4-A)
Length = 390
Score = 65.1 bits (157), Expect = 2e-10
Identities = 65/271 (23%), Positives = 116/271 (42%), Gaps = 28/271 (10%)
Frame = +3
Query: 45 NKDEPVCISPLAILGNLNLVLQSTTSQNVIQQIDQVLHFN----------AXXXXXXXXX 194
+K+ + SP++I L +VL N QQI +VLHF+ A
Sbjct: 22 SKENNIFYSPISITSALGMVLLGA-KDNTAQQIKKVLHFDQVTENTTGKAATYHVDRSGN 80
Query: 195 XXXMISDLITHIEN--------------GDKEFVQFHQENGACFPSGMALENLTAFKNIK 332
L+T G+K ++ F QE + + T+ +++
Sbjct: 81 VHHQFQKLLTEFNKSTDAYELKIANKLFGEKTYL-FLQE----YLDAIKKFYQTSVESVD 135
Query: 333 FCK-DDGAIKSVNEEVEKLTNHKVKDFLNSHN-KPKTGITLFNFIQLKAPFCNIFRPDST 506
F + + K +N VE TN K+K+ + N T + L N I K + F + T
Sbjct: 136 FANAPEESRKKINSWVESQTNEKIKNLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDT 195
Query: 507 EIGEFHVNSSKTIKIPMLKSGGMVMYNEDKEIGARVMYHSFLGCNFSILAIVPSKKFGLS 686
+ +F N + I M++ + +++ A+V+ + G + S++ ++P++ GL
Sbjct: 196 KEEKFWPNKNTYKSIQMMRQYTSFHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQ 255
Query: 687 EMEKKLTAEKYSHLTG--NMRSVLGSLSIPK 773
++E+KLTAEK T NMR L +P+
Sbjct: 256 KLEEKLTAEKLMEWTSLQNMRETRVDLHLPR 286
>sp|P07758|A1AT1_MOUSE Alpha-1-antitrypsin 1-1 precursor (Serine protease inhibitor 1-1)
(Alpha-1 protease inhibitor 1) (Alpha-1-antiproteinase)
(AAT)
Length = 413
Score = 63.9 bits (154), Expect = 6e-10
Identities = 40/150 (26%), Positives = 74/150 (49%)
Frame = +3
Query: 324 NIKFCKDDGAIKSVNEEVEKLTNHKVKDFLNSHNKPKTGITLFNFIQLKAPFCNIFRPDS 503
++ F + + A K +N+ VEK T K+ + + ++ T L N+I K + F P++
Sbjct: 162 SVNFAESEEAKKVINDFVEKGTQGKIAEAVKKLDQD-TVFALANYILFKGKWKKPFDPEN 220
Query: 504 TEIGEFHVNSSKTIKIPMLKSGGMVMYNEDKEIGARVMYHSFLGCNFSILAIVPSKKFGL 683
TE EFHV+ S T+K+PM+ GM+ + + + V+ + G ++ + K +
Sbjct: 221 TEEAEFHVDESTTVKVPMMTLSGMLHVHHCSTLSSWVLLMDYAGNATAVFLLPDDGK--M 278
Query: 684 SEMEKKLTAEKYSHLTGNMRSVLGSLSIPK 773
+E+ L+ E S N R L + P+
Sbjct: 279 QHLEQTLSKELISKFLLNRRRRLAQIHFPR 308
>sp|P22599|A1AT2_MOUSE Alpha-1-antitrypsin 1-2 precursor (Serine protease inhibitor 1-2)
(Alpha-1 protease inhibitor 2) (Alpha-1-antiproteinase)
(AAT)
Length = 413
Score = 63.9 bits (154), Expect = 6e-10
Identities = 43/150 (28%), Positives = 78/150 (52%)
Frame = +3
Query: 324 NIKFCKDDGAIKSVNEEVEKLTNHKVKDFLNSHNKPKTGITLFNFIQLKAPFCNIFRPDS 503
++ F + + A K +N+ VEK T K+ + + ++ T L N+I K + F P++
Sbjct: 162 SVNFAESEEAKKVINDFVEKGTQGKIVEAVKELDQD-TVFALANYILFKGKWKKPFDPEN 220
Query: 504 TEIGEFHVNSSKTIKIPMLKSGGMVMYNEDKEIGARVMYHSFLGCNFSILAIVPSKKFGL 683
TE EFHV+ S T+K+PM+ GM+ + + + V+ + G N S + ++P + +
Sbjct: 221 TEEAEFHVDKSTTVKVPMMMLSGMLDVHHCSILSSWVLLMDYAG-NASAVFLLP-EDGKM 278
Query: 684 SEMEKKLTAEKYSHLTGNMRSVLGSLSIPK 773
+E+ L E S + N R L + IP+
Sbjct: 279 QHLEQTLNKELISKILLNRRRRLVQIHIPR 308
>sp|P81105|A1AT6_MOUSE Alpha-1-antitrypsin 1-6 precursor (Serine protease inhibitor 1-6)
(Alpha-1 protease inhibitor 6)
Length = 412
Score = 63.2 bits (152), Expect = 9e-10
Identities = 40/150 (26%), Positives = 74/150 (49%)
Frame = +3
Query: 324 NIKFCKDDGAIKSVNEEVEKLTNHKVKDFLNSHNKPKTGITLFNFIQLKAPFCNIFRPDS 503
++ F + + A K +N+ VEK T K+ + + ++ T L N+I K + F P++
Sbjct: 162 SVNFAESEEAKKVINDFVEKGTQGKIVEAVKKLDQD-TVFALANYILFKGKWKKPFDPEN 220
Query: 504 TEIGEFHVNSSKTIKIPMLKSGGMVMYNEDKEIGARVMYHSFLGCNFSILAIVPSKKFGL 683
TE EFHV+ S T+K+PM+ GM+ + + + V+ + G ++ + K +
Sbjct: 221 TEEAEFHVDESTTVKVPMMTLSGMLDVHHCSTLSSWVLLMDYAGNATAVFLLPDDGK--M 278
Query: 684 SEMEKKLTAEKYSHLTGNMRSVLGSLSIPK 773
+E+ L+ E S N R L + P+
Sbjct: 279 QHLEQTLSKELISKFLLNRRRRLAQIHFPR 308
>sp|Q00898|A1AT5_MOUSE Alpha-1-antitrypsin 1-5 precursor (Serine protease inhibitor 1-5)
(Alpha-1 protease inhibitor 5)
Length = 413
Score = 62.8 bits (151), Expect = 1e-09
Identities = 47/186 (25%), Positives = 83/186 (44%)
Frame = +3
Query: 324 NIKFCKDDGAIKSVNEEVEKLTNHKVKDFLNSHNKPKTGITLFNFIQLKAPFCNIFRPDS 503
++ F + + A K +N+ VEK T K+ + + + T L N+I K + F P++
Sbjct: 162 SVNFAESEEAKKVINDFVEKGTQGKIVEAVKKLEQD-TVFVLANYILFKGKWKKPFDPEN 220
Query: 504 TEIGEFHVNSSKTIKIPMLKSGGMVMYNEDKEIGARVMYHSFLGCNFSILAIVPSKKFGL 683
T+ EFHV+ S T+K+PM+ GM+ + + + V+ + G ++ + K +
Sbjct: 221 TKQAEFHVDESTTVKVPMMTLSGMLDVHHCSTLSSWVLLMDYAGNATAVFLLPDDGK--M 278
Query: 684 SEMEKKLTAEKYSHLTGNMRSVLGSLSIPKXXXXXXXXXXXXXXXXXXXXXFDASAAHLS 863
+E+ L E S N R L + IP+ F+ S A LS
Sbjct: 279 QHLEQTLNKELISKFLLNRRRRLAQIHIPRLSISGNYNLETLMSPLGITRIFN-SGADLS 337
Query: 864 KLTKSN 881
+T+ N
Sbjct: 338 GITEEN 343
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 92,729,030
Number of Sequences: 369166
Number of extensions: 1805679
Number of successful extensions: 5241
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5076
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5222
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8790245790
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)