Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_N21
(891 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-... 275 1e-73
sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-... 273 5e-73
sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I)... 269 9e-72
sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-... 265 1e-70
sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-... 262 1e-69
sp|Q26563|CATC_SCHMA Cathepsin C precursor 228 2e-59
sp|Q90686|CATK_CHICK Cathepsin K precursor (JTAP-1) 70 8e-12
sp|Q91BH1|CATV_NPVST Viral cathepsin (V-cath) (Cysteine pro... 68 4e-11
sp|P55097|CATK_MOUSE Cathepsin K precursor 66 1e-10
sp|O35186|CATK_RAT Cathepsin K precursor 66 1e-10
>sp|P97821|CATC_MOUSE Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 275 bits (703), Expect = 1e-73
Identities = 144/298 (48%), Positives = 186/298 (62%), Gaps = 12/298 (4%)
Frame = +3
Query: 30 SDTPANCTYQDVIGKWQVFTG----NFNVSCSTSKLVATKTLTLIYP-NWAVDEFGNYGK 194
SDTPANCTY D++G W G +++CS + K + + + A DE GN G
Sbjct: 24 SDTPANCTYPDLLGTWVFQVGPRSSRSDINCSVMEATEEKVVVHLKKLDTAYDELGNSGH 83
Query: 195 WTLIYNQGFEVTITNKKYFGFFDYKKINSTYTISYCDRLQPNWFHDVLIRQWQCFKAQRI 374
+TLIYNQGFE+ + + K+F FF Y+ T ISYC W HDVL R W CF +++
Sbjct: 84 FTLIYNQGFEIVLNDYKWFAFFKYEVRGHT-AISYCHETMTGWVHDVLGRNWACFVGKKV 142
Query: 375 TTLKEKNNVLPHSNIFALTSLR-------YGSQKRIVDKINLENNGWTAKDYPEFHEKTL 533
+ EK N+ N L L+ Y V IN WTA Y E+ + +L
Sbjct: 143 ESHIEKVNM----NAAHLGGLQERYSERLYTHNHNFVKAINTVQKSWTATAYKEYEKMSL 198
Query: 534 YEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNYVSPVRNQGGCGSC 713
++I +G S+ ++ RPKPAP+T I + +P+S+DWRNV GVNYVSPVRNQ CGSC
Sbjct: 199 RDLIRRSGHSQ-RIPRPKPAPMTDEIQQQILNLPESWDWRNVQGVNYVSPVRNQESCGSC 257
Query: 714 YSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGM 887
YSFAS GMLEAR RI +NN+ PILSPQ+VV CSPY+QGCDGGFPYLIAGK+A+DFG+
Sbjct: 258 YSFASMGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYLIAGKYAQDFGV 315
>sp|P53634|CATC_HUMAN Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 273 bits (698), Expect = 5e-73
Identities = 140/299 (46%), Positives = 183/299 (61%), Gaps = 14/299 (4%)
Frame = +3
Query: 33 DTPANCTYQDVIGKWQVFTGNF----NVSCSTSKLVATKTLTLIYP-NWAVDEFGNYGKW 197
DTPANCTY D++G W G+ +V+CS K + + + A D+ GN G +
Sbjct: 25 DTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKVVVYLQKLDTAYDDLGNSGHF 84
Query: 198 TLIYNQGFEVTITNKKYFGFFDYKKINSTYTISYCDRLQPNWFHDVLIRQWQCFKAQRIT 377
T+IYNQGFE+ + + K+F FF YK+ S T +YC+ W HDVL R W CF +++
Sbjct: 85 TIIYNQGFEIVLNDYKWFAFFKYKEEGSKVT-TYCNETMTGWVHDVLGRNWACFTGKKVG 143
Query: 378 TLKE---------KNNVLPHSNIFALTSLRYGSQKRIVDKINLENNGWTAKDYPEFHEKT 530
T E KN+ +SN Y V IN WTA Y E+ T
Sbjct: 144 TASENVYVNTAHLKNSQEKYSNRL------YKYDHNFVKAINAIQKSWTATTYMEYETLT 197
Query: 531 LYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNYVSPVRNQGGCGS 710
L ++I +GG K+ RPKPAP+T I + +P S+DWRNV+G+N+VSPVRNQ CGS
Sbjct: 198 LGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGS 257
Query: 711 CYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGM 887
CYSFAS GMLEAR RI +NN+ PILSPQ+VV CS Y+QGC+GGFPYLIAGK+A+DFG+
Sbjct: 258 CYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKYAQDFGL 316
>sp|P80067|CATC_RAT Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 462
Score = 269 bits (687), Expect = 9e-72
Identities = 144/311 (46%), Positives = 188/311 (60%), Gaps = 16/311 (5%)
Frame = +3
Query: 3 AFCLVQLSV----SDTPANCTYQDVIGKWQVFTG----NFNVSCSTSKLVATKTLTLIYP 158
A LV L V SDTPANCTY D++G W G +++CS + K + +
Sbjct: 11 ALLLVLLGVCTVSSDTPANCTYPDLLGTWVFQVGPRHPRSHINCSVMEPTEEKVVIHLKK 70
Query: 159 -NWAVDEFGNYGKWTLIYNQGFEVTITNKKYFGFFDYKKINSTYTISYCDRLQPNWFHDV 335
+ A DE GN G +TLIYNQGFE+ + + K+F FF Y+ + + ISYC W HD
Sbjct: 71 LDTAYDEVGNSGYFTLIYNQGFEIVLNDYKWFAFFKYE-VKGSRAISYCHETMTGWVHDY 129
Query: 336 LIRQWQCFKAQRITTLKEKNNVLPHSNIFALTSLR-------YGSQKRIVDKINLENNGW 494
L R W CF +++ EK V N+ L L+ Y V IN W
Sbjct: 130 LGRNWACFVGKKMANHSEKVYV----NVAHLGGLQEKYSERLYSHHHNFVKAINSVQKSW 185
Query: 495 TAKDYPEFHEKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNY 674
TA Y + + ++ ++I +G S ++ RPKPAPIT I + +P+S+DWRNV G+N+
Sbjct: 186 TATTYRRYEKLSIRDLIRRSGHS-GRILRPKPAPITDEIQQQILSLPESWDWRNVRGINF 244
Query: 675 VSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYL 854
VSPVRNQ CGSCYSFAS GMLEAR RI +NN+ PILSPQ+VV CSPY+QGCDGGFPYL
Sbjct: 245 VSPVRNQESCGSCYSFASIGMLEARIRILTNNSQTPILSPQEVVSCSPYAQGCDGGFPYL 304
Query: 855 IAGKFAEDFGM 887
IAGK+A+DFG+
Sbjct: 305 IAGKYAQDFGV 315
>sp|Q60HG6|CATC_MACFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain; Dipeptidyl-peptidase
I light chain]
Length = 463
Score = 265 bits (677), Expect = 1e-70
Identities = 137/299 (45%), Positives = 179/299 (59%), Gaps = 14/299 (4%)
Frame = +3
Query: 33 DTPANCTYQDVIGKWQVFTGNF----NVSCSTSKLVATKTLTLIYP-NWAVDEFGNYGKW 197
DTPANCTY D++G W G+ +V+CS K + + + A D+ GN G +
Sbjct: 25 DTPANCTYLDLLGTWVFQVGSSGSLRDVNCSVMGPPEKKVVVHLQKLDTAYDDLGNSGHF 84
Query: 198 TLIYNQGFEVTITNKKYFGFFDYKKINSTYTISYCDRLQPNWFHDVLIRQWQCFKAQRIT 377
T+IYNQGFE+ + + K+F FF YK+ TI YC+ W HDVL R W CF +++
Sbjct: 85 TIIYNQGFEIVLNDYKWFAFFKYKEEGIKVTI-YCNETMTGWVHDVLGRNWACFTGKKVG 143
Query: 378 TLKE---------KNNVLPHSNIFALTSLRYGSQKRIVDKINLENNGWTAKDYPEFHEKT 530
T E KN+ +SN Y V IN WTA Y E+ T
Sbjct: 144 TASENVYVNTAHLKNSQEKYSNRL------YKYDHNFVKAINAIQKSWTATTYMEYETLT 197
Query: 531 LYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNYVSPVRNQGGCGS 710
L ++I +GG K+ RPKP P+T I + +P S+DWRNV+G+N+VSPVRNQ CGS
Sbjct: 198 LGDMIKRSGGHSRKIPRPKPTPLTAEIQQKILHLPTSWDWRNVHGINFVSPVRNQASCGS 257
Query: 711 CYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGM 887
CYSFAS GMLEAR RI +NN+ PILS Q+VV CS Y+QGC+GGFPYL AGK+A+DFG+
Sbjct: 258 CYSFASVGMLEARIRILTNNSQTPILSSQEVVSCSQYAQGCEGGFPYLTAGKYAQDFGL 316
>sp|O97578|CATC_CANFA Dipeptidyl-peptidase I precursor (DPP-I) (DPPI) (Cathepsin C)
(Cathepsin J) (Dipeptidyl transferase) [Contains:
Dipeptidyl-peptidase I exclusion domain chain;
Dipeptidyl-peptidase I heavy chain 1;
Dipeptidyl-peptidase I heavy chain 2;
Dipeptidyl-peptidase I heavy chain 3;
Dipeptidyl-peptidase I heavy chain 4;
Dipeptidyl-peptidase I light chain]
Length = 435
Score = 262 bits (669), Expect = 1e-69
Identities = 138/297 (46%), Positives = 179/297 (60%), Gaps = 12/297 (4%)
Frame = +3
Query: 33 DTPANCTYQDVIGKWQVF----TGNFNVSCSTSKLVATKTLTLIYP-NWAVDEFGNYGKW 197
DTPANCT+ +++G W VF G+ +V+CS K + + + A D FGN G +
Sbjct: 1 DTPANCTHPELLGTW-VFQVGPAGSRSVNCSVMGPPEKKVVVHLEKLDTAYDNFGNTGHF 59
Query: 198 TLIYNQGFEVTITNKKYFGFFDYKKINSTYTISYCDRLQPNWFHDVLIRQWQCFKAQRIT 377
T+IYNQGFE+ + + K+F FF YK+ T SYC+ W HDVL R W CF ++
Sbjct: 60 TIIYNQGFEIVLNDYKWFAFFKYKEEGHKVT-SYCNETMTGWVHDVLGRNWACFTGTKMG 118
Query: 378 TLKEKNNV-------LPHSNIFALTSLRYGSQKRIVDKINLENNGWTAKDYPEFHEKTLY 536
T EK V L +N L Y V IN WTA Y E+ TL
Sbjct: 119 TTSEKAKVNTKHIERLQENNSNRLYKYNY----EFVKAINTIQKSWTATRYIEYETLTLR 174
Query: 537 EVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNYVSPVRNQGGCGSCY 716
+++ GG K+ RPKP P+T I + + +P S+DWRNV G N+VSPVRNQ CGSCY
Sbjct: 175 DMMTRVGGR--KIPRPKPTPLTAEIHEEISRLPTSWDWRNVRGTNFVSPVRNQASCGSCY 232
Query: 717 SFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGM 887
+FAS MLEAR RI +NNT PILSPQ++V CS Y+QGC+GGFPYLIAGK+A+DFG+
Sbjct: 233 AFASTAMLEARIRILTNNTQTPILSPQEIVSCSQYAQGCEGGFPYLIAGKYAQDFGL 289
>sp|Q26563|CATC_SCHMA Cathepsin C precursor
Length = 454
Score = 228 bits (580), Expect = 2e-59
Identities = 128/299 (42%), Positives = 176/299 (58%), Gaps = 8/299 (2%)
Frame = +3
Query: 15 VQLSVSDTPANCTYQDVIGKWQVFTGNFNVSCSTSKLVATKT--LTLIYPNWAVDEFGNY 188
++ + +DTPANCTY+D G+W+ G++ C KL + ++ ++L+YP+ A+DEFGN
Sbjct: 15 LRFTCADTPANCTYEDAHGRWKFHIGDYQSKCP-EKLNSKQSVVISLLYPDIAIDEFGNR 73
Query: 189 GKWTLIYNQGFEVTITNKKYFGFFDYKKINSTYTISYCDRLQPNWFHDVLIRQWQCFKAQ 368
G WTLIYNQGFEVTI ++K+ F YK N + C + P W HD LI +
Sbjct: 74 GHWTLIYNQGFEVTINHRKWLVIFAYKS-NGEFN---CHKSMPMWTHDTLIDSGSVCSGK 129
Query: 369 RITTLKEKNNVLPHSNIFALTSLRYGSQKRIVDKINLENNGWTAKDYPEFHEKTLYEVIN 548
K N L S F T Y V KIN W + YPE + T+ E+ N
Sbjct: 130 IGVHDKFHINKLFGSKSFGRTL--YHINPSFVGKINAHQKSWRGEIYPELSKYTIDELRN 187
Query: 549 MAGGSRSKLERP----KPAPITKSILDSVKLIPKSFDWRNV--NGVNYVSPVRNQGGCGS 710
AGG +S + RP + P +K ++ +P FDW + + V+P+RNQG CGS
Sbjct: 188 RAGGVKSMVTRPSVLNRKTP-SKELISLTGNLPLEFDWTSPPDGSRSPVTPIRNQGICGS 246
Query: 711 CYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGFPYLIAGKFAEDFGM 887
CY+ SA LEAR R+ SN + +PILSPQ VV+CSPYS+GC+GGFP+LIAGK+ EDFG+
Sbjct: 247 CYASPSAAALEARIRLVSNFSEQPILSPQTVVDCSPYSEGCNGGFPFLIAGKYGEDFGL 305
>sp|Q90686|CATK_CHICK Cathepsin K precursor (JTAP-1)
Length = 334
Score = 70.1 bits (170), Expect = 8e-12
Identities = 40/108 (37%), Positives = 59/108 (54%)
Frame = +3
Query: 522 EKTLYEVINMAGGSRSKLERPKPAPITKSILDSVKLIPKSFDWRNVNGVNYVSPVRNQGG 701
+ T EV+ G R RP+P T + D P + DWR YV+PV++QG
Sbjct: 85 DMTSEEVVRTMTGLRVPRSRPRPNG-TLYVPDWSSRAPAAVDWRRKG---YVTPVKDQGQ 140
Query: 702 CGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVECSPYSQGCDGGF 845
CGSC++F+S G LE + + R+ + LSPQ++V C + GC GG+
Sbjct: 141 CGSCWAFSSVGALEGQLKRRTGKLLS--LSPQNLVYCVSNNNGCGGGY 186
>sp|Q91BH1|CATV_NPVST Viral cathepsin (V-cath) (Cysteine proteinase) (CP)
Length = 337
Score = 67.8 bits (164), Expect = 4e-11
Identities = 32/74 (43%), Positives = 49/74 (66%)
Frame = +3
Query: 633 PKSFDWRNVNGVNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVEC 812
P+SFDWR +N V + V+ QG CGSC++FA+ G +E++Y I ++ + LS Q +++C
Sbjct: 127 PESFDWRKLNKV---TKVKEQGVCGSCWAFAAIGNIESQYAIMHDSLID--LSEQQLLDC 181
Query: 813 SPYSQGCDGGFPYL 854
QGCDGG +L
Sbjct: 182 DRVDQGCDGGLMHL 195
>sp|P55097|CATK_MOUSE Cathepsin K precursor
Length = 329
Score = 65.9 bits (159), Expect = 1e-10
Identities = 31/72 (43%), Positives = 48/72 (66%)
Frame = +3
Query: 630 IPKSFDWRNVNGVNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVE 809
+P S D+R YV+PV+NQG CGSC++F+SAG LE + + ++ + LSPQ++V+
Sbjct: 115 VPDSIDYRKKG---YVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLL--ALSPQNLVD 169
Query: 810 CSPYSQGCDGGF 845
C + GC GG+
Sbjct: 170 CVTENYGCGGGY 181
>sp|O35186|CATK_RAT Cathepsin K precursor
Length = 329
Score = 65.9 bits (159), Expect = 1e-10
Identities = 31/72 (43%), Positives = 48/72 (66%)
Frame = +3
Query: 630 IPKSFDWRNVNGVNYVSPVRNQGGCGSCYSFASAGMLEARYRIRSNNTVRPILSPQDVVE 809
+P S D+R YV+PV+NQG CGSC++F+SAG LE + + ++ + LSPQ++V+
Sbjct: 115 VPDSIDYRKKG---YVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLL--ALSPQNLVD 169
Query: 810 CSPYSQGCDGGF 845
C + GC GG+
Sbjct: 170 CVSENYGCGGGY 181
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 108,691,049
Number of Sequences: 369166
Number of extensions: 2291111
Number of successful extensions: 5855
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5425
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5680
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8934348180
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)