Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_N18
(852 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q92122|KPYK_XENLA Pyruvate kinase, muscle isozyme (Cytos... 217 3e-56
sp|O62619|KPYK_DROME Pyruvate kinase (PK) 209 6e-54
sp|P11980|KPYM_RAT Pyruvate kinase, isozymes M1/M2 (Pyruvat... 207 2e-53
sp|P11974|KPYM_RABIT Pyruvate kinase, isozymes M1/M2 (Pyruv... 207 3e-53
sp|Q29536|KPYR_CANFA Pyruvate kinase, isozyme R 207 4e-53
sp|P14618|KPYM_HUMAN Pyruvate kinase, isozymes M1/M2 (Pyruv... 206 7e-53
sp|P11979|KPYM_FELCA Pyruvate kinase, isozyme M1 (Pyruvate ... 206 7e-53
sp|P30613|KPYR_HUMAN Pyruvate kinase, isozymes R/L (R-type/... 205 1e-52
sp|P00548|KPYK_CHICK Pyruvate kinase, muscle isozyme 204 2e-52
sp|P52480|KPYM_MOUSE Pyruvate kinase, isozyme M2 201 2e-51
>sp|Q92122|KPYK_XENLA Pyruvate kinase, muscle isozyme (Cytosolic thyroid hormone binding
protein) (CTHBP)
Length = 527
Score = 217 bits (553), Expect = 3e-56
Identities = 113/212 (53%), Positives = 147/212 (69%)
Frame = +2
Query: 5 KPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQTMHRV 184
KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++ H +
Sbjct: 318 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAI 377
Query: 185 CREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTSGRSAT 364
REAE+A+FHRQLF +L+ S DPT+ T IIV+T SGRSA
Sbjct: 378 AREAEAAIFHRQLFEELR--RVSPLTRDPTEATAVGAVEASFKCSSGAIIVLTKSGRSAH 435
Query: 365 LIASYRPQCPVITVTRQAQVARQCHLWRGLHPLVYTEYKADDWSEDMDLRINYAIDWGCN 544
L++ YRP+ P+I+VTR Q ARQ HL+RG+ P++Y E + W+ED+D R+N+A+D G
Sbjct: 436 LLSRYRPRAPIISVTRNGQTARQAHLYRGIFPVLYREAVHEAWAEDVDSRVNFAMDIGKA 495
Query: 545 RGFLKPGDPVIIVTGWIAGTGSTNTVRVFYVP 640
RGF K GD VI++TGW G+G TNT+RV VP
Sbjct: 496 RGFFKSGDVVIVLTGWRPGSGFTNTMRVVPVP 527
>sp|O62619|KPYK_DROME Pyruvate kinase (PK)
Length = 533
Score = 209 bits (533), Expect = 6e-54
Identities = 106/211 (50%), Positives = 142/211 (67%)
Frame = +2
Query: 5 KPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQTMHRV 184
KPV+ TQMLESM KPR TRAEISDVANAVLDGAD ++LS ET++G YP+E + TM +
Sbjct: 325 KPVICATQMLESMVKKPRPTRAEISDVANAVLDGADCVMLSGETAKGEYPLECVLTMAKT 384
Query: 185 CREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTSGRSAT 364
C+EAE+A++H+ LF DL + ID + I+V+TTSG+SA
Sbjct: 385 CKEAEAALWHQNLFNDLV---RGAGTIDASHAAAIAAVEAATKAKASAIVVITTSGKSAF 441
Query: 365 LIASYRPQCPVITVTRQAQVARQCHLWRGLHPLVYTEYKADDWSEDMDLRINYAIDWGCN 544
++ YRP+CP+I VTR AQ ARQ HL+RGL PL+Y E DW +D+D+R+ + + G
Sbjct: 442 QVSKYRPRCPIIAVTRFAQTARQAHLYRGLVPLIYKEPGLGDWLKDVDVRVQFGLQVGKK 501
Query: 545 RGFLKPGDPVIIVTGWIAGTGSTNTVRVFYV 637
GF+K GD V++VTGW G+G TNT+R+ V
Sbjct: 502 NGFIKTGDSVVVVTGWKQGSGFTNTIRIVTV 532
>sp|P11980|KPYM_RAT Pyruvate kinase, isozymes M1/M2 (Pyruvate kinase muscle isozyme)
Length = 531
Score = 207 bits (528), Expect = 2e-53
Identities = 110/212 (51%), Positives = 142/212 (66%)
Frame = +2
Query: 5 KPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQTMHRV 184
KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++ H +
Sbjct: 322 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLI 381
Query: 185 CREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTSGRSAT 364
REAE+A+FHR LF +L ASS DP + +IV+T SGRSA
Sbjct: 382 AREAEAAVFHRLLFEELA--RASSQSTDPLEAMAMGSVEASYKCLAAALIVLTESGRSAH 439
Query: 365 LIASYRPQCPVITVTRQAQVARQCHLWRGLHPLVYTEYKADDWSEDMDLRINYAIDWGCN 544
+A YRP+ P+I VTR Q ARQ HL+RG+ P++ + D W+ED+DLR+N A++ G
Sbjct: 440 QVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLDAWAEDVDLRVNLAMNVGKA 499
Query: 545 RGFLKPGDPVIIVTGWIAGTGSTNTVRVFYVP 640
RGF K GD VI++TGW G+G TNT+RV VP
Sbjct: 500 RGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 531
>sp|P11974|KPYM_RABIT Pyruvate kinase, isozymes M1/M2 (Pyruvate kinase muscle isozyme)
Length = 531
Score = 207 bits (527), Expect = 3e-53
Identities = 110/212 (51%), Positives = 143/212 (67%)
Frame = +2
Query: 5 KPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQTMHRV 184
KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++ H +
Sbjct: 322 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLI 381
Query: 185 CREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTSGRSAT 364
REAE+AMFHR+LF +L +SSH D + +IV+T SGRSA
Sbjct: 382 AREAEAAMFHRKLFEELA--RSSSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAH 439
Query: 365 LIASYRPQCPVITVTRQAQVARQCHLWRGLHPLVYTEYKADDWSEDMDLRINYAIDWGCN 544
+A YRP+ P+I VTR Q ARQ HL+RG+ P+V + + W+ED+DLR+N A++ G
Sbjct: 440 QVARYRPRAPIIAVTRNHQTARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKA 499
Query: 545 RGFLKPGDPVIIVTGWIAGTGSTNTVRVFYVP 640
RGF K GD VI++TGW G+G TNT+RV VP
Sbjct: 500 RGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 531
>sp|Q29536|KPYR_CANFA Pyruvate kinase, isozyme R
Length = 519
Score = 207 bits (526), Expect = 4e-53
Identities = 109/211 (51%), Positives = 144/211 (68%)
Frame = +2
Query: 5 KPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQTMHRV 184
KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G +PVE ++ HR+
Sbjct: 310 KPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGKFPVEAVKMQHRI 369
Query: 185 CREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTSGRSAT 364
REAE+A++HRQLF +L+ A+ DPT+ T IIV+T +GRSA
Sbjct: 370 AREAEAAVYHRQLFEELR--RAAPLSRDPTEVTAIATVEAAFKCCAAAIIVLTKTGRSAQ 427
Query: 365 LIASYRPQCPVITVTRQAQVARQCHLWRGLHPLVYTEYKADDWSEDMDLRINYAIDWGCN 544
L++ YRP+ VI VTR AQ ARQ HL RG+ PL+Y+E W++D+D R+ + I+ G
Sbjct: 428 LLSRYRPRAAVIAVTRSAQAARQAHLCRGVFPLLYSEPPEAIWADDVDRRVQFGIESGKL 487
Query: 545 RGFLKPGDPVIIVTGWIAGTGSTNTVRVFYV 637
RGFL+ GD VI+VTGW G+G TN +RV +
Sbjct: 488 RGFLRVGDLVIVVTGWRPGSGYTNIMRVLSI 518
>sp|P14618|KPYM_HUMAN Pyruvate kinase, isozymes M1/M2 (Pyruvate kinase muscle isozyme)
(Cytosolic thyroid hormone-binding protein) (CTHBP)
(THBP1)
Length = 531
Score = 206 bits (524), Expect = 7e-53
Identities = 108/212 (50%), Positives = 144/212 (67%)
Frame = +2
Query: 5 KPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQTMHRV 184
KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++ H +
Sbjct: 322 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLI 381
Query: 185 CREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTSGRSAT 364
REAE+A++H QLF +L+ + DPT+ T IIV+T SGRSA
Sbjct: 382 AREAEAAIYHLQLFEELR--RLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAH 439
Query: 365 LIASYRPQCPVITVTRQAQVARQCHLWRGLHPLVYTEYKADDWSEDMDLRINYAIDWGCN 544
+A YRP+ P+I VTR Q ARQ HL+RG+ P++ + + W+ED+DLR+N+A++ G
Sbjct: 440 QVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKA 499
Query: 545 RGFLKPGDPVIIVTGWIAGTGSTNTVRVFYVP 640
RGF K GD VI++TGW G+G TNT+RV VP
Sbjct: 500 RGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 531
>sp|P11979|KPYM_FELCA Pyruvate kinase, isozyme M1 (Pyruvate kinase muscle isozyme)
Length = 531
Score = 206 bits (524), Expect = 7e-53
Identities = 110/212 (51%), Positives = 142/212 (66%)
Frame = +2
Query: 5 KPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQTMHRV 184
KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++ H +
Sbjct: 322 KPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLI 381
Query: 185 CREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTSGRSAT 364
REAE+AMFHR+LF +L SSH D + +IV+T SGRSA
Sbjct: 382 AREAEAAMFHRKLFEELV--RGSSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRSAH 439
Query: 365 LIASYRPQCPVITVTRQAQVARQCHLWRGLHPLVYTEYKADDWSEDMDLRINYAIDWGCN 544
+A YRP+ P+I VTR Q ARQ HL+RG+ P+V + + W+ED+DLR+N A++ G
Sbjct: 440 QVARYRPRAPIIAVTRNHQTARQAHLYRGIFPVVCKDPVQEAWAEDVDLRVNLAMNVGKA 499
Query: 545 RGFLKPGDPVIIVTGWIAGTGSTNTVRVFYVP 640
RGF K GD VI++TGW G+G TNT+RV VP
Sbjct: 500 RGFFKHGDVVIVLTGWRPGSGFTNTMRVVPVP 531
>sp|P30613|KPYR_HUMAN Pyruvate kinase, isozymes R/L (R-type/L-type pyruvate kinase) (Red
cell/liver pyruvate kinase)
Length = 574
Score = 205 bits (522), Expect = 1e-52
Identities = 109/211 (51%), Positives = 143/211 (67%)
Frame = +2
Query: 5 KPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQTMHRV 184
KPV+ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G +PVE ++ H +
Sbjct: 365 KPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKMQHAI 424
Query: 185 CREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTSGRSAT 364
REAE+A++HRQLF +L+ A+ DPT+ T IIV+TT+GRSA
Sbjct: 425 AREAEAAVYHRQLFEELR--RAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRSAQ 482
Query: 365 LIASYRPQCPVITVTRQAQVARQCHLWRGLHPLVYTEYKADDWSEDMDLRINYAIDWGCN 544
L++ YRP+ VI VTR AQ ARQ HL RG+ PL+Y E W++D+D R+ + I+ G
Sbjct: 483 LLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESGKL 542
Query: 545 RGFLKPGDPVIIVTGWIAGTGSTNTVRVFYV 637
RGFL+ GD VI+VTGW G+G TN +RV +
Sbjct: 543 RGFLRVGDLVIVVTGWRPGSGYTNIMRVLSI 573
>sp|P00548|KPYK_CHICK Pyruvate kinase, muscle isozyme
Length = 530
Score = 204 bits (520), Expect = 2e-52
Identities = 107/212 (50%), Positives = 141/212 (66%)
Frame = +2
Query: 5 KPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQTMHRV 184
KP++ TQMLESM KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++ H +
Sbjct: 321 KPIICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHAI 380
Query: 185 CREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTSGRSAT 364
REAE+AMFHRQ F ++ H S H +P +IV+T SGRSA
Sbjct: 381 AREAEAAMFHRQQFEEILRH--SVHHREPADAMAAGAVEASFKCLAAALIVMTESGRSAH 438
Query: 365 LIASYRPQCPVITVTRQAQVARQCHLWRGLHPLVYTEYKADDWSEDMDLRINYAIDWGCN 544
L++ YRP+ P+I VTR Q ARQ HL+RG+ P++ + D W+ED+DLR+N ++ G
Sbjct: 439 LVSRYRPRAPIIAVTRNDQTARQAHLYRGVFPVLCKQPAHDAWAEDVDLRVNLGMNVGKA 498
Query: 545 RGFLKPGDPVIIVTGWIAGTGSTNTVRVFYVP 640
RGF K GD VI++TGW G+G TNT+RV VP
Sbjct: 499 RGFFKTGDLVIVLTGWRPGSGYTNTMRVVPVP 530
>sp|P52480|KPYM_MOUSE Pyruvate kinase, isozyme M2
Length = 531
Score = 201 bits (512), Expect = 2e-51
Identities = 107/212 (50%), Positives = 141/212 (66%)
Frame = +2
Query: 5 KPVMVVTQMLESMRYKPRATRAEISDVANAVLDGADGLVLSVETSRGMYPVETLQTMHRV 184
KPV+ TQMLE M KPR TRAE SDVANAVLDGAD ++LS ET++G YP+E ++ H +
Sbjct: 322 KPVICSTQMLEIMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLI 381
Query: 185 CREAESAMFHRQLFLDLKIHEASSHMIDPTKTTXXXXXXXXXXXXXXCIIVVTTSGRSAT 364
REAE+A++H QLF +L+ + DPT+ IIV+T SGRSA
Sbjct: 382 AREAEAAIYHLQLFEELR--RLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRSAH 439
Query: 365 LIASYRPQCPVITVTRQAQVARQCHLWRGLHPLVYTEYKADDWSEDMDLRINYAIDWGCN 544
+A YRP+ P+I VTR Q ARQ HL+RG+ P++ + + W+ED+DLR+N A+D G
Sbjct: 440 QVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDAVLNAWAEDVDLRVNLAMDVGKA 499
Query: 545 RGFLKPGDPVIIVTGWIAGTGSTNTVRVFYVP 640
RGF K GD VI++TGW G+G TNT+RV VP
Sbjct: 500 RGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP 531
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 98,631,178
Number of Sequences: 369166
Number of extensions: 1922841
Number of successful extensions: 5230
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4980
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5157
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8390082510
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)