Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_N17
(703 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P24156|L2CC_DROME L(2)37Cc protein 272 7e-73
sp|P67778|PHB_MOUSE Prohibitin (B-cell receptor associated ... 260 3e-69
sp|P35232|PHB_HUMAN Prohibitin 258 8e-69
sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex prote... 247 2e-65
sp|P40961|PHB_YEAST Prohibitin 224 1e-58
sp|O35129|PHB2_MOUSE Prohibitin-2 (B-cell receptor-associat... 186 7e-47
sp|Q5XIH7|PHB2_RAT Prohibitin-2 (B-cell receptor-associated... 186 7e-47
sp|P50085|PHB2_YEAST Prohibitin-2 183 3e-46
sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex prote... 174 2e-43
sp|O28852|Y1420_ARCFU Hypothetical protein AF1420 49 2e-05
>sp|P24156|L2CC_DROME L(2)37Cc protein
Length = 276
Score = 272 bits (695), Expect = 7e-73
Identities = 135/215 (62%), Positives = 170/215 (79%)
Frame = +3
Query: 6 IPWIQRPIIYDIRTRPRNIPVNTGSKDLQKVNITLRILYKPVAEMLPKIYTNLGLDFEER 185
IPW+QRPII+DIR++PRN+PV TGSKDLQ VNITLRILY+P+ + LPKIYT LG D++ER
Sbjct: 58 IPWVQRPIIFDIRSQPRNVPVITGSKDLQNVNITLRILYRPIPDQLPKIYTILGQDYDER 117
Query: 186 VLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTTRADNFGLTLDDISLTHLTFGS 365
VLPSI EVLK VVAQFDA +LITQRE+VSQ+V++ LT RA FG LDDISLTHLTFG
Sbjct: 118 VLPSIAPEVLKAVVAQFDAGELITQREMVSQRVSQELTVRAKQFGFILDDISLTHLTFGR 177
Query: 366 EFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEGDSQAALLLAKSFNQCGEGFIE 545
EF+ ++VEKAEQ+KLA+IISAEGD++AA LLAKSF + G+G +E
Sbjct: 178 EFTLAVEMKQVAQQEAEKARFVVEKAEQQKLASIISAEGDAEAAGLLAKSFGEAGDGLVE 237
Query: 546 LQRIQTSEEIAHLLSKNRNIVYLPDKQGTLINLPA 650
L+RI+ +E+IA+ LS++R + YLP Q TL+NLP+
Sbjct: 238 LRRIEAAEDIAYQLSRSRGVAYLPSGQSTLLNLPS 272
>sp|P67778|PHB_MOUSE Prohibitin (B-cell receptor associated protein 32) (BAP 32)
sp|P67779|PHB_RAT Prohibitin
Length = 272
Score = 260 bits (664), Expect = 3e-69
Identities = 130/215 (60%), Positives = 168/215 (78%)
Frame = +3
Query: 3 LIPWIQRPIIYDIRTRPRNIPVNTGSKDLQKVNITLRILYKPVAEMLPKIYTNLGLDFEE 182
LIPW+Q+PII+D R+RPRN+PV TGSKDLQ VNITLRIL++PVA LP+IYT++G D++E
Sbjct: 57 LIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDE 116
Query: 183 RVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTTRADNFGLTLDDISLTHLTFG 362
RVLPSIT E+LK+VVA+FDA +LITQRELVS++V++ LT RA FGL LDD+SLTHLTFG
Sbjct: 117 RVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFG 176
Query: 363 SEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEGDSQAALLLAKSFNQCGEGFI 542
EF+ ++VEKAEQ+K AAIISAEGDS+AA L+A S G+G I
Sbjct: 177 KEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLI 236
Query: 543 ELQRIQTSEEIAHLLSKNRNIVYLPDKQGTLINLP 647
EL++++ +E+IA+ LS++RNI YLP Q L+ LP
Sbjct: 237 ELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLP 271
>sp|P35232|PHB_HUMAN Prohibitin
Length = 272
Score = 258 bits (660), Expect = 8e-69
Identities = 129/215 (60%), Positives = 168/215 (78%)
Frame = +3
Query: 3 LIPWIQRPIIYDIRTRPRNIPVNTGSKDLQKVNITLRILYKPVAEMLPKIYTNLGLDFEE 182
LIPW+Q+PII+D R+RPRN+PV TGSKDLQ VNITLRIL++PVA LP+I+T++G D++E
Sbjct: 57 LIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIFTSIGEDYDE 116
Query: 183 RVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTTRADNFGLTLDDISLTHLTFG 362
RVLPSIT E+LK+VVA+FDA +LITQRELVS++V++ LT RA FGL LDD+SLTHLTFG
Sbjct: 117 RVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFG 176
Query: 363 SEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEGDSQAALLLAKSFNQCGEGFI 542
EF+ ++VEKAEQ+K AAIISAEGDS+AA L+A S G+G I
Sbjct: 177 KEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLI 236
Query: 543 ELQRIQTSEEIAHLLSKNRNIVYLPDKQGTLINLP 647
EL++++ +E+IA+ LS++RNI YLP Q L+ LP
Sbjct: 237 ELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLP 271
>sp|Q9BKU4|PHB1_CAEEL Mitochondrial prohibitin complex protein 1 (Prohibitin-1)
Length = 275
Score = 247 bits (631), Expect = 2e-65
Identities = 124/214 (57%), Positives = 158/214 (73%)
Frame = +3
Query: 3 LIPWIQRPIIYDIRTRPRNIPVNTGSKDLQKVNITLRILYKPVAEMLPKIYTNLGLDFEE 182
LIPW+Q+PII+DIR+ PR + TGSKDLQ VNITLRIL++P + LP IY N+GLD+ E
Sbjct: 60 LIPWVQKPIIFDIRSTPRAVTTITGSKDLQNVNITLRILHRPSPDRLPNIYLNIGLDYAE 119
Query: 183 RVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTTRADNFGLTLDDISLTHLTFG 362
RVLPSIT EVLK VVAQFDA ++ITQRE+VSQ+ + L RA FGL LDDI++THL FG
Sbjct: 120 RVLPSITNEVLKAVVAQFDAHEMITQREVVSQRASVALRERAAQFGLLLDDIAITHLNFG 179
Query: 363 SEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEGDSQAALLLAKSFNQCGEGFI 542
EF+ YLVEKAEQ K+AA+ +AEGD+QAA LLAK+F G+G +
Sbjct: 180 REFTEAVEMKQVAQQEAEKARYLVEKAEQMKIAAVTTAEGDAQAAKLLAKAFASAGDGLV 239
Query: 543 ELQRIQTSEEIAHLLSKNRNIVYLPDKQGTLINL 644
EL++I+ +EEIA ++KN+N+ YLP Q TL+NL
Sbjct: 240 ELRKIEAAEEIAERMAKNKNVTYLPGNQQTLLNL 273
>sp|P40961|PHB_YEAST Prohibitin
Length = 287
Score = 224 bits (572), Expect = 1e-58
Identities = 103/207 (49%), Positives = 158/207 (76%)
Frame = +3
Query: 3 LIPWIQRPIIYDIRTRPRNIPVNTGSKDLQKVNITLRILYKPVAEMLPKIYTNLGLDFEE 182
L+PW+Q+ IIYD+RT+P++I NTG+KDLQ V++TLR+L++P LP IY NLGLD++E
Sbjct: 59 LVPWLQKAIIYDVRTKPKSIATNTGTKDLQMVSLTLRVLHRPEVLQLPAIYQNLGLDYDE 118
Query: 183 RVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTTRADNFGLTLDDISLTHLTFG 362
RVLPSI EVLK++VAQFDA++LITQRE++SQK+ + L+TRA+ FG+ L+D+S+TH+TFG
Sbjct: 119 RVLPSIGNEVLKSIVAQFDAAELITQREIISQKIRKELSTRANEFGIKLEDVSITHMTFG 178
Query: 363 SEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEGDSQAALLLAKSFNQCGEGFI 542
EF+ +LVEKAEQE+ A++I AEG++++A ++K+ + G+G +
Sbjct: 179 PEFTKAVEQKQIAQQDAERAKFLVEKAEQERQASVIRAEGEAESAEFISKALAKVGDGLL 238
Query: 543 ELQRIQTSEEIAHLLSKNRNIVYLPDK 623
++R++ S++IA L+ + N+VYLP +
Sbjct: 239 LIRRLEASKDIAQTLANSSNVVYLPSQ 265
>sp|O35129|PHB2_MOUSE Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor
of estrogen receptor activity)
sp|Q99623|PHB2_HUMAN Prohibitin-2 (B-cell receptor-associated protein BAP37) (Repressor
of estrogen receptor activity) (D-prohibitin)
Length = 299
Score = 186 bits (471), Expect = 7e-47
Identities = 97/203 (47%), Positives = 139/203 (68%)
Frame = +3
Query: 6 IPWIQRPIIYDIRTRPRNIPVNTGSKDLQKVNITLRILYKPVAEMLPKIYTNLGLDFEER 185
IPW Q PIIYDIR RPR I TGSKDLQ VNI+LR+L +P A+ LP +Y LGLD+EER
Sbjct: 72 IPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEER 131
Query: 186 VLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTTRADNFGLTLDDISLTHLTFGS 365
VLPSI EVLK+VVA+F+AS LITQR VS + LT RA +F L LDD+++T L+F
Sbjct: 132 VLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSR 191
Query: 366 EFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEGDSQAALLLAKSFNQCGEGFIE 545
E++ +LVEKA+QE+ I+ AEG+++AA +L ++ ++ G+I+
Sbjct: 192 EYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSK-NPGYIK 250
Query: 546 LQRIQTSEEIAHLLSKNRNIVYL 614
L++I+ ++ I+ ++ ++N +YL
Sbjct: 251 LRKIRAAQNISKTIATSQNRIYL 273
>sp|Q5XIH7|PHB2_RAT Prohibitin-2 (B-cell receptor-associated protein BAP37) (BAP-37)
Length = 299
Score = 186 bits (471), Expect = 7e-47
Identities = 97/203 (47%), Positives = 139/203 (68%)
Frame = +3
Query: 6 IPWIQRPIIYDIRTRPRNIPVNTGSKDLQKVNITLRILYKPVAEMLPKIYTNLGLDFEER 185
IPW Q PIIYDIR RPR I TGSKDLQ VNI+LR+L +P A+ LP +Y LGLD+EER
Sbjct: 72 IPWFQYPIIYDIRARPRKISSPTGSKDLQMVNISLRVLSRPNAQELPSMYQRLGLDYEER 131
Query: 186 VLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTTRADNFGLTLDDISLTHLTFGS 365
VLPSI EVLK+VVA+F+AS LITQR VS + LT RA +F L LDD+++T L+F
Sbjct: 132 VLPSIVNEVLKSVVAKFNASQLITQRAQVSLLIRRELTERAKDFSLILDDVAITELSFSR 191
Query: 366 EFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEGDSQAALLLAKSFNQCGEGFIE 545
E++ +LVEKA+QE+ I+ AEG+++AA +L ++ ++ G+I+
Sbjct: 192 EYTAAVEAKQVAQQEAQRAQFLVEKAKQEQRQKIVQAEGEAEAAKMLGEALSK-NPGYIK 250
Query: 546 LQRIQTSEEIAHLLSKNRNIVYL 614
L++I+ ++ I+ ++ ++N +YL
Sbjct: 251 LRKIRAAQNISKTIATSQNRIYL 273
>sp|P50085|PHB2_YEAST Prohibitin-2
Length = 315
Score = 183 bits (465), Expect = 3e-46
Identities = 94/213 (44%), Positives = 138/213 (64%)
Frame = +3
Query: 3 LIPWIQRPIIYDIRTRPRNIPVNTGSKDLQKVNITLRILYKPVAEMLPKIYTNLGLDFEE 182
+ PW+ PIIYD+R +PRN+ TG+KDLQ VNIT R+L +P LP IY LG D++E
Sbjct: 88 IFPWLDTPIIYDVRAKPRNVASLTGTKDLQMVNITCRVLSRPDVVQLPTIYRTLGQDYDE 147
Query: 183 RVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTTRADNFGLTLDDISLTHLTFG 362
RVLPSI EVLK VVAQF+AS LITQRE VS+ + E L RA F + LDD+S+T++TF
Sbjct: 148 RVLPSIVNEVLKAVVAQFNASQLITQREKVSRLIRENLVRRASKFNILLDDVSITYMTFS 207
Query: 363 SEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEGDSQAALLLAKSFNQCGEGFI 542
EF+ ++V+KA QEK ++ A+G++++A L+ ++ + ++
Sbjct: 208 PEFTNAVEAKQIAQQDAQRAAFVVDKARQEKQGMVVRAQGEAKSAELIGEAIKK-SRDYV 266
Query: 543 ELQRIQTSEEIAHLLSKNRNIVYLPDKQGTLIN 641
EL+R+ T+ +IA +L+ + N V L D + L+N
Sbjct: 267 ELKRLDTARDIAKILASSPNRVIL-DNEALLLN 298
>sp|P50093|PHB2_CAEEL Mitochondrial prohibitin complex protein 2 (Prohibitin-2)
Length = 286
Score = 174 bits (442), Expect = 2e-43
Identities = 98/213 (46%), Positives = 137/213 (64%)
Frame = +3
Query: 6 IPWIQRPIIYDIRTRPRNIPVNTGSKDLQKVNITLRILYKPVAEMLPKIYTNLGLDFEER 185
IPW Q PIIYDIR RP I TGSKDLQ VNI LR+L +P E L IY LG ++EER
Sbjct: 63 IPWFQYPIIYDIRARPNQIRSPTGSKDLQMVNIGLRVLSRPNPEHLVHIYRTLGQNWEER 122
Query: 186 VLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTTRADNFGLTLDDISLTHLTFGS 365
VLPSI EVLK VVA+F+AS LITQR+ VS V + L RA +F + LDD+SLT L F
Sbjct: 123 VLPSICNEVLKGVVAKFNASQLITQRQQVSMLVRKTLIERALDFNIILDDVSLTELAFSP 182
Query: 366 EFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEGDSQAALLLAKSFNQCGEGFIE 545
++S + VE+A+Q+K I+ AEG++++A LL ++ GF++
Sbjct: 183 QYSAAVEAKQVAAQEAQRATFYVERAKQQKQEKIVQAEGEAESAKLLGEAMKN-DPGFLK 241
Query: 546 LQRIQTSEEIAHLLSKNRNIVYLPDKQGTLINL 644
L++I+ +++IA ++S++ N YLP G ++N+
Sbjct: 242 LRKIRAAQKIARIVSESGNKTYLP-TGGLMLNI 273
>sp|O28852|Y1420_ARCFU Hypothetical protein AF1420
Length = 249
Score = 48.5 bits (114), Expect = 2e-05
Identities = 39/197 (19%), Positives = 94/197 (47%), Gaps = 5/197 (2%)
Frame = +3
Query: 3 LIPWIQRPIIYDIRTRPRNIPVNTGSKDLQKVNITLRI---LYKPVAEMLPKIYTNLGLD 173
+IP ++ ++ D+RT ++P + + K N+T+++ +Y V + +
Sbjct: 48 IIPILENMVVVDLRTVTYDVP---SQEVVTKDNVTVKVNAVVYYRVVDPAKAVTEVFDYQ 104
Query: 174 FEERVLPSITYEVLKTVVAQFDASDLITQRELVSQKVNEMLTTRADNFGLTLDDISLTHL 353
+ L T L++++ Q + +++++R+ ++ K+ +++ + +G+ + + + +
Sbjct: 105 YATAQLAQTT---LRSIIGQAELDEVLSERDKLNVKLQQIIDEETNPWGIKVTAVEIKDV 161
Query: 354 TFGSEFSXXXXXXXXXXXXXXXXXYLVEKAEQEKLAAIISAEGDSQAALLLAKSFNQC-- 527
E + +AE+E+ + II AEG+ QAA+ L ++ +
Sbjct: 162 ELPEEMRRIMA--------------MQAEAERERRSKIIRAEGEYQAAMKLREAADVLAQ 207
Query: 528 GEGFIELQRIQTSEEIA 578
EG I L+ +QT EI+
Sbjct: 208 SEGAILLRYLQTLNEIS 224
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 72,433,538
Number of Sequences: 369166
Number of extensions: 1314410
Number of successful extensions: 3004
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2953
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2989
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 6122130210
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)