Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_M22
(567 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9BUL8|PDC10_HUMAN Programmed cell death protein 10 (TF-... 135 5e-32
sp|Q8VE70|PDC10_MOUSE Programmed cell death protein 10 (TF-... 135 7e-32
sp|Q6NX65|PDC10_RAT Programmed cell death protein 10 135 7e-32
sp|Q8AVR4|PDC10_XENLA Programmed cell death protein 10 135 9e-32
sp|Q6DF07|PDC10_XENTR Programmed cell death protein 10 134 1e-31
sp|Q6PHH3|PDC10_BRARE Programmed cell death protein 10 134 1e-31
sp|Q5ZIV5|PDC10_CHICK Programmed cell death protein 10 134 2e-31
sp|O42649|SMC3_SCHPO Structural maintenance of chromosome 3... 35 0.13
sp|Q9Y446|PKP3_HUMAN Plakophilin-3 34 0.29
sp|Q15075|EEA1_HUMAN Early endosome antigen 1 (Endosome-ass... 33 0.49
>sp|Q9BUL8|PDC10_HUMAN Programmed cell death protein 10 (TF-1 cell apoptosis-related
protein 15) (Cerebral cavernous malformations 3 protein)
Length = 212
Score = 135 bits (341), Expect = 5e-32
Identities = 78/176 (44%), Positives = 112/176 (63%)
Frame = +3
Query: 39 VFEPVFEKLEQKSLSHTHTLKQSFAKVEQQYPGFSQNFLIGILNKLGLENEVDMSETFLR 218
V PVF +LE+ +LS TL+ +F K E++ PG +Q+ ++ IL K +E V+ +E+ LR
Sbjct: 25 VMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVE--VNFTESLLR 82
Query: 219 MASMAETGVVRNMRKQIYNLLESKAHTLKEVLSRIPDEISDRRSFLDTIKEIASAIKNLL 398
MA+ + + + L KA LK++LS+IPDEI+DR FL TIK+IASAIK LL
Sbjct: 83 MAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELL 142
Query: 399 DCVSEVITHLPTDGHKTSLEQAKRDFVKYSKRFSNTLKAFFRDNKPSEVYASANLL 566
D V+ V ++ +LE K++FVKYSK FS+TLK +F+D K V+ SAN L
Sbjct: 143 DTVNNVFKKYQYQ-NRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFVSANRL 197
>sp|Q8VE70|PDC10_MOUSE Programmed cell death protein 10 (TF-1 cell apoptosis-related
protein 15)
Length = 212
Score = 135 bits (340), Expect = 7e-32
Identities = 78/176 (44%), Positives = 112/176 (63%)
Frame = +3
Query: 39 VFEPVFEKLEQKSLSHTHTLKQSFAKVEQQYPGFSQNFLIGILNKLGLENEVDMSETFLR 218
V PVF +LE+ +LS TL+ +F K E++ PG +Q+ ++ IL K +E V+ +E+ LR
Sbjct: 25 VMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVE--VNFTESLLR 82
Query: 219 MASMAETGVVRNMRKQIYNLLESKAHTLKEVLSRIPDEISDRRSFLDTIKEIASAIKNLL 398
MA+ + + + L KA LK++LS+IPDEI+DR FL TIK+IASAIK LL
Sbjct: 83 MAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELL 142
Query: 399 DCVSEVITHLPTDGHKTSLEQAKRDFVKYSKRFSNTLKAFFRDNKPSEVYASANLL 566
D V+ V ++ +LE K++FVKYSK FS+TLK +F+D K V+ SAN L
Sbjct: 143 DTVNNVFKKYQYQ-NRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFISANRL 197
>sp|Q6NX65|PDC10_RAT Programmed cell death protein 10
Length = 210
Score = 135 bits (340), Expect = 7e-32
Identities = 78/176 (44%), Positives = 112/176 (63%)
Frame = +3
Query: 39 VFEPVFEKLEQKSLSHTHTLKQSFAKVEQQYPGFSQNFLIGILNKLGLENEVDMSETFLR 218
V PVF +LE+ +LS TL+ +F K E++ PG +Q+ ++ IL K +E V+ +E+ LR
Sbjct: 23 VMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVE--VNFTESLLR 80
Query: 219 MASMAETGVVRNMRKQIYNLLESKAHTLKEVLSRIPDEISDRRSFLDTIKEIASAIKNLL 398
MA+ + + + L KA LK++LS+IPDEI+DR FL TIK+IASAIK LL
Sbjct: 81 MAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELL 140
Query: 399 DCVSEVITHLPTDGHKTSLEQAKRDFVKYSKRFSNTLKAFFRDNKPSEVYASANLL 566
D V+ V ++ +LE K++FVKYSK FS+TLK +F+D K V+ SAN L
Sbjct: 141 DTVNNVFKKYQYQ-NRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFISANRL 195
>sp|Q8AVR4|PDC10_XENLA Programmed cell death protein 10
Length = 212
Score = 135 bits (339), Expect = 9e-32
Identities = 78/176 (44%), Positives = 111/176 (63%)
Frame = +3
Query: 39 VFEPVFEKLEQKSLSHTHTLKQSFAKVEQQYPGFSQNFLIGILNKLGLENEVDMSETFLR 218
V PVF +LE+ +LS TL+ +F K E++ PG +Q+ + IL K +E V+ +E+ LR
Sbjct: 25 VMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIITKILEKKSVE--VNFTESLLR 82
Query: 219 MASMAETGVVRNMRKQIYNLLESKAHTLKEVLSRIPDEISDRRSFLDTIKEIASAIKNLL 398
MA+ + + + L KA LK++LS+IPDEI+DR FL TIK+IASAIK LL
Sbjct: 83 MAADDVEEYMVERPEPEFQELNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELL 142
Query: 399 DCVSEVITHLPTDGHKTSLEQAKRDFVKYSKRFSNTLKAFFRDNKPSEVYASANLL 566
D V+ V ++ +LE K++FVKYSK FS+TLK +F+D K V+ SAN L
Sbjct: 143 DTVNNVFKKYQYQ-NRRALEHQKKEFVKYSKSFSDTLKTYFKDGKALNVFISANRL 197
>sp|Q6DF07|PDC10_XENTR Programmed cell death protein 10
Length = 212
Score = 134 bits (338), Expect = 1e-31
Identities = 78/176 (44%), Positives = 110/176 (62%)
Frame = +3
Query: 39 VFEPVFEKLEQKSLSHTHTLKQSFAKVEQQYPGFSQNFLIGILNKLGLENEVDMSETFLR 218
V PVF +LE +LS TL+ +F K E++ PG +Q+ + IL K +E V+ +E+ LR
Sbjct: 25 VMYPVFNELEHVNLSAAQTLRAAFIKAEKENPGLTQDIITKILEKKSVE--VNFTESLLR 82
Query: 219 MASMAETGVVRNMRKQIYNLLESKAHTLKEVLSRIPDEISDRRSFLDTIKEIASAIKNLL 398
MA+ + + + L KA LK++LS+IPDEI+DR FL TIK+IASAIK LL
Sbjct: 83 MAADDVEEYMVERPEPEFQELNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELL 142
Query: 399 DCVSEVITHLPTDGHKTSLEQAKRDFVKYSKRFSNTLKAFFRDNKPSEVYASANLL 566
D V+ V ++ +LE K++FVKYSK FS+TLK +F+D K V+ SAN L
Sbjct: 143 DTVNNVFKKYQYQ-NRRALEHQKKEFVKYSKSFSDTLKTYFKDGKALNVFISANRL 197
>sp|Q6PHH3|PDC10_BRARE Programmed cell death protein 10
Length = 205
Score = 134 bits (338), Expect = 1e-31
Identities = 76/176 (43%), Positives = 114/176 (64%)
Frame = +3
Query: 39 VFEPVFEKLEQKSLSHTHTLKQSFAKVEQQYPGFSQNFLIGILNKLGLENEVDMSETFLR 218
V PVF +LE +LS TL+ +F K E++ PG +Q+ ++ IL K +E ++ +E+ LR
Sbjct: 18 VMYPVFNELESVNLSAAQTLRAAFKKAEKENPGLTQDIIMKILEKKNVE--INFTESLLR 75
Query: 219 MASMAETGVVRNMRKQIYNLLESKAHTLKEVLSRIPDEISDRRSFLDTIKEIASAIKNLL 398
MA+ + + ++ + L +A LK++LS+IPDEI+DR FL TIK+IASAIK LL
Sbjct: 76 MAADDVEEYMIDRPEREFQDLNERARALKQILSKIPDEINDRVRFLQTIKDIASAIKELL 135
Query: 399 DCVSEVITHLPTDGHKTSLEQAKRDFVKYSKRFSNTLKAFFRDNKPSEVYASANLL 566
D V+ V ++ +LE K++FVK+SK FS+TLK +F+D K V+ASAN L
Sbjct: 136 DTVNNVFKKYQYQ-NRRALEHQKKEFVKHSKSFSDTLKTYFKDGKAINVFASANRL 190
>sp|Q5ZIV5|PDC10_CHICK Programmed cell death protein 10
Length = 212
Score = 134 bits (337), Expect = 2e-31
Identities = 77/176 (43%), Positives = 112/176 (63%)
Frame = +3
Query: 39 VFEPVFEKLEQKSLSHTHTLKQSFAKVEQQYPGFSQNFLIGILNKLGLENEVDMSETFLR 218
V PVF +LE+ +LS TL+ +F K E++ PG +Q+ ++ IL K ++ V+ +E+ LR
Sbjct: 25 VMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVD--VNFTESLLR 82
Query: 219 MASMAETGVVRNMRKQIYNLLESKAHTLKEVLSRIPDEISDRRSFLDTIKEIASAIKNLL 398
MA+ + + + L KA LK++LS+IPDEI+DR FL TIK+IASAIK LL
Sbjct: 83 MAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELL 142
Query: 399 DCVSEVITHLPTDGHKTSLEQAKRDFVKYSKRFSNTLKAFFRDNKPSEVYASANLL 566
D V+ V ++ +LE K++FVKYSK FS+TLK +F+D K V+ SAN L
Sbjct: 143 DTVNNVFKKYQYQ-NRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFISANRL 197
>sp|O42649|SMC3_SCHPO Structural maintenance of chromosome 3 (Cohesin complex Psm3 subunit)
Length = 1194
Score = 35.0 bits (79), Expect = 0.13
Identities = 30/113 (26%), Positives = 51/113 (45%), Gaps = 2/113 (1%)
Frame = +3
Query: 171 KLGLENEVDMSETFLRMASMAETGVVRNMRKQIYNL--LESKAHTLKEVLSRIPDEISDR 344
++G +N +D SE V R++ K L ++S + L+E + RI EISD+
Sbjct: 835 EIGSDNRIDESEL---------NSVKRSLLKYENKLQIIKSSSSGLEEQMQRINSEISDK 885
Query: 345 RSFLDTIKEIASAIKNLLDCVSEVITHLPTDGHKTSLEQAKRDFVKYSKRFSN 503
R+ L++++E+ EV T + D AKR + K+ N
Sbjct: 886 RNELESLEELQ----------HEVATRIEQDAKINERNAAKRSLLLARKKECN 928
>sp|Q9Y446|PKP3_HUMAN Plakophilin-3
Length = 797
Score = 33.9 bits (76), Expect = 0.29
Identities = 23/122 (18%), Positives = 55/122 (45%), Gaps = 6/122 (4%)
Frame = +3
Query: 51 VFEKLEQKSLSHTHTLKQSFAKVEQQYPGFSQNFLIGILNKLGLENE------VDMSETF 212
++ +L Q+ + HT + + ++ G + G+L++L LE E +D T
Sbjct: 610 LYNRLLQRCELNRHTTEAAAGALQNITAGDRR--WAGVLSRLALEQERILNPLLDRVRTA 667
Query: 213 LRMASMAETGVVRNMRKQIYNLLESKAHTLKEVLSRIPDEISDRRSFLDTIKEIASAIKN 392
+ TG++RN+ + N E + ++ ++P + ++ + + I + + N
Sbjct: 668 DHHQLRSLTGLIRNLSRNARNKDEMSTKVVSHLIEKLPGSVGEKSPPAEVLVNIIAVLNN 727
Query: 393 LL 398
L+
Sbjct: 728 LV 729
>sp|Q15075|EEA1_HUMAN Early endosome antigen 1 (Endosome-associated protein p162) (Zinc
finger FYVE domain-containing protein 2)
Length = 1411
Score = 33.1 bits (74), Expect = 0.49
Identities = 31/136 (22%), Positives = 59/136 (43%), Gaps = 1/136 (0%)
Frame = +3
Query: 57 EKLEQKSLSHTHTLKQSFAKVEQQYPGFSQNFLIGILNKLGLENEVDMSETFLRMASMAE 236
EK EQ+ + + LKQS + ++Q I +L K LEN++ T AE
Sbjct: 951 EKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAE 1010
Query: 237 TGVVRNMRKQIYNLLESKAHTLKEVLSRIPDEISDRRS-FLDTIKEIASAIKNLLDCVSE 413
K+ ++L++ +E ++ + R S L T +++ S + L +
Sbjct: 1011 --------KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQED 1062
Query: 414 VITHLPTDGHKTSLEQ 461
+I++ G++ L Q
Sbjct: 1063 LISNRNQIGNQNKLIQ 1078
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,557,459
Number of Sequences: 369166
Number of extensions: 1306831
Number of successful extensions: 3511
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3416
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3490
length of database: 68,354,980
effective HSP length: 104
effective length of database: 49,142,540
effective search space used: 4127973360
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)