Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_L19
(827 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 284 2e-76
sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted pr... 278 1e-74
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 277 2e-74
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 277 3e-74
sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted ... 275 1e-73
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 273 5e-73
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 272 7e-73
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 270 5e-72
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 268 1e-71
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 267 3e-71
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 284 bits (726), Expect = 2e-76
Identities = 140/252 (55%), Positives = 170/252 (67%), Gaps = 1/252 (0%)
Frame = +2
Query: 5 FADMTNEEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSC 184
F DMT EEF A P R +VF K G VDWRT+G VTPVK+Q QCGSC
Sbjct: 72 FGDMTLEEFNAVMKGNIPRRSAPVSVFYPKKETGPQATEVDWRTKGAVTPVKDQGQCGSC 131
Query: 185 WSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYIE-KFGIES 361
W+FS TGSLEGQHF KTG+L S +EQQLVD M++AF+YI+ GI++
Sbjct: 132 WAFSTTGSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDT 191
Query: 362 EDAYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQ 541
E AYPY A DG+C +D + V +C+G+ +I GSET L A +GPISV IDA++ SFQ
Sbjct: 192 EAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQ 251
Query: 542 LYKSGIYNEPDCSSTQLDHGVLVVGYGTEDGSNYWLVKNSWGTVWGIDGYIKMSKDANNQ 721
Y SG+Y EP CS + LDH VL VGYG+E G ++WLVKNSW T WG GYIKMS++ NN
Sbjct: 252 FYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNN 311
Query: 722 CGIATMASYPLV 757
CGIAT+ASYPLV
Sbjct: 312 CGIATVASYPLV 323
>sp|P07154|CATL_RAT Cathepsin L precursor (Major excreted protein) (MEP) (Cyclic
protein 2) (CP-2) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 278 bits (712), Expect = 1e-74
Identities = 147/256 (57%), Positives = 173/256 (67%), Gaps = 5/256 (1%)
Frame = +2
Query: 5 FADMTNEEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSC 184
F DMTNEEFR + K +F P M ++P TVDWR +G VTPVKNQ QCGSC
Sbjct: 80 FGDMTNEEFRQIVNGYRHQKHKKGRLFQEPL-MLQIPKTVDWREKGCVTPVKNQGQCGSC 138
Query: 185 WSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIES 361
W+FSA+G LEGQ F KTG L S SEQ LVD LMD AF+YI E G++S
Sbjct: 139 WAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDS 198
Query: 362 EDAYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQ 541
E++YPY A+DG+C Y V + TG+VDIP E +L A ATVGPISVA+DAS+ S Q
Sbjct: 199 EESYPYEAKDGSCKYRAEYAVANDTGFVDIP-QQEKALMKAVATVGPISVAMDASHPSLQ 257
Query: 542 LYKSGIYNEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKD 709
Y SGIY EP+CSS LDHGVLVVGYG E + YWLVKNSWG WG+DGYIK++KD
Sbjct: 258 FYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKD 317
Query: 710 ANNQCGIATMASYPLV 757
NN CG+AT ASYP+V
Sbjct: 318 RNNHCGLATAASYPIV 333
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 277 bits (709), Expect = 2e-74
Identities = 144/256 (56%), Positives = 169/256 (66%), Gaps = 5/256 (1%)
Frame = +2
Query: 5 FADMTNEEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSC 184
F DMTNEEFR + + VF P + LP +VDWR +GYVTPVKNQ+QCGSC
Sbjct: 80 FGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSC 138
Query: 185 WSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIES 361
W+FSATG+LEGQ FRKTG L S SEQ LVD M AF+Y+ E G++S
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDS 198
Query: 362 EDAYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQ 541
E++YPY A D C Y V + TG+ + G E +L A ATVGPISVA+DA + SFQ
Sbjct: 199 EESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQ 258
Query: 542 LYKSGIYNEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKD 709
YKSGIY EPDCSS LDHGVLVVGYG E + S YWLVKNSWG WG +GY+K++KD
Sbjct: 259 FYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKD 318
Query: 710 ANNQCGIATMASYPLV 757
NN CGIAT ASYP V
Sbjct: 319 KNNHCGIATAASYPNV 334
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 277 bits (708), Expect = 3e-74
Identities = 143/256 (55%), Positives = 171/256 (66%), Gaps = 5/256 (1%)
Frame = +2
Query: 5 FADMTNEEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSC 184
F DMTNEEFR + K +F P ++P +VDWR +GYVTPVKNQ QCGSC
Sbjct: 80 FGDMTNEEFRQVMNGFQNQKHKKGKMFQEPL-FAEIPKSVDWREKGYVTPVKNQGQCGSC 138
Query: 185 WSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIES 361
W+FSATG+LEGQ FRKTG L S SEQ LVD LMDNAF Y+ + G++S
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKDNGGLDS 198
Query: 362 EDAYPYTAED-GTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSF 538
E++YPY D TC Y + TG+VD+P E +L A AT+GPISVAIDA + SF
Sbjct: 199 EESYPYLGRDTETCNYKPECSAANDTGFVDLP-QREKALMKAVATLGPISVAIDAGHQSF 257
Query: 539 QLYKSGIYNEPDCSSTQLDHGVLVVGY---GTEDGSNYWLVKNSWGTVWGIDGYIKMSKD 709
Q YKSGIY +PDCSS LDHGVLVVGY GT+ + +W+VKNSWG WG +GY+KM+KD
Sbjct: 258 QFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGYVKMAKD 317
Query: 710 ANNQCGIATMASYPLV 757
NN CGIAT ASYP V
Sbjct: 318 QNNHCGIATAASYPTV 333
>sp|P06797|CATL_MOUSE Cathepsin L precursor (Major excreted protein) (MEP) (p39 cysteine
proteinase) [Contains: Cathepsin L heavy chain;
Cathepsin L light chain]
Length = 334
Score = 275 bits (702), Expect = 1e-73
Identities = 144/256 (56%), Positives = 175/256 (68%), Gaps = 5/256 (1%)
Frame = +2
Query: 5 FADMTNEEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSC 184
F DMTNEEFR + K +F P M K+P +VDWR +G VTPVKNQ QCGSC
Sbjct: 80 FGDMTNEEFRQVVNGYRHQKHKKGRLFQEPL-MLKIPKSVDWREKGCVTPVKNQGQCGSC 138
Query: 185 WSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIES 361
W+FSA+G LEGQ F KTG L S SEQ LVD LMD AF+YI E G++S
Sbjct: 139 WAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDS 198
Query: 362 EDAYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQ 541
E++YPY A+DG+C Y V + TG+VDIP E +L A ATVGPISVA+DAS+ S Q
Sbjct: 199 EESYPYEAKDGSCKYRAEFAVANDTGFVDIP-QQEKALMKAVATVGPISVAMDASHPSLQ 257
Query: 542 LYKSGIYNEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKD 709
Y SGIY EP+CSS LDHGVL+VGYG E + + YWLVKNSWG+ WG++GYIK++KD
Sbjct: 258 FYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKD 317
Query: 710 ANNQCGIATMASYPLV 757
+N CG+AT ASYP+V
Sbjct: 318 RDNHCGLATAASYPVV 333
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 273 bits (697), Expect = 5e-73
Identities = 142/256 (55%), Positives = 170/256 (66%), Gaps = 5/256 (1%)
Frame = +2
Query: 5 FADMTNEEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSC 184
F DMT+EEFR + + VF P + P +VDWR +GYVTPVKNQ QCGSC
Sbjct: 80 FGDMTSEEFRQVMNGFQNRKPRKGKVFQEPL-FYEAPRSVDWREKGYVTPVKNQGQCGSC 138
Query: 185 WSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIES 361
W+FSATG+LEGQ FRKTG L S SEQ LVD LMD AF+Y+ + G++S
Sbjct: 139 WAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDS 198
Query: 362 EDAYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSFQ 541
E++YPY A + +C Y+ V + TG+VDIP E +L A ATVGPISVAIDA + SF
Sbjct: 199 EESYPYEATEESCKYNPKYSVANDTGFVDIP-KQEKALMKAVATVGPISVAIDAGHESFL 257
Query: 542 LYKSGIYNEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSKD 709
YK GIY EPDCSS +DHGVLVVGYG E D + YWLVKNSWG WG+ GY+KM+KD
Sbjct: 258 FYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKD 317
Query: 710 ANNQCGIATMASYPLV 757
N CGIA+ ASYP V
Sbjct: 318 RRNHCGIASAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 272 bits (696), Expect = 7e-73
Identities = 144/257 (56%), Positives = 171/257 (66%), Gaps = 6/257 (2%)
Frame = +2
Query: 5 FADMTNEEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSC 184
F DMTNEEFR + K +F P + +P +VDW +GYVTPVKNQ QCGSC
Sbjct: 80 FGDMTNEEFRQVMNGFQNQKHKKGKLFHEPL-LVDVPKSVDWTKKGYVTPVKNQGQCGSC 138
Query: 185 WSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIES 361
W+FSATG+LEGQ FRKTG L S SEQ LVD LMDNAF+YI + G++S
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKDNGGLDS 198
Query: 362 EDAYPYTAED-GTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSF 538
E++YPY A D +C Y + TG+VDIP E +L A ATVGPISVAIDA + SF
Sbjct: 199 EESYPYLATDTNSCNYKPECSAANDTGFVDIP-QREKALMKAVATVGPISVAIDAGHTSF 257
Query: 539 QLYKSGIYNEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSK 706
Q YKSGIY +PDCS LDHGVLVVGYG E + + +W+VKNSWG WG +GY+KM+K
Sbjct: 258 QFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNGYVKMAK 317
Query: 707 DANNQCGIATMASYPLV 757
D NN CGIAT ASYP V
Sbjct: 318 DQNNHCGIATAASYPTV 334
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 270 bits (689), Expect = 5e-72
Identities = 142/257 (55%), Positives = 171/257 (66%), Gaps = 6/257 (2%)
Frame = +2
Query: 5 FADMTNEEFRAKYLSVPPSRKKISTVFMAPKNMGKLPDTVDWRTEGYVTPVKNQEQCGSC 184
F DMTNEEFR + K VF + ++P +VDWR +GYVT VKNQ QCGSC
Sbjct: 80 FGDMTNEEFRQVMNGFQNQKHKKGKVFHESLVL-EVPKSVDWREKGYVTAVKNQGQCGSC 138
Query: 185 WSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI-EKFGIES 361
W+FSATG+LEGQ FRKTG L S SEQ LVD LMDNAF+Y+ + G+++
Sbjct: 139 WAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKDNGGLDT 198
Query: 362 EDAYPYTA-EDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAIDASNYSF 538
E++YPY E +C Y + TG+VDIP E +L A ATVGPISVAIDA + SF
Sbjct: 199 EESYPYLGRETNSCTYKPECSAANDTGFVDIP-QREKALMKAVATVGPISVAIDAGHSSF 257
Query: 539 QLYKSGIYNEPDCSSTQLDHGVLVVGYGTE----DGSNYWLVKNSWGTVWGIDGYIKMSK 706
Q YKSGIY +PDCSS LDHGVLVVGYG E + S +W+VKNSWG WG +GY+KM+K
Sbjct: 258 QFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNSSKFWIVKNSWGPEWGWNGYVKMAK 317
Query: 707 DANNQCGIATMASYPLV 757
D NN CGI+T ASYP V
Sbjct: 318 DQNNHCGISTAASYPTV 334
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 268 bits (685), Expect = 1e-71
Identities = 134/261 (51%), Positives = 173/261 (66%), Gaps = 10/261 (3%)
Frame = +2
Query: 5 FADMTNEEFRAKYLSVPPSRKK--------ISTVFMAPKNMGKLPDTVDWRTEGYVTPVK 160
+ADM + EF+ + ++ + ++ P ++ +P +VDWR G VT VK
Sbjct: 80 YADMLHHEFKETMNGYNHTLRQLMRERTGLVGATYIPPAHV-TVPKSVDWREHGAVTGVK 138
Query: 161 NQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXXXXXXXXXXLMDNAFEYI 340
+Q CGSCW+FS+TG+LEGQHFRK G L S SEQ LVD LMDNAF YI
Sbjct: 139 DQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYI 198
Query: 341 -EKFGIESEDAYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSETSLATAAATVGPISVAI 517
+ GI++E +YPY D +C ++K+ + + TG+VDIP G E + A AT+GP+SVAI
Sbjct: 199 KDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVATMGPVSVAI 258
Query: 518 DASNYSFQLYKSGIYNEPDCSSTQLDHGVLVVGYGT-EDGSNYWLVKNSWGTVWGIDGYI 694
DAS+ SFQLY G+YNEP+C LDHGVLVVGYGT E G +YWLVKNSWGT WG GYI
Sbjct: 259 DASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWGTTWGEQGYI 318
Query: 695 KMSKDANNQCGIATMASYPLV 757
KM+++ NNQCGIAT +SYP V
Sbjct: 319 KMARNQNNQCGIATASSYPTV 339
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 267 bits (682), Expect = 3e-71
Identities = 135/218 (61%), Positives = 155/218 (71%), Gaps = 2/218 (0%)
Frame = +2
Query: 110 LPDTVDWRTEGYVTPVKNQEQCGSCWSFSATGSLEGQHFRKTGNLTSFSEQQLVDXXXXX 289
+P +VDW +GYVTPVKNQ QCGSCW+FSATG+LEGQ FRKTG L S SEQ LVD
Sbjct: 1 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQ 60
Query: 290 XXXXXXXXLMDNAFEYI-EKFGIESEDAYPYTAEDGTCLYDKSKVVGSCTGYVDIPGGSE 466
LMDNAF+YI E G++SE++YPY A D +C Y TG+VDIP E
Sbjct: 61 GNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDIP-QRE 119
Query: 467 TSLATAAATVGPISVAIDASNYSFQLYKSGIYNEPDCSSTQLDHGVLVVGYGTEDGSN-Y 643
+L A ATVGPISVAIDA + SFQ YKSGIY +PDCSS LDHGVLVVGYG E +N +
Sbjct: 120 KALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKF 179
Query: 644 WLVKNSWGTVWGIDGYIKMSKDANNQCGIATMASYPLV 757
W+VKNSWG WG GY+KM+KD NN CGIAT ASYP V
Sbjct: 180 WIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 94,035,408
Number of Sequences: 369166
Number of extensions: 1952174
Number of successful extensions: 6397
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5652
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5888
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8004331590
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)