Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_L04
(855 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P38657|PDIA3_BOVIN Protein disulfide-isomerase A3 precur... 290 4e-78
sp|P30101|PDIA3_HUMAN Protein disulfide-isomerase A3 precur... 286 4e-77
sp|P27773|PDIA3_MOUSE Protein disulfide-isomerase A3 precur... 280 3e-75
sp|P11598|PDIA3_RAT Protein disulfide-isomerase A3 precurso... 276 4e-74
sp|P38658|ERP60_SCHMA Probable protein disulfide-isomerase ... 226 6e-59
sp|P13667|PDIA4_HUMAN Protein disulfide-isomerase A4 precur... 197 3e-50
sp|P38659|PDIA4_RAT Protein disulfide-isomerase A4 precurso... 196 7e-50
sp|P08003|PDIA4_MOUSE Protein disulfide-isomerase A4 precur... 195 1e-49
sp|P34329|PDIA4_CAEEL Probable protein disulfide-isomerase ... 178 1e-44
sp|P55059|PDI_HUMIN Protein disulfide-isomerase precursor (... 163 5e-40
>sp|P38657|PDIA3_BOVIN Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERP60) (58 kDa microsomal protein) (P58) (ERp57)
Length = 505
Score = 290 bits (742), Expect = 4e-78
Identities = 135/227 (59%), Positives = 173/227 (76%), Gaps = 2/227 (0%)
Frame = +3
Query: 6 LLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIESP 185
LL+A Y VDYEKN KG+NYWRNR+M VAKKF+D+G+ +HFA+++ + SHELS+FG+ES
Sbjct: 260 LLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGQKLHFAVASRKTFSHELSDFGLEST 319
Query: 186 DSNKVYIVARDEKNQKFKMAEDFTME--AFEKFINDFLNEQVPVYLKSETIPEKNDEPVK 359
+ R K +KF M E+F+ + A E+F+ D+ + + YLKSE IPE ND PVK
Sbjct: 320 TGEIPVVAVRTAKGEKFVMQEEFSRDGKALERFLEDYFDGNLKRYLKSEPIPESNDGPVK 379
Query: 360 VVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN 539
VVVA+NFD +VN+ KDVLIEFYAPWCGHCK+L PKY+EL +KL + +IVIAKMDATAN
Sbjct: 380 VVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLRKDPNIVIAKMDATAN 439
Query: 540 DVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 680
DVPSPYEV GFPTIYF+P N K +PK Y GGRE+ D + Y+ E+T+
Sbjct: 440 DVPSPYEVRGFPTIYFSPANKKQNPKKYEGGRELSDFISYLKREATN 486
Score = 72.8 bits (177), Expect = 1e-12
Identities = 37/103 (35%), Positives = 63/103 (61%), Gaps = 3/103 (2%)
Frame = +3
Query: 375 NFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN-DV 545
NF++ + D +L+EF+APWCGHCK LAP+YE A +L G + +AK+D TAN +
Sbjct: 34 NFESRITDTGSSGLMLVEFFAPWCGHCKKLAPEYEAAATRLKG--IVPLAKVDCTANTNT 91
Query: 546 PSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 674
+ Y V+G+PT+ ++ +Y+G R D ++ ++ ++
Sbjct: 92 CNKYGVSGYPTLKIFRDGEESG--AYDGPRTADGIVSHLKKQA 132
>sp|P30101|PDIA3_HUMAN Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
(58 kDa glucose regulated protein)
Length = 505
Score = 286 bits (733), Expect = 4e-77
Identities = 135/227 (59%), Positives = 173/227 (76%), Gaps = 2/227 (0%)
Frame = +3
Query: 6 LLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIESP 185
LL+A Y VDYEKN KG+NYWRNR+M VAKKF+D+G ++FA+++ + SHELS+FG+ES
Sbjct: 260 LLIAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFGLEST 319
Query: 186 DSNKVYIVARDEKNQKFKMAEDFTME--AFEKFINDFLNEQVPVYLKSETIPEKNDEPVK 359
+ R K +KF M E+F+ + A E+F+ D+ + + YLKSE IPE ND PVK
Sbjct: 320 AGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQDYFDGNLKRYLKSEPIPESNDGPVK 379
Query: 360 VVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN 539
VVVA+NFD +VN+ KDVLIEFYAPWCGHCK+L PKY+EL +KLS + +IVIAKMDATAN
Sbjct: 380 VVVAENFDEIVNNENKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN 439
Query: 540 DVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 680
DVPSPYEV GFPTIYF+P N K +PK Y GGRE+ D + Y+ E+T+
Sbjct: 440 DVPSPYEVRGFPTIYFSPANKKLNPKKYEGGRELSDFISYLQREATN 486
Score = 70.9 bits (172), Expect = 4e-12
Identities = 37/103 (35%), Positives = 63/103 (61%), Gaps = 3/103 (2%)
Frame = +3
Query: 375 NFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN-DV 545
NF++ ++D +L+EF+APWCGHCK LAP+YE A +L G + +AK+D TAN +
Sbjct: 34 NFESRISDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKG--IVPLAKVDCTANTNT 91
Query: 546 PSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 674
+ Y V+G+PT+ + +Y+G R D ++ ++ ++
Sbjct: 92 CNKYGVSGYPTLKIFRDGEEAG--AYDGPRTADGIVSHLKKQA 132
>sp|P27773|PDIA3_MOUSE Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
Length = 504
Score = 280 bits (717), Expect = 3e-75
Identities = 132/227 (58%), Positives = 172/227 (75%), Gaps = 2/227 (0%)
Frame = +3
Query: 6 LLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIESP 185
LL A Y VDYEKN KG+NYWRNR+M VAKKF+D+G ++FA+++ + SHELS+F +ES
Sbjct: 259 LLTAYYDVDYEKNAKGSNYWRNRVMMVAKKFLDAGHKLNFAVASRKTFSHELSDFSLEST 318
Query: 186 DSNKVYIVARDEKNQKFKMAEDFTME--AFEKFINDFLNEQVPVYLKSETIPEKNDEPVK 359
+ R K +KF M E+F+ + A E+F+ ++ + + YLKSE IPE N+ PVK
Sbjct: 319 TGEVPVVAIRTAKGEKFVMQEEFSRDGKALEQFLQEYFDGNLKRYLKSEPIPESNEGPVK 378
Query: 360 VVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN 539
VVVA+NFD +VN+ KDVLIEFYAPWCGHCK+L PKY+EL +KLS + +IVIAKMDATAN
Sbjct: 379 VVVAENFDDIVNEEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN 438
Query: 540 DVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 680
DVPSPYEV GFPTIYF+P N K +PK Y GGRE++D + Y+ E+T+
Sbjct: 439 DVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATN 485
Score = 68.9 bits (167), Expect = 2e-11
Identities = 37/104 (35%), Positives = 63/104 (60%), Gaps = 3/104 (2%)
Frame = +3
Query: 372 KNFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN-D 542
+NF++ V+D +L+EF+APWCGHCK LAP+YE A +L + +AK+D TAN +
Sbjct: 33 ENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRL---KIVPLAKVDCTANTN 89
Query: 543 VPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 674
+ Y V+G+PT+ + +Y+G R D ++ ++ ++
Sbjct: 90 TCNKYGVSGYPTLKIF--RAGEEAGAYDGPRTADGIVSHLKKQA 131
>sp|P11598|PDIA3_RAT Protein disulfide-isomerase A3 precursor (Disulfide isomerase
ER-60) (ERp60) (58 kDa microsomal protein) (p58) (ERp57)
(HIP-70) (Q-2)
Length = 505
Score = 276 bits (707), Expect = 4e-74
Identities = 131/227 (57%), Positives = 171/227 (75%), Gaps = 2/227 (0%)
Frame = +3
Query: 6 LLVALYSVDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIESP 185
LL A Y VDYEKN KG+NYWRNR+M VAK F+D+G ++FA+++ + SHELS+FG+ES
Sbjct: 260 LLTAYYDVDYEKNTKGSNYWRNRVMMVAKTFLDAGHKLNFAVASRKTFSHELSDFGLEST 319
Query: 186 DSNKVYIVARDEKNQKFKMAEDFTME--AFEKFINDFLNEQVPVYLKSETIPEKNDEPVK 359
+ R K +KF M E+F+ + A E+F+ ++ + + YLKSE IPE N+ PVK
Sbjct: 320 TGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQEYFDGNLKRYLKSEPIPETNEGPVK 379
Query: 360 VVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATAN 539
VVVA++FD +VN KDVLIEFYAPWCGHCK+L PKY+EL +KLS + +IVIAKMDATAN
Sbjct: 380 VVVAESFDDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATAN 439
Query: 540 DVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTS 680
DVPSPYEV GFPTIYF+P N K +PK Y GGRE++D + Y+ E+T+
Sbjct: 440 DVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATN 486
Score = 72.0 bits (175), Expect = 2e-12
Identities = 43/127 (33%), Positives = 73/127 (57%), Gaps = 3/127 (2%)
Frame = +3
Query: 303 VPVYLKSETIPEKNDEPVKVVVAKNFDALVNDPTKD--VLIEFYAPWCGHCKSLAPKYEE 476
V + L S + +D V + +NF++ V+D +L+EF+APWCGHCK LAP+YE
Sbjct: 12 VALLLASALLASASD--VLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEA 69
Query: 477 LAKKLSGESDIVIAKMDATAN-DVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDML 653
A +L G + +AK+D TAN + + Y V+G+PT+ + +Y+G R D ++
Sbjct: 70 AATRLKG--IVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAG--AYDGPRTADGIV 125
Query: 654 KYIASES 674
++ ++
Sbjct: 126 SHLKKQA 132
>sp|P38658|ERP60_SCHMA Probable protein disulfide-isomerase ER-60 precursor (ERP60)
Length = 484
Score = 226 bits (576), Expect = 6e-59
Identities = 113/241 (46%), Positives = 163/241 (67%), Gaps = 1/241 (0%)
Frame = +3
Query: 9 LVALYS-VDYEKNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIESP 185
LV LY+ + P G Y RNR++K K K++ FA S + + S+E+S++GIE+
Sbjct: 248 LVVLYNNQSIDSYPSGVKYLRNRVLKTLKDNPQKFKNLVFAYSFADDFSYEISDYGIEA- 306
Query: 186 DSNKVYIVARDEKNQKFKMAEDFTMEAFEKFINDFLNEQVPVYLKSETIPEKNDEPVKVV 365
+K+ V K++K+K+ E F+++AF F+N F + + ++KSE +P + VK +
Sbjct: 307 --DKLPAVVIQSKDKKYKL-EKFSLDAFSDFLNKFEDGLLTPHVKSEPLPTDDSSAVKKL 363
Query: 366 VAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATANDV 545
VA NFD +VN+ KDV++ F+A WCGHCK+L PKYEE A K+ E ++V+A MDATANDV
Sbjct: 364 VALNFDEIVNNEEKDVMVVFHAGWCGHCKNLMPKYEEAASKVKNEPNLVLAAMDATANDV 423
Query: 546 PSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTSSLKSYDRQGRVRKSD 725
PSPY+V GFPTIYF PK K+SP SY GGR+ +D++KY+A E+T L YDR G +KS+
Sbjct: 424 PSPYQVRGFPTIYFVPKGKKSSPVSYEGGRDTNDIIKYLAREATEELIGYDRSGNPKKSE 483
Query: 726 L 728
L
Sbjct: 484 L 484
Score = 67.4 bits (163), Expect = 5e-11
Identities = 32/89 (35%), Positives = 54/89 (60%), Gaps = 2/89 (2%)
Frame = +3
Query: 414 LIEFYAPWCGHCKSLAPKYEELAKKLSGE-SDIVIAKMDATAND-VPSPYEVTGFPTIYF 587
L++FYAPWCGHCK LAP++ A+ +SG+ +D+ + K+D T + + S + V+G+PT+
Sbjct: 38 LVKFYAPWCGHCKKLAPEFTSAAQIISGKTNDVKLVKVDCTTQESICSEFGVSGYPTLKI 97
Query: 588 APKNSKNSPKSYNGGREVDDMLKYIASES 674
+ YNG R + + Y+ S +
Sbjct: 98 FRNGDLDG--EYNGPRNANGIANYMISRA 124
>sp|P13667|PDIA4_HUMAN Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
Length = 645
Score = 197 bits (501), Expect = 3e-50
Identities = 103/229 (44%), Positives = 146/229 (63%), Gaps = 4/229 (1%)
Frame = +3
Query: 3 PLLVALYSVDYEKNPKG-TNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIE 179
PL+V YSVD+ + + T +WR+++++VAK F + FAI++ ++ + E+ + G+
Sbjct: 413 PLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPE----YTFAIADEEDYAGEVKDLGL- 467
Query: 180 SPDSNKVYIVARDEKNQKFKMA-EDFTMEAFEKFINDFLNEQVPVYLKSETIPEKNDEPV 356
S V DE +KF M E+F + +F+ F ++ +KS+ +P+ N PV
Sbjct: 468 SESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPV 527
Query: 357 KVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATA 536
KVVV K FD++V DP KDVLIEFYAPWCGHCK L P Y LAKK G+ +VIAKMDATA
Sbjct: 528 KVVVGKTFDSIVMDPKKDVLIEFYAPWCGHCKQLEPVYNSLAKKYKGQKGLVIAKMDATA 587
Query: 537 NDVPSP-YEVTGFPTIYFAPKNSKNSPKSYNGG-REVDDMLKYIASEST 677
NDVPS Y+V GFPTIYFAP K +P + GG R+++ + K+I +T
Sbjct: 588 NDVPSDRYKVEGFPTIYFAPSGDKKNPVKFEGGDRDLEHLSKFIEEHAT 636
Score = 92.8 bits (229), Expect = 1e-18
Identities = 51/111 (45%), Positives = 71/111 (63%), Gaps = 2/111 (1%)
Frame = +3
Query: 348 EPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES-DIVIAKM 524
E V+ +NFD +VND +L+EFYAPWCGHCK LAP+YE+ AK+LS S I +AK+
Sbjct: 177 EVTLVLTKENFDEVVND-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKV 235
Query: 525 DATA-NDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 674
DATA D+ ++V+G+PT+ K P YNG RE ++ Y+ +S
Sbjct: 236 DATAETDLAKRFDVSGYPTLKIF---RKGRPYDYNGpreKYGIVDYMIEQS 283
Score = 76.6 bits (187), Expect = 8e-14
Identities = 47/122 (38%), Positives = 70/122 (57%), Gaps = 3/122 (2%)
Frame = +3
Query: 318 KSETIPEKNDEPVKVVVAKNFDALVNDPTKD-VLIEFYAPWCGHCKSLAPKYEELAKKLS 494
+ + + K + V V+ NFD V D KD VL+EFYAPWCGHCK AP+YE++A L
Sbjct: 52 EEDDLEVKEENGVLVLNDANFDNFVAD--KDTVLLEFYAPWCGHCKQFAPEYEKIANILK 109
Query: 495 G-ESDIVIAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIAS 668
+ I +AK+DAT A+ + S ++V+G+PTI K Y G R ++++ +
Sbjct: 110 DKDPPIPVAKIDATSASVLASRFDVSGYPTIKIL---KKGQAVDYEGSRTQEEIVAKVRE 166
Query: 669 ES 674
S
Sbjct: 167 VS 168
>sp|P38659|PDIA4_RAT Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
(Calcium-binding protein 2) (CaBP2)
Length = 643
Score = 196 bits (498), Expect = 7e-50
Identities = 102/229 (44%), Positives = 147/229 (64%), Gaps = 4/229 (1%)
Frame = +3
Query: 3 PLLVALYSVDYEKNPK-GTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIE 179
PL+V YSVD+ + + T +WRN++++VAK F + FAI++ ++ + E+ + G+
Sbjct: 411 PLVVVYYSVDFSFDYRTATQFWRNKVLEVAKDFPE----YTFAIADEEDYATEVKDLGL- 465
Query: 180 SPDSNKVYIVARDEKNQKFKMA-EDFTMEAFEKFINDFLNEQVPVYLKSETIPEKNDEPV 356
S V DE +KF M E+F +A ++F+ F ++ +KS+ +P+ N PV
Sbjct: 466 SESGEDVNAAILDESGKKFAMEPEEFDSDALQEFVMAFKKGKLKPVIKSQPVPKNNKGPV 525
Query: 357 KVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATA 536
+VVV K FDA+V DP KDVLIEFYAPWCGHCK L P Y L KK G+ D+VIAKMDATA
Sbjct: 526 RVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPVYTSLGKKYKGQKDLVIAKMDATA 585
Query: 537 NDVPSP-YEVTGFPTIYFAPKNSKNSPKSYNGG-REVDDMLKYIASEST 677
ND+ + Y+V GFPTIYFAP K +P + GG R+++ + K+I +T
Sbjct: 586 NDITNDRYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLSKFIDEHAT 634
Score = 87.0 bits (214), Expect = 6e-17
Identities = 48/111 (43%), Positives = 69/111 (62%), Gaps = 2/111 (1%)
Frame = +3
Query: 348 EPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES-DIVIAKM 524
E + +NFD +VN+ +L+EFYAPWCGHCK LAP+YE+ AK+LS S I +AK+
Sbjct: 175 EVTLTLTKENFDDVVNN-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKV 233
Query: 525 DAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 674
DAT D+ ++V+G+PT+ K P YNG RE ++ Y+ +S
Sbjct: 234 DATEQTDLAKRFDVSGYPTLKIF---RKGRPFDYNGpreKYGIVDYMVEQS 281
Score = 79.3 bits (194), Expect = 1e-14
Identities = 47/115 (40%), Positives = 69/115 (60%), Gaps = 3/115 (2%)
Frame = +3
Query: 339 KNDEPVKVVVAKNFDALVNDPTKD-VLIEFYAPWCGHCKSLAPKYEELAKKL-SGESDIV 512
K + V V+ +NFD V D KD VL+EFYAPWCGHCK AP+YE++A L + I
Sbjct: 57 KEENGVWVLNDENFDNFVAD--KDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIA 114
Query: 513 IAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 674
+AK+DAT A+ + S ++V+G+PTI K Y+G R ++++ + S
Sbjct: 115 VAKIDATSASMLASKFDVSGYPTIKIL---KKGQAVDYDGSRTQEEIVAKVREVS 166
>sp|P08003|PDIA4_MOUSE Protein disulfide-isomerase A4 precursor (Protein ERp-72) (ERp72)
Length = 638
Score = 195 bits (496), Expect = 1e-49
Identities = 102/229 (44%), Positives = 145/229 (63%), Gaps = 4/229 (1%)
Frame = +3
Query: 3 PLLVALYSVDYEKNPKG-TNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGIE 179
PL+V YSVD+ + + T +WRN++++VAK F + FAI++ ++ + E+ + G+
Sbjct: 406 PLVVVYYSVDFSFDYRAATQFWRNKVLEVAKDFPE----YTFAIADEEDYATEVKDLGL- 460
Query: 180 SPDSNKVYIVARDEKNQKFKMA-EDFTMEAFEKFINDFLNEQVPVYLKSETIPEKNDEPV 356
S V DE +KF M E+F + +F+ F ++ +KS+ +P+ N PV
Sbjct: 461 SESGEDVNAAILDESGKKFAMEPEEFDSDTLREFVTAFKKGKLKPVIKSQPVPKNNKGPV 520
Query: 357 KVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDATA 536
KVVV K FDA+V DP KDVLIEFYAPWCGHCK L P Y L KK G+ D+VIAKMDATA
Sbjct: 521 KVVVGKTFDAIVMDPKKDVLIEFYAPWCGHCKQLEPIYTSLGKKYKGQKDLVIAKMDATA 580
Query: 537 NDVPS-PYEVTGFPTIYFAPKNSKNSPKSYNGG-REVDDMLKYIASEST 677
ND+ + Y+V GFPTIYFAP K +P + GG R+++ + K+I +T
Sbjct: 581 NDITNDQYKVEGFPTIYFAPSGDKKNPIKFEGGNRDLEHLSKFIDEHAT 629
Score = 85.9 bits (211), Expect = 1e-16
Identities = 47/102 (46%), Positives = 66/102 (64%), Gaps = 2/102 (1%)
Frame = +3
Query: 375 NFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGES-DIVIAKMDAT-ANDVP 548
NFD +VN+ +L+EFYAPWCGHCK LAP+YE+ AK+LS S I +AK+DAT D+
Sbjct: 179 NFDDVVNN-ADIILVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATEQTDLA 237
Query: 549 SPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 674
++V+G+PT+ K P YNG RE ++ Y+ +S
Sbjct: 238 KRFDVSGYPTLKIF---RKGRPFDYNGpreKYGIVDYMIEQS 276
Score = 78.2 bits (191), Expect = 3e-14
Identities = 47/115 (40%), Positives = 68/115 (59%), Gaps = 3/115 (2%)
Frame = +3
Query: 339 KNDEPVKVVVAKNFDALVNDPTKD-VLIEFYAPWCGHCKSLAPKYEELAKKL-SGESDIV 512
K + V V+ NFD V D KD VL+EFYAPWCGHCK AP+YE++A L + I
Sbjct: 52 KEENGVWVLNDGNFDNFVAD--KDTVLLEFYAPWCGHCKQFAPEYEKIASTLKDNDPPIA 109
Query: 513 IAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASES 674
+AK+DAT A+ + S ++V+G+PTI K Y+G R ++++ + S
Sbjct: 110 VAKIDATSASMLASKFDVSGYPTIKIL---KKGQAVDYDGSRTQEEIVAKVREVS 161
>sp|P34329|PDIA4_CAEEL Probable protein disulfide-isomerase A4 precursor (ERp-72 homolog)
Length = 618
Score = 178 bits (452), Expect = 1e-44
Identities = 96/240 (40%), Positives = 143/240 (59%), Gaps = 8/240 (3%)
Frame = +3
Query: 3 PLLVALYSVDYE-KNPKGTNYWRNRIMKVAKKFVDSGKSVHFAISNSQEQSHELSEFGI- 176
PL+V Y+ D+ + +G+ YWR++++ +A+K+ FA+++ +E + EL E G+
Sbjct: 382 PLVVVYYNADFSVQYREGSEYWRSKVLNIAQKYQKD--KYKFAVADEEEFAKELEELGLG 439
Query: 177 ESPDSNKVYIVARDEKNQKFKMAE-----DFTMEAFEKFINDFLNEQVPVYLKSETIPEK 341
+S + V + D K E D +EAF K I+ + + ++KS P+
Sbjct: 440 DSGLEHNVVVFGYDGKKYPMNPDEFDGELDENLEAFMKQIS---SGKAKAHVKSAPAPKD 496
Query: 342 NDEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKL-SGESDIVIA 518
+ PVK VV NFD +VND +KDVLIEFYAPWCGHCKS KY ELA+ L + ++V+A
Sbjct: 497 DKGPVKTVVGSNFDKIVNDESKDVLIEFYAPWCGHCKSFESKYVELAQALKKTQPNVVLA 556
Query: 519 KMDATANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTSSLKSYD 698
KMDAT ND PS + V GFPTIYFAP K+ P Y+G R+++D+ K++ S + D
Sbjct: 557 KMDATINDAPSQFAVEGFPTIYFAPAGKKSEPIKYSGNRDLEDLKKFMTKHGVKSFQKKD 616
Score = 88.2 bits (217), Expect = 3e-17
Identities = 51/131 (38%), Positives = 80/131 (61%), Gaps = 5/131 (3%)
Frame = +3
Query: 312 YLKSETIPEKNDEPVKVVV--AKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAK 485
+++S P P +VV +NFD +++ + VL+EFYAPWCGHCK LAP+YE+ A+
Sbjct: 133 WVESRVDPNYKPPPEEVVTLTTENFDDFISN-NELVLVEFYAPWCGHCKKLAPEYEKAAQ 191
Query: 486 KLSGE-SDIVIAKMDAT-ANDVPSPYEVTGFPTIYFAPKNSKNSPK-SYNGGREVDDMLK 656
KL + S + + K+DAT D+ + Y V+G+PT+ K +N + YNG RE ++K
Sbjct: 192 KLKAQGSKVKLGKVDATIEKDLGTKYGVSGYPTM----KIIRNGRRFDYNGpreAAGIIK 247
Query: 657 YIASESTSSLK 689
Y+ +S + K
Sbjct: 248 YMTDQSKPAAK 258
Score = 86.7 bits (213), Expect = 8e-17
Identities = 48/116 (41%), Positives = 73/116 (62%), Gaps = 1/116 (0%)
Frame = +3
Query: 345 DEPVKVVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKM 524
DE V V+ KNFDA + VL++FYAPWCGHCK LAP+YE+ + K+S I +AK+
Sbjct: 35 DEGVVVLTDKNFDAFLKK-NPSVLVKFYAPWCGHCKHLAPEYEKASSKVS----IPLAKV 89
Query: 525 DATA-NDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIASESTSSLK 689
DAT ++ +E+ G+PT+ F K+ K P Y+GGR+ +++++ S + K
Sbjct: 90 DATVETELGKRFEIQGYPTLKFW-KDGK-GPNDYDGGRDEAGIVEWVESRVDPNYK 143
>sp|P55059|PDI_HUMIN Protein disulfide-isomerase precursor (PDI)
Length = 505
Score = 163 bits (413), Expect = 5e-40
Identities = 84/165 (50%), Positives = 111/165 (67%), Gaps = 5/165 (3%)
Frame = +3
Query: 186 DSNKVYIVARDEKNQKFKMAED--FTMEAFEKFINDFLNEQVPVYLKSETIPEKNDEPVK 359
D + + KNQKF ++ T EA + F++DF+ ++ +KSE IPEK + PV
Sbjct: 299 DKFPAFAIQEVAKNQKFPFDQEKEITFEAIKAFVDDFVAGKIEPSIKSEPIPEKQEGPVT 358
Query: 360 VVVAKNFDALVNDPTKDVLIEFYAPWCGHCKSLAPKYEELA---KKLSGESDIVIAKMDA 530
VVVAKN++ +V D TKDVLIEFYAPWCGHCK+LAPKYEEL K + +VIAK+DA
Sbjct: 359 VVVAKNYNEIVLDDTKDVLIEFYAPWCGHCKALAPKYEELGALYAKSEFKDRVVIAKVDA 418
Query: 531 TANDVPSPYEVTGFPTIYFAPKNSKNSPKSYNGGREVDDMLKYIA 665
TANDVP E+ GFPTI P +K P +Y+G R V+D++K+IA
Sbjct: 419 TANDVPD--EIQGFPTIKLYPAGAKGQPVTYSGSRTVEDLIKFIA 461
Score = 68.2 bits (165), Expect = 3e-11
Identities = 44/117 (37%), Positives = 64/117 (54%), Gaps = 3/117 (2%)
Frame = +3
Query: 411 VLIEFYAPWCGHCKSLAPKYEELAKKLSGESDIVIAKMDAT-ANDVPSPYEVTGFPTIYF 587
VL EF+APWCGHCK+LAP+YEE A L E +I +AK+D T D+ + V G+PT+
Sbjct: 41 VLAEFFAPWCGHCKALAPEYEEAATTLK-EKNIKLAKVDCTEETDLCQQHGVEGYPTLKV 99
Query: 588 APKNSKNSPKSYNGGREVDDMLKYIASESTSSLK--SYDRQGRVRKSDL*KIKIVEY 752
SP Y G R+ + Y+ +S ++ + D +K+D K +V Y
Sbjct: 100 FRGLDNVSP--YKGQRKAAAITSYMIKQSLPAVSEVTKDNLEEFKKAD--KAVLVAY 152
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,572,536
Number of Sequences: 369166
Number of extensions: 1864013
Number of successful extensions: 6130
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5765
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6024
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8438301375
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)