Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_K14
(833 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinas... 149 9e-36
sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinas... 149 9e-36
sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (S... 149 1e-35
sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinas... 148 2e-35
sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24 147 3e-35
sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinas... 144 2e-34
sp|Q64303|PAK2_RAT Serine/threonine-protein kinase PAK 2 (p... 140 3e-33
sp|Q62829|PAK3_RAT Serine/threonine-protein kinase PAK 3 (p... 140 3e-33
sp|Q8CIN4|PAK2_MOUSE Serine/threonine-protein kinase PAK 2 ... 140 3e-33
sp|Q13177|PAK2_HUMAN Serine/threonine-protein kinase PAK 2 ... 140 3e-33
>sp|Q99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (MAPK/ERK kinase
kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis
signal-regulating kinase 1) (ASK-1)
Length = 1374
Score = 149 bits (376), Expect = 9e-36
Identities = 84/217 (38%), Positives = 125/217 (57%), Gaps = 7/217 (3%)
Frame = +3
Query: 30 KHSNHPRIVKYERNFQTDNAVFLVMEYMKGGSLRGYLEGK--PLPENK--IKKYSKQILE 197
KH H IV+Y +F + + + ME + GGSL L K PL +N+ I Y+KQILE
Sbjct: 730 KHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQILE 789
Query: 198 ALQYLHEQKILHRDIKSDNILLNEDDNV-KLCDFGLSKILTDLATKDFLNGVIQTFVGTV 374
L+YLH+ +I+HRDIK DN+L+N V K+ DFG SK L +N +TF GT+
Sbjct: 790 GLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAG------INPCTETFTGTL 843
Query: 375 NYVAPEIMNEEPSGF--SADVWSFGATMVEMVTGFPPYHKMSVCIVMKIISESRKIEYNY 548
Y+APEI+++ P G+ +AD+WS G T++EM TG PP++++ K+
Sbjct: 844 QYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEI 903
Query: 549 PNDLSDNLKSFIDSCLQSEPSKRLTSKQLMNHPFLQI 659
P +S K+FI C + +P KR + L+ FL++
Sbjct: 904 PESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKV 940
>sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 (Arabidospsis
NPK1-related protein kinase 3)
Length = 651
Score = 149 bits (376), Expect = 9e-36
Identities = 84/217 (38%), Positives = 127/217 (58%), Gaps = 1/217 (0%)
Frame = +3
Query: 6 ERELQFYSKHSNHPRIVKYERNFQTDNAVFLVMEYMKGGSLRGYLEG-KPLPENKIKKYS 182
E E+Q K+ +HP IV+Y + +++ ++ME++ GGS+ LE PE I Y+
Sbjct: 119 EEEVQLL-KNLSHPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVIIMYT 177
Query: 183 KQILEALQYLHEQKILHRDIKSDNILLNEDDNVKLCDFGLSKILTDLATKDFLNGVIQTF 362
KQ+L L+YLH I+HRDIK NIL++ ++L DFG SK + +LAT +NG ++
Sbjct: 178 KQLLLGLEYLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELAT---VNGA-KSM 233
Query: 363 VGTVNYVAPEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHKMSVCIVMKIISESRKIEY 542
GT ++APE++ + FSAD+WS G T++EM TG PP+ + + K
Sbjct: 234 KGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIGRTKAHP 293
Query: 543 NYPNDLSDNLKSFIDSCLQSEPSKRLTSKQLMNHPFL 653
P DLS K F+ CL EPS RL++ +L+ HPF+
Sbjct: 294 PIPEDLSPEAKDFLMKCLHKEPSLRLSATELLQHPFV 330
>sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (STE20-like kinase MST3) (MST-3)
(Mammalian STE20-like protein kinase 3)
Length = 443
Score = 149 bits (375), Expect = 1e-35
Identities = 80/205 (39%), Positives = 122/205 (59%), Gaps = 2/205 (0%)
Frame = +3
Query: 45 PRIVKYERNFQTDNAVFLVMEYMKGGSLRGYLEGKPLPENKIKKYSKQILEALQYLHEQK 224
P + KY ++ D ++++MEY+ GGS LE PL E +I ++IL+ L YLH +K
Sbjct: 92 PYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEK 151
Query: 225 ILHRDIKSDNILLNEDDNVKLCDFGLSKILTDLATKDFLNGVIQTFVGTVNYVAPEIMNE 404
+HRDIK+ N+LL+E VKL DFG++ LTD K TFVGT ++APE++ +
Sbjct: 152 KIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKR------NTFVGTPFWMAPEVIKQ 205
Query: 405 EPSGFSADVWSFGATMVEMVTGFPPYHKMSVCIVMKIISESR--KIEYNYPNDLSDNLKS 578
AD+WS G T +E+ G PP+ ++ V+ +I ++ +E NY S LK
Sbjct: 206 SAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNY----SKPLKE 261
Query: 579 FIDSCLQSEPSKRLTSKQLMNHPFL 653
F+++CL EPS R T+K+L+ H F+
Sbjct: 262 FVEACLNKEPSFRPTAKELLKHKFI 286
>sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinase kinase 1 (Arabidospsis
NPK1-related protein kinase 1)
Length = 666
Score = 148 bits (373), Expect = 2e-35
Identities = 78/209 (37%), Positives = 126/209 (60%), Gaps = 1/209 (0%)
Frame = +3
Query: 30 KHSNHPRIVKYERNFQTDNAVFLVMEYMKGGSLRGYLEG-KPLPENKIKKYSKQILEALQ 206
K+ +HP IV+Y + D+ + +++E++ GGS+ LE P PE+ ++ Y++Q+L L+
Sbjct: 127 KNLSHPNIVRYLGTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVVRTYTRQLLLGLE 186
Query: 207 YLHEQKILHRDIKSDNILLNEDDNVKLCDFGLSKILTDLATKDFLNGVIQTFVGTVNYVA 386
YLH I+HRDIK NIL++ +KL DFG SK + +LAT + G ++ GT ++A
Sbjct: 187 YLHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELAT---MTGA-KSMKGTPYWMA 242
Query: 387 PEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHKMSVCIVMKIISESRKIEYNYPNDLSD 566
PE++ + FSAD+WS G T++EMVTG P+ + + + K P+ LS
Sbjct: 243 PEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTTKSHPPIPDTLSS 302
Query: 567 NLKSFIDSCLQSEPSKRLTSKQLMNHPFL 653
+ K F+ CLQ P+ R T+ +L+ HPF+
Sbjct: 303 DAKDFLLKCLQEVPNLRPTASELLKHPFV 331
>sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24
Length = 431
Score = 147 bits (372), Expect = 3e-35
Identities = 80/205 (39%), Positives = 122/205 (59%), Gaps = 2/205 (0%)
Frame = +3
Query: 45 PRIVKYERNFQTDNAVFLVMEYMKGGSLRGYLEGKPLPENKIKKYSKQILEALQYLHEQK 224
P + KY ++ D ++++MEY+ GGS LE PL E +I ++IL+ L YLH +K
Sbjct: 80 PYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEPGPLDEIQIATILREILKGLDYLHSEK 139
Query: 225 ILHRDIKSDNILLNEDDNVKLCDFGLSKILTDLATKDFLNGVIQTFVGTVNYVAPEIMNE 404
+HRDIK+ N+LL+E VKL DFG++ LTD K TFVGT ++APE++ +
Sbjct: 140 KIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIKR------NTFVGTPFWMAPEVIKQ 193
Query: 405 EPSGFSADVWSFGATMVEMVTGFPPYHKMSVCIVMKIISESR--KIEYNYPNDLSDNLKS 578
AD+WS G T +E+ G PP+ ++ V+ +I ++ +E NY S LK
Sbjct: 194 SAYDSKADIWSLGITAIELAKGEPPHSELHPMKVLFLIPKNNPPTLEGNY----SKPLKE 249
Query: 579 FIDSCLQSEPSKRLTSKQLMNHPFL 653
F+++CL EPS R T+K+L+ H F+
Sbjct: 250 FVEACLNKEPSFRPTAKELLKHKFI 274
>sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinase kinase 2 (Arabidospsis
NPK1-related protein kinase 2)
Length = 651
Score = 144 bits (364), Expect = 2e-34
Identities = 77/209 (36%), Positives = 125/209 (59%), Gaps = 1/209 (0%)
Frame = +3
Query: 30 KHSNHPRIVKYERNFQTDNAVFLVMEYMKGGSLRGYLEG-KPLPENKIKKYSKQILEALQ 206
K+ +HP IV+Y + D + +++E++ GGS+ LE PE+ ++ Y+ Q+L L+
Sbjct: 126 KNLSHPNIVRYLGTVREDETLNILLEFVPGGSISSLLEKFGAFPESVVRTYTNQLLLGLE 185
Query: 207 YLHEQKILHRDIKSDNILLNEDDNVKLCDFGLSKILTDLATKDFLNGVIQTFVGTVNYVA 386
YLH I+HRDIK NIL++ +KL DFG SK + +LAT ++G ++ GT ++A
Sbjct: 186 YLHNHAIMHRDIKGANILVDNQGCIKLADFGASKQVAELAT---ISGA-KSMKGTPYWMA 241
Query: 387 PEIMNEEPSGFSADVWSFGATMVEMVTGFPPYHKMSVCIVMKIISESRKIEYNYPNDLSD 566
PE++ + FSAD+WS G T++EMVTG P+ + I + K P+++S
Sbjct: 242 PEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTTKSHPPIPDNISS 301
Query: 567 NLKSFIDSCLQSEPSKRLTSKQLMNHPFL 653
+ F+ CLQ EP+ R T+ +L+ HPF+
Sbjct: 302 DANDFLLKCLQQEPNLRPTASELLKHPFV 330
>sp|Q64303|PAK2_RAT Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2) (Gamma-PAK) (p62-PAK)
Length = 524
Score = 140 bits (354), Expect = 3e-33
Identities = 73/210 (34%), Positives = 120/210 (57%)
Frame = +3
Query: 30 KHSNHPRIVKYERNFQTDNAVFLVMEYMKGGSLRGYLEGKPLPENKIKKYSKQILEALQY 209
K +P IV + ++ + +F+VMEY+ GGSL + + E +I ++ L+AL++
Sbjct: 299 KELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEF 358
Query: 210 LHEQKILHRDIKSDNILLNEDDNVKLCDFGLSKILTDLATKDFLNGVIQTFVGTVNYVAP 389
LH +++HRDIKSDN+LL + +VKL DFG +T +K T VGT ++AP
Sbjct: 359 LHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKR------STMVGTPYWMAP 412
Query: 390 EIMNEEPSGFSADVWSFGATMVEMVTGFPPYHKMSVCIVMKIISESRKIEYNYPNDLSDN 569
E++ + G D+WS G +EMV G PPY + + +I+ + E P LS
Sbjct: 413 EVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPI 472
Query: 570 LKSFIDSCLQSEPSKRLTSKQLMNHPFLQI 659
+ F++ CL+ + KR ++K+L+ HPFL++
Sbjct: 473 FRDFLNRCLEMDVEKRGSAKELLQHPFLKL 502
>sp|Q62829|PAK3_RAT Serine/threonine-protein kinase PAK 3 (p21-activated kinase 3)
(PAK-3) (Beta-PAK) (p65-PAK)
Length = 544
Score = 140 bits (354), Expect = 3e-33
Identities = 73/210 (34%), Positives = 120/210 (57%)
Frame = +3
Query: 30 KHSNHPRIVKYERNFQTDNAVFLVMEYMKGGSLRGYLEGKPLPENKIKKYSKQILEALQY 209
+ + +P IV Y ++ + +++VMEY+ GGSL + + E +I ++ L+AL +
Sbjct: 318 RENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDF 377
Query: 210 LHEQKILHRDIKSDNILLNEDDNVKLCDFGLSKILTDLATKDFLNGVIQTFVGTVNYVAP 389
LH +++HRDIKSDNILL D +VKL DFG +T +K T VGT ++AP
Sbjct: 378 LHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKR------STMVGTPYWMAP 431
Query: 390 EIMNEEPSGFSADVWSFGATMVEMVTGFPPYHKMSVCIVMKIISESRKIEYNYPNDLSDN 569
E++ + G D+WS G +EMV G PPY + + +I+ + E P LS
Sbjct: 432 EVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAV 491
Query: 570 LKSFIDSCLQSEPSKRLTSKQLMNHPFLQI 659
+ F++ CL+ + +R ++K+L+ HPFL++
Sbjct: 492 FRDFLNRCLEMDVDRRGSAKELLQHPFLKL 521
>sp|Q8CIN4|PAK2_MOUSE Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2)
Length = 524
Score = 140 bits (354), Expect = 3e-33
Identities = 73/210 (34%), Positives = 120/210 (57%)
Frame = +3
Query: 30 KHSNHPRIVKYERNFQTDNAVFLVMEYMKGGSLRGYLEGKPLPENKIKKYSKQILEALQY 209
K +P IV + ++ + +F+VMEY+ GGSL + + E +I ++ L+AL++
Sbjct: 299 KELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEF 358
Query: 210 LHEQKILHRDIKSDNILLNEDDNVKLCDFGLSKILTDLATKDFLNGVIQTFVGTVNYVAP 389
LH +++HRDIKSDN+LL + +VKL DFG +T +K T VGT ++AP
Sbjct: 359 LHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKR------STMVGTPYWMAP 412
Query: 390 EIMNEEPSGFSADVWSFGATMVEMVTGFPPYHKMSVCIVMKIISESRKIEYNYPNDLSDN 569
E++ + G D+WS G +EMV G PPY + + +I+ + E P LS
Sbjct: 413 EVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPI 472
Query: 570 LKSFIDSCLQSEPSKRLTSKQLMNHPFLQI 659
+ F++ CL+ + KR ++K+L+ HPFL++
Sbjct: 473 FRDFLNRCLEMDVEKRGSAKELLQHPFLKL 502
>sp|Q13177|PAK2_HUMAN Serine/threonine-protein kinase PAK 2 (p21-activated kinase 2)
(PAK-2) (PAK65) (Gamma-PAK) (S6/H4 kinase)
Length = 524
Score = 140 bits (354), Expect = 3e-33
Identities = 73/210 (34%), Positives = 120/210 (57%)
Frame = +3
Query: 30 KHSNHPRIVKYERNFQTDNAVFLVMEYMKGGSLRGYLEGKPLPENKIKKYSKQILEALQY 209
K +P IV + ++ + +F+VMEY+ GGSL + + E +I ++ L+AL++
Sbjct: 299 KELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEF 358
Query: 210 LHEQKILHRDIKSDNILLNEDDNVKLCDFGLSKILTDLATKDFLNGVIQTFVGTVNYVAP 389
LH +++HRDIKSDN+LL + +VKL DFG +T +K T VGT ++AP
Sbjct: 359 LHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKR------STMVGTPYWMAP 412
Query: 390 EIMNEEPSGFSADVWSFGATMVEMVTGFPPYHKMSVCIVMKIISESRKIEYNYPNDLSDN 569
E++ + G D+WS G +EMV G PPY + + +I+ + E P LS
Sbjct: 413 EVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPI 472
Query: 570 LKSFIDSCLQSEPSKRLTSKQLMNHPFLQI 659
+ F++ CL+ + KR ++K+L+ HPFL++
Sbjct: 473 FRDFLNRCLEMDVEKRGSAKELLQHPFLKL 502
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,361,698
Number of Sequences: 369166
Number of extensions: 2068275
Number of successful extensions: 10664
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 7277
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7774
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8100769320
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)