Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_J09
(765 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P35670|ATP7B_HUMAN Copper-transporting ATPase 2 (Copper ... 157 3e-38
sp|Q64446|ATP7B_MOUSE Copper-transporting ATPase 2 (Copper ... 156 7e-38
sp|Q04656|ATP7A_HUMAN Copper-transporting ATPase 1 (Copper ... 152 1e-36
sp|P70705|ATP7A_RAT Copper-transporting ATPase 1 (Copper pu... 150 3e-36
sp|Q9XT50|ATP7B_SHEEP Copper-transporting ATPase 2 (Copper ... 150 5e-36
sp|Q64430|ATP7A_MOUSE Copper-transporting ATPase 1 (Copper ... 149 6e-36
sp|Q64535|ATP7B_RAT Copper-transporting ATPase 2 (Copper pu... 147 4e-35
sp|P49015|ATP7A_CRIGR Copper-transporting ATPase 1 (Copper ... 147 4e-35
sp|Q9SH30|AHM7_ARATH Putative copper-transporting ATPase 3 128 2e-29
sp|Q9S7J8|AHM5_ARATH Copper-transporting ATPase RAN1 (Respo... 128 2e-29
>sp|P35670|ATP7B_HUMAN Copper-transporting ATPase 2 (Copper pump 2) (Wilson
disease-associated protein)
Length = 1465
Score = 157 bits (397), Expect = 3e-38
Identities = 84/150 (56%), Positives = 102/150 (68%)
Frame = +1
Query: 58 KSTCVAMVGDGINDSPALAQADVGIAIGTGTDVAVEAADVVLIRNSLFDVIAAMKLSKAT 237
K VAMVGDG+NDSPALAQAD+G+AIGTGTDVA+EAADVVLIRN L DV+A++ LSK T
Sbjct: 1258 KGKKVAMVGDGVNDSPALAQADMGVAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRT 1317
Query: 238 VRRIRQNFVAATMYNLIGIPIAAGVLMPFRVAFMPWMASVAMAAXXXXXXXXXXXXKFWK 417
VRRIR N V A +YNL+GIPIAAGV MP + PWM S AMAA K +K
Sbjct: 1318 VRRIRINLVLALIYNLVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYK 1377
Query: 418 KPNEEKLINEDFKQHLEYLKNNDIEVGINL 507
KP+ E+ H++ L + + V I +
Sbjct: 1378 KPDLER-YEAQAHGHMKPLTASQVSVHIGM 1406
>sp|Q64446|ATP7B_MOUSE Copper-transporting ATPase 2 (Copper pump 2) (Wilson
disease-associated protein homolog)
Length = 1462
Score = 156 bits (394), Expect = 7e-38
Identities = 79/122 (64%), Positives = 92/122 (75%)
Frame = +1
Query: 70 VAMVGDGINDSPALAQADVGIAIGTGTDVAVEAADVVLIRNSLFDVIAAMKLSKATVRRI 249
VAMVGDG+NDSPALAQADVGIAIGTGTDVA+EAADVVLIRN L DV+A++ LSK TVRRI
Sbjct: 1259 VAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKRTVRRI 1318
Query: 250 RQNFVAATMYNLIGIPIAAGVLMPFRVAFMPWMASVAMAAXXXXXXXXXXXXKFWKKPNE 429
R N V A +YN++GIPIAAGV MP + PWM S AMAA K ++KP+
Sbjct: 1319 RVNLVLALIYNMVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDL 1378
Query: 430 EK 435
E+
Sbjct: 1379 ER 1380
>sp|Q04656|ATP7A_HUMAN Copper-transporting ATPase 1 (Copper pump 1) (Menkes
disease-associated protein)
Length = 1500
Score = 152 bits (383), Expect = 1e-36
Identities = 78/121 (64%), Positives = 90/121 (74%)
Frame = +1
Query: 70 VAMVGDGINDSPALAQADVGIAIGTGTDVAVEAADVVLIRNSLFDVIAAMKLSKATVRRI 249
VAMVGDGINDSPALA A+VGIAIGTGTDVA+EAADVVLIRN L DV+A++ LS+ TV+RI
Sbjct: 1296 VAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRI 1355
Query: 250 RQNFVAATMYNLIGIPIAAGVLMPFRVAFMPWMASVAMAAXXXXXXXXXXXXKFWKKPNE 429
R NFV A +YNL+GIPIAAGV MP + PWM S AMAA K ++KP
Sbjct: 1356 RINFVFALIYNLVGIPIAAGVFMPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTY 1415
Query: 430 E 432
E
Sbjct: 1416 E 1416
>sp|P70705|ATP7A_RAT Copper-transporting ATPase 1 (Copper pump 1) (Menkes
disease-associated protein homolog)
Length = 1492
Score = 150 bits (380), Expect = 3e-36
Identities = 80/147 (54%), Positives = 100/147 (68%)
Frame = +1
Query: 70 VAMVGDGINDSPALAQADVGIAIGTGTDVAVEAADVVLIRNSLFDVIAAMKLSKATVRRI 249
VAMVGDGINDSPALA A VGIAIGTGTDVA+EAADVVLIRN L DV+A++ LS+ TV+RI
Sbjct: 1288 VAMVGDGINDSPALAMASVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRI 1347
Query: 250 RQNFVAATMYNLIGIPIAAGVLMPFRVAFMPWMASVAMAAXXXXXXXXXXXXKFWKKPNE 429
R NFV A +YNLIGIPIAAGV +P + PWM S AMAA K ++KP
Sbjct: 1348 RINFVFALIYNLIGIPIAAGVFLPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTY 1407
Query: 430 EKLINEDFKQHLEYLKNNDIEVGINLG 510
+ N + + + + E+ +++G
Sbjct: 1408 D---NYELRPRSHTGQRSPSEISVHVG 1431
>sp|Q9XT50|ATP7B_SHEEP Copper-transporting ATPase 2 (Copper pump 2) (Wilson
disease-associated protein homolog)
Length = 1505
Score = 150 bits (378), Expect = 5e-36
Identities = 77/119 (64%), Positives = 89/119 (74%)
Frame = +1
Query: 70 VAMVGDGINDSPALAQADVGIAIGTGTDVAVEAADVVLIRNSLFDVIAAMKLSKATVRRI 249
VAMVGDG+NDSPALAQADVGIAIGTGTDVA+EAADVVLIRN L DV+A++ LS+ TV RI
Sbjct: 1302 VAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSRRTVWRI 1361
Query: 250 RQNFVAATMYNLIGIPIAAGVLMPFRVAFMPWMASVAMAAXXXXXXXXXXXXKFWKKPN 426
R N V A +YNLIGIP+AAGV +P V PWM S AMAA K ++KP+
Sbjct: 1362 RLNLVLALIYNLIGIPVAAGVFIPIGVVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPD 1420
>sp|Q64430|ATP7A_MOUSE Copper-transporting ATPase 1 (Copper pump 1) (Menkes
disease-associated protein homolog)
Length = 1491
Score = 149 bits (377), Expect = 6e-36
Identities = 76/118 (64%), Positives = 89/118 (75%)
Frame = +1
Query: 70 VAMVGDGINDSPALAQADVGIAIGTGTDVAVEAADVVLIRNSLFDVIAAMKLSKATVRRI 249
VAMVGDGINDSPALA A+VGIAIGTGTDVA+EAADVVLIRN L DV+A++ LS+ TV+RI
Sbjct: 1287 VAMVGDGINDSPALAMANVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRI 1346
Query: 250 RQNFVAATMYNLIGIPIAAGVLMPFRVAFMPWMASVAMAAXXXXXXXXXXXXKFWKKP 423
R NFV A +YNL+GIPIAAGV +P + PWM S AMAA K ++KP
Sbjct: 1347 RINFVFALIYNLVGIPIAAGVFLPIGLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKP 1404
>sp|Q64535|ATP7B_RAT Copper-transporting ATPase 2 (Copper pump 2) (Wilson
disease-associated protein homolog) (Pinal night-specific
ATPase)
Length = 1451
Score = 147 bits (370), Expect = 4e-35
Identities = 77/126 (61%), Positives = 91/126 (72%)
Frame = +1
Query: 58 KSTCVAMVGDGINDSPALAQADVGIAIGTGTDVAVEAADVVLIRNSLFDVIAAMKLSKAT 237
K VAMVGDG+NDSPALAQADVGIAIGTGTDVA++AADVVLIRN L DV+A++ LSK T
Sbjct: 1246 KGKKVAMVGDGVNDSPALAQADVGIAIGTGTDVAIDAADVVLIRNDLLDVVASIHLSKRT 1305
Query: 238 VRRIRQNFVAATMYNLIGIPIAAGVLMPFRVAFMPWMASVAMAAXXXXXXXXXXXXKFWK 417
VRRIR N V A +YN++GIPIAAGV MP + PWM S AA K ++
Sbjct: 1306 VRRIRVNLVLALIYNMVGIPIAAGVFMPIGIVLQPWMGSA--AASSVSVVLSSLQLKCYR 1363
Query: 418 KPNEEK 435
KP+ E+
Sbjct: 1364 KPDLER 1369
>sp|P49015|ATP7A_CRIGR Copper-transporting ATPase 1 (Copper pump 1)
Length = 1476
Score = 147 bits (370), Expect = 4e-35
Identities = 76/147 (51%), Positives = 99/147 (67%)
Frame = +1
Query: 70 VAMVGDGINDSPALAQADVGIAIGTGTDVAVEAADVVLIRNSLFDVIAAMKLSKATVRRI 249
VAMVGDGINDSPALA A+VGIAIGTGTDV +EAADVV IRN L DV+A++ LS+ TV+RI
Sbjct: 1286 VAMVGDGINDSPALAMANVGIAIGTGTDVTIEAADVVFIRNDLLDVVASIDLSRKTVKRI 1345
Query: 250 RQNFVAATMYNLIGIPIAAGVLMPFRVAFMPWMASVAMAAXXXXXXXXXXXXKFWKKPNE 429
R NF+ +YNL+GIPIAAGV +P + F PWM S AMAA K ++KP
Sbjct: 1346 RINFLFPLIYNLVGIPIAAGVFLPIGLVFQPWMGSAAMAASSVSVVLSSLFLKLYRKPTY 1405
Query: 430 EKLINEDFKQHLEYLKNNDIEVGINLG 510
+ N + + + + E+ +++G
Sbjct: 1406 D---NYELRTRSHTGQRSPSEISVHVG 1429
>sp|Q9SH30|AHM7_ARATH Putative copper-transporting ATPase 3
Length = 995
Score = 128 bits (321), Expect = 2e-29
Identities = 69/121 (57%), Positives = 85/121 (70%), Gaps = 1/121 (0%)
Frame = +1
Query: 70 VAMVGDGINDSPALAQADVGIAIGTGTDVAVEAADVVLIRNSLFDVIAAMKLSKATVRRI 249
VAMVGDGINDSPAL ADVG+AIG GTD+A+EAAD+VL++++L DVI A+ LS+ T RI
Sbjct: 861 VAMVGDGINDSPALVAADVGMAIGAGTDIAIEAADIVLMKSNLEDVITAIDLSRKTFSRI 920
Query: 250 RQNFVAATMYNLIGIPIAAGVLMP-FRVAFMPWMASVAMAAXXXXXXXXXXXXKFWKKPN 426
R N+V A YNL+GIPIAAGVL P R PW+A AMAA K +K+P
Sbjct: 921 RLNYVWALGYNLMGIPIAAGVLFPGTRFRLPPWIAGAAMAASSVSVVCCSLLLKNYKRPK 980
Query: 427 E 429
+
Sbjct: 981 K 981
>sp|Q9S7J8|AHM5_ARATH Copper-transporting ATPase RAN1 (Responsive-to-antagonist 1)
Length = 1001
Score = 128 bits (321), Expect = 2e-29
Identities = 73/139 (52%), Positives = 87/139 (62%), Gaps = 1/139 (0%)
Frame = +1
Query: 10 MPRKTKSFFNCLSKNFKSTCVAMVGDGINDSPALAQADVGIAIGTGTDVAVEAADVVLIR 189
MP L K+ + VAMVGDGINDSPALA ADVG+AIG GTDVA+EAAD VL+R
Sbjct: 854 MPAGKADVIRSLQKD--GSTVAMVGDGINDSPALAAADVGMAIGAGTDVAIEAADYVLMR 911
Query: 190 NSLFDVIAAMKLSKATVRRIRQNFVAATMYNLIGIPIAAGVLMP-FRVAFMPWMASVAMA 366
N+L DVI A+ LS+ T+ RIR N+V A YN++ IPIAAGV P RV PW A MA
Sbjct: 912 NNLEDVITAIDLSRKTLTRIRLNYVFAMAYNVVSIPIAAGVFFPVLRVQLPPWAAGACMA 971
Query: 367 AXXXXXXXXXXXXKFWKKP 423
+ +KKP
Sbjct: 972 LSSVSVVCSSLLLRRYKKP 990
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 71,414,982
Number of Sequences: 369166
Number of extensions: 1214988
Number of successful extensions: 3766
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3556
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3676
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7066925600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)