Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_J01
(903 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q8MJU1|CASP3_FELCA Caspase-3 precursor (CASP-3) [Contain... 197 4e-50
sp|P42574|CASP3_HUMAN Caspase-3 precursor (CASP-3) (Apopain... 194 3e-49
sp|Q5IS54|CASP3_PANTR Caspase-3 precursor (CASP-3) [Contain... 194 3e-49
sp|Q8MKI5|CASP3_CANFA Caspase-3 precursor (CASP-3) [Contain... 193 6e-49
sp|Q60431|CASP3_CRILO Caspase-3 precursor (CASP-3) (Apopain... 191 2e-48
sp|P70677|CASP3_MOUSE Caspase-3 precursor (CASP-3) (Apopain... 189 9e-48
sp|Q8MJC3|CASP3_RABIT Caspase-3 precursor (CASP-3) (Apopain... 188 2e-47
sp|P55213|CASP3_RAT Caspase-3 precursor (CASP-3) (Apopain) ... 188 2e-47
sp|Q95ND5|CASP3_PIG Caspase-3 precursor (CASP-3) [Contains:... 187 3e-47
sp|P55214|CASP7_MESAU Caspase-7 precursor (CASP-7) (ICE-lik... 171 3e-42
>sp|Q8MJU1|CASP3_FELCA Caspase-3 precursor (CASP-3) [Contains: Caspase-3 p17 subunit;
Caspase-3 p12 subunit]
Length = 277
Score = 197 bits (500), Expect = 4e-50
Identities = 97/236 (41%), Positives = 139/236 (58%), Gaps = 2/236 (0%)
Frame = +3
Query: 108 DVSKIKLCYIINNEEFYTKLNLPKRLGTDEDFKRLKQVFTKLGFKVENYKDFKKDEICSN 287
D ++ LC IINN+ F+ +P R GTD D L++ FT L ++V N D +++I +
Sbjct: 40 DYPEMGLCIIINNKNFHESTGMPSRSGTDVDAANLRETFTNLKYEVRNKNDLTREQIVAL 99
Query: 288 LRELSERKELKNVSILVCIILSHGADGIIYGIDGPVELDRIFGYFKGDKCRQLAGKPKVF 467
L +S K S +C++LSHG +GIIYG +GPV+L ++ G+F+GD CR L GKPK+F
Sbjct: 100 LDSVSREDHSKRSSF-ICVLLSHGEEGIIYGTNGPVDLKKLTGFFRGDYCRSLTGKPKLF 158
Query: 468 LFQACRGEKFDKGVQADGLFQTSV--EKIPVEADFLIGYSTVAGYFSWRNGRNGSWYIQA 641
+ QACRG + D G++ D + + +KIPVEADFL YST GY+SWRN ++GSW+IQ+
Sbjct: 159 IIQACRGTELDCGIETDSGTEDDIACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQS 218
Query: 642 LCRELERSAQSMELIQXXXXXXXXXXXXXXSMTKNDKTDAMVQIPSFVCMLRKPLW 809
LC L A +E + S + + QIP V ML K L+
Sbjct: 219 LCSMLRLYAHELEFMHILTRVNRKVATEFESFSLDSAFHGKKQIPCIVSMLTKELY 274
>sp|P42574|CASP3_HUMAN Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
(Yama protein) (CPP-32) (SREBP cleavage activity 1)
(SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12
subunit]
Length = 277
Score = 194 bits (493), Expect = 3e-49
Identities = 97/236 (41%), Positives = 140/236 (59%), Gaps = 2/236 (0%)
Frame = +3
Query: 108 DVSKIKLCYIINNEEFYTKLNLPKRLGTDEDFKRLKQVFTKLGFKVENYKDFKKDEICSN 287
D ++ LC IINN+ F+ + R GTD D L++ F L ++V N D ++EI
Sbjct: 40 DYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVEL 99
Query: 288 LRELSERKELKNVSILVCIILSHGADGIIYGIDGPVELDRIFGYFKGDKCRQLAGKPKVF 467
+R++S+ K S VC++LSHG +GII+G +GPV+L +I +F+GD+CR L GKPK+F
Sbjct: 100 MRDVSKEDHSKRSSF-VCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLF 158
Query: 468 LFQACRGEKFDKGVQADGLFQTSV--EKIPVEADFLIGYSTVAGYFSWRNGRNGSWYIQA 641
+ QACRG + D G++ D + KIPVEADFL YST GY+SWRN ++GSW+IQ+
Sbjct: 159 IIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQS 218
Query: 642 LCRELERSAQSMELIQXXXXXXXXXXXXXXSMTKNDKTDAMVQIPSFVCMLRKPLW 809
LC L++ A +E + S + + A QIP V ML K L+
Sbjct: 219 LCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELY 274
>sp|Q5IS54|CASP3_PANTR Caspase-3 precursor (CASP-3) [Contains: Caspase-3 p17 subunit;
Caspase-3 p12 subunit]
Length = 277
Score = 194 bits (493), Expect = 3e-49
Identities = 97/236 (41%), Positives = 140/236 (59%), Gaps = 2/236 (0%)
Frame = +3
Query: 108 DVSKIKLCYIINNEEFYTKLNLPKRLGTDEDFKRLKQVFTKLGFKVENYKDFKKDEICSN 287
D ++ LC IINN+ F+ + R GTD D L++ F L ++V N D ++EI
Sbjct: 40 DYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVEL 99
Query: 288 LRELSERKELKNVSILVCIILSHGADGIIYGIDGPVELDRIFGYFKGDKCRQLAGKPKVF 467
+R++S+ K S VC++LSHG +GII+G +GPV+L +I +F+GD+CR L GKPK+F
Sbjct: 100 MRDVSKEDHSKRSSF-VCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLF 158
Query: 468 LFQACRGEKFDKGVQADGLFQTSV--EKIPVEADFLIGYSTVAGYFSWRNGRNGSWYIQA 641
+ QACRG + D G++ D + KIPVEADFL YST GY+SWRN ++GSW+IQ+
Sbjct: 159 IIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQS 218
Query: 642 LCRELERSAQSMELIQXXXXXXXXXXXXXXSMTKNDKTDAMVQIPSFVCMLRKPLW 809
LC L++ A +E + S + + A QIP V ML K L+
Sbjct: 219 LCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELY 274
>sp|Q8MKI5|CASP3_CANFA Caspase-3 precursor (CASP-3) [Contains: Caspase-3 p17 subunit;
Caspase-3 p12 subunit]
Length = 277
Score = 193 bits (490), Expect = 6e-49
Identities = 97/237 (40%), Positives = 139/237 (58%), Gaps = 2/237 (0%)
Frame = +3
Query: 108 DVSKIKLCYIINNEEFYTKLNLPKRLGTDEDFKRLKQVFTKLGFKVENYKDFKKDEICSN 287
D ++ LC IINN+ F+ + R GTD D L++ FT L ++V N D +EI
Sbjct: 40 DYPEMGLCIIINNKNFHKSTGMAPRSGTDVDAANLRETFTNLKYEVRNKNDLTCEEILEL 99
Query: 288 LRELSERKELKNVSILVCIILSHGADGIIYGIDGPVELDRIFGYFKGDKCRQLAGKPKVF 467
+ +S+ K S VC++LSHG +GII+G +GPV+L ++ G+F+GD CR L GKPK+F
Sbjct: 100 MNSVSKEDHSKRSSF-VCVLLSHGDEGIIFGTNGPVDLRKVTGFFRGDYCRSLTGKPKLF 158
Query: 468 LFQACRGEKFDKGVQADGLFQTSV--EKIPVEADFLIGYSTVAGYFSWRNGRNGSWYIQA 641
+ QACRG + D G++ D + + +KIPVEADFL YST GY+SWRN ++GSW+IQ+
Sbjct: 159 IIQACRGTELDCGIETDSGIEDDMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQS 218
Query: 642 LCRELERSAQSMELIQXXXXXXXXXXXXXXSMTKNDKTDAMVQIPSFVCMLRKPLWL 812
LC L+ A +E + S + + QIP V ML K L+L
Sbjct: 219 LCAMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSAFHGKKQIPCIVSMLTKELYL 275
>sp|Q60431|CASP3_CRILO Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
(Yama protein) (CPP-32) (SREBP cleavage activity 1)
(SCA-1) [Contains: Caspase-3 p17 subunit; Caspase-3 p12
subunit]
Length = 277
Score = 191 bits (485), Expect = 2e-48
Identities = 95/236 (40%), Positives = 139/236 (58%), Gaps = 2/236 (0%)
Frame = +3
Query: 108 DVSKIKLCYIINNEEFYTKLNLPKRLGTDEDFKRLKQVFTKLGFKVENYKDFKKDEICSN 287
D ++ +C IINN+ F+ + R GTD D +L++ F L ++V N D ++EI
Sbjct: 40 DYPEMGVCIIINNKNFHKSTGMTPRSGTDVDAAKLRETFMALKYEVRNKNDLTREEIVEL 99
Query: 288 LRELSERKELKNVSILVCIILSHGADGIIYGIDGPVELDRIFGYFKGDKCRQLAGKPKVF 467
++ S+ K S VC+ILSHG +G+I+G DGP++L ++ YF+GD CR L GKPK+F
Sbjct: 100 MKNASKEDHSKRSSF-VCVILSHGDEGVIFGTDGPIDLKKLTSYFRGDYCRSLIGKPKLF 158
Query: 468 LFQACRGEKFDKGVQADGLFQTSV--EKIPVEADFLIGYSTVAGYFSWRNGRNGSWYIQA 641
+ QACRG + D G++ D + + +KIPVEADFL YST GY+SWRN ++GSW+IQ+
Sbjct: 159 IIQACRGTELDCGIETDSGTEDDMTCQKIPVEADFLYAYSTAPGYYSWRNPKDGSWFIQS 218
Query: 642 LCRELERSAQSMELIQXXXXXXXXXXXXXXSMTKNDKTDAMVQIPSFVCMLRKPLW 809
LC L+ A +E + S + + A QIP V ML K L+
Sbjct: 219 LCSMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSTFHAKKQIPCIVSMLTKELY 274
>sp|P70677|CASP3_MOUSE Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
(Yama protein) (CPP-32) (SREBP cleavage activity 1)
(SCA-1) (LICE) [Contains: Caspase-3 p17 subunit;
Caspase-3 p12 subunit]
Length = 277
Score = 189 bits (480), Expect = 9e-48
Identities = 95/236 (40%), Positives = 138/236 (58%), Gaps = 2/236 (0%)
Frame = +3
Query: 108 DVSKIKLCYIINNEEFYTKLNLPKRLGTDEDFKRLKQVFTKLGFKVENYKDFKKDEICSN 287
D ++ +C IINN+ F+ + R GTD D L++ F L ++V N D +++I
Sbjct: 40 DYPEMGICIIINNKNFHKSTGMSSRSGTDVDAANLRETFMGLKYQVRNKNDLTREDILEL 99
Query: 288 LRELSERKELKNVSILVCIILSHGADGIIYGIDGPVELDRIFGYFKGDKCRQLAGKPKVF 467
+ +S+ K S VC+ILSHG +G+IYG +GPVEL ++ +F+GD CR L GKPK+F
Sbjct: 100 MDSVSKEDHSKRSSF-VCVILSHGDEGVIYGTNGPVELKKLTSFFRGDYCRSLTGKPKLF 158
Query: 468 LFQACRGEKFDKGVQADGLF--QTSVEKIPVEADFLIGYSTVAGYFSWRNGRNGSWYIQA 641
+ QACRG + D G++ D + + +KIPVEADFL YST GY+SWRN ++GSW+IQ+
Sbjct: 159 IIQACRGTELDCGIETDSGTDEEMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQS 218
Query: 642 LCRELERSAQSMELIQXXXXXXXXXXXXXXSMTKNDKTDAMVQIPSFVCMLRKPLW 809
LC L+ A +E + S + + A QIP V ML K L+
Sbjct: 219 LCSMLKLYAHKLEFMHILTRVNRKVATEFESFSLDSTFHAKKQIPCIVSMLTKELY 274
>sp|Q8MJC3|CASP3_RABIT Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
[Contains: Caspase-3 p17 subunit; Caspase-3 p12 subunit]
Length = 277
Score = 188 bits (478), Expect = 2e-47
Identities = 94/236 (39%), Positives = 135/236 (57%), Gaps = 2/236 (0%)
Frame = +3
Query: 108 DVSKIKLCYIINNEEFYTKLNLPKRLGTDEDFKRLKQVFTKLGFKVENYKDFKKDEICSN 287
D ++ LC IINN+ F+ + R GTD + L + F L ++V N D ++EI
Sbjct: 40 DYPEMGLCIIINNKNFHKNTGMSSRSGTDVNAANLGETFMNLKYEVRNKNDLTREEIMEL 99
Query: 288 LRELSERKELKNVSILVCIILSHGADGIIYGIDGPVELDRIFGYFKGDKCRQLAGKPKVF 467
+ +S+ K S +C+ILSHG +G+IYG +GP+EL ++ +F+GD CR L GKPK+F
Sbjct: 100 MYNVSKEDHSKRSSF-ICVILSHGDEGVIYGTNGPIELKKLTSFFRGDYCRSLTGKPKLF 158
Query: 468 LFQACRGEKFDKGVQADG--LFQTSVEKIPVEADFLIGYSTVAGYFSWRNGRNGSWYIQA 641
+ QACRG + D G++ D + + +KIPVEADFL YST GY+SWRN GSW+IQ+
Sbjct: 159 IIQACRGTELDSGIETDSGVDYDMACQKIPVEADFLYAYSTAPGYYSWRNSEEGSWFIQS 218
Query: 642 LCRELERSAQSMELIQXXXXXXXXXXXXXXSMTKNDKTDAMVQIPSFVCMLRKPLW 809
LC L+ A +E + S + + A QIP V ML K L+
Sbjct: 219 LCAMLKEYAHKLEFMHILTRVNRKVATEFESYSLDATFHAKKQIPCIVSMLTKELY 274
>sp|P55213|CASP3_RAT Caspase-3 precursor (CASP-3) (Apopain) (Cysteine protease CPP32)
(Yama protein) (CPP-32) (SREBP cleavage activity 1)
(SCA-1) (LICE) (IRP) [Contains: Caspase-3 p17 subunit;
Caspase-3 p12 subunit]
Length = 277
Score = 188 bits (477), Expect = 2e-47
Identities = 96/236 (40%), Positives = 137/236 (58%), Gaps = 2/236 (0%)
Frame = +3
Query: 108 DVSKIKLCYIINNEEFYTKLNLPKRLGTDEDFKRLKQVFTKLGFKVENYKDFKKDEICSN 287
D ++ LC IINN+ F+ + R GTD D L++ F L ++V N D ++EI
Sbjct: 40 DYPEMGLCIIINNKNFHKSTGMSARNGTDVDAANLRETFMALKYEVRNKNDLTREEIMEL 99
Query: 288 LRELSERKELKNVSILVCIILSHGADGIIYGIDGPVELDRIFGYFKGDKCRQLAGKPKVF 467
+ +S+ K S VC+ILSHG +G+I+G +GPV+L ++ +F+GD CR L GKPK+F
Sbjct: 100 MDSVSKEDHSKRSSF-VCVILSHGDEGVIFGTNGPVDLKKLTSFFRGDYCRSLTGKPKLF 158
Query: 468 LFQACRGEKFDKGVQADGLFQTSV--EKIPVEADFLIGYSTVAGYFSWRNGRNGSWYIQA 641
+ QACRG + D G++ D + +KIPVEADFL YST GY+SWRN R+GSW+IQ+
Sbjct: 159 IIQACRGTELDCGIETDSGTDDDMACQKIPVEADFLYAYSTAPGYYSWRNSRDGSWFIQS 218
Query: 642 LCRELERSAQSMELIQXXXXXXXXXXXXXXSMTKNDKTDAMVQIPSFVCMLRKPLW 809
LC L+ A +E + S + + A QIP V ML K L+
Sbjct: 219 LCAMLKLYAHKLEFMHILTRVNRKVATEFESFSLDATFHAKKQIPCIVSMLTKELY 274
>sp|Q95ND5|CASP3_PIG Caspase-3 precursor (CASP-3) [Contains: Caspase-3 p17 subunit;
Caspase-3 p12 subunit]
Length = 277
Score = 187 bits (476), Expect = 3e-47
Identities = 94/236 (39%), Positives = 138/236 (58%), Gaps = 2/236 (0%)
Frame = +3
Query: 108 DVSKIKLCYIINNEEFYTKLNLPKRLGTDEDFKRLKQVFTKLGFKVENYKDFKKDEICSN 287
D ++ LC IINN+ F + R GTD D L++ FT L ++V N D ++EI
Sbjct: 40 DYPEMGLCIIINNKNFDKNTGMACRSGTDVDAANLRETFTNLKYEVRNKNDLTREEILEL 99
Query: 288 LRELSERKELKNVSILVCIILSHGADGIIYGIDGPVELDRIFGYFKGDKCRQLAGKPKVF 467
+ +S+ K S +C++LSHG +G I+G +GPV+L ++ +F+GD CR L GKPK+F
Sbjct: 100 MHSVSKEDHSKRSSF-ICVLLSHGEEGKIFGTNGPVDLKKLTSFFRGDCCRTLTGKPKLF 158
Query: 468 LFQACRGEKFDKGVQADGLFQTSV--EKIPVEADFLIGYSTVAGYFSWRNGRNGSWYIQA 641
+ QACRG + D G++ D + + +KIPVEADFL YST GY+SWRN ++GSW+IQ+
Sbjct: 159 IIQACRGTELDCGIETDSGTEDDMACQKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQS 218
Query: 642 LCRELERSAQSMELIQXXXXXXXXXXXXXXSMTKNDKTDAMVQIPSFVCMLRKPLW 809
LC L++ +EL+ S + + A QIP V ML K L+
Sbjct: 219 LCAALKQYVHKLELMHILTRVNRKVAVEFESFSTDSTFHAKKQIPCIVSMLTKELY 274
>sp|P55214|CASP7_MESAU Caspase-7 precursor (CASP-7) (ICE-like apoptotic protease 3)
(ICE-LAP3) (Apoptotic protease Mch-3) (SREBP cleavage
activity 2) (SCA-2) [Contains: Caspase-7 subunit p20;
Caspase-7 subunit p11]
Length = 303
Score = 171 bits (432), Expect = 3e-42
Identities = 95/239 (39%), Positives = 132/239 (55%), Gaps = 5/239 (2%)
Frame = +3
Query: 108 DVSKIKLCYIINNEEFYTKLNLPKRLGTDEDFKRLKQVFTKLGFKVENYKDFKKDEICSN 287
D K+ C IINN+ F + R GTD+D + L + F LGF V Y D ++
Sbjct: 63 DFEKMGKCIIINNKNFDKVTGMDVRNGTDKDAEALFKCFRSLGFDVVVYNDCSCAKMQDL 122
Query: 288 LRELSERKELKNVSILVCIILSHGADGIIYGIDGPVELDRIFGYFKGDKCRQLAGKPKVF 467
LR+ SE ++ N + C++LSHG + +IYG DG + + +F+GD+C+ L KPK+F
Sbjct: 123 LRKASE-EDHSNSACFACVLLSHGEENLIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLF 181
Query: 468 LFQACRGEKFDKGVQADG--LFQTSVE---KIPVEADFLIGYSTVAGYFSWRNGRNGSWY 632
QACRG + D GVQAD + +T KIPVEADFL YSTV GY+SWRN GSW+
Sbjct: 182 FIQACRGTELDDGVQADSGPINETDANPRYKIPVEADFLFAYSTVPGYYSWRNPGKGSWF 241
Query: 633 IQALCRELERSAQSMELIQXXXXXXXXXXXXXXSMTKNDKTDAMVQIPSFVCMLRKPLW 809
+QALC L+ + +E++Q S + + QIP V ML K L+
Sbjct: 242 VQALCSILDEHGKDLEIMQILTRVNDRVARHFESQCDDPCFNEKKQIPCMVSMLTKELY 300
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,039,804
Number of Sequences: 369166
Number of extensions: 1922358
Number of successful extensions: 4622
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4402
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4532
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 9126484700
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)