Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_I23
(859 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P37276|DYHC_DROME Dynein heavy chain, cytosolic (DYHC) 257 3e-68
sp|Q9JHU4|DYHC_MOUSE Dynein heavy chain, cytosolic (DYHC) (... 246 8e-65
sp|Q14204|DYHC_HUMAN Dynein heavy chain, cytosolic (DYHC) (... 241 2e-63
sp|P38650|DYHC_RAT Dynein heavy chain, cytosolic (DYHC) (Cy... 239 7e-63
sp|Q19020|DYHC_CAEEL Dynein heavy chain, cytosolic (DYHC) 192 1e-48
sp|P34036|DYHC_DICDI Dynein heavy chain, cytosolic (DYHC) 169 7e-42
sp|Q27171|DYHC_PARTE Dynein heavy chain, cytosolic (DYHC) (... 152 9e-37
sp|Q9NYC9|DYH9_HUMAN Ciliary dynein heavy chain 9 (Axonemal... 62 2e-09
sp|P23098|DYHC_TRIGR Dynein beta chain, ciliary 60 6e-09
sp|P39057|DYHC_ANTCR Dynein beta chain, ciliary 58 3e-08
>sp|P37276|DYHC_DROME Dynein heavy chain, cytosolic (DYHC)
Length = 4639
Score = 257 bits (656), Expect = 3e-68
Identities = 132/261 (50%), Positives = 176/261 (67%), Gaps = 4/261 (1%)
Frame = +1
Query: 52 DGRPAWMRQLYQSTQTWLQILPKSVTPLQRTSENIKDPMYRCFEREVNSGCNLLIAVRRD 231
DGRP+WM+ L+ S WL++LPK++ L+RT ENIKDP+YR FEREV SG LL V D
Sbjct: 4361 DGRPSWMKTLHNSATAWLELLPKNLQVLKRTVENIKDPLYRYFEREVTSGSRLLQTVILD 4420
Query: 232 LEDVAEVCKGAKKPTNHHRSMMADLAKGIIPKTWVRYAIPPGLTVIQWIQDFADRVKQLI 411
L+DV +C+G KK TNHHRSM+++L +GIIPK W RY +P G TVIQWI DF++RV+QL
Sbjct: 4421 LQDVVLICQGEKKQTNHHRSMLSELVRGIIPKGWKRYTVPAGCTVIQWITDFSNRVQQLQ 4480
Query: 412 SISDTAAKSGVSALRDSKVWLGGLFMAEAYITATRQSVAQANKWALEELFLDVELGDG-- 585
+S +++G L+ VWLGGL EAYITATRQ VAQAN W+LEEL LDV + D
Sbjct: 4481 KVSQLVSQAGAKELQGFPVWLGGLLNPEAYITATRQCVAQANSWSLEELALDVTITDAGL 4540
Query: 586 KVDGNTCV--VTGLRLMGSEIVDSRTLKLSTLIYKDIDICRLKWIRVEKSQQLLDASSVS 759
K D C VTGL+L G++ ++ L ST I D+ + LKWI++ ++
Sbjct: 4541 KNDQKDCCFGVTGLKLQGAQCKNNELLLAST-IMMDLPVTILKWIKISSEPRI------- 4592
Query: 760 KDKVCLPIYLNAARSTVLFTL 822
K+ LP+YLN+ R+ +LFT+
Sbjct: 4593 -SKLTLPVYLNSTRTELLFTV 4612
>sp|Q9JHU4|DYHC_MOUSE Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain)
Length = 4644
Score = 246 bits (627), Expect = 8e-65
Identities = 124/271 (45%), Positives = 180/271 (66%), Gaps = 3/271 (1%)
Frame = +1
Query: 25 KSKRTIEVGDGRPAWMRQLYQSTQTWLQILPKSVTPLQRTSENIKDPMYRCFEREVNSGC 204
K RT DGRPAWMR L+ + WL ++P++++PL+RT ENIKDP++R FEREV G
Sbjct: 4360 KKARTDSTSDGRPAWMRTLHTTASNWLHLIPQTLSPLKRTVENIKDPLFRFFEREVKMGA 4419
Query: 205 NLLIAVRRDLEDVAEVCKGAKKPTNHHRSMMADLAKGIIPKTWVRYAIPPGLTVIQWIQD 384
LL VR+DL DV +VC+G KK TN+ R+++ +L KGI+P++W Y +P G+TVIQW+ D
Sbjct: 4420 KLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSD 4479
Query: 385 FADRVKQLISISDTAAKSGVSALRDSKVWLGGLFMAEAYITATRQSVAQANKWALEELFL 564
F++R+KQL +IS AA G L++ V LGGLF+ EAYITATRQ VAQAN W+LEEL L
Sbjct: 4480 FSERIKQLQNISQAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCL 4539
Query: 565 DVEL---GDGKVDGNTCVVTGLRLMGSEIVDSRTLKLSTLIYKDIDICRLKWIRVEKSQQ 735
+V + +D + VTGL+L G+ +++ L LS I + + +L+W++ +++
Sbjct: 4540 EVNVTASQSATLDACSFGVTGLKLQGATCSNNK-LSLSNAISTVLPLTQLRWVKQTSAEK 4598
Query: 736 LLDASSVSKDKVCLPIYLNAARSTVLFTLYF 828
V LP+YLN R+ ++FT+ F
Sbjct: 4599 -------KASVVTLPVYLNFTRADLIFTVDF 4622
>sp|Q14204|DYHC_HUMAN Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain
1) (DHC1)
Length = 4646
Score = 241 bits (615), Expect = 2e-63
Identities = 123/271 (45%), Positives = 179/271 (66%), Gaps = 3/271 (1%)
Frame = +1
Query: 25 KSKRTIEVGDGRPAWMRQLYQSTQTWLQILPKSVTPLQRTSENIKDPMYRCFEREVNSGC 204
K RT DGRPAWMR L+ + WL ++P++++ L+RT ENIKDP++R FEREV G
Sbjct: 4362 KKTRTDSTSDGRPAWMRTLHTTASNWLHLIPQTLSHLKRTVENIKDPLFRFFEREVKMGA 4421
Query: 205 NLLIAVRRDLEDVAEVCKGAKKPTNHHRSMMADLAKGIIPKTWVRYAIPPGLTVIQWIQD 384
LL VR+DL DV +VC+G KK TN+ R+++ +L KGI+P++W Y +P G+TVIQW+ D
Sbjct: 4422 KLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSD 4481
Query: 385 FADRVKQLISISDTAAKSGVSALRDSKVWLGGLFMAEAYITATRQSVAQANKWALEELFL 564
F++R+KQL +IS AA G L++ V LGGLF+ EAYITATRQ VAQAN W+LEEL L
Sbjct: 4482 FSERIKQLQNISLAAASGGAKELKNIHVCLGGLFVPEAYITATRQYVAQANSWSLEELCL 4541
Query: 565 DVELGDGK---VDGNTCVVTGLRLMGSEIVDSRTLKLSTLIYKDIDICRLKWIRVEKSQQ 735
+V + + +D + VTGL+L G+ ++ L LS I + + +L+W++ +++
Sbjct: 4542 EVNVTTSQGATLDACSFGVTGLKLQGA-TCNNNKLSLSNAISTALPLTQLRWVKQTNTEK 4600
Query: 736 LLDASSVSKDKVCLPIYLNAARSTVLFTLYF 828
V LP+YLN R+ ++FT+ F
Sbjct: 4601 -------KASVVTLPVYLNFTRADLIFTVDF 4624
>sp|P38650|DYHC_RAT Dynein heavy chain, cytosolic (DYHC) (Cytoplasmic dynein heavy chain)
(MAP 1C)
Length = 4644
Score = 239 bits (610), Expect = 7e-63
Identities = 123/271 (45%), Positives = 179/271 (66%), Gaps = 3/271 (1%)
Frame = +1
Query: 25 KSKRTIEVGDGRPAWMRQLYQSTQTWLQILPKSVTPLQRTSENIKDPMYRCFEREVNSGC 204
K RT DGRPAWMR L+ + WL ++P++++PL+RT ENIKDP++R FEREV G
Sbjct: 4360 KKTRTDFTSDGRPAWMRTLHTTASNWLHLIPQTLSPLKRTVENIKDPLFRFFEREVKMGA 4419
Query: 205 NLLIAVRRDLEDVAEVCKGAKKPTNHHRSMMADLAKGIIPKTWVRYAIPPGLTVIQWIQD 384
LL VR+DL DV +VC+G KK TN+ R+++ +L KGI+P++W Y +P G+TVIQW+ D
Sbjct: 4420 KLLQDVRQDLADVVQVCEGKKKQTNYLRTLINELVKGILPRSWSHYTVPAGMTVIQWVSD 4479
Query: 385 FADRVKQLISISDTAAKSGVSALRDSKVWLGGLFMAEAYITATRQSVAQANKWALEELFL 564
F++R+KQL +IS AA G L++ V LG LF+ EAYITATRQ VAQAN W+LEEL L
Sbjct: 4480 FSERIKQLQNISQAAAAGGAKELKNIHVCLGALFVPEAYITATRQYVAQANSWSLEELCL 4539
Query: 565 DVELGDGK---VDGNTCVVTGLRLMGSEIVDSRTLKLSTLIYKDIDICRLKWIRVEKSQQ 735
+V + + +D + VTGL+L G+ +++ L LS I + + +L+W + +++
Sbjct: 4540 EVNVTASQSTTLDACSFGVTGLKLQGATCSNNK-LSLSNAISTVLPLTQLRWGKQTSAEK 4598
Query: 736 LLDASSVSKDKVCLPIYLNAARSTVLFTLYF 828
V LP+YLN R+ ++FT+ F
Sbjct: 4599 -------KASVVTLPVYLNFTRADLIFTVDF 4622
>sp|Q19020|DYHC_CAEEL Dynein heavy chain, cytosolic (DYHC)
Length = 4568
Score = 192 bits (488), Expect = 1e-48
Identities = 104/259 (40%), Positives = 148/259 (57%), Gaps = 1/259 (0%)
Frame = +1
Query: 58 RPAWMRQLYQSTQTWLQILPKSVTPLQRTSENIKDPMYRCFEREVNSGCNLLIAVRRDLE 237
+P WM QL + + WLQ+LPK + ++RT ENIKDP++R FEREVN G LL +RRDL
Sbjct: 4310 KPQWMAQLGELAKQWLQLLPKEIVKMRRTVENIKDPLFRFFEREVNLGSQLLKDIRRDLN 4369
Query: 238 DVAEVCKGAKKPTNHHRSMMADLAKGIIPKTWVRYAIPPGLTVIQWIQDFADRVKQLISI 417
+++ VC+ KK N R++ A L KG +P W RY +P +TV+ W+ D +R+KQLI I
Sbjct: 4370 EISAVCRAEKKQNNETRALAASLQKGEVPTGWKRYTVpreVTVMDWMTDLNERLKQLIRI 4429
Query: 418 SDTAAKSGVSALRDSKVWLGGLFMAEAYITATRQSVAQANKWALEELFLDVELGDGKVDG 597
G L+ WLGG F EAYITATRQ VAQAN W+LE+L L + + G+ D
Sbjct: 4430 ------GGADNLKRETFWLGGTFSPEAYITATRQQVAQANTWSLEQLNLHIHI--GRTDS 4481
Query: 598 NTCV-VTGLRLMGSEIVDSRTLKLSTLIYKDIDICRLKWIRVEKSQQLLDASSVSKDKVC 774
++G+ + G++ V L+L L+ + DI W Q + D +
Sbjct: 4482 TDVFRISGIDIRGAKSVGGNKLELCELVKSECDIVEFSW-----KQDVADGTR------- 4529
Query: 775 LPIYLNAARSTVLFTLYFN 831
LP+YL R ++ L F+
Sbjct: 4530 LPLYLYGDRRQLISPLAFH 4548
>sp|P34036|DYHC_DICDI Dynein heavy chain, cytosolic (DYHC)
Length = 4725
Score = 169 bits (429), Expect = 7e-42
Identities = 98/253 (38%), Positives = 152/253 (60%), Gaps = 2/253 (0%)
Frame = +1
Query: 100 WLQILPKSVTPLQRTSENIKDPMYRCFEREVNSGCNLLIAVRRDLEDVAEVCKGAKKPTN 279
W ++LPK + L+RT++NIKDP++RCFERE+++G L+ + DL ++ E+ G K TN
Sbjct: 4468 WTKLLPKPLKQLKRTTQNIKDPLFRCFEREISTGGKLVKKITNDLANLLELISGNIKSTN 4527
Query: 280 HHRSMMADLAKGIIPKTWVRYAIPPGLTVIQWIQDFADRVKQLISISDTAAKSGVSALRD 459
+ RS+ ++KGI+PK W Y++P +++ WI DF+ R++QL IS+++ S +
Sbjct: 4528 YLRSLTTSISKGIVPKEWKWYSVPETISLSVWISDFSKRMQQLSEISESSDYSSI----- 4582
Query: 460 SKVWLGGLFMAEAYITATRQSVAQANKWALEELFLDV-ELGDGKVDGNTCV-VTGLRLMG 633
+VWLGGL EAYITATRQS +Q N W+LE L L LG +G V G+ L G
Sbjct: 4583 -QVWLGGLLNPEAYITATRQSASQLNGWSLENLRLHASSLGKISSEGGASFNVKGMALEG 4641
Query: 634 SEIVDSRTLKLSTLIYKDIDICRLKWIRVEKSQQLLDASSVSKDKVCLPIYLNAARSTVL 813
+ + ++ L + ++ I I L W +K + + SS K+ +P+YLN RS +L
Sbjct: 4642 A-VWNNDQLTPTDILSTPISIATLTW--KDKDDPIFNNSS---SKLSVPVYLNETRSELL 4695
Query: 814 FTLYFNTTDLSYD 852
F++ DL YD
Sbjct: 4696 FSI-----DLPYD 4703
>sp|Q27171|DYHC_PARTE Dynein heavy chain, cytosolic (DYHC) (DHC08)
Length = 4540
Score = 152 bits (385), Expect = 9e-37
Identities = 85/256 (33%), Positives = 143/256 (55%), Gaps = 4/256 (1%)
Frame = +1
Query: 67 WMRQLYQSTQTWLQILPKSVTPLQRTSENIKDPMYRCFEREVNSGCNLLIAVRRDLEDVA 246
W++ L + + + ILP ++PL+RT+++I DP++R +RE+ LL AVR+++E++
Sbjct: 4278 WLQDLLEKVEKFKAILPNKISPLERTADSINDPLFRFLDREITVASKLLKAVRQNIEELI 4337
Query: 247 EVCKGAKKPTNHHRSMMADLAKGIIPKTWVRYAIPPGLTVIQWIQDFADRVKQLISISDT 426
++ +G TN R + D+ I+P W +Y + + + W+ DF R+ Q + T
Sbjct: 4338 QLAQGKILATNILRQLAKDVFNNIVPAQWNKYNVIT-MPLNDWVGDFKRRIDQFDLLGKT 4396
Query: 427 AAKSGVSALRDSKVWLGGLFMAEAYITATRQSVAQANKWALEELFLDVELGDGKVDGNTC 606
+ +VW GGL EAY+TATRQ VAQANKW+LEEL L + D +D ++
Sbjct: 4397 ------KDFQKGQVWFGGLLFPEAYLTATRQYVAQANKWSLEELELQMIPEDQGIDEDSF 4450
Query: 607 VVTGLRLMGSEIVDSRTLKLSTLIYKDIDIC----RLKWIRVEKSQQLLDASSVSKDKVC 774
V+ G+ + G + DS+TL++ I +I + LKW + + V D++
Sbjct: 4451 VIEGVSMEGGHL-DSKTLQVR--IVNEISVALKPITLKWCKTSQK------GVVGDDEIV 4501
Query: 775 LPIYLNAARSTVLFTL 822
LP+YLN R ++F+L
Sbjct: 4502 LPVYLNKTRKNLIFSL 4517
>sp|Q9NYC9|DYH9_HUMAN Ciliary dynein heavy chain 9 (Axonemal beta dynein heavy chain 9)
Length = 4486
Score = 62.4 bits (150), Expect = 2e-09
Identities = 34/119 (28%), Positives = 62/119 (52%)
Frame = +1
Query: 220 VRRDLEDVAEVCKGAKKPTNHHRSMMADLAKGIIPKTWVRYAIPPGLTVIQWIQDFADRV 399
++R L ++ KG T+H ++ L ++P++W R A P + W D +R+
Sbjct: 4269 IQRSLRELELGLKGELTMTSHMENLQNALYFDMVPESWARRAYPSTAGLAAWFPDLLNRI 4328
Query: 400 KQLISISDTAAKSGVSALRDSKVWLGGLFMAEAYITATRQSVAQANKWALEELFLDVEL 576
K+L A +G + S VWL G F ++++TA QS A+ N+W L+++ L ++
Sbjct: 4329 KEL------EAWTGDFTM-PSTVWLTGFFNPQSFLTAIMQSTARKNEWPLDQIALQCDM 4380
>sp|P23098|DYHC_TRIGR Dynein beta chain, ciliary
Length = 4466
Score = 60.5 bits (145), Expect = 6e-09
Identities = 36/119 (30%), Positives = 58/119 (48%)
Frame = +1
Query: 220 VRRDLEDVAEVCKGAKKPTNHHRSMMADLAKGIIPKTWVRYAIPPGLTVIQWIQDFADRV 399
+RR L+++ KG T + L IP TWV+ A P + W D R+
Sbjct: 4249 IRRSLKELDLGLKGELTITPDMEDLSNALFLDQIPATWVKRAYPSLFGLTSWYADLLQRI 4308
Query: 400 KQLISISDTAAKSGVSALRDSKVWLGGLFMAEAYITATRQSVAQANKWALEELFLDVEL 576
K+L + A V VWLGG F ++++TA QS+A+ N+W L+++ L ++
Sbjct: 4309 KELEQWTADFALPNV-------VWLGGFFNPQSFLTAIMQSMARKNEWPLDKMCLQCDV 4360
>sp|P39057|DYHC_ANTCR Dynein beta chain, ciliary
Length = 4466
Score = 58.2 bits (139), Expect = 3e-08
Identities = 35/119 (29%), Positives = 58/119 (48%)
Frame = +1
Query: 220 VRRDLEDVAEVCKGAKKPTNHHRSMMADLAKGIIPKTWVRYAIPPGLTVIQWIQDFADRV 399
+RR L+++ KG T + L IP +WV+ A P + W D R+
Sbjct: 4249 IRRSLKELDLGLKGELTITPDMEDLSNALFLDQIPASWVKRAYPSLFGLSAWYADLLQRI 4308
Query: 400 KQLISISDTAAKSGVSALRDSKVWLGGLFMAEAYITATRQSVAQANKWALEELFLDVEL 576
K+L + A V VWLGG F ++++TA QS+A+ N+W L+++ L ++
Sbjct: 4309 KELEQWTADFALPNV-------VWLGGFFNPQSFLTAIMQSMARKNEWPLDKMCLQCDV 4360
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,565,848
Number of Sequences: 369166
Number of extensions: 1934199
Number of successful extensions: 4721
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4557
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4706
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8486520240
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)