Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_I07
(783 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinas... 130 5e-30
sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinas... 129 1e-29
sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinas... 125 1e-28
sp|P27636|CDC15_YEAST Cell division control protein 15 124 3e-28
sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (S... 115 1e-25
sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinas... 115 2e-25
sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24 114 2e-25
sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinas... 114 3e-25
sp|Q01389|BCK1_YEAST Serine/threonine-protein kinase BCK1/S... 113 5e-25
sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinas... 113 5e-25
>sp|Q9FZ36|M3K2_ARATH Mitogen-activated protein kinase kinase kinase 2 (Arabidospsis
NPK1-related protein kinase 2)
Length = 651
Score = 130 bits (326), Expect = 5e-30
Identities = 81/222 (36%), Positives = 121/222 (54%), Gaps = 1/222 (0%)
Frame = +3
Query: 15 LKKLMVEFSIYEKLGDHPRILKCNGFFRSVKASYIKLDYMANGSLRSWLHKNGAQKEPSI 194
+++L E + + L HP I++ G R + I L+++ GS+ S L K GA E +
Sbjct: 115 IQELEEEVKLLKNLS-HPNIVRYLGTVREDETLNILLEFVPGGSISSLLEKFGAFPESVV 173
Query: 195 IRFSKQILEALDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHV 374
++ Q+L L++LH+ I+HRD+KG IL+DN IKL F ++K + ++ +
Sbjct: 174 RTYTNQLLLGLEYLHNHAIMHRDIKGANILVDNQGCIKLADFGASKQVAELATIS----G 229
Query: 375 AESNHGTANWTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLF-FLASFQAIYRLGTQ 551
A+S GT W APEVI G+ SADIWS G ++E++TGKAP AI+ +GT
Sbjct: 230 AKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEIAAIFHIGTT 289
Query: 552 KKIEFAYPLKCSDALKSFVDPCLDPEPLNRPTVKDLMKHEFL 677
K P S F+ CL EP RPT +L+KH F+
Sbjct: 290 KS-HPPIPDNISSDANDFLLKCLQQEPNLRPTASELLKHPFV 330
>sp|O22040|M3K1_ARATH Mitogen-activated protein kinase kinase kinase 1 (Arabidospsis
NPK1-related protein kinase 1)
Length = 666
Score = 129 bits (323), Expect = 1e-29
Identities = 92/255 (36%), Positives = 135/255 (52%), Gaps = 1/255 (0%)
Frame = +3
Query: 15 LKKLMVEFSIYEKLGDHPRILKCNGFFRSVKASYIKLDYMANGSLRSWLHKNGAQKEPSI 194
+++L E + + L HP I++ G R I L+++ GS+ S L K G E +
Sbjct: 116 IQELEEEVKLLKNLS-HPNIVRYLGTVREDDTLNILLEFVPGGSISSLLEKFGPFPESVV 174
Query: 195 IRFSKQILEALDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHV 374
+++Q+L L++LH+ I+HRD+KG IL+DN IKL F ++K + ++ T
Sbjct: 175 RTYTRQLLLGLEYLHNHAIMHRDIKGANILVDNKGCIKLADFGASKQVAELATMT----G 230
Query: 375 AESNHGTANWTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLF-FLASFQAIYRLGTQ 551
A+S GT W APEVI G+ SADIWS G ++E++TGKAP AI+ +GT
Sbjct: 231 AKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMVTGKAPWSQQYKEVAAIFFIGTT 290
Query: 552 KKIEFAYPLKCSDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNSAMEAD*FT*RVDIFSW 731
K SDA K F+ CL P RPT +L+KH F+ + T D+ S
Sbjct: 291 KSHPPIPDTLSSDA-KDFLLKCLQEVPNLRPTASELLKHPFVMGKHKESAST---DLGSV 346
Query: 732 IN*NNTYMLPK*INN 776
+N N + LP INN
Sbjct: 347 LN-NLSTPLPLQINN 360
>sp|O22042|M3K3_ARATH Mitogen-activated protein kinase kinase kinase 3 (Arabidospsis
NPK1-related protein kinase 3)
Length = 651
Score = 125 bits (315), Expect = 1e-28
Identities = 78/222 (35%), Positives = 122/222 (54%), Gaps = 1/222 (0%)
Frame = +3
Query: 15 LKKLMVEFSIYEKLGDHPRILKCNGFFRSVKASYIKLDYMANGSLRSWLHKNGAQKEPSI 194
+++L E + + L HP I++ G R + I ++++ GS+ S L K G+ EP I
Sbjct: 115 IRELEEEVQLLKNLS-HPNIVRYLGTVRESDSLNILMEFVPGGSISSLLEKFGSFPEPVI 173
Query: 195 IRFSKQILEALDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHV 374
I ++KQ+L L++LH+ I+HRD+KG IL+DN I+L F ++K + ++ +
Sbjct: 174 IMYTKQLLLGLEYLHNNGIMHRDIKGANILVDNKGCIRLADFGASKKVVELATV----NG 229
Query: 375 AESNHGTANWTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLF-FLASFQAIYRLGTQ 551
A+S GT W APEVI G+ SADIWS G ++E+ TGK P F A+ +G +
Sbjct: 230 AKSMKGTPYWMAPEVILQTGHSFSADIWSVGCTVIEMATGKPPWSEQYQQFAAVLHIG-R 288
Query: 552 KKIEFAYPLKCSDALKSFVDPCLDPEPLNRPTVKDLMKHEFL 677
K P S K F+ CL EP R + +L++H F+
Sbjct: 289 TKAHPPIPEDLSPEAKDFLMKCLHKEPSLRLSATELLQHPFV 330
>sp|P27636|CDC15_YEAST Cell division control protein 15
Length = 974
Score = 124 bits (311), Expect = 3e-28
Identities = 77/227 (33%), Positives = 111/227 (48%), Gaps = 1/227 (0%)
Frame = +3
Query: 6 DEELKKLMVEFSIYEKLGDHPRILKCNGFFRSVKASYIKLDYMANGSLRSWLHKNGAQ-K 182
DEEL +M E S+ + L +H I+K +GF R YI L+Y ANGSLR + ++
Sbjct: 61 DEELNDIMAEISLLKNL-NHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLS 119
Query: 183 EPSIIRFSKQILEALDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETF 362
E + Q L L +LH + ++HRD+K ILL + +KL F T
Sbjct: 120 ENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADF---------GVSTI 170
Query: 363 RNHVAESNHGTANWTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRL 542
N A + GT NW APE++ G + +DIWS GA +VE++T P L Y +
Sbjct: 171 VNSSALTLAGTLNWMAPEILGNRGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAV 230
Query: 543 GTQKKIEFAYPLKCSDALKSFVDPCLDPEPLNRPTVKDLMKHEFLNS 683
+ + P S+ LK F+ C RPT L+KH ++NS
Sbjct: 231 ---ENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLLKHVWINS 274
>sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (STE20-like kinase MST3) (MST-3)
(Mammalian STE20-like protein kinase 3)
Length = 443
Score = 115 bits (288), Expect = 1e-25
Identities = 74/226 (32%), Positives = 113/226 (50%), Gaps = 2/226 (0%)
Frame = +3
Query: 6 DEELKKLMVEFSIYEKLGDHPRILKCNGFFRSVKASYIKLDYMANGSLRSWLHKNGAQKE 185
++E++ + E ++ + D P + K G + +I ++Y+ GS L G E
Sbjct: 73 EDEIEDIQQEITVLSQC-DSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDE 130
Query: 186 PSIIRFSKQILEALDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFR 365
I ++IL+ LD+LHS+ +HRD+K +LL + ++KL F A D + R
Sbjct: 131 TQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK--R 188
Query: 366 NHVAESNHGTANWTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRL- 542
N GT W APEVI Y S ADIWS G +EL G+ P L + ++ +
Sbjct: 189 NTFV----GTPFWMAPEVIKQSAYDSKADIWSLGITAIELARGEPPHSELHPMKVLFLIP 244
Query: 543 -GTQKKIEFAYPLKCSDALKSFVDPCLDPEPLNRPTVKDLMKHEFL 677
+E Y S LK FV+ CL+ EP RPT K+L+KH+F+
Sbjct: 245 KNNPPTLEGNY----SKPLKEFVEACLNKEPSFRPTAKELLKHKFI 286
>sp|Q99759|M3K3_HUMAN Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 115 bits (287), Expect = 2e-25
Identities = 77/225 (34%), Positives = 119/225 (52%), Gaps = 3/225 (1%)
Frame = +3
Query: 9 EELKKLMVEFSIYEKLGDHPRILKCNGFFR--SVKASYIKLDYMANGSLRSWLHKNGAQK 182
+E+ L E + + L H RI++ G R + K I ++YM GS++ L GA
Sbjct: 404 KEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALT 462
Query: 183 EPSIIRFSKQILEALDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPD-ASSET 359
E ++++QILE + +LHS I+HRD+KG IL D+ ++KL F ++K S T
Sbjct: 463 ESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGT 522
Query: 360 FRNHVAESNHGTANWTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYR 539
V GT W +PEVI+GEGYG AD+WS G +VE++T K P + AI++
Sbjct: 523 GMRSVT----GTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFK 578
Query: 540 LGTQKKIEFAYPLKCSDALKSFVDPCLDPEPLNRPTVKDLMKHEF 674
+ TQ P S+ + F+ + E RP+ ++L+ H F
Sbjct: 579 IATQ-PTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHF 621
>sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24
Length = 431
Score = 114 bits (286), Expect = 2e-25
Identities = 74/226 (32%), Positives = 113/226 (50%), Gaps = 2/226 (0%)
Frame = +3
Query: 6 DEELKKLMVEFSIYEKLGDHPRILKCNGFFRSVKASYIKLDYMANGSLRSWLHKNGAQKE 185
++E++ + E ++ + D P + K G + +I ++Y+ GS L G E
Sbjct: 61 EDEIEDIQQEITVLSQC-DSPYVTKYYGSYLKDTKLWIIMEYLGGGSALDLLEP-GPLDE 118
Query: 186 PSIIRFSKQILEALDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFR 365
I ++IL+ LD+LHS+ +HRD+K +LL + ++KL F A D + R
Sbjct: 119 IQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAGQLTDTQIK--R 176
Query: 366 NHVAESNHGTANWTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRL- 542
N GT W APEVI Y S ADIWS G +EL G+ P L + ++ +
Sbjct: 177 NTFV----GTPFWMAPEVIKQSAYDSKADIWSLGITAIELAKGEPPHSELHPMKVLFLIP 232
Query: 543 -GTQKKIEFAYPLKCSDALKSFVDPCLDPEPLNRPTVKDLMKHEFL 677
+E Y S LK FV+ CL+ EP RPT K+L+KH+F+
Sbjct: 233 KNNPPTLEGNY----SKPLKEFVEACLNKEPSFRPTAKELLKHKFI 274
>sp|Q61084|M3K3_MOUSE Mitogen-activated protein kinase kinase kinase 3 (MAPK/ERK kinase
kinase 3) (MEK kinase 3) (MEKK 3)
Length = 626
Score = 114 bits (285), Expect = 3e-25
Identities = 75/224 (33%), Positives = 118/224 (52%), Gaps = 2/224 (0%)
Frame = +3
Query: 9 EELKKLMVEFSIYEKLGDHPRILKCNGFFR--SVKASYIKLDYMANGSLRSWLHKNGAQK 182
+E+ L E + + L H RI++ G R + K I ++YM GS++ L GA
Sbjct: 404 KEVSALECEIQLLKNL-QHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALT 462
Query: 183 EPSIIRFSKQILEALDFLHSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETF 362
E ++++QILE + +LHS I+HRD+KG IL D+ ++KL F ++K +
Sbjct: 463 ESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRL---QTICM 519
Query: 363 RNHVAESNHGTANWTAPEVINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRL 542
S GT W +PEVI+GEGYG AD+WS G +VE++T K P + AI+++
Sbjct: 520 SGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKI 579
Query: 543 GTQKKIEFAYPLKCSDALKSFVDPCLDPEPLNRPTVKDLMKHEF 674
TQ P S+ + F+ + E RP+ ++L+ H F
Sbjct: 580 ATQ-PTNPQLPSHISEHGRDFLRR-IFVEARQRPSAEELLTHHF 621
>sp|Q01389|BCK1_YEAST Serine/threonine-protein kinase BCK1/SLK1/SSP31
Length = 1478
Score = 113 bits (283), Expect = 5e-25
Identities = 69/210 (32%), Positives = 108/210 (51%), Gaps = 5/210 (2%)
Frame = +3
Query: 60 DHPRILKCNGFFRSVKASYIKLDYMANGSLRSWLHKNGAQKEPSIIRFSKQILEALDFLH 239
DH I++ GF + L+Y+A GS+ S + G EP I + Q+L+ L +LH
Sbjct: 1236 DHLNIVQYLGFENKNNIYSLFLEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLH 1295
Query: 240 SQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANWTAPEV 419
S+ ILHRD+K +LLD + K+ F ++ D S + + GT W APE+
Sbjct: 1296 SKGILHRDMKADNLLLDQDGICKISDFGISRKSKDIYSNS-----DMTMRGTVFWMAPEM 1350
Query: 420 IN-GEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKI----EFAYPLKC 584
++ +GY + DIWS G +++E+ GK P L A++++G K E PL
Sbjct: 1351 VDTKQGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVVAAMFKIGKSKSAPPIPEDTLPL-I 1409
Query: 585 SDALKSFVDPCLDPEPLNRPTVKDLMKHEF 674
S ++F+D C + P RPT +L+ H F
Sbjct: 1410 SQIGRNFLDACFEINPEKRPTANELLSHPF 1439
>sp|Q9Y2U5|M3K2_HUMAN Mitogen-activated protein kinase kinase kinase 2 (MAPK/ERK kinase
kinase 2) (MEK kinase 2) (MEKK 2)
Length = 618
Score = 113 bits (283), Expect = 5e-25
Identities = 72/208 (34%), Positives = 110/208 (52%), Gaps = 2/208 (0%)
Frame = +3
Query: 63 HPRILKCNGFFRSV--KASYIKLDYMANGSLRSWLHKNGAQKEPSIIRFSKQILEALDFL 236
H RI++ G R K I ++YM GS++ L GA E ++++QILE + +L
Sbjct: 414 HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENGTRKYTRQILEGVHYL 473
Query: 237 HSQNILHRDLKGPKILLDNNLDIKLCGFMSAKMFPDASSETFRNHVAESNHGTANWTAPE 416
HS ILHRD+KG IL D+ ++KL F ++K + +S GT W +PE
Sbjct: 474 HSNMILHRDIKGANILRDSTGNVKLGDFGASKRL---QTICLSGTGMKSVTGTPYWMSPE 530
Query: 417 VINGEGYGSSADIWSFGAVMVELITGKAPLFFLASFQAIYRLGTQKKIEFAYPLKCSDAL 596
VI+G+GYG ADIWS +VE++T K P + AI+++ TQ P SD
Sbjct: 531 VISGQGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQ-PTNPKLPPHVSDYT 589
Query: 597 KSFVDPCLDPEPLNRPTVKDLMKHEFLN 680
+ F+ L RP+ +L++H F++
Sbjct: 590 RDFLKRIFVEAKL-RPSADELLRHMFVH 616
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 97,126,349
Number of Sequences: 369166
Number of extensions: 2065152
Number of successful extensions: 8388
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6396
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6788
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7357347200
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)