Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_H09
(893 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6 54 5e-07
sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Int... 53 1e-06
sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2 49 2e-05
sp|Q91XL2|LNX2_MOUSE Ligand of Numb-protein X 2 (Numb-bindi... 47 6e-05
sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cys... 47 7e-05
sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tum... 46 2e-04
sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cys... 45 2e-04
sp|Q9R1A8|RFWD2_MOUSE Ring finger and WD repeat domain prot... 44 5e-04
sp|Q8N448|LNX2_HUMAN Ligand of Numb-protein X 2 (Numb-bindi... 44 6e-04
sp|Q8NHY2|RFWD2_HUMAN Ring finger and WD repeat domain prot... 44 8e-04
>sp|P70196|TRAF6_MOUSE TNF receptor-associated factor 6
Length = 530
Score = 54.3 bits (129), Expect = 5e-07
Identities = 31/102 (30%), Positives = 48/102 (47%)
Frame = +2
Query: 128 CIICKRLLINAYQSSCGCRYCHDCIENYLQNEKRICPGKMDECKELMININDVHVDHVAN 307
C IC L A Q+ CG R+C CI +++ CP E+++ N + D+ A
Sbjct: 70 CPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVD----NEILLE-NQLFPDNFAK 124
Query: 308 VKVSKIQVKCPEAFCQFSDELRKIEIHINSHQIKCPYFDIGC 433
++ + VKCP C ELR H+ HQ+ C + + C
Sbjct: 125 REILSLTVKCPNKGCLQKMELR----HLEDHQVHCEFALVNC 162
>sp|Q9Y4K3|TRAF6_HUMAN TNF receptor-associated factor 6 (Interleukin 1 signal transducer)
(RING finger protein 85)
Length = 522
Score = 52.8 bits (125), Expect = 1e-06
Identities = 31/102 (30%), Positives = 47/102 (46%)
Frame = +2
Query: 128 CIICKRLLINAYQSSCGCRYCHDCIENYLQNEKRICPGKMDECKELMININDVHVDHVAN 307
C IC L A Q+ CG R+C CI +++ CP E+++ N + D+ A
Sbjct: 70 CPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVD----NEILLE-NQLFPDNFAK 124
Query: 308 VKVSKIQVKCPEAFCQFSDELRKIEIHINSHQIKCPYFDIGC 433
++ + VKCP C ELR H+ HQ C + + C
Sbjct: 125 REILSLMVKCPNEGCLHKMELR----HLEDHQAHCEFALMDC 162
>sp|P39429|TRAF2_MOUSE TNF receptor-associated factor 2
Length = 501
Score = 48.5 bits (114), Expect = 2e-05
Identities = 33/125 (26%), Positives = 54/125 (43%), Gaps = 4/125 (3%)
Frame = +2
Query: 125 MCIICKRLLINAYQSSCGCRYCHDCIENYLQNEKRICPGKMDE-CKELMINI---NDVHV 292
+C CK +L +Q+ CG RYC C+ + L + + C + E E I+I +
Sbjct: 33 LCSACKNILRRPFQAQCGHRYCSFCLTSILSSGPQNCAACVYEGLYEEGISILESSSAFP 92
Query: 293 DHVANVKVSKIQVKCPEAFCQFSDELRKIEIHINSHQIKCPYFDIGCNKSGINCSNIVNH 472
D+ A +V + CP C + L++ E + H+ CP+ C C +V
Sbjct: 93 DNAARREVESLPAVCPNDGCTWKGTLKEYE---SCHEGLCPFLLTECPA----CKGLVRL 145
Query: 473 MTSEH 487
EH
Sbjct: 146 SEKEH 150
>sp|Q91XL2|LNX2_MOUSE Ligand of Numb-protein X 2 (Numb-binding protein 2)
Length = 687
Score = 47.4 bits (111), Expect = 6e-05
Identities = 33/116 (28%), Positives = 55/116 (47%), Gaps = 8/116 (6%)
Frame = +2
Query: 92 FNIEWKNYQDLMCIICKRLLINAYQSSCGCRYCHDCIENYLQNEKRICPGKMDE------ 253
+N + + DL+C IC + L+ + CG +CH C+ N+LQ EK CP +D
Sbjct: 39 YNYQGEVDDDLVCHICLQPLLQPLDTPCGHTFCHKCLRNFLQ-EKDFCP--LDRKRLHFK 95
Query: 254 -CKELMININDVHVDHVANVKVSKIQVKCP-EAFCQFSDELRKIEIHINSHQIKCP 415
CK+ I ++ + + K+ V CP CQ + +E H+ + +CP
Sbjct: 96 LCKKSSILVHKL---------LDKLLVLCPFSPVCQDVMQRCDLEAHLKN---RCP 139
>sp|Q61382|TRAF4_MOUSE TNF receptor-associated factor 4 (Cysteine-rich motif associated to
RING and Traf domains protein 1)
Length = 470
Score = 47.0 bits (110), Expect = 7e-05
Identities = 27/104 (25%), Positives = 56/104 (53%), Gaps = 6/104 (5%)
Frame = +2
Query: 122 LMCIICKRLLINAYQ-SSCGCRYCHDCIENYLQNEKRICPGKMDECKELMININDVHVDH 298
L+C +C + + ++ + S+CG RYC +C++ +L CP +L ++ ++ D
Sbjct: 16 LLCPLCGKPMRDSVEVSTCGHRYCDNCLQEFLSEGVFKCPE-----DQLPLDYAKIYPDP 70
Query: 299 VANVKVSKIQVKC--PEAFCQFSDELRKIEIHINS---HQIKCP 415
V+V + ++C E C++S LR ++ H+N+ + + CP
Sbjct: 71 ELEVQVLGLAIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVVPCP 114
>sp|Q12933|TRAF2_HUMAN TNF receptor-associated factor 2 (Tumor necrosis factor type 2
receptor-associated protein 3)
Length = 501
Score = 45.8 bits (107), Expect = 2e-04
Identities = 28/107 (26%), Positives = 49/107 (45%), Gaps = 4/107 (3%)
Frame = +2
Query: 125 MCIICKRLLINAYQSSCGCRYCHDCIENYLQNEKRICPGKMDE-CKELMINI---NDVHV 292
+C C+ +L +Q+ CG RYC C+ + L + + C + E E I+I +
Sbjct: 33 LCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILESSSAFP 92
Query: 293 DHVANVKVSKIQVKCPEAFCQFSDELRKIEIHINSHQIKCPYFDIGC 433
D+ A +V + CP C + L++ E + H+ +CP C
Sbjct: 93 DNAARREVESLPAVCPSDGCTWKGTLKEYE---SCHEGRCPLMLTEC 136
>sp|Q9BUZ4|TRAF4_HUMAN TNF receptor-associated factor 4 (Cysteine-rich domain associated
with RING and Traf domains protein 1) (Malignant 62)
(RING finger protein 83)
Length = 470
Score = 45.4 bits (106), Expect = 2e-04
Identities = 29/116 (25%), Positives = 58/116 (50%), Gaps = 6/116 (5%)
Frame = +2
Query: 86 YNFNIEWKNYQDLMCIICKRLLINAYQ-SSCGCRYCHDCIENYLQNEKRICPGKMDECKE 262
+++ K + L+C +C + + Q S+CG R+C C++ +L CP +
Sbjct: 4 FDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPE-----DQ 58
Query: 263 LMININDVHVDHVANVKVSKIQVKC--PEAFCQFSDELRKIEIHINS---HQIKCP 415
L ++ ++ D V+V + ++C E C++S LR ++ H+N+ + I CP
Sbjct: 59 LPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCP 114
>sp|Q9R1A8|RFWD2_MOUSE Ring finger and WD repeat domain protein 2 (Ubiquitin ligase
protein COP1) (Constitutive photomorphogenesis protein 1
homolog) (mCOP1)
Length = 733
Score = 44.3 bits (103), Expect = 5e-04
Identities = 49/255 (19%), Positives = 108/255 (42%)
Frame = +2
Query: 74 LLNKYNFNIEWKNYQDLMCIICKRLLINAYQSSCGCRYCHDCIENYLQNEKRICPGKMDE 253
LLN Y D +C IC ++ AY + CG +C+ CI L++ R CP +
Sbjct: 125 LLNSYE-----DKSNDFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNR-CP----K 174
Query: 254 CKELMININDVHVDHVANVKVSKIQVKCPEAFCQFSDELRKIEIHINSHQIKCPYFDIGC 433
C ++ NI+ ++ N V+++ +K + F + +L N H+ + +G
Sbjct: 175 CNYVVDNIDHLY----PNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDLLGT 230
Query: 434 NKSGINCSNIVNHMTSEHIPHATLLMDSIQNMKNEISCLREDLYKKDCFINITQTHMEKM 613
++ ++ +N+ L+++ + K ++ ++H ++
Sbjct: 231 DQDNLDLANV------------NLMLELLVQKKKQLE---------------AESHAAQL 263
Query: 614 KLENNNYYNTIELLRKNVNENQNLIRKLQGEMLMLTKDMKSIKNAQNKREVPVNPHLKKP 793
++ +++ R+N E + ++Q E+ +L +D+K ++ PV+ P
Sbjct: 264 QI----LMEFLKVARRNKREQ---LEQIQKELSVLEEDIKRVEEMSGLYS-PVSEDSTVP 315
Query: 794 SNLQGTSPSPTQVKV 838
Q +PSP+ +
Sbjct: 316 ---QFEAPSPSHSSI 327
>sp|Q8N448|LNX2_HUMAN Ligand of Numb-protein X 2 (Numb-binding protein 2) (PDZ
domain-containing RING finger protein 1)
Length = 690
Score = 43.9 bits (102), Expect = 6e-04
Identities = 33/115 (28%), Positives = 55/115 (47%), Gaps = 13/115 (11%)
Frame = +2
Query: 110 NYQ-----DLMCIICKRLLINAYQSSCGCRYCHDCIENYLQNEKRICPGKMDE------- 253
NYQ DL+C IC + L+ + CG +C+ C+ N+LQ EK CP +D
Sbjct: 39 NYQNEVDDDLVCHICLQPLLQPLDTPCGHTFCYKCLRNFLQ-EKDFCP--LDRKRLHFKL 95
Query: 254 CKELMININDVHVDHVANVKVSKIQVKCP-EAFCQFSDELRKIEIHINSHQIKCP 415
CK+ I ++ + + K+ V CP + C+ + +E H+ + +CP
Sbjct: 96 CKKSSILVHKL---------LDKLLVLCPFSSVCKDVMQRCDLEAHLKN---RCP 138
>sp|Q8NHY2|RFWD2_HUMAN Ring finger and WD repeat domain protein 2 (Ubiquitin ligase
protein COP1) (Constitutive photomorphogenesis protein 1
homolog) (hCOP1)
Length = 731
Score = 43.5 bits (101), Expect = 8e-04
Identities = 45/240 (18%), Positives = 104/240 (43%)
Frame = +2
Query: 119 DLMCIICKRLLINAYQSSCGCRYCHDCIENYLQNEKRICPGKMDECKELMININDVHVDH 298
D +C IC ++ AY + CG +C+ CI L++ R CP +C ++ NI+ ++
Sbjct: 133 DFVCPICFDMIEEAYMTKCGHSFCYKCIHQSLEDNNR-CP----KCNYVVDNIDHLY--- 184
Query: 299 VANVKVSKIQVKCPEAFCQFSDELRKIEIHINSHQIKCPYFDIGCNKSGINCSNIVNHMT 478
N V+++ +K + F + +L N H+ + +G ++ ++ +N+
Sbjct: 185 -PNFLVNELILKQKQRFEEKRFKLDHSVSSTNGHRWQIFQDWLGTDQDNLDLANV----- 238
Query: 479 SEHIPHATLLMDSIQNMKNEISCLREDLYKKDCFINITQTHMEKMKLENNNYYNTIELLR 658
L+++ + K ++ ++H ++++ +++ R
Sbjct: 239 -------NLMLELLVQKKKQLE---------------AESHAAQLQI----LMEFLKVAR 272
Query: 659 KNVNENQNLIRKLQGEMLMLTKDMKSIKNAQNKREVPVNPHLKKPSNLQGTSPSPTQVKV 838
+N E + ++Q E+ +L +D+K ++ PV+ P Q +PSP+ +
Sbjct: 273 RNKREQ---LEQIQKELSVLEEDIKRVEEMSGLYS-PVSEDSTVP---QFEAPSPSHSSI 325
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 89,918,385
Number of Sequences: 369166
Number of extensions: 1818259
Number of successful extensions: 6611
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6007
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6568
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8982382310
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)