Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_G22
(763 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9ULA0|DNPEP_HUMAN Aspartyl aminopeptidase 253 4e-67
sp|Q9Z2W0|DNPEP_MOUSE Aspartyl aminopeptidase 247 2e-65
sp|Q19087|DNPEP_CAEEL Putative aspartyl aminopeptidase 214 2e-55
sp|O36014|DNPEP_SCHPO Putative aspartyl aminopeptidase 205 9e-53
sp|P38821|DNPEP_YEAST Putative aspartyl aminopeptidase 187 2e-47
sp|Q87YC5|APEB_PSESM Probable M18-family aminopeptidase 2 181 1e-45
sp|Q9HYZ3|APEB_PSEAE Probable M18-family aminopeptidase 2 179 9e-45
sp|Q88M44|APEB_PSEPK Probable M18-family aminopeptidase 2 172 9e-43
sp|Q50022|APEB_MYCLE Probable M18-family aminopeptidase 2 148 2e-35
sp|P59951|APEB_MYCBO Probable M18-family aminopeptidase 2 145 2e-34
>sp|Q9ULA0|DNPEP_HUMAN Aspartyl aminopeptidase
Length = 475
Score = 253 bits (646), Expect = 4e-67
Identities = 123/233 (52%), Positives = 173/233 (74%), Gaps = 3/233 (1%)
Frame = +2
Query: 5 QPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLE---SVSDDTNIRAVCLFDNEEIGS 175
QP+ +GG + EF+FAPRLDNL +C+ ++QAL++S S++ + ++R V L+DNEE+GS
Sbjct: 246 QPAVLGGAYDEFIFAPRLDNLHSCFCALQALIDSCAGPGSLATEPHVRMVTLYDNEEVGS 305
Query: 176 QSAQGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISADQAHGVHPNYEEKH 355
+SAQGAQS TEL+LRR+ + CQ+ + +E AI S +ISAD AH VHPNY +KH
Sbjct: 306 ESAQGAQSLLTELVLRRI-SASCQHP-----TAFEEAIPKSFMISADMAHAVHPNYLDKH 359
Query: 356 ERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVVRQDMACGSTIGP 535
E H+PL H+G V+K+NS QRYASNA++ +++REVANK +VPLQ+ +VR D CG+TIGP
Sbjct: 360 EENHRPLFHKGPVIKVNSKQRYASNAVSEALIREVANKVKVPLQDLMVRNDTPCGTTIGP 419
Query: 536 IMSANMGLATVDVGGPQLSMHSCREMTDVSSVEQAVHLFKGFFNLYPDLSRRV 694
I+++ +GL +D+G PQL+MHS REM + V Q + LFKGFF L+P LS +
Sbjct: 420 ILASRLGLRVLDLGSPQLAMHSIREMACTTGVLQTLTLFKGFFELFPSLSHNL 472
>sp|Q9Z2W0|DNPEP_MOUSE Aspartyl aminopeptidase
Length = 473
Score = 247 bits (631), Expect = 2e-65
Identities = 120/233 (51%), Positives = 168/233 (72%), Gaps = 3/233 (1%)
Frame = +2
Query: 5 QPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLES---VSDDTNIRAVCLFDNEEIGS 175
QP+ +GG ++EF+FAPRLDNL +C+ ++QAL++S S ++ D ++R V L+DNEE+GS
Sbjct: 244 QPAVLGGAYEEFIFAPRLDNLHSCFCALQALIDSCASPASLARDPHVRMVTLYDNEEVGS 303
Query: 176 QSAQGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISADQAHGVHPNYEEKH 355
+SAQGAQS TELILRR+ + + +E AI S +ISAD AH VHPNY +KH
Sbjct: 304 ESAQGAQSLLTELILRRI------SASPQRLTAFEEAIPKSFMISADMAHAVHPNYSDKH 357
Query: 356 ERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVVRQDMACGSTIGP 535
E H+P H+G V+K+NS QRYASNA++ S++REVA + VPLQ+ +VR D CG+TIGP
Sbjct: 358 EENHRPSFHKGPVIKVNSKQRYASNAVSESMIREVAGQVGVPLQDLMVRNDSPCGTTIGP 417
Query: 536 IMSANMGLATVDVGGPQLSMHSCREMTDVSSVEQAVHLFKGFFNLYPDLSRRV 694
I+++ +GL +D+G PQL+MHS RE + V Q + LFKGFF L+P +SR +
Sbjct: 418 ILASRLGLRVLDLGSPQLAMHSIRETACTTGVLQTLTLFKGFFELFPSVSRNL 470
>sp|Q19087|DNPEP_CAEEL Putative aspartyl aminopeptidase
Length = 470
Score = 214 bits (546), Expect = 2e-55
Identities = 110/220 (50%), Positives = 144/220 (65%), Gaps = 2/220 (0%)
Frame = +2
Query: 11 STIGGIHQEFVFAPRLDNLFNCYTSVQALVESL--ESVSDDTNIRAVCLFDNEEIGSQSA 184
+ I G+ EF+ RLDN YT++ L+ESL ES +D IR FDNEE+GS SA
Sbjct: 247 AAIVGMEDEFISGARLDNQVGTYTAISGLLESLTGESFKNDPQIRIAACFDNEEVGSDSA 306
Query: 185 QGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISADQAHGVHPNYEEKHERQ 364
GA S+FTE +LRR+ S + +E AI S+LISADQAH HPNY KHE
Sbjct: 307 MGASSSFTEFVLRRL-------SAGGSTTAFEEAIGKSMLISADQAHATHPNYSAKHEEN 359
Query: 365 HKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVVRQDMACGSTIGPIMS 544
H+P H G+V+K+N NQRYA+ + T + L++VA +++VPLQ VVR D CGST+GPI++
Sbjct: 360 HRPAFHGGVVVKVNVNQRYATTSTTHAALKQVAFEAQVPLQVVVVRNDSPCGSTVGPILA 419
Query: 545 ANMGLATVDVGGPQLSMHSCREMTDVSSVEQAVHLFKGFF 664
+GL TVDVG PQL+MHS RE D SS+ QA L+ F+
Sbjct: 420 TKLGLQTVDVGCPQLAMHSIREFADTSSIYQATTLYSTFY 459
>sp|O36014|DNPEP_SCHPO Putative aspartyl aminopeptidase
Length = 467
Score = 205 bits (522), Expect = 9e-53
Identities = 107/234 (45%), Positives = 157/234 (67%), Gaps = 2/234 (0%)
Frame = +2
Query: 5 QPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLE--SVSDDTNIRAVCLFDNEEIGSQ 178
+ + +GGIH+EFVF+PRLDNL + + QAL +SLE S+ +++ +R V FD+EEIGS
Sbjct: 238 EKARLGGIHEEFVFSPRLDNLGMTFCASQALTKSLENNSLDNESCVRVVPSFDHEEIGSV 297
Query: 179 SAQGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISADQAHGVHPNYEEKHE 358
SAQGA+S F +L+R IC+ G S S + ++ S L+SAD AH +HPNY ++E
Sbjct: 298 SAQGAESTFLPAVLQR----ICE-LGKES-SLFSISMVKSFLVSADMAHAMHPNYSSRYE 351
Query: 359 RQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVVRQDMACGSTIGPI 538
+ P ++G V+K+N+NQRY +N+ +L++VA ++VP+Q+FVVR D CGSTIGP
Sbjct: 352 NSNTPFLNKGTVIKVNANQRYTTNSAGIVLLKKVAQLADVPIQSFVVRNDSPCGSTIGPK 411
Query: 539 MSANMGLATVDVGGPQLSMHSCREMTDVSSVEQAVHLFKGFFNLYPDLSRRVTL 700
++A G+ T+D+G P LSMHSCREM E AV LF FF + +L ++ +
Sbjct: 412 LAAMTGMRTLDLGNPMLSMHSCREMCGSKDFEYAVVLFSSFFQNFANLEEKIII 465
>sp|P38821|DNPEP_YEAST Putative aspartyl aminopeptidase
Length = 490
Score = 187 bits (476), Expect = 2e-47
Identities = 105/236 (44%), Positives = 147/236 (62%), Gaps = 6/236 (2%)
Frame = +2
Query: 11 STIGGIHQEFVFAPRLDNLFNCYTSVQALVESLESVSD-DTNIRAVCLFDNEEIGSQSAQ 187
ST+GG + EFVF+ RLDNL +C+TS+ L + ++ D ++ IR + FD+EEIGS SAQ
Sbjct: 257 STLGGFNDEFVFSGRLDNLTSCFTSMHGLTLAADTEIDRESGIRLMACFDHEEIGSSSAQ 316
Query: 188 GAQSAFTELILRRVVNTICQNCGVASFSH-YERAI----ANSLLISADQAHGVHPNYEEK 352
GA S F IL R+ +I + G + AI A S +S+D AH VHPNY K
Sbjct: 317 GADSNFLPNILERL--SILKGDGSDQTKPLFHSAILETSAKSFFLSSDVAHAVHPNYANK 374
Query: 353 HERQHKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVVRQDMACGSTIG 532
+E QHKPL G V+KIN+NQRY +N+ +++ +A ++VPLQ FVV D CGSTIG
Sbjct: 375 YESQHKPLLGGGPVIKINANQRYMTNSPGLVLVKRLAEAAKVPLQLFVVANDSPCGSTIG 434
Query: 533 PIMSANMGLATVDVGGPQLSMHSCREMTDVSSVEQAVHLFKGFFNLYPDLSRRVTL 700
PI+++ G+ T+D+G P LSMHS RE + +E + LFK FF Y + + +
Sbjct: 435 PILASKTGIRTLDLGNPVLSMHSIRETGGSADLEFQIKLFKEFFERYTSIESEIVV 490
>sp|Q87YC5|APEB_PSESM Probable M18-family aminopeptidase 2
Length = 429
Score = 181 bits (460), Expect = 1e-45
Identities = 97/220 (44%), Positives = 137/220 (62%)
Frame = +2
Query: 5 QPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLESVSDDTNIRAVCLFDNEEIGSQSA 184
Q + + G++ +F+ RLDNL +C+ +QAL L + SD+T + VC D+EE+GS SA
Sbjct: 218 QSAAVVGLNGDFLAGARLDNLLSCFAGMQAL---LNTESDETAL-LVCT-DHEEVGSSSA 272
Query: 185 QGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISADQAHGVHPNYEEKHERQ 364
GA A E I++R++ S Y R I SLLISAD AHG+HPNY +KH+
Sbjct: 273 CGADGAMLEQIVQRLL---------PSSEDYVRTIQKSLLISADNAHGIHPNYADKHDAN 323
Query: 365 HKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVVRQDMACGSTIGPIMS 544
H P + G V+K+NSNQRYA+N+ T R + EVP+Q+FVVR DM CGSTIGPI +
Sbjct: 324 HGPKLNAGPVIKVNSNQRYATNSETAGFFRHLCMAEEVPVQSFVVRSDMGCGSTIGPITA 383
Query: 545 ANMGLATVDVGGPQLSMHSCREMTDVSSVEQAVHLFKGFF 664
+++G+ TVD+G P +MHS RE+ + V + F+
Sbjct: 384 SHLGIRTVDIGLPTFAMHSIRELAGSHDLAHLVKVLGAFY 423
>sp|Q9HYZ3|APEB_PSEAE Probable M18-family aminopeptidase 2
Length = 429
Score = 179 bits (453), Expect = 9e-45
Identities = 94/220 (42%), Positives = 132/220 (60%)
Frame = +2
Query: 5 QPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLESVSDDTNIRAVCLFDNEEIGSQSA 184
Q + + G++ EF+ RLDNL +C+ ++AL+ + D N VC D+EE+GS S
Sbjct: 218 QSAAVVGLNDEFIAGARLDNLLSCHAGLEALLNA----EGDENCILVCT-DHEEVGSCSH 272
Query: 185 QGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISADQAHGVHPNYEEKHERQ 364
GA F E +LRR++ + RAI SLL+SAD AHGVHPNY ++H+
Sbjct: 273 CGADGPFLEQVLRRLL---------PEGDAFSRAIQRSLLVSADNAHGVHPNYADRHDAN 323
Query: 365 HKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVVRQDMACGSTIGPIMS 544
H P + G V+KINSNQRYA+N+ T R + SEVP+Q+FV R DM CGSTIGPI +
Sbjct: 324 HGPALNGGPVIKINSNQRYATNSETAGFFRHLCQDSEVPVQSFVTRSDMGCGSTIGPITA 383
Query: 545 ANMGLATVDVGGPQLSMHSCREMTDVSSVEQAVHLFKGFF 664
+ +G+ TVD+G P +MHS RE+ + V + F+
Sbjct: 384 SQVGVRTVDIGLPTFAMHSIRELAGSHDLAHLVKVLGAFY 423
>sp|Q88M44|APEB_PSEPK Probable M18-family aminopeptidase 2
Length = 429
Score = 172 bits (436), Expect = 9e-43
Identities = 93/220 (42%), Positives = 134/220 (60%)
Frame = +2
Query: 5 QPSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLESVSDDTNIRAVCLFDNEEIGSQSA 184
Q + + G++ +F+ RLDNL +CY +QAL L + SD+T + VC D+EE+GS SA
Sbjct: 218 QDAALIGLNGDFIAGARLDNLLSCYAGLQAL---LAADSDETCV-LVCN-DHEEVGSCSA 272
Query: 185 QGAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISADQAHGVHPNYEEKHERQ 364
GA E L+R++ Y R + SL++SAD AHGVHPNY +KH+
Sbjct: 273 CGADGPMLEQTLQRLL---------PDGDTYVRTVQRSLMVSADNAHGVHPNYADKHDGN 323
Query: 365 HKPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVVRQDMACGSTIGPIMS 544
H P + G V+K+N+NQRYA+N+ T R + EVP+Q+FVVR DM CGSTIGPI +
Sbjct: 324 HGPKLNAGPVIKVNNNQRYATNSETAGFFRHLCMAEEVPVQSFVVRSDMGCGSTIGPITA 383
Query: 545 ANMGLATVDVGGPQLSMHSCREMTDVSSVEQAVHLFKGFF 664
+++G+ TVD+G P +MHS RE+ + V + F+
Sbjct: 384 SHLGVRTVDIGLPTFAMHSIRELCGSHDLAHLVKVLTAFY 423
>sp|Q50022|APEB_MYCLE Probable M18-family aminopeptidase 2
Length = 426
Score = 148 bits (373), Expect = 2e-35
Identities = 88/220 (40%), Positives = 118/220 (53%)
Frame = +2
Query: 8 PSTIGGIHQEFVFAPRLDNLFNCYTSVQALVESLESVSDDTNIRAVCLFDNEEIGSQSAQ 187
PS + G + APRLDN +CY ++AL L SV D + + LFD+EE+GS S +
Sbjct: 212 PSMVIGADANLLSAPRLDNQVSCYAGMEAL---LASVPHDC-LPVLALFDHEEVGSTSDR 267
Query: 188 GAQSAFTELILRRVVNTICQNCGVASFSHYERAIANSLLISADQAHGVHPNYEEKHERQH 367
GA+S +L R+V Y R + SLL+SAD AH HPNY E HE H
Sbjct: 268 GARSNLLSTVLERIVLA-----AGGGRDDYLRRLPASLLVSADMAHATHPNYPECHEPSH 322
Query: 368 KPLPHQGIVLKINSNQRYASNAMTTSILREVANKSEVPLQNFVVRQDMACGSTIGPIMSA 547
+ G VLK++ N RYA++ T + ++ V LQ + R D CGSTIGP+ SA
Sbjct: 323 LIEVNAGPVLKVHPNLRYATDGRTAAAFEVACQQAGVRLQRYEHRADRPCGSTIGPLASA 382
Query: 548 NMGLATVDVGGPQLSMHSCREMTDVSSVEQAVHLFKGFFN 667
G+ TVDVG QL+MHS RE+ V + FF+
Sbjct: 383 RTGIPTVDVGAAQLAMHSARELMGAHDVAVYSAALQAFFS 422
>sp|P59951|APEB_MYCBO Probable M18-family aminopeptidase 2
Length = 433
Score = 145 bits (365), Expect = 2e-34
Identities = 78/205 (38%), Positives = 115/205 (56%), Gaps = 3/205 (1%)
Frame = +2
Query: 47 APRLDNLFNCYTSVQALVESLESVSDDTNIRAVCLFDNEEIGSQSAQGAQSAFTELILRR 226
APRLDN +CY ++AL+ + + + +FD+EE+GS S GAQS +L R
Sbjct: 226 APRLDNQASCYAGMEALLAVDVDSASSGFVPVLAIFDHEEVGSASGHGAQSDLLSSVLER 285
Query: 227 VVNTICQNCGVASFSHYERAIANSLLISADQAHGVHPNYEEKHERQHKPLPHQGIVLKIN 406
+V + + R + S+L SAD AH HPNY ++HE H + G VLK++
Sbjct: 286 IVLA-----AGGTREDFLRRLTTSMLASADMAHATHPNYPDRHEPSHPIEVNAGPVLKVH 340
Query: 407 SNQRYASNAMTTSILREVANKSEVPLQNFVVRQDMACGSTIGPIMSANMGLATVDVGGPQ 586
N RYA++ T + ++ VP+Q + R D+ CGSTIGP+ +A G+ TVDVG Q
Sbjct: 341 PNLRYATDGRTAAAFALACQRAGVPMQRYEHRADLPCGSTIGPLAAARTGIPTVDVGAAQ 400
Query: 587 LSMHSCREMT---DVSSVEQAVHLF 652
L+MHS RE+ DV++ A+ F
Sbjct: 401 LAMHSARELMGAHDVAAYSAALQAF 425
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 90,628,287
Number of Sequences: 369166
Number of extensions: 1885404
Number of successful extensions: 4844
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4603
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4814
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7018522000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)