Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_G04
(852 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathe... 287 2e-77
sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) ... 286 4e-77
sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted ... 286 7e-77
sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathe... 283 4e-76
sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathe... 282 9e-76
sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precu... 278 1e-74
sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine protei... 278 1e-74
sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precu... 276 7e-74
sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Catheps... 271 2e-72
sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L hea... 270 3e-72
>sp|Q26636|CATL_SARPE Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 339
Score = 287 bits (735), Expect = 2e-77
Identities = 145/270 (53%), Positives = 181/270 (67%), Gaps = 9/270 (3%)
Frame = +1
Query: 1 IRHEVGLNQFADMTNEEFKAKYLG-------IMKTKPTLEGSTYMAPENIGVLPASVDWR 159
+ +++GLN++ADM + EFK G +M+ + L G+TY+ P ++ V P SVDWR
Sbjct: 71 VSYKLGLNKYADMLHHEFKETMNGYNHTLRQLMRERTGLVGATYIPPAHVTV-PKSVDWR 129
Query: 160 QKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXX 339
+ G VT VK+Q CGSCW+FS+TG+LEGQ+FRK L+S SEQ LVDCS
Sbjct: 130 EHGAVTGVKDQGHCGSCWAFSSTGALEGQHFRKAGVLVSLSEQNLVDCSTKYGNNGCNGG 189
Query: 340 LMDNAFRYIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVA 516
LMDNAFRYIKD G I++E YPY D +C N + I TGF DI +E + AVA
Sbjct: 190 LMDNAFRYIKDNGGIDTEKSYPYEGIDDSCHFNKATIGATDTGFVDIPEGDEEKMKKAVA 249
Query: 517 TVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSWD 693
T+GPVSVAIDA H SFQLY G+YNE C LDHGVL VGYGT + G YW+VKNSW
Sbjct: 250 TMGPVSVAIDASHESFQLYSEGVYNEPECDEQNLDHGVLVVGYGTDESGMDYWLVKNSWG 309
Query: 694 VTWGESGYIKMSKDKKNQCGIATMASYPLV 783
TWGE GYIKM++++ NQCGIAT +SYP V
Sbjct: 310 TTWGEQGYIKMARNQNNQCGIATASSYPTV 339
>sp|O60911|CATL2_HUMAN Cathepsin L2 precursor (Cathepsin V) (Cathepsin U)
Length = 334
Score = 286 bits (733), Expect = 4e-77
Identities = 143/262 (54%), Positives = 174/262 (66%), Gaps = 5/262 (1%)
Frame = +1
Query: 13 VGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQ 192
+ +N F DMTNEEF+ + +G + + +G + P + LP SVDWR+KGYVTPVKNQ
Sbjct: 75 MAMNAFGDMTNEEFR-QMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQ 132
Query: 193 QQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKD 372
+QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS M AF+Y+K+
Sbjct: 133 KQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKE 192
Query: 373 Q-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDA 549
G++SE YPY A D CK P V TGFT + E L AVATVGP+SVA+DA
Sbjct: 193 NGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDA 252
Query: 550 GHASFQLYKSGIYNEESCSTTQLDHGVLAVGYG----TQIGKKYWIVKNSWDVTWGESGY 717
GH+SFQ YKSGIY E CS+ LDHGVL VGYG KYW+VKNSW WG +GY
Sbjct: 253 GHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGY 312
Query: 718 IKMSKDKKNQCGIATMASYPLV 783
+K++KDK N CGIAT ASYP V
Sbjct: 313 VKIAKDKNNHCGIATAASYPNV 334
>sp|P07711|CATL_HUMAN Cathepsin L precursor (Major excreted protein) (MEP) [Contains:
Cathepsin L heavy chain; Cathepsin L light chain]
Length = 333
Score = 286 bits (731), Expect = 7e-77
Identities = 147/262 (56%), Positives = 173/262 (66%), Gaps = 5/262 (1%)
Frame = +1
Query: 13 VGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQ 192
+ +N F DMT+EEF+ G KP +G + P P SVDWR+KGYVTPVKNQ
Sbjct: 75 MAMNAFGDMTSEEFRQVMNGFQNRKPR-KGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQ 132
Query: 193 QQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKD 372
QCGSCW+FSATG+LEGQ FRK RLIS SEQ LVDCS LMD AF+Y++D
Sbjct: 133 GQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQD 192
Query: 373 Q-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAIDA 549
G++SE YPY AT+ +CK NP V TGF DI Q E L AVATVGP+SVAIDA
Sbjct: 193 NGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQ-EKALMKAVATVGPISVAIDA 251
Query: 550 GHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQI----GKKYWIVKNSWDVTWGESGY 717
GH SF YK GIY E CS+ +DHGVL VGYG + KYW+VKNSW WG GY
Sbjct: 252 GHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGY 311
Query: 718 IKMSKDKKNQCGIATMASYPLV 783
+KM+KD++N CGIA+ ASYP V
Sbjct: 312 VKMAKDRRNHCGIASAASYPTV 333
>sp|Q9GL24|CATL_CANFA Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 333
Score = 283 bits (724), Expect = 4e-76
Identities = 147/262 (56%), Positives = 171/262 (65%), Gaps = 5/262 (1%)
Frame = +1
Query: 13 VGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQ 192
+ +N F DMTNEEF+ G K +G + P +P SVDWR+KGYVTPVKNQ
Sbjct: 75 MAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKMFQEPL-FAEIPKSVDWREKGYVTPVKNQ 132
Query: 193 QQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKD 372
QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAFRY+KD
Sbjct: 133 GQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNEGCNGGLMDNAFRYVKD 192
Query: 373 Q-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAID 546
G++SE YPY D TC P TGF D+ Q E L AVAT+GP+SVAID
Sbjct: 193 NGGLDSEESYPYLGRDTETCNYKPECSAANDTGFVDL-PQREKALMKAVATLGPISVAID 251
Query: 547 AGHASFQLYKSGIYNEESCSTTQLDHGVLAVGY---GTQIGKKYWIVKNSWDVTWGESGY 717
AGH SFQ YKSGIY + CS+ LDHGVL VGY GT K+WIVKNSW WG +GY
Sbjct: 252 AGHQSFQFYKSGIYFDPDCSSKDLDHGVLVVGYGFEGTDSNNKFWIVKNSWGPEWGWNGY 311
Query: 718 IKMSKDKKNQCGIATMASYPLV 783
+KM+KD+ N CGIAT ASYP V
Sbjct: 312 VKMAKDQNNHCGIATAASYPTV 333
>sp|P25975|CATL_BOVIN Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 282 bits (721), Expect = 9e-76
Identities = 149/263 (56%), Positives = 172/263 (65%), Gaps = 6/263 (2%)
Frame = +1
Query: 13 VGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQ 192
+ +N F DMTNEEF+ G K +G + P + V P SVDW +KGYVTPVKNQ
Sbjct: 75 MAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKLFHEPLLVDV-PKSVDWTKKGYVTPVKNQ 132
Query: 193 QQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKD 372
QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+YIKD
Sbjct: 133 GQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRAQGNQGCNGGLMDNAFQYIKD 192
Query: 373 Q-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAID 546
G++SE YPY ATD +C P TGF DI Q E L AVATVGP+SVAID
Sbjct: 193 NGGLDSEESYPYLATDTNSCNYKPECSAANDTGFVDI-PQREKALMKAVATVGPISVAID 251
Query: 547 AGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGESG 714
AGH SFQ YKSGIY + CS LDHGVL VGYG + K+WIVKNSW WG +G
Sbjct: 252 AGHTSFQFYKSGIYYDPDCSCKDLDHGVLVVGYGFEGTDSNNNKFWIVKNSWGPEWGWNG 311
Query: 715 YIKMSKDKKNQCGIATMASYPLV 783
Y+KM+KD+ N CGIAT ASYP V
Sbjct: 312 YVKMAKDQNNHCGIATAASYPTV 334
>sp|P25784|CYSP3_HOMAM Digestive cysteine proteinase 3 precursor
Length = 321
Score = 278 bits (712), Expect = 1e-74
Identities = 140/262 (53%), Positives = 176/262 (67%), Gaps = 1/262 (0%)
Frame = +1
Query: 1 IRHEVGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTP 180
+ +V +NQF DMTNEEF A G K + + A G + A VDWR K VTP
Sbjct: 63 VTFKVAMNQFGDMTNEEFNAVMKGYKKGSRGEPKAVFTA--EAGPMAADVDWRTKALVTP 120
Query: 181 VKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFR 360
VK+Q+QCGSCW+FSATG+LEGQ+F KN+ L+S SEQQLVDCS M +AF
Sbjct: 121 VKDQEQCGSCWAFSATGALEGQHFLKNDELVSLSEQQLVDCSTDYGNDGCGGGWMTSAFD 180
Query: 361 YIKDQG-IESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSV 537
YIKD G I++E YPY A D +C+ + + I CTG ++Q E L AV+ VGP+SV
Sbjct: 181 YIKDNGGIDTESSYPYEAEDRSCRFDANSIGAICTGSVEVQHTEEA-LQEAVSGVGPISV 239
Query: 538 AIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGY 717
AIDA H SFQ Y SG+Y E++CS T LDHGVLAVGYGT+ K YW+VKNSW +WG++GY
Sbjct: 240 AIDASHFSFQFYSSGVYYEQNCSPTFLDHGVLAVGYGTESTKDYWLVKNSWGSSWGDAGY 299
Query: 718 IKMSKDKKNQCGIATMASYPLV 783
IKMS+++ N CGIA+ SYP V
Sbjct: 300 IKMSRNRDNNCGIASEPSYPTV 321
>sp|Q95029|CATL_DROME Cathepsin L precursor (Cysteine proteinase 1) [Contains: Cathepsin
L heavy chain; Cathepsin L light chain]
Length = 341
Score = 278 bits (711), Expect = 1e-74
Identities = 139/271 (51%), Positives = 180/271 (66%), Gaps = 10/271 (3%)
Frame = +1
Query: 1 IRHEVGLNQFADMTNEEFKAKYLGIMKT--------KPTLEGSTYMAPENIGVLPASVDW 156
+ ++ +N++AD+ + EF+ G T + +G T+++P ++ LP SVDW
Sbjct: 72 VSFKLAVNKYADLLHHEFRQLMNGFNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDW 130
Query: 157 RQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXX 336
R KG VT VK+Q CGSCW+FS+TG+LEGQ+FRK+ L+S SEQ LVDCS
Sbjct: 131 RTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNG 190
Query: 337 XLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAV 513
LMDNAFRYIKD GI++E YPY A D +C N + GFTDI +E +A AV
Sbjct: 191 GLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAV 250
Query: 514 ATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGT-QIGKKYWIVKNSW 690
ATVGPVSVAIDA H SFQ Y G+YNE C LDHGVL VG+GT + G+ YW+VKNSW
Sbjct: 251 ATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSW 310
Query: 691 DVTWGESGYIKMSKDKKNQCGIATMASYPLV 783
TWG+ G+IKM ++K+NQCGIA+ +SYPLV
Sbjct: 311 GTTWGDKGFIKMLRNKENQCGIASASSYPLV 341
>sp|P25782|CYSP2_HOMAM Digestive cysteine proteinase 2 precursor
Length = 323
Score = 276 bits (705), Expect = 7e-74
Identities = 134/262 (51%), Positives = 177/262 (67%), Gaps = 1/262 (0%)
Frame = +1
Query: 1 IRHEVGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTP 180
+ + +N+F DMT EEF A G + + + S + + G VDWR KG VTP
Sbjct: 63 VTFNLAMNKFGDMTLEEFNAVMKGNIPRR-SAPVSVFYPKKETGPQATEVDWRTKGAVTP 121
Query: 181 VKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFR 360
VK+Q QCGSCW+FS TGSLEGQ+F K LIS +EQQLVDCS M++AF
Sbjct: 122 VKDQGQCGSCWAFSTTGSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFD 181
Query: 361 YIK-DQGIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSV 537
YIK + GI++E YPY A DG+C+ + + + C+G T+I S +ET L AV +GP+SV
Sbjct: 182 YIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISV 241
Query: 538 AIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQIGKKYWIVKNSWDVTWGESGY 717
IDA H+SFQ Y SG+Y E SCS + LDH VLAVGYG++ G+ +W+VKNSW +WG++GY
Sbjct: 242 TIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGY 301
Query: 718 IKMSKDKKNQCGIATMASYPLV 783
IKMS+++ N CGIAT+ASYPLV
Sbjct: 302 IKMSRNRNNNCGIATVASYPLV 323
>sp|Q28944|CATL_PIG Cathepsin L precursor [Contains: Cathepsin L heavy chain; Cathepsin
L light chain]
Length = 334
Score = 271 bits (692), Expect = 2e-72
Identities = 142/263 (53%), Positives = 171/263 (65%), Gaps = 6/263 (2%)
Frame = +1
Query: 13 VGLNQFADMTNEEFKAKYLGIMKTKPTLEGSTYMAPENIGVLPASVDWRQKGYVTPVKNQ 192
+ +N F DMTNEEF+ G K +G + + V P SVDWR+KGYVT VKNQ
Sbjct: 75 MAMNAFGDMTNEEFRQVMNGFQNQKHK-KGKVFHESLVLEV-PKSVDWREKGYVTAVKNQ 132
Query: 193 QQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXXXXXXXXXXLMDNAFRYIKD 372
QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVDCS LMDNAF+Y+KD
Sbjct: 133 GQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGLMDNAFQYVKD 192
Query: 373 Q-GIESEGDYPYTATD-GTCKRNPSKIVTKCTGFTDIQSQNETDLANAVATVGPVSVAID 546
G+++E YPY + +C P TGF DI Q E L AVATVGP+SVAID
Sbjct: 193 NGGLDTEESYPYLGRETNSCTYKPECSAANDTGFVDI-PQREKALMKAVATVGPISVAID 251
Query: 547 AGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ----IGKKYWIVKNSWDVTWGESG 714
AGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K+WIVKNSW WG +G
Sbjct: 252 AGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTDSNSSKFWIVKNSWGPEWGWNG 311
Query: 715 YIKMSKDKKNQCGIATMASYPLV 783
Y+KM+KD+ N CGI+T ASYP V
Sbjct: 312 YVKMAKDQNNHCGISTAASYPTV 334
>sp|Q10991|CATL_SHEEP Cathepsin L [Contains: Cathepsin L heavy chain; Cathepsin L light
chain]
Length = 217
Score = 270 bits (691), Expect = 3e-72
Identities = 134/218 (61%), Positives = 154/218 (70%), Gaps = 2/218 (0%)
Frame = +1
Query: 136 LPASVDWRQKGYVTPVKNQQQCGSCWSFSATGSLEGQYFRKNNRLISFSEQQLVDCSXXX 315
+P SVDW +KGYVTPVKNQ QCGSCW+FSATG+LEGQ FRK +L+S SEQ LVD S
Sbjct: 1 VPKSVDWTKKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDSSRPQ 60
Query: 316 XXXXXXXXLMDNAFRYIKDQ-GIESEGDYPYTATDGTCKRNPSKIVTKCTGFTDIQSQNE 492
LMDNAF+YIK+ G++SE YPY ATD +C P K TGF DI Q E
Sbjct: 61 GNQGCNGGLMDNAFQYIKENGGLDSEESYPYEATDTSCNYKPEYSAAKDTGFVDI-PQRE 119
Query: 493 TDLANAVATVGPVSVAIDAGHASFQLYKSGIYNEESCSTTQLDHGVLAVGYGTQ-IGKKY 669
L AVATVGP+SVAIDAGH+SFQ YKSGIY + CS+ LDHGVL VGYG + K+
Sbjct: 120 KALMKAVATVGPISVAIDAGHSSFQFYKSGIYYDPDCSSKDLDHGVLVVGYGFEGTNNKF 179
Query: 670 WIVKNSWDVTWGESGYIKMSKDKKNQCGIATMASYPLV 783
WIVKNSW WG GY+KM+KD+ N CGIAT ASYP V
Sbjct: 180 WIVKNSWGPEWGNKGYVKMAKDQNNHCGIATAASYPTV 217
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 96,385,897
Number of Sequences: 369166
Number of extensions: 1923194
Number of successful extensions: 5868
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5111
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5291
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8390082510
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)