Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_E08
(869 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q96NX5|KCC1G_HUMAN Calcium/calmodulin-dependent protein ... 122 2e-27
sp|Q91VB2|KCC1G_MOUSE Calcium/calmodulin-dependent protein ... 119 1e-26
sp|Q7TNJ7|KCC1G_RAT Calcium/calmodulin-dependent protein ki... 119 1e-26
sp|O70405|ULK1_MOUSE Serine/threonine-protein kinase ULK1 (... 109 9e-24
sp|Q8IU85|KCC1D_HUMAN Calcium/calmodulin-dependent protein ... 108 2e-23
sp|Q8BW96|KCC1D_MOUSE Calcium/calmodulin-dependent protein ... 108 2e-23
sp|Q15139|KPCD1_HUMAN Protein kinase, D1 type (nPKC-D1) (Pr... 107 3e-23
sp|O94806|KPCN_HUMAN Protein kinase C, nu type (nPKC-nu) (P... 107 3e-23
sp|Q8ICR0|CDPK2_PLAF7 Calcium-dependent protein kinase 2 (P... 107 3e-23
sp|O15865|CDPK2_PLAFK Calcium-dependent protein kinase 2 (P... 107 3e-23
>sp|Q96NX5|KCC1G_HUMAN Calcium/calmodulin-dependent protein kinase type 1G (CaM kinase IG)
(CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI
gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III)
Length = 476
Score = 122 bits (305), Expect = 2e-27
Identities = 79/233 (33%), Positives = 116/233 (49%), Gaps = 27/233 (11%)
Frame = +1
Query: 7 TGKTVAIKVIKNFGF--DSDNERELDNLKKLSGENIVQLIDFIIKYNTAYLIMELCKGD- 177
TGK A+K IK DS E E+ LKK+ ENIV L D YL+M+L G
Sbjct: 45 TGKLFALKCIKKSPAFRDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGE 104
Query: 178 ----VSETGKLTGPKLKDFIQQTTTGLKIIHDKGMIHRDIKPQNILHVTKGKRTIYKLTD 345
+ E G T IQQ + +K +H+ G++HRD+KP+N+L++T + + +TD
Sbjct: 105 LFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 346 FGLSKMISRTHRMTKCGTPVFMAPEVAEGTEANSSADIWSLGITFCYMISG--------- 498
FGLSKM T CGTP ++APEV + + D WS+G+ ++ G
Sbjct: 165 FGLSKMEQNGIMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETE 224
Query: 499 -----DIKDLGYE------DKTKGDLKDLISKMVKEKFRERITVDQILSHPYL 624
IK+ YE D KD I ++++ ER T ++ LSHP++
Sbjct: 225 SKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWI 277
>sp|Q91VB2|KCC1G_MOUSE Calcium/calmodulin-dependent protein kinase type 1G (CaM kinase IG)
(CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI
gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III)
Length = 477
Score = 119 bits (297), Expect = 1e-26
Identities = 77/233 (33%), Positives = 115/233 (49%), Gaps = 27/233 (11%)
Frame = +1
Query: 7 TGKTVAIKVIKNFGF--DSDNERELDNLKKLSGENIVQLIDFIIKYNTAYLIMELCKGD- 177
TGK A+K IK DS E E+ LK++ ENIV L D YL+M+L G
Sbjct: 45 TGKLFALKCIKKSPAFRDSSLENEIAVLKRIKHENIVTLEDIYESTTHYYLVMQLVSGGE 104
Query: 178 ----VSETGKLTGPKLKDFIQQTTTGLKIIHDKGMIHRDIKPQNILHVTKGKRTIYKLTD 345
+ E G T IQQ + +K +H+ G++HRD+KP+N+L++T + + +TD
Sbjct: 105 LFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 346 FGLSKMISRTHRMTKCGTPVFMAPEVAEGTEANSSADIWSLGITFCYMISG--------- 498
FGLSKM T CGTP ++APEV + + D WS+G+ ++ G
Sbjct: 165 FGLSKMEQNGVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETE 224
Query: 499 -----DIKDLGYE------DKTKGDLKDLISKMVKEKFRERITVDQILSHPYL 624
IK+ YE D KD I ++++ ER T ++ L HP++
Sbjct: 225 SKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALRHPWI 277
>sp|Q7TNJ7|KCC1G_RAT Calcium/calmodulin-dependent protein kinase type 1G (CaM kinase IG)
(CaM kinase I gamma) (CaMKI gamma) (CaMKI-gamma) (CaM-KI
gamma) (CaMKIG) (CaMK-like CREB kinase III) (CLICK III)
Length = 476
Score = 119 bits (297), Expect = 1e-26
Identities = 77/233 (33%), Positives = 115/233 (49%), Gaps = 27/233 (11%)
Frame = +1
Query: 7 TGKTVAIKVIKNFGF--DSDNERELDNLKKLSGENIVQLIDFIIKYNTAYLIMELCKGD- 177
TGK A+K IK DS E E+ LK++ ENIV L D YL+M+L G
Sbjct: 45 TGKLFALKCIKKSPAFRDSSLENEIAVLKRIKHENIVTLEDIYESTTHYYLVMQLVSGGE 104
Query: 178 ----VSETGKLTGPKLKDFIQQTTTGLKIIHDKGMIHRDIKPQNILHVTKGKRTIYKLTD 345
+ E G T IQQ + +K +H+ G++HRD+KP+N+L++T + + +TD
Sbjct: 105 LFDRILERGVYTEKDASLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITD 164
Query: 346 FGLSKMISRTHRMTKCGTPVFMAPEVAEGTEANSSADIWSLGITFCYMISG--------- 498
FGLSKM T CGTP ++APEV + + D WS+G+ ++ G
Sbjct: 165 FGLSKMEQNGVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETE 224
Query: 499 -----DIKDLGYE------DKTKGDLKDLISKMVKEKFRERITVDQILSHPYL 624
IK+ YE D KD I ++++ ER T ++ L HP++
Sbjct: 225 SKLFEKIKEGYYEFESPFWDDISESAKDFICHLLEKDPNERYTCEKALRHPWI 277
>sp|O70405|ULK1_MOUSE Serine/threonine-protein kinase ULK1 (Unc-51-like kinase 1)
(Serine/threonine-protein kinase Unc51.1)
Length = 1051
Score = 109 bits (273), Expect = 9e-24
Identities = 71/218 (32%), Positives = 112/218 (51%), Gaps = 32/218 (14%)
Frame = +1
Query: 67 RELDNLKKLSGENIVQLIDFIIKYNTAYLIMELCKG----DVSETGK-LTGPKLKDFIQQ 231
+E+ LK+L ENIV L DF N+ YL+ME C G D T + L+ ++ F+QQ
Sbjct: 62 KEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHTMRTLSEDTVRLFLQQ 121
Query: 232 TTTGLKIIHDKGMIHRDIKPQNILHVTKGKRTI------YKLTDFGLSKMI-SRTHRMTK 390
++++H KG+IHRD+KPQNIL G R K+ DFG ++ + S T
Sbjct: 122 IAGAMRLLHSKGIIHRDLKPQNILLSNPGGRRANPSNIRVKIADFGFARYLQSNMMAATL 181
Query: 391 CGTPVFMAPEVAEGTEANSSADIWSLGITFCYMISG----------DIKDLGYED----- 525
CG+P++MAPEV + AD+WS+G ++G D++ L YE
Sbjct: 182 CGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLR-LFYEKNKTLV 240
Query: 526 -----KTKGDLKDLISKMVKEKFRERITVDQILSHPYL 624
+T L+ L+ +++ ++R+ D+ HP+L
Sbjct: 241 PAIpreTSAPLRQLLLALLQRNHKDRMDFDEFFHHPFL 278
>sp|Q8IU85|KCC1D_HUMAN Calcium/calmodulin-dependent protein kinase type 1D (CaM kinase ID)
(CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI
delta) (Camk1D) (CamKI-like protein kinase) (CKLiK)
Length = 385
Score = 108 bits (270), Expect = 2e-23
Identities = 73/235 (31%), Positives = 113/235 (48%), Gaps = 29/235 (12%)
Frame = +1
Query: 7 TGKTVAIKVIKNF---GFDSDNERELDNLKKLSGENIVQLIDFIIKYNTAYLIMELCKGD 177
TGK A+K I G +S E E+ L+K+ ENIV L D N YL+M+L G
Sbjct: 45 TGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGG 104
Query: 178 -----VSETGKLTGPKLKDFIQQTTTGLKIIHDKGMIHRDIKPQNILHVTKGKRTIYKLT 342
+ E G T I+Q + +H G++HRD+KP+N+L+ ++ + + ++
Sbjct: 105 ELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMIS 164
Query: 343 DFGLSKMISRTHRM-TKCGTPVFMAPEVAEGTEANSSADIWSLGITFCYMISG------- 498
DFGLSKM + M T CGTP ++APEV + + D WS+G+ ++ G
Sbjct: 165 DFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDE 224
Query: 499 -DIK------------DLGYEDKTKGDLKDLISKMVKEKFRERITVDQILSHPYL 624
D K D Y D KD I ++++ +R T +Q HP++
Sbjct: 225 NDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 279
>sp|Q8BW96|KCC1D_MOUSE Calcium/calmodulin-dependent protein kinase type 1D (CaM kinase ID)
(CaM kinase I delta) (CaMKI-delta) (CaM-KI delta) (CaMKI
delta) (Camk1D) (CamKI-like protein kinase) (CKLiK)
(mCKLiK)
Length = 385
Score = 108 bits (270), Expect = 2e-23
Identities = 73/235 (31%), Positives = 113/235 (48%), Gaps = 29/235 (12%)
Frame = +1
Query: 7 TGKTVAIKVIKNF---GFDSDNERELDNLKKLSGENIVQLIDFIIKYNTAYLIMELCKGD 177
TGK A+K I G +S E E+ L+K+ ENIV L D N YL+M+L G
Sbjct: 45 TGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESPNHLYLVMQLVSGG 104
Query: 178 -----VSETGKLTGPKLKDFIQQTTTGLKIIHDKGMIHRDIKPQNILHVTKGKRTIYKLT 342
+ E G T I+Q + +H G++HRD+KP+N+L+ ++ + + ++
Sbjct: 105 ELFDRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMIS 164
Query: 343 DFGLSKMISRTHRM-TKCGTPVFMAPEVAEGTEANSSADIWSLGITFCYMISG------- 498
DFGLSKM + M T CGTP ++APEV + + D WS+G+ ++ G
Sbjct: 165 DFGLSKMEGKGDVMSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDE 224
Query: 499 -DIK------------DLGYEDKTKGDLKDLISKMVKEKFRERITVDQILSHPYL 624
D K D Y D KD I ++++ +R T +Q HP++
Sbjct: 225 NDSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI 279
>sp|Q15139|KPCD1_HUMAN Protein kinase, D1 type (nPKC-D1) (Protein kinase D) (Protein kinase
C, mu type) (nPKC-mu)
Length = 912
Score = 107 bits (268), Expect = 3e-23
Identities = 73/238 (30%), Positives = 118/238 (49%), Gaps = 29/238 (12%)
Frame = +1
Query: 4 KTGKTVAIKVIKNFGFDSDNERELDN----LKKLSGENIVQLIDFIIKYNTAYLIMELCK 171
KTG+ VAIK+I F + E +L N L+ L +V L +++ME
Sbjct: 604 KTGRDVAIKIIDKLRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLH 663
Query: 172 GDV------SETGKLTGPKLKDFIQQTTTGLKIIHDKGMIHRDIKPQNILHVTKGKRTIY 333
GD+ SE G+L K I Q L+ +H K ++H D+KP+N+L +
Sbjct: 664 GDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQV 723
Query: 334 KLTDFGLSKMI-SRTHRMTKCGTPVFMAPEVAEGTEANSSADIWSLGITFCYMISGDI-- 504
KL DFG +++I ++ R + GTP ++APEV N S D+WS+G+ +SG
Sbjct: 724 KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPF 783
Query: 505 -KDLGYEDKTKG---------------DLKDLISKMVKEKFRERITVDQILSHPYLRN 630
+D D+ + + DLI+ +++ K R+R +VD+ LSHP+L++
Sbjct: 784 NEDEDIHDQIQNAAFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQD 841
>sp|O94806|KPCN_HUMAN Protein kinase C, nu type (nPKC-nu) (Protein kinase EPK2)
Length = 890
Score = 107 bits (268), Expect = 3e-23
Identities = 74/238 (31%), Positives = 116/238 (48%), Gaps = 29/238 (12%)
Frame = +1
Query: 4 KTGKTVAIKVIKNFGFDSDNERELDN----LKKLSGENIVQLIDFIIKYNTAYLIMELCK 171
KTG+ VAIKVI F + E +L N L+ L IV L +++ME
Sbjct: 597 KTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLH 656
Query: 172 GDV------SETGKLTGPKLKDFIQQTTTGLKIIHDKGMIHRDIKPQNILHVTKGKRTIY 333
GD+ SE +L K + Q L+ +H K ++H D+KP+N+L +
Sbjct: 657 GDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQV 716
Query: 334 KLTDFGLSKMI-SRTHRMTKCGTPVFMAPEVAEGTEANSSADIWSLGITFCYMISGDIKD 510
KL DFG +++I ++ R + GTP ++APEV N S D+WS+G+ +SG
Sbjct: 717 KLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPF 776
Query: 511 LGYED------------------KTKGDLKDLISKMVKEKFRERITVDQILSHPYLRN 630
ED + G+ DLI+ +++ K R+R +VD+ LSHP+L++
Sbjct: 777 NEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQD 834
>sp|Q8ICR0|CDPK2_PLAF7 Calcium-dependent protein kinase 2 (PfCDPK2)
Length = 509
Score = 107 bits (268), Expect = 3e-23
Identities = 71/234 (30%), Positives = 115/234 (49%), Gaps = 28/234 (11%)
Frame = +1
Query: 7 TGKTVAIKVIKNFGFDSDNE--RELDNLKKLSGENIVQLIDFIIKYNTAYLIMELCKG-- 174
T + AIK K + N +E++ +KKL NIV+L + N YLIMELC G
Sbjct: 94 TNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVKLYETYENDNYIYLIMELCSGRE 153
Query: 175 ---DVSETGKLTGPKLKDFIQQTTTGLKIIHDKGMIHRDIKPQNILHVTKGKRTIYKLTD 345
+ E G T ++Q + + +H ++HRD+KP+N L ++ K ++ K+ D
Sbjct: 154 LFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIID 213
Query: 346 FGLSKMI-SRTHRMTKCGTPVFMAPEVAEGTEANSSADIWSLGITFCYMISGDIKDLGYE 522
FGLSK + + TK GTP ++AP+V +G + + DIWS G+ ++ G G
Sbjct: 214 FGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-KYDKKCDIWSSGVIMYTLLCGYPPFYGDT 272
Query: 523 D--------------------KTKGDLKDLISKMVKEKFRERITVDQILSHPYL 624
D D K+LI+K++ ER T+++ L+HP++
Sbjct: 273 DNEVLKKVKKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWI 326
>sp|O15865|CDPK2_PLAFK Calcium-dependent protein kinase 2 (PfCDPK2)
Length = 513
Score = 107 bits (268), Expect = 3e-23
Identities = 71/234 (30%), Positives = 115/234 (49%), Gaps = 28/234 (11%)
Frame = +1
Query: 7 TGKTVAIKVIKNFGFDSDNE--RELDNLKKLSGENIVQLIDFIIKYNTAYLIMELCKG-- 174
T + AIK K + N +E++ +KKL NIV+L + N YLIMELC G
Sbjct: 94 TNQLYAIKEEKKDRLKNINRFFQEIEIMKKLDHPNIVKLYETYENDNYIYLIMELCSGRE 153
Query: 175 ---DVSETGKLTGPKLKDFIQQTTTGLKIIHDKGMIHRDIKPQNILHVTKGKRTIYKLTD 345
+ E G T ++Q + + +H ++HRD+KP+N L ++ K ++ K+ D
Sbjct: 154 LFDSIIENGSFTEKNAATIMKQIFSAIFYLHSLNIVHRDLKPENFLFQSENKDSLLKIID 213
Query: 346 FGLSKMI-SRTHRMTKCGTPVFMAPEVAEGTEANSSADIWSLGITFCYMISGDIKDLGYE 522
FGLSK + + TK GTP ++AP+V +G + + DIWS G+ ++ G G
Sbjct: 214 FGLSKNLGTGEFTTTKAGTPYYVAPQVLDG-KYDKKCDIWSSGVIMYTLLCGYPPFYGDT 272
Query: 523 D--------------------KTKGDLKDLISKMVKEKFRERITVDQILSHPYL 624
D D K+LI+K++ ER T+++ L+HP++
Sbjct: 273 DNEVLKKVKKGEFCFYENDWGSISSDAKNLITKLLTYNPNERCTIEEALNHPWI 326
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,251,166
Number of Sequences: 369166
Number of extensions: 1678009
Number of successful extensions: 8609
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6091
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 6623
length of database: 68,354,980
effective HSP length: 110
effective length of database: 48,034,130
effective search space used: 8598109270
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)