Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_E06
(764 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9NX52|RHBD2_HUMAN Rhomboid-related protein 2 (RRP2) (Rh... 169 1e-41
sp|P20350|RHOM_DROME Rhomboid protein (Veinlet protein) 158 2e-38
sp|P58872|RHBD4_HUMAN Rhomboid-related protein 4 (Ventrhoid... 149 1e-35
sp|Q19821|ROM1_CAEEL Rhomboid related protein 1 148 1e-35
sp|P58873|RHBD4_MOUSE Rhomboid-related protein 4 (Ventrhoid... 145 9e-35
sp|Q8VC82|RHBD1_MOUSE Rhomboid-related protein 1 (RRP) (Rho... 144 2e-34
sp|O75783|RHB1_HUMAN Rhomboid-related protein 1 (RRP) (Rhom... 144 2e-34
sp|P34356|ROM2_CAEEL Rhomboid related protein 2 122 1e-27
sp|O88779|RHBD1_RAT Rhomboid-related protein 1 (RRP) (Rhomb... 108 2e-23
sp|P54493|YQGP_BACSU Hypothetical protein yqgP 49 1e-05
>sp|Q9NX52|RHBD2_HUMAN Rhomboid-related protein 2 (RRP2) (Rhomboid-like protein 2)
Length = 303
Score = 169 bits (427), Expect = 1e-41
Identities = 90/208 (43%), Positives = 124/208 (59%), Gaps = 1/208 (0%)
Frame = +2
Query: 8 LRSPLIYSPYRRIQAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYIL 187
L SP IYSP +R +AWRFI YM +H G H++ N MQLVLG LE+VHK RVG+VY+
Sbjct: 106 LESPFIYSPEKREEAWRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLA 165
Query: 188 GVLAGSLAHSCFDASKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVF 367
GV+AGSLA S FD +YLVGASGG YAL+G +F ++ N+ M + +F
Sbjct: 166 GVIAGSLASSIFDPLRYLVGASGGVYALMGGYFMNVLVNFQEM----------IPAFGIF 215
Query: 368 RLIVLFLLAGGDTGIAIYDR-FAKEVPTPIGFSAHFGGALAGFLIGIPVLRNLEVRKWEK 544
RL+++ L+ D G A+Y R F E +P+ F+AH G AG IG V + +
Sbjct: 216 RLLIIILIIVLDMGFALYRRFFVPEDGSPVSFAAHIAGGFAGMSIGYTVFSCFDKALLKD 275
Query: 545 ICFWISLALYCLFMIGAIVFNVICASKN 628
FWI++A Y ++ A+ FN+ + N
Sbjct: 276 PRFWIAIAAYLACVLFAVFFNIFLSPAN 303
>sp|P20350|RHOM_DROME Rhomboid protein (Veinlet protein)
Length = 355
Score = 158 bits (399), Expect = 2e-38
Identities = 86/204 (42%), Positives = 120/204 (58%), Gaps = 4/204 (1%)
Frame = +2
Query: 14 SPLIYSPYRRIQAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGV 193
S L+Y P RR+Q WRF YMFLH + HL FN ++QL G LEV+H R+G++Y+ GV
Sbjct: 138 SVLVYRPDRRLQVWRFFSYMFLHANWFHLGFNIVIQLFFGIPLEVMHGTARIGVIYMAGV 197
Query: 194 LAGSLAHSCFDASKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRL 373
AGSL S D+ +LVGASGG YAL+ AH A I N+ M+ SA +L
Sbjct: 198 FAGSLGTSVVDSEVFLVGASGGVYALLAAHLANITLNYAHMK------------SASTQL 245
Query: 374 IVLFLLAGGDTGIAIYDRF----AKEVPTPIGFSAHFGGALAGFLIGIPVLRNLEVRKWE 541
+ + D G A+Y ++ A + + AH GALAG IG VL+N R++E
Sbjct: 246 GSVVIFVSCDLGYALYTQYFDGSAFAKGPQVSYIAHLTGALAGLTIGFLVLKNFGHREYE 305
Query: 542 KICFWISLALYCLFMIGAIVFNVI 613
++ +W++L +YC F + AIVFN+I
Sbjct: 306 QLIWWLALGVYCAFTVFAIVFNLI 329
>sp|P58872|RHBD4_HUMAN Rhomboid-related protein 4 (Ventrhoid transmembrane protein)
Length = 404
Score = 149 bits (375), Expect = 1e-35
Identities = 77/205 (37%), Positives = 121/205 (59%), Gaps = 3/205 (1%)
Frame = +2
Query: 5 HLRSPLIYSPYRRIQAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYI 184
+L++ L+Y P R Q WR++ Y+F+H G HL N ++QL++G LE+VH R+G+VY+
Sbjct: 196 YLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYV 255
Query: 185 LGVLAGSLAHSCFDASKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAV 364
GV+AGSLA S D + +VG+SGG YAL+ AH A I+ NW M+ ++ +
Sbjct: 256 AGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQF----------KL 305
Query: 365 FRLIVLFLLAGGDTGIAIYDRFAKEVPTPI---GFSAHFGGALAGFLIGIPVLRNLEVRK 535
R+ V + + G A++ RF P F AH GG G +G+ VLRN E R
Sbjct: 306 LRMAVALICMSMEFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRL 365
Query: 536 WEKICFWISLALYCLFMIGAIVFNV 610
++ +WI +A+Y +F++ A+ +N+
Sbjct: 366 QDQSLWWIFVAMYTVFVLFAVFWNI 390
>sp|Q19821|ROM1_CAEEL Rhomboid related protein 1
Length = 356
Score = 148 bits (374), Expect = 1e-35
Identities = 84/205 (40%), Positives = 113/205 (55%), Gaps = 2/205 (0%)
Frame = +2
Query: 23 IYSPYRRIQAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLAG 202
I++P R +AWRF YMFLH G HL+ N ++QL++G LEV HK WR+G +Y+L V +G
Sbjct: 157 IFAPKLRGEAWRFTSYMFLHAGLNHLLGNVIIQLLVGIPLEVAHKIWRIGPIYLLAVTSG 216
Query: 203 SLAHSCFDASKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIVL 382
SL D + LVGAS G YALI AH A +I NW M +W+ R++VL
Sbjct: 217 SLLQYAIDPNSLLVGASAGVYALIFAHVANVILNWHEMPLRWI------------RVLVL 264
Query: 383 FLLAGGDTGIAIYDRFAKEVPTPIGFSAHFGGALAGFLIGIPVLRNLEVRKWEKICFWIS 562
F+ D G AI+ RF + AH GA+ G G VL N+ + EKI ++
Sbjct: 265 FVFIFLDFGGAIHRRFYTNDCDSVSHLAHIAGAVTGLFFGYVVLYNVVEHRIEKIIRYVC 324
Query: 563 LALYCLFMIGAIVFNVICA--SKNL 631
L LY F I+F ++ SKNL
Sbjct: 325 LFLYSAFFATTIIFVIVRQPYSKNL 349
>sp|P58873|RHBD4_MOUSE Rhomboid-related protein 4 (Ventrhoid transmembrane protein)
Length = 404
Score = 145 bits (367), Expect = 9e-35
Identities = 76/205 (37%), Positives = 119/205 (58%), Gaps = 3/205 (1%)
Frame = +2
Query: 5 HLRSPLIYSPYRRIQAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYI 184
+L++ L+Y P R QAWR++ Y+F+H G L N +QL++G LE+VH R+G+VY+
Sbjct: 196 YLKNSLVYHPQLRAQAWRYVTYIFMHAGVEQLGLNVALQLLVGVPLEMVHGATRIGLVYV 255
Query: 185 LGVLAGSLAHSCFDASKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAV 364
GV+AGSLA S D + +VG+SGG YAL+ AH A I+ NW M+ ++ +
Sbjct: 256 AGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQF----------KL 305
Query: 365 FRLIVLFLLAGGDTGIAIYDRFAKEVPTPI---GFSAHFGGALAGFLIGIPVLRNLEVRK 535
R+ V + + G A++ RF P F AH GG G +G+ VLRN E R
Sbjct: 306 LRMAVALICMSMEFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRL 365
Query: 536 WEKICFWISLALYCLFMIGAIVFNV 610
++ +WI + +Y +F++ A+ +N+
Sbjct: 366 QDQSLWWIFVTMYTIFVLFAVFWNI 390
>sp|Q8VC82|RHBD1_MOUSE Rhomboid-related protein 1 (RRP) (Rhomboid-like protein 1)
Length = 373
Score = 144 bits (364), Expect = 2e-34
Identities = 76/205 (37%), Positives = 118/205 (57%), Gaps = 3/205 (1%)
Frame = +2
Query: 5 HLRSPLIYSPYRRIQAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYI 184
+++SPL+Y P R +AWRF+ YMF+H G L FN L+QL++G LE+VH R+ ++Y+
Sbjct: 165 YMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGVLRISLLYL 224
Query: 185 LGVLAGSLAHSCFDASKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAV 364
GVLAGSL S D +VG SGG YAL AH A ++ NW M+ + +
Sbjct: 225 AGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPY----------KL 274
Query: 365 FRLIVLFLLAGGDTGIAIYDRFAKEVPT---PIGFSAHFGGALAGFLIGIPVLRNLEVRK 535
R+++ + + G A++ RF+ +P F AH GA+ G +G+ +LR+ E R
Sbjct: 275 LRMVLALVCMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERL 334
Query: 536 WEKICFWISLALYCLFMIGAIVFNV 610
++ +W+ L Y F++ AI +NV
Sbjct: 335 RDQCGWWVVLLAYGTFLLFAIFWNV 359
>sp|O75783|RHB1_HUMAN Rhomboid-related protein 1 (RRP) (Rhomboid-like protein 1)
Length = 438
Score = 144 bits (364), Expect = 2e-34
Identities = 75/205 (36%), Positives = 118/205 (57%), Gaps = 3/205 (1%)
Frame = +2
Query: 5 HLRSPLIYSPYRRIQAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYI 184
+++SPL+Y P R +AWRF+ YMF+H G L FN L+QL++G LE+VH R+ ++Y+
Sbjct: 230 YMKSPLVYHPGHRARAWRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGLLRISLLYL 289
Query: 185 LGVLAGSLAHSCFDASKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAV 364
GVLAGSL S D +VG SGG YAL AH A ++ NW M+ + +
Sbjct: 290 AGVLAGSLTVSITDMRAPVVGGSGGVYALCSAHLANVVMNWAGMRCPY----------KL 339
Query: 365 FRLIVLFLLAGGDTGIAIYDRFAKEVPT---PIGFSAHFGGALAGFLIGIPVLRNLEVRK 535
R+++ + + G A++ RF+ +P F AH GA+ G +G+ +LR+ E R
Sbjct: 340 LRMVLALVCMSSEVGRAVWLRFSPPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERL 399
Query: 536 WEKICFWISLALYCLFMIGAIVFNV 610
++ +W+ L Y F++ A+ +NV
Sbjct: 400 RDQCGWWVVLLAYGTFLLFAVFWNV 424
>sp|P34356|ROM2_CAEEL Rhomboid related protein 2
Length = 435
Score = 122 bits (306), Expect = 1e-27
Identities = 70/204 (34%), Positives = 106/204 (51%)
Frame = +2
Query: 14 SPLIYSPYRRIQAWRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGV 193
SPLI S Y + WR Y ++ G H+IFN L+QL +G LE+VH+ WR+ I+Y +GV
Sbjct: 157 SPLIVSQYHLPELWRLFTYCLINVGIFHIIFNILIQLAIGVPLELVHR-WRIYILYFMGV 215
Query: 194 LAGSLAHSCFDASKYLVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRL 373
L GS+ D + +L G + G ++LI +H TI TN+ M+ +A RL
Sbjct: 216 LFGSILSLALDPTVFLCGGAAGSFSLIASHITTIATNFKEME------------NATCRL 263
Query: 374 IVLFLLAGGDTGIAIYDRFAKEVPTPIGFSAHFGGALAGFLIGIPVLRNLEVRKWEKICF 553
+L + A D +A+Y RF + H GG +AG L + R + ++ + F
Sbjct: 264 PILIVFAALDYVLAVYQRFFAPRIDKVSMYGHLGGLVAGILFTFILFRGSKPSRFYTVSF 323
Query: 554 WISLALYCLFMIGAIVFNVICASK 625
W+SL L F+ AI +I A +
Sbjct: 324 WVSLVLSGFFI--AICITLIAAPR 345
>sp|O88779|RHBD1_RAT Rhomboid-related protein 1 (RRP) (Rhomboid-like protein 1)
Length = 164
Score = 108 bits (270), Expect = 2e-23
Identities = 60/174 (34%), Positives = 94/174 (54%), Gaps = 3/174 (1%)
Frame = +2
Query: 74 FLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLAGSLAHSCFDASKYLVGAS 253
F+H G L FN L+QL++G LE+VH R+ ++Y+ GVLAGSL S D +VG S
Sbjct: 1 FMHVGLEQLGFNALLQLMIGVPLEMVHGVLRISLLYLAGVLAGSLTVSITDMRAPVVGGS 60
Query: 254 GGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIVLFLLAGGDTGIAIYDRFA 433
GG YAL AH A ++ NW M+ + + R+++ + + G A++ RF+
Sbjct: 61 GGVYALCSAHLANVVMNWAGMRCPY----------KLLRMVLALVCMSSEVGRAVWLRFS 110
Query: 434 KEVPT---PIGFSAHFGGALAGFLIGIPVLRNLEVRKWEKICFWISLALYCLFM 586
+P F AH GA+ G +G+ +LR+ E R ++ +W+ L Y F+
Sbjct: 111 PPLPASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFL 164
>sp|P54493|YQGP_BACSU Hypothetical protein yqgP
Length = 507
Score = 48.9 bits (115), Expect = 1e-05
Identities = 44/157 (28%), Positives = 69/157 (43%), Gaps = 5/157 (3%)
Frame = +2
Query: 53 WRFIGYMFLHQGYIHLIFNCLMQLVLGTLLEVVHKFWRVGIVYILGVLAGSLAHSCFDAS 232
WR + + LH G HL FN L +GT +E ++ R ++Y+ + GS+A F S
Sbjct: 223 WRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIASFVF--S 280
Query: 233 KY-LVGASGGCYALIGAHFATIITNWDTMQKKWLENPINFLSSAVFRLIVLFLLAGGDTG 409
Y GASG + +GA ++N FL + +IV+ ++ G G
Sbjct: 281 PYPSAGASGAIFGCLGALLYVALSNRKM-----------FLRTIGTNIIVIIIINLG-FG 328
Query: 410 IAIYDRFAKEVPTPIGFSAHFGGALAGFL----IGIP 508
A+ + I S H GG + GF +G+P
Sbjct: 329 FAV---------SNIDNSGHIGGLIGGFFAAAALGLP 356
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 88,893,510
Number of Sequences: 369166
Number of extensions: 1930948
Number of successful extensions: 5199
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 5045
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 5182
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7066925600
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)