Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_D20
(624 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9Y794|ORC4_SCHPO Origin recognition complex subunit 4 41 0.002
sp|P22058|CPD1_DROME Chromosomal protein D1 40 0.006
sp|Q9U7E0|ATRX_CAEEL Transcriptional regulator ATRX homolog... 40 0.006
sp|Q8WXA9|SFR12_HUMAN Splicing factor, arginine/serine-rich... 38 0.018
sp|P14196|AAC2_DICDI AAC-rich mRNA clone AAC11 protein 37 0.031
sp|O01761|UNC89_CAEEL Muscle M-line assembly protein unc-89... 37 0.053
sp|P40631|MLH_TETTH Micronuclear linker histone polyprotein... 35 0.12
sp|P45481|CBP_MOUSE CREB-binding protein 34 0.26
sp|Q8BRH4|MLL3_MOUSE Myeloid/lymphoid or mixed-lineage leuk... 34 0.35
sp|P49711|CTCF_HUMAN Transcriptional repressor CTCF (CCCTC-... 33 0.45
>sp|Q9Y794|ORC4_SCHPO Origin recognition complex subunit 4
Length = 972
Score = 41.2 bits (95), Expect = 0.002
Identities = 48/182 (26%), Positives = 75/182 (41%), Gaps = 29/182 (15%)
Frame = +1
Query: 70 EIREKKFRGRPRKTVLDDEKSSLSNGEP-----QAKKSRGRPKKYTMREDM-NTPSS--- 222
E++ K+ RGRPRK + +E SS NG AK+ RGRP + + + NTP S
Sbjct: 197 ELKPKRGRGRPRK-IKPEEGSSSQNGLSPLVVLPAKRGRGRPPLHRSEQKIANTPISNNV 255
Query: 223 -VKESNDNVKQXXXXXXXXXXXXXXXXXTGDSTEASEK---------QDNEIVVKKHKGR 372
V+ + N+ +E ++ ++ VK+ +GR
Sbjct: 256 TVESTGTNLHTHSQLNPENEQSSSEFYSLNPQSEIRKEVVVTDQPLFSTADVPVKRKRGR 315
Query: 373 P---------SKSQKNEID-NKDKKPRGRPKSNLVSEMHKDASETTNNYDSVVFISRERP 522
P S +N+ID N+ K+ RGRP+ S + D+ S+ R RP
Sbjct: 316 PPLNKPKILFGTSTENKIDENRPKRGRGRPRLERPSGLPLDSKS-----QSLFKRKRGRP 370
Query: 523 KK 528
K
Sbjct: 371 PK 372
Score = 30.0 bits (66), Expect = 5.0
Identities = 17/56 (30%), Positives = 26/56 (46%)
Frame = +1
Query: 7 RKSRGRPRKLFVDDRSSDTAPEIREKKFRGRPRKTVLDDEKSSLSNGEPQAKKSRG 174
++ RGRP K+ S+ ++ K+ RGRPR L + S+ G Q G
Sbjct: 123 KRKRGRPPKIKSSSPSTKLDDPLKPKRGRGRPRLHPLPVVQPSVDEGTTQNNLQMG 178
>sp|P22058|CPD1_DROME Chromosomal protein D1
Length = 355
Score = 39.7 bits (91), Expect = 0.006
Identities = 30/120 (25%), Positives = 47/120 (39%), Gaps = 3/120 (2%)
Frame = +1
Query: 94 GRPRKTVLDDEKSSLSNGEPQAKKSRGRPKKYTMREDMNT---PSSVKESNDNVKQXXXX 264
GRP+K ++ S +GEPQ K RGRP + +T P+
Sbjct: 177 GRPKKRAVE----SNGDGEPQVPKKRGRPPQNKSGSGGSTGYVPTGRPRGRPKANAAPVE 232
Query: 265 XXXXXXXXXXXXXTGDSTEASEKQDNEIVVKKHKGRPSKSQKNEIDNKDKKPRGRPKSNL 444
+G+ +S ++ +V K +GRPS + + KPR RP N+
Sbjct: 233 KHEDNDDDQDDENSGEEEHSSPEKT--VVAPKKRGRPSLAAGKVSKEETTKPRSRPAKNI 290
Score = 35.4 bits (80), Expect = 0.12
Identities = 55/219 (25%), Positives = 83/219 (37%), Gaps = 44/219 (20%)
Frame = +1
Query: 10 KSRGRPRKLFVDDRSSDTA-----PEIREKKFRGRPRKTVLDDEKSSLSNGEPQAKKSRG 174
K RGRP K V +SS A P I++ RGRP K ++ SS G+ RG
Sbjct: 7 KKRGRPSKASVGGKSSTAAVAAISPGIKK---RGRPAK----NKGSSGGGGQ------RG 53
Query: 175 RPKKYTMREDMNTP------------SSVKESNDNVKQXXXXXXXXXXXXXXXXXTGDS- 315
RP K + ++ P S + +N++ +GDS
Sbjct: 54 RPPKASKIQNDEDPEDEGEEDGDGDGSGAELANNSSPSPTKGRGRPKSSGGAGSGSGDSV 113
Query: 316 -TEASEKQDNEIVVKKHKGRPSKSQKNEIDNKD--------------KKPRGRPKSNLVS 450
T S K K+ GRP K Q ++ +N+D ++P GRP + V+
Sbjct: 114 KTPGSAK-------KRKAGRPKKHQPSDSENEDDQDEDDDGNSSIEERRPVGRPSAGSVN 166
Query: 451 -----------EMHKDASETTNNYDSVVFISRERPKKSK 534
K A E+ + + V R RP ++K
Sbjct: 167 LNISRTGRGLGRPKKRAVESNGDGEPQVPKKRGRPPQNK 205
>sp|Q9U7E0|ATRX_CAEEL Transcriptional regulator ATRX homolog (X-linked nuclear protein 1)
Length = 1359
Score = 39.7 bits (91), Expect = 0.006
Identities = 45/192 (23%), Positives = 79/192 (41%), Gaps = 16/192 (8%)
Frame = +1
Query: 7 RKSRGRPRKLFV-DDRSSDTAPEIREKKFRGRPRKTVLDDEKSSLSNGEPQAKKSRGRPK 183
+KS+ + +K+ + S D APE ++ + R R + + + +S S+ E + K+S +PK
Sbjct: 219 KKSKKKSKKVVKKESESEDEAPEKKKTEKRKRSKTSSEESSESEKSDEEEEEKESSPKPK 278
Query: 184 KYTMREDMNTPSSVKESNDNVKQXXXXXXXXXXXXXXXXXTGDSTEASEKQDNEIVVKKH 363
K P +VK+ + S E SE+ D E++ +K
Sbjct: 279 K-------KKPLAVKKLS-------------------------SDEESEESDVEVLPQKK 306
Query: 364 K------------GRPSKSQKNEIDNKDKKPRGRPKSNLVSEMHKDASE---TTNNYDSV 498
K + KS+ D ++K + + K SE D+SE T N
Sbjct: 307 KRGAVTLISDSEDEKDQKSESEASDVEEKVSKKKAKKQESSESGSDSSEGSITVNRKSK- 365
Query: 499 VFISRERPKKSK 534
+E+P+K K
Sbjct: 366 ---KKEKPEKKK 374
Score = 34.7 bits (78), Expect = 0.20
Identities = 45/203 (22%), Positives = 77/203 (37%), Gaps = 35/203 (17%)
Frame = +1
Query: 46 DRSSDTAPEIREKKFRGRPRKTVLDDEKSSLSNGE---------PQAKKSRGRPKKYTMR 198
++ + E RE++ + P+K K+S S + +KKSR R K +
Sbjct: 33 EKRAQKLKEKREREGKPPPKKRPAKKRKASSSEEDDDDEEESPRKSSKKSRKRAKSESES 92
Query: 199 EDMNTPSSVKESNDNVKQXXXXXXXXXXXXXXXXXTGD---------------------S 315
++ + K+S K + S
Sbjct: 93 DESDEEEDRKKSKSKKKVDQKKKEKSKKKRTTSSSEDEDSDEEREQKSKKKSKKTKKQTS 152
Query: 316 TEASEKQDNEIVVKKHKGRPSKSQK-----NEIDNKDKKPRGRPKSNLVSEMHKDASETT 480
+E+SE+ + E VKK K KS K +E ++D+KP + K L + K SE+
Sbjct: 153 SESSEESEEERKVKKSKKNKEKSVKKRAETSEESDEDEKPSKKSKKGL-KKKAKSESESE 211
Query: 481 NNYDSVVFISRERPKKSKIPESE 549
+ + V S+++ KK ESE
Sbjct: 212 SEDEKEVKKSKKKSKKVVKKESE 234
>sp|Q8WXA9|SFR12_HUMAN Splicing factor, arginine/serine-rich 12 (Serine-arginine-rich
splicing regulatory protein 86) (SRrp86) (Splicing
regulatory protein 508) (SRrp508)
Length = 508
Score = 38.1 bits (87), Expect = 0.018
Identities = 37/143 (25%), Positives = 51/143 (35%), Gaps = 8/143 (5%)
Frame = +1
Query: 7 RKSRGRPRKLFVDDRSSDTAPEIREKKFRGR---PRKTVLDDEKSSLS-----NGEPQAK 162
+KSR PR RS ++ E R ++ R PR + KSS S + K
Sbjct: 359 KKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKK 418
Query: 163 KSRGRPKKYTMREDMNTPSSVKESNDNVKQXXXXXXXXXXXXXXXXXTGDSTEASEKQDN 342
+ + R RE + S K SND D E EK
Sbjct: 419 REKERDHISERRERERSTSMRKSSNDR----------------------DGKEKLEKNST 456
Query: 343 EIVVKKHKGRPSKSQKNEIDNKD 411
+ K+H P S E+D+KD
Sbjct: 457 SLKEKEHNKEPDSSVSKEVDDKD 479
Score = 32.7 bits (73), Expect = 0.77
Identities = 35/155 (22%), Positives = 58/155 (37%)
Frame = +1
Query: 7 RKSRGRPRKLFVDDRSSDTAPEIREKKFRGRPRKTVLDDEKSSLSNGEPQAKKSRGRPKK 186
RKSR R D+ DT +I+EK+ R D EK E + +K RG+ K
Sbjct: 249 RKSRSRSHSR---DKRKDTREKIKEKE-----RVKEKDREKEREREKEREKEKERGKNKD 300
Query: 187 YTMREDMNTPSSVKESNDNVKQXXXXXXXXXXXXXXXXXTGDSTEASEKQDNEIVVKKHK 366
+ + ++ + ++ E ++QD E K +
Sbjct: 301 RDKEREKDREKDKEKDREREREKEHEKDR-------------DKEKEKEQDKE----KER 343
Query: 367 GRPSKSQKNEIDNKDKKPRGRPKSNLVSEMHKDAS 471
+ + +E KDKK R P+S S + +S
Sbjct: 344 EKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSS 378
>sp|P14196|AAC2_DICDI AAC-rich mRNA clone AAC11 protein
Length = 448
Score = 37.4 bits (85), Expect = 0.031
Identities = 25/62 (40%), Positives = 34/62 (54%), Gaps = 2/62 (3%)
Frame = +1
Query: 7 RKSRGRPRKLFVDDRSSDTAPEIREKKFRGRPRKTVLDDEKSSLSNGEPQ--AKKSRGRP 180
++SRGRPRK + + P K+ RGRP K +D+E + PQ + K RGRP
Sbjct: 161 KRSRGRPRKNPPSEPKDTSGP----KRKRGRPPK--MDEEGNPQPKPVPQPGSNKKRGRP 214
Query: 181 KK 186
KK
Sbjct: 215 KK 216
Score = 35.0 bits (79), Expect = 0.16
Identities = 36/152 (23%), Positives = 56/152 (36%), Gaps = 1/152 (0%)
Frame = +1
Query: 34 LFVDDRSSDTAPEIREKKFRGRPRKTVLDDEKSSLSNGEPQAKKSRGRPKKYTMREDMN- 210
L ++ + ++ +K+ RGRPRK + K + K+ RGRP K M E+ N
Sbjct: 145 LGINSSPTQSSANSADKRSRGRPRKNPPSEPKDTSG-----PKRKRGRPPK--MDEEGNP 197
Query: 211 TPSSVKESNDNVKQXXXXXXXXXXXXXXXXXTGDSTEASEKQDNEIVVKKHKGRPSKSQK 390
P V + N K+ D S N K +GRP K+
Sbjct: 198 QPKPVPQPGSNKKR-------GRPKKPKDENESDYNNTSFSDSNTDGTPKKRGRPPKA-- 248
Query: 391 NEIDNKDKKPRGRPKSNLVSEMHKDASETTNN 486
K + P P N + +++ NN
Sbjct: 249 -----KGESPSASPTHNTLGNGILNSNNNNNN 275
>sp|O01761|UNC89_CAEEL Muscle M-line assembly protein unc-89 (Uncoordinated protein 89)
Length = 8081
Score = 36.6 bits (83), Expect = 0.053
Identities = 45/191 (23%), Positives = 72/191 (37%), Gaps = 11/191 (5%)
Frame = +1
Query: 10 KSRGRPRKLFVDDRSS--DTAPEIREKKFRG------RPRKTVLDDEKSSLSNGEPQAKK 165
K P K V++ S + +PE E+K + P K+ ++ KS + K
Sbjct: 1706 KKEKSPEKSVVEEVKSPKEKSPEKAEEKPKSPTKKEKSPEKSAAEEVKSPTKKEKSPEKS 1765
Query: 166 SRGRPKKYTMREDMNTPSSVKESNDNVKQXXXXXXXXXXXXXXXXXTGDSTEASEKQDNE 345
+ +PK T +E S VK ++D VK + EK E
Sbjct: 1766 AEEKPKSPTKKES----SPVKMADDEVKSPTKKEKSPEKVEEKPASPTKKEKTPEKSAAE 1821
Query: 346 IV---VKKHKGRPSKSQKNEIDNKDKKPRGRPKSNLVSEMHKDASETTNNYDSVVFISRE 516
+ KK K S ++K ++K+K P +P+ S K +
Sbjct: 1822 ELKSPTKKEKSPSSPTKKTGDESKEKSPE-KPEEKPKSPTPKKSPP-----------GSP 1869
Query: 517 RPKKSKIPESE 549
+ KKSK PE+E
Sbjct: 1870 KKKKSKSPEAE 1880
>sp|P40631|MLH_TETTH Micronuclear linker histone polyprotein (MIC LH) [Contains:
Micronuclear linker histone-alpha; Micronuclear linker
histone-beta; Micronuclear linker histone-delta;
Micronuclear linker histone-gamma]
Length = 633
Score = 35.4 bits (80), Expect = 0.12
Identities = 31/165 (18%), Positives = 57/165 (34%), Gaps = 6/165 (3%)
Frame = +1
Query: 13 SRGRPRKLFVDDRSSDTAPEIREKKFRGRPRKTVLDDEKSSLSNGEPQAKKSRGRPKKYT 192
S+GR + R+ +A + R + RK ++ + +A S+GR +
Sbjct: 197 SKGRTKSTSSKRRADSSASQGRSQSSSSNRRKASSSKDQKGTRSSSRKASNSKGRKNSTS 256
Query: 193 MREDMNTPSSVKESNDNVKQXXXXXXXXXXXXXXXXXTGDSTEASEKQDNEIVVKKH--- 363
+ + ++ S S+ N K + +AS ++ + K
Sbjct: 257 NKRNSSSSSKRSSSSKNKKSSSSKNKKSSSSKGRKSSSSRGRKASSSKNRKSSKSKDRKS 316
Query: 364 ---KGRPSKSQKNEIDNKDKKPRGRPKSNLVSEMHKDASETTNNY 489
KGR S S K RGR S+ + E N++
Sbjct: 317 SSSKGRKSSSSSKSNKRKASSSRGRKSSSSKGRKSSKSQERKNSH 361
Score = 33.1 bits (74), Expect = 0.59
Identities = 37/180 (20%), Positives = 66/180 (36%), Gaps = 2/180 (1%)
Frame = +1
Query: 7 RKSRGRPRKLFVDDRSSDTAPEIREKKFRGRPRKTVLDDEKSSLSNGEPQAKKSRGRPKK 186
+KSR K ++++ + K K+ + S S G+ +S +PK
Sbjct: 389 KKSRRNSMKEARTKKANNKSASKASKSGSKSKGKSASKSKGKSSSKGKNSKSRSASKPKS 448
Query: 187 YTMREDMNTPSSVKESNDNVKQXXXXXXXXXXXXXXXXXTGDSTEASEKQDNEIVVKKHK 366
+ NT + +S++N T T +++ ++V +K
Sbjct: 449 NAAQNSNNTHQTA-DSSENASST----------------TQTRTRGRQREQKDMVNEKSN 491
Query: 367 GRPS-KSQKNEIDNKDKKPRGRPKSNLVSEMHKDASETTNNYDSVVFISRERPK-KSKIP 540
+ S K +KN N K + + S K +TTN+ SR K KS+ P
Sbjct: 492 SKSSSKGKKNSKSNTRSKSKSKSASKSRKNASKSKKDTTNHGRQTRSKSRSESKSKSEAP 551
>sp|P45481|CBP_MOUSE CREB-binding protein
Length = 2441
Score = 34.3 bits (77), Expect = 0.26
Identities = 14/37 (37%), Positives = 21/37 (56%)
Frame = +1
Query: 142 NGEPQAKKSRGRPKKYTMREDMNTPSSVKESNDNVKQ 252
+ EP+ +S+G P+ M ED+ S VKE D +Q
Sbjct: 1006 DAEPEPTESKGEPRSEMMEEDLQGSSQVKEETDTTEQ 1042
>sp|Q8BRH4|MLL3_MOUSE Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog
(Histone-lysine N-methyltransferase, H3 lysine-4
specific MLL3)
Length = 4903
Score = 33.9 bits (76), Expect = 0.35
Identities = 18/48 (37%), Positives = 23/48 (47%)
Frame = +1
Query: 355 KKHKGRPSKSQKNEIDNKDKKPRGRPKSNLVSEMHKDASETTNNYDSV 498
K+ +GRP K + KKPR R KS + E D ETT + V
Sbjct: 34 KRPRGRPRKDGASPFQRARKKPRSRGKSTVEDEDSMDGLETTETENIV 81
>sp|P49711|CTCF_HUMAN Transcriptional repressor CTCF (CCCTC-binding factor) (CTCFL
paralog) (11-zinc finger protein)
Length = 727
Score = 33.5 bits (75), Expect = 0.45
Identities = 22/80 (27%), Positives = 38/80 (47%), Gaps = 1/80 (1%)
Frame = +1
Query: 4 GRKSRGRPRKLFVDDRSSDTAPEIREKKFRGRPRKTVLDD-EKSSLSNGEPQAKKSRGRP 180
GRK + R +K D S + P++ + + P + + E ++ P AKK RGRP
Sbjct: 597 GRKRKMRSKKEDSSD-SENAEPDLDDNEDEEEPAVEIEPEPEPQPVTPAPPPAKKRRGRP 655
Query: 181 KKYTMREDMNTPSSVKESND 240
T + N P+++ + D
Sbjct: 656 PGRTNQPKQNQPTAIIQVED 675
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.304 0.123 0.330
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,082,135
Number of Sequences: 369166
Number of extensions: 1157689
Number of successful extensions: 2831
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 2630
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 2804
length of database: 68,354,980
effective HSP length: 106
effective length of database: 48,773,070
effective search space used: 4926080070
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)