Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_D10
(863 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q27433|MEC2_CAEEL Mechanosensory protein 2 259 9e-69
sp|Q19958|STO2_CAEEL Stomatin protein 2 255 1e-67
sp|Q22165|STO4_CAEEL Stomatin protein 4 252 8e-67
sp|P54116|STOM_MOUSE Erythrocyte band 7 integral membrane p... 248 1e-65
sp|P27105|STOM_HUMAN Erythrocyte band 7 integral membrane p... 248 2e-65
sp|Q6PE84|STML3_MOUSE Stomatin-like protein 3 (Stomatin-rel... 231 2e-60
sp|Q8TAV4|STML3_HUMAN Stomatin-like protein 3 230 3e-60
sp|Q21190|UNC1_CAEEL Uncoordinated protein 1 (Protein unc-1) 230 3e-60
sp|Q19200|STO1_CAEEL Stomatin protein 1 204 3e-52
sp|Q8K4G9|PODO_RAT Podocin 184 3e-46
>sp|Q27433|MEC2_CAEEL Mechanosensory protein 2
Length = 481
Score = 259 bits (661), Expect = 9e-69
Identities = 138/246 (56%), Positives = 167/246 (67%)
Frame = +3
Query: 126 EMKTCDSSLGLCSYLLIGLSYLVFVVTLPFSLIFSIKVVAEYERVVIFRLGRIKSGKALG 305
E + G+C ++L LSYL+ TLP S IKVV EYER VIFRLGR+ G A G
Sbjct: 106 EKANIQNEFGVCGWILTILSYLLIFFTLPISACMCIKVVQEYERAVIFRLGRLMPGGAKG 165
Query: 306 PGLFCILPCLDSITKIDLRTVTFEVPPQEVLTKDSVTVSVDAVVYYRIHNPIISVINVED 485
PG+F I+PC+D+ K+DLR ++FEVPPQE+L+KDSVTV+VDAVVY+RI N ISV NVED
Sbjct: 166 PGIFFIVPCIDTYRKVDLRVLSFEVPPQEILSKDSVTVAVDAVVYFRISNATISVTNVED 225
Query: 486 ADRSTRLLAATTLQNVLGTKKLTEVLSERESISSMMQNMLDEATHPWGXXXXXXXXXXXX 665
A RST+LLA TTL+N+LGTK L E+LS+RE+IS MQ LDEAT PWG
Sbjct: 226 AARSTKLLAQTTLRNILGTKTLAEMLSDREAISHQMQTTLDEATEPWGVKVERVEVKDVR 285
Query: 666 LPLQLQRVMXXXXXXXXXXXXXXXXXXGERNASVALKMAADVMNDFPVALQLRYLQVLNA 845
LP+QLQR M GE+ AS ALK AA+V+ + P ALQLRYLQ LN+
Sbjct: 286 LPVQLQRAMAAEAEAAREARAKVIVAEGEQKASRALKEAAEVIAESPSALQLRYLQTLNS 345
Query: 846 ISAEKN 863
ISAEKN
Sbjct: 346 ISAEKN 351
>sp|Q19958|STO2_CAEEL Stomatin protein 2
Length = 314
Score = 255 bits (651), Expect = 1e-67
Identities = 129/240 (53%), Positives = 167/240 (69%)
Frame = +3
Query: 141 DSSLGLCSYLLIGLSYLVFVVTLPFSLIFSIKVVAEYERVVIFRLGRIKSGKALGPGLFC 320
D+ LG C + L+GLS+++ + T P S+ F +KVV EYER VIFRLGR+ G A GPG+F
Sbjct: 63 DTGLGFCGWFLMGLSWIMVISTFPVSIYFCMKVVQEYERAVIFRLGRLIGGGAKGPGIFF 122
Query: 321 ILPCLDSITKIDLRTVTFEVPPQEVLTKDSVTVSVDAVVYYRIHNPIISVINVEDADRST 500
+LPC++S TK+DLRTV+F VPPQE+LTKDSVT SVDAV+YYRI N +SV NVE+A ST
Sbjct: 123 VLPCIESYTKVDLRTVSFSVPPQEILTKDSVTTSVDAVIYYRISNATVSVANVENAHHST 182
Query: 501 RLLAATTLQNVLGTKKLTEVLSERESISSMMQNMLDEATHPWGXXXXXXXXXXXXLPLQL 680
RLLA TTL+N+LGT+ L+E+LS+RE++++ MQ +LDEAT WG LP+QL
Sbjct: 183 RLLAQTTLRNMLGTRSLSEILSDRETLAASMQTILDEATESWGIKVERVEIKDVRLPIQL 242
Query: 681 QRVMXXXXXXXXXXXXXXXXXXGERNASVALKMAADVMNDFPVALQLRYLQVLNAISAEK 860
QR M GE+ AS AL+ AA V+ P ALQLRYLQ LN+++ EK
Sbjct: 243 QRAMAAEAEATREARAKVIAAEGEQKASRALRDAASVIAQSPAALQLRYLQTLNSVAREK 302
>sp|Q22165|STO4_CAEEL Stomatin protein 4
Length = 281
Score = 252 bits (644), Expect = 8e-67
Identities = 133/236 (56%), Positives = 164/236 (69%)
Frame = +3
Query: 156 LCSYLLIGLSYLVFVVTLPFSLIFSIKVVAEYERVVIFRLGRIKSGKALGPGLFCILPCL 335
+C +++ +SYLV + TLP S F +KVV EYER VIFRLGR+K G A GPG+F I+PC+
Sbjct: 25 VCGWIITIISYLVVLFTLPLSAFFCLKVVQEYERAVIFRLGRLKHGGARGPGIFFIIPCI 84
Query: 336 DSITKIDLRTVTFEVPPQEVLTKDSVTVSVDAVVYYRIHNPIISVINVEDADRSTRLLAA 515
+S KIDLR V+F+VPPQE+L+KDSVTVSVDAV+Y+RI N +SVINVEDA RST+LLA
Sbjct: 85 ESFKKIDLRVVSFDVPPQEILSKDSVTVSVDAVIYFRISNATVSVINVEDAARSTKLLAQ 144
Query: 516 TTLQNVLGTKKLTEVLSERESISSMMQNMLDEATHPWGXXXXXXXXXXXXLPLQLQRVMX 695
TTL+N LGT+ L E+LS R++IS MQ LDEAT PWG LP+QLQR M
Sbjct: 145 TTLRNFLGTRTLAEMLSSRDAISMQMQAALDEATDPWGVKVERVEIKDVRLPIQLQRAMA 204
Query: 696 XXXXXXXXXXXXXXXXXGERNASVALKMAADVMNDFPVALQLRYLQVLNAISAEKN 863
GE+ AS AL AADV+ P A+QLRYLQ LN+IS+EKN
Sbjct: 205 AEAEAARAAGAKIIAAEGEQLASRALADAADVIATSPCAIQLRYLQTLNSISSEKN 260
>sp|P54116|STOM_MOUSE Erythrocyte band 7 integral membrane protein (Stomatin) (Protein
7.2b)
Length = 284
Score = 248 bits (634), Expect = 1e-65
Identities = 125/240 (52%), Positives = 163/240 (67%)
Frame = +3
Query: 144 SSLGLCSYLLIGLSYLVFVVTLPFSLIFSIKVVAEYERVVIFRLGRIKSGKALGPGLFCI 323
+ LG C ++L+ +S++ ++T P S+ IK+V EYERV+IFRLGRI G A GPGLF I
Sbjct: 25 TELGACGWILVAVSFIFVLITFPISIWICIKIVKEYERVIIFRLGRILQGGAKGPGLFFI 84
Query: 324 LPCLDSITKIDLRTVTFEVPPQEVLTKDSVTVSVDAVVYYRIHNPIISVINVEDADRSTR 503
LPC DS K+D+RT++F++PPQEVLTKDSVT+SVD VVYYR+ N ++V N+ +AD +TR
Sbjct: 85 LPCTDSFIKVDMRTISFDIPPQEVLTKDSVTISVDGVVYYRVQNATLAVANITNADSATR 144
Query: 504 LLAATTLQNVLGTKKLTEVLSERESISSMMQNMLDEATHPWGXXXXXXXXXXXXLPLQLQ 683
LLA TTL+N LGTK L+++LS+RE I+ MQ+ LD+AT WG LP+QLQ
Sbjct: 145 LLAQTTLRNALGTKNLSQILSDREEIAHHMQSTLDDATDDWGIKVERVEIKDVKLPVQLQ 204
Query: 684 RVMXXXXXXXXXXXXXXXXXXGERNASVALKMAADVMNDFPVALQLRYLQVLNAISAEKN 863
R M GE NAS ALK A+ V+ + P ALQLRYLQ L I+AEKN
Sbjct: 205 RAMAAEAEAAREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKN 264
>sp|P27105|STOM_HUMAN Erythrocyte band 7 integral membrane protein (Stomatin) (Protein
7.2b)
Length = 288
Score = 248 bits (632), Expect = 2e-65
Identities = 125/238 (52%), Positives = 161/238 (67%)
Frame = +3
Query: 150 LGLCSYLLIGLSYLVFVVTLPFSLIFSIKVVAEYERVVIFRLGRIKSGKALGPGLFCILP 329
LG C ++L+ S+L V+T P S+ IK++ EYER +IFRLGRI G A GPGLF ILP
Sbjct: 27 LGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILP 86
Query: 330 CLDSITKIDLRTVTFEVPPQEVLTKDSVTVSVDAVVYYRIHNPIISVINVEDADRSTRLL 509
C DS K+D+RT++F++PPQE+LTKDSVT+SVD VVYYR+ N ++V N+ +AD +TRLL
Sbjct: 87 CTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLL 146
Query: 510 AATTLQNVLGTKKLTEVLSERESISSMMQNMLDEATHPWGXXXXXXXXXXXXLPLQLQRV 689
A TTL+NVLGTK L+++LS+RE I+ MQ+ LD+AT WG LP+QLQR
Sbjct: 147 AQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRA 206
Query: 690 MXXXXXXXXXXXXXXXXXXGERNASVALKMAADVMNDFPVALQLRYLQVLNAISAEKN 863
M GE NAS ALK A+ V+ + P ALQLRYLQ L I+AEKN
Sbjct: 207 MAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKN 264
>sp|Q6PE84|STML3_MOUSE Stomatin-like protein 3 (Stomatin-related olfactory protein)
Length = 287
Score = 231 bits (590), Expect = 2e-60
Identities = 118/243 (48%), Positives = 160/243 (65%)
Frame = +3
Query: 135 TCDSSLGLCSYLLIGLSYLVFVVTLPFSLIFSIKVVAEYERVVIFRLGRIKSGKALGPGL 314
T S LG+C ++L LS+L+ +VT P S+ +K++ EYER V+FRLGRI++ KA GPGL
Sbjct: 15 TNKSRLGVCGWILFFLSFLLMLVTFPISVWMCLKIIKEYERAVVFRLGRIQADKAKGPGL 74
Query: 315 FCILPCLDSITKIDLRTVTFEVPPQEVLTKDSVTVSVDAVVYYRIHNPIISVINVEDADR 494
+LPC+D K+DLRTVT +PPQE+LT+DSVT VD VVYYRI++ + +V NV D +
Sbjct: 75 ILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQ 134
Query: 495 STRLLAATTLQNVLGTKKLTEVLSERESISSMMQNMLDEATHPWGXXXXXXXXXXXXLPL 674
+T LLA TTL+NVLGT+ L+++LS RE I+ +Q +LD+AT WG +P+
Sbjct: 135 ATFLLAQTTLRNVLGTQTLSQILSGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPV 194
Query: 675 QLQRVMXXXXXXXXXXXXXXXXXXGERNASVALKMAADVMNDFPVALQLRYLQVLNAISA 854
QLQR M GE NAS +LK A+ V+ + PVALQLRYLQ L ++
Sbjct: 195 QLQRSMAAEAEATREARAKVLAAEGEMNASKSLKSASMVLAESPVALQLRYLQTLTTVAT 254
Query: 855 EKN 863
EKN
Sbjct: 255 EKN 257
>sp|Q8TAV4|STML3_HUMAN Stomatin-like protein 3
Length = 291
Score = 230 bits (587), Expect = 3e-60
Identities = 113/238 (47%), Positives = 159/238 (66%)
Frame = +3
Query: 150 LGLCSYLLIGLSYLVFVVTLPFSLIFSIKVVAEYERVVIFRLGRIKSGKALGPGLFCILP 329
LG+C ++L LS+L+ ++T P S+ +K++ EYER V+FRLGRI++ KA GPGL +LP
Sbjct: 24 LGVCGWILFSLSFLLVIITFPISIWMCLKIIKEYERAVVFRLGRIQADKAKGPGLILVLP 83
Query: 330 CLDSITKIDLRTVTFEVPPQEVLTKDSVTVSVDAVVYYRIHNPIISVINVEDADRSTRLL 509
C+D K+DLRTVT +PPQE+LT+DSVT VD VVYYRI++ + +V NV D ++T LL
Sbjct: 84 CIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQATFLL 143
Query: 510 AATTLQNVLGTKKLTEVLSERESISSMMQNMLDEATHPWGXXXXXXXXXXXXLPLQLQRV 689
A TTL+NVLGT+ L+++L+ RE I+ +Q +LD+AT WG +P+QLQR
Sbjct: 144 AQTTLRNVLGTQTLSQILAGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRS 203
Query: 690 MXXXXXXXXXXXXXXXXXXGERNASVALKMAADVMNDFPVALQLRYLQVLNAISAEKN 863
M GE NAS +LK A+ V+ + P+ALQLRYLQ L+ ++ EKN
Sbjct: 204 MAAEAEATREARAKVLAAEGEMNASKSLKSASMVLAESPIALQLRYLQTLSTVATEKN 261
>sp|Q21190|UNC1_CAEEL Uncoordinated protein 1 (Protein unc-1)
Length = 285
Score = 230 bits (587), Expect = 3e-60
Identities = 123/233 (52%), Positives = 157/233 (67%)
Frame = +3
Query: 165 YLLIGLSYLVFVVTLPFSLIFSIKVVAEYERVVIFRLGRIKSGKALGPGLFCILPCLDSI 344
Y L LS+++ +VT PFS+ +KV+ EYERVVIFR+GR+ G A GPG+ I+PC+D+
Sbjct: 33 YALQALSWILIIVTFPFSMCVCLKVIKEYERVVIFRIGRLVFGGARGPGMIFIIPCIDTY 92
Query: 345 TKIDLRTVTFEVPPQEVLTKDSVTVSVDAVVYYRIHNPIISVINVEDADRSTRLLAATTL 524
KIDLR V++ VPPQE+L+KDSVTVSVDAVVY+R +PI SV NV+DA ST+LLA TTL
Sbjct: 93 RKIDLRVVSYAVPPQEILSKDSVTVSVDAVVYFRTSDPIASVNNVDDAIYSTKLLAQTTL 152
Query: 525 QNVLGTKKLTEVLSERESISSMMQNMLDEATHPWGXXXXXXXXXXXXLPLQLQRVMXXXX 704
+N LG K LTE+L+ERE+I+ + + +LDE T WG LP QL R M
Sbjct: 153 RNALGMKTLTEMLTEREAIAQLCETILDEGTEHWGVKVERVEVKDIRLPQQLTRAMAAEA 212
Query: 705 XXXXXXXXXXXXXXGERNASVALKMAADVMNDFPVALQLRYLQVLNAISAEKN 863
GE+ AS ALK AADV+ PVALQLR+LQ LN+I+AE N
Sbjct: 213 EAAREARAKVVAAEGEQKASRALKEAADVIQANPVALQLRHLQALNSIAAEHN 265
>sp|Q19200|STO1_CAEEL Stomatin protein 1
Length = 330
Score = 204 bits (518), Expect = 3e-52
Identities = 109/236 (46%), Positives = 147/236 (62%)
Frame = +3
Query: 153 GLCSYLLIGLSYLVFVVTLPFSLIFSIKVVAEYERVVIFRLGRIKSGKALGPGLFCILPC 332
G I +SY++ +T P S+ IK+V EY+R V+FRLGR+ GPG+F I+PC
Sbjct: 38 GCTEMFCIAMSYVLIFLTFPVSVFMCIKIVQEYQRAVVFRLGRLVPD-VKGPGIFFIIPC 96
Query: 333 LDSITKIDLRTVTFEVPPQEVLTKDSVTVSVDAVVYYRIHNPIISVINVEDADRSTRLLA 512
+D+ IDLR ++ VP QE+L++DSVTVSVDAVVY+++ +PI SV+ V +A ST+LLA
Sbjct: 97 IDTFLNIDLRVASYNVPSQEILSRDSVTVSVDAVVYFKVFDPITSVVGVGNATDSTKLLA 156
Query: 513 ATTLQNVLGTKKLTEVLSERESISSMMQNMLDEATHPWGXXXXXXXXXXXXLPLQLQRVM 692
TTL+ +LGT L+E+LS+RE IS+ M+ LDEAT PWG LP Q+QR M
Sbjct: 157 QTTLRTILGTHTLSEILSDREKISADMKISLDEATEPWGIKVERVELRDVRLPSQMQRAM 216
Query: 693 XXXXXXXXXXXXXXXXXXGERNASVALKMAADVMNDFPVALQLRYLQVLNAISAEK 860
GE AS AL AA +++ A+QLRYL LNAIS+EK
Sbjct: 217 AAEAEATRDAGAKIIAAEGELRASAALAEAATIISKSEGAMQLRYLHTLNAISSEK 272
>sp|Q8K4G9|PODO_RAT Podocin
Length = 383
Score = 184 bits (467), Expect = 3e-46
Identities = 97/239 (40%), Positives = 140/239 (58%)
Frame = +3
Query: 144 SSLGLCSYLLIGLSYLVFVVTLPFSLIFSIKVVAEYERVVIFRLGRIKSGKALGPGLFCI 323
S LG C +LL+ S + +VT PFS+ F IKVV EYERV+IFRLG + G+A GPGLF
Sbjct: 96 SGLGACEWLLVLSSLIFIIVTFPFSIWFCIKVVQEYERVIIFRLGHLLPGRAKGPGLFFF 155
Query: 324 LPCLDSITKIDLRTVTFEVPPQEVLTKDSVTVSVDAVVYYRIHNPIISVINVEDADRSTR 503
LPCLD+ K+DLR T E+P EV+TKD + +DAV YYR+ N + + ++ ++ +
Sbjct: 156 LPCLDTYHKVDLRLQTLEIPFHEVVTKDMFIMEIDAVCYYRMENASLLLSSLAHVSKAIQ 215
Query: 504 LLAATTLQNVLGTKKLTEVLSERESISSMMQNMLDEATHPWGXXXXXXXXXXXXLPLQLQ 683
L TT++ +L + LTE+L ER+SI+ ++ LD T WG LP LQ
Sbjct: 216 FLVQTTMKRLLAHRSLTEILLERKSIAQDVKVALDSVTCVWGIKVERTEIKDVRLPAGLQ 275
Query: 684 RVMXXXXXXXXXXXXXXXXXXGERNASVALKMAADVMNDFPVALQLRYLQVLNAISAEK 860
+ GE+ AS +L+MAA++++ P A+QLRYL L ++S +K
Sbjct: 276 HSLAVEAEAQRQAKVRVIAAEGEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTDK 334
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 81,435,145
Number of Sequences: 369166
Number of extensions: 1438337
Number of successful extensions: 3758
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3640
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3732
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8582957970
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)