Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_C16
(671 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase I ... 82 1e-15
sp|Q9D7G0|PRPS1_MOUSE Ribose-phosphate pyrophosphokinase I ... 82 1e-15
sp|Q4R4R7|PRPS2_MACFA Ribose-phosphate pyrophosphokinase II... 80 5e-15
sp|P09330|PRPS2_RAT Ribose-phosphate pyrophosphokinase II (... 80 6e-15
sp|Q9CS42|PRPS2_MOUSE Ribose-phosphate pyrophosphokinase II... 80 6e-15
sp|P21108|PRPS3_HUMAN Ribose-phosphate pyrophosphokinase II... 78 2e-14
sp|O60256|KPRB_HUMAN Phosphoribosyl pyrophosphate synthetas... 74 3e-13
sp|Q8R574|KPRB_MOUSE Phosphoribosyl pyrophosphate synthetas... 73 8e-13
sp|O08618|KPRB_RAT Phosphoribosyl pyrophosphate synthetase-... 73 8e-13
sp|Q14558|KPRA_HUMAN Phosphoribosyl pyrophosphate synthetas... 72 1e-12
>sp|P60891|PRPS1_HUMAN Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I) (PPRibP)
sp|P60892|PRPS1_RAT Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I)
Length = 318
Score = 82.4 bits (202), Expect = 1e-15
Identities = 39/89 (43%), Positives = 63/89 (70%), Gaps = 2/89 (2%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F++PVDNL +E + WI++NIS+W TI S + A+RV ++A+ L V F LI+ E+K
Sbjct: 138 FDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIADRLNVDFALIHKERK 197
Query: 182 EASE--QIILVGDVFSRIAVILLDIIDNC 262
+A+E +++LVGDV R+A+++ D+ D C
Sbjct: 198 KANEVDRMVLVGDVKDRVAILVDDMADTC 226
Score = 68.6 bits (166), Expect = 1e-11
Identities = 35/82 (42%), Positives = 53/82 (64%)
Frame = +1
Query: 301 RLKEVGAAGVYVIATHGMLSERLMKQVDDSIITKLGVTHTICQEKYVKQSDKIACLDVSV 480
+L GA VY I THG+ S + +++++ + VT+TI QE +K KI +D+S+
Sbjct: 235 KLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISM 294
Query: 481 IFAEAIRRIHYGESVSCLYNNL 546
I AEAIRR H GESVS L++++
Sbjct: 295 ILAEAIRRTHNGESVSYLFSHV 316
>sp|Q9D7G0|PRPS1_MOUSE Ribose-phosphate pyrophosphokinase I (Phosphoribosyl pyrophosphate
synthetase I) (PRS-I)
Length = 318
Score = 82.0 bits (201), Expect = 1e-15
Identities = 39/89 (43%), Positives = 62/89 (69%), Gaps = 2/89 (2%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F++PVDNL +E + WI++NIS+W TI S + A+RV ++A L V F LI+ E+K
Sbjct: 138 FDIPVDNLYAEPAVLKWIRENISEWRNCTIVSPDAGGAKRVTSIAERLNVDFALIHKERK 197
Query: 182 EASE--QIILVGDVFSRIAVILLDIIDNC 262
+A+E +++LVGDV R+A+++ D+ D C
Sbjct: 198 KANEVDRMVLVGDVKDRVAILVDDMADTC 226
Score = 68.6 bits (166), Expect = 1e-11
Identities = 35/82 (42%), Positives = 53/82 (64%)
Frame = +1
Query: 301 RLKEVGAAGVYVIATHGMLSERLMKQVDDSIITKLGVTHTICQEKYVKQSDKIACLDVSV 480
+L GA VY I THG+ S + +++++ + VT+TI QE +K KI +D+S+
Sbjct: 235 KLLSAGATRVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQEDKMKHCSKIQVIDISM 294
Query: 481 IFAEAIRRIHYGESVSCLYNNL 546
I AEAIRR H GESVS L++++
Sbjct: 295 ILAEAIRRTHNGESVSYLFSHV 316
>sp|Q4R4R7|PRPS2_MACFA Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
sp|P11908|PRPS2_HUMAN Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II) (PPRibP)
Length = 318
Score = 80.1 bits (196), Expect = 5e-15
Identities = 37/89 (41%), Positives = 63/89 (70%), Gaps = 2/89 (2%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F++PVDNL +E + WI++NI++W+ I S + A+RV ++A+ L V F LI+ E+K
Sbjct: 138 FDIPVDNLYAEPAVLQWIRENIAEWKNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERK 197
Query: 182 EASE--QIILVGDVFSRIAVILLDIIDNC 262
+A+E +++LVGDV R+A+++ D+ D C
Sbjct: 198 KANEVDRMVLVGDVKDRVAILVDDMADTC 226
Score = 68.2 bits (165), Expect = 2e-11
Identities = 35/82 (42%), Positives = 53/82 (64%)
Frame = +1
Query: 301 RLKEVGAAGVYVIATHGMLSERLMKQVDDSIITKLGVTHTICQEKYVKQSDKIACLDVSV 480
+L GA VY I THG+ S + +++++ + VT+TI QE +K KI +D+S+
Sbjct: 235 KLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCTKIQVIDISM 294
Query: 481 IFAEAIRRIHYGESVSCLYNNL 546
I AEAIRR H GESVS L++++
Sbjct: 295 ILAEAIRRTHNGESVSYLFSHV 316
>sp|P09330|PRPS2_RAT Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
Length = 318
Score = 79.7 bits (195), Expect = 6e-15
Identities = 37/89 (41%), Positives = 62/89 (69%), Gaps = 2/89 (2%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F++PVDNL +E + WI++NI++W I S + A+RV ++A+ L V F LI+ E+K
Sbjct: 138 FDIPVDNLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERK 197
Query: 182 EASE--QIILVGDVFSRIAVILLDIIDNC 262
+A+E +++LVGDV R+A+++ D+ D C
Sbjct: 198 KANEVDRMVLVGDVKDRVAILVDDMADTC 226
Score = 68.6 bits (166), Expect = 1e-11
Identities = 35/82 (42%), Positives = 53/82 (64%)
Frame = +1
Query: 301 RLKEVGAAGVYVIATHGMLSERLMKQVDDSIITKLGVTHTICQEKYVKQSDKIACLDVSV 480
+L GA VY I THG+ S + +++++ + VT+TI QE +K KI +D+S+
Sbjct: 235 KLLSAGATKVYAILTHGIFSGPAISRINNAAFEAVVVTNTIPQEDKMKHCSKIQVIDISM 294
Query: 481 IFAEAIRRIHYGESVSCLYNNL 546
I AEAIRR H GESVS L++++
Sbjct: 295 ILAEAIRRTHNGESVSYLFSHV 316
>sp|Q9CS42|PRPS2_MOUSE Ribose-phosphate pyrophosphokinase II (Phosphoribosyl pyrophosphate
synthetase II) (PRS-II)
Length = 318
Score = 79.7 bits (195), Expect = 6e-15
Identities = 37/89 (41%), Positives = 62/89 (69%), Gaps = 2/89 (2%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F++PVDNL +E + WI++NI++W I S + A+RV ++A+ L V F LI+ E+K
Sbjct: 138 FDIPVDNLYAEPAVLQWIRENITEWRNCIIVSPDAGGAKRVTSIADRLNVEFALIHKERK 197
Query: 182 EASE--QIILVGDVFSRIAVILLDIIDNC 262
+A+E +++LVGDV R+A+++ D+ D C
Sbjct: 198 KANEVDRMVLVGDVKDRVAILVDDMADTC 226
Score = 68.2 bits (165), Expect = 2e-11
Identities = 35/82 (42%), Positives = 52/82 (63%)
Frame = +1
Query: 301 RLKEVGAAGVYVIATHGMLSERLMKQVDDSIITKLGVTHTICQEKYVKQSDKIACLDVSV 480
+L GA VY I THG+ S + +++ + + VT+TI QE +K KI +D+S+
Sbjct: 235 KLLSAGATKVYAILTHGIFSGPAISRINSAAFEAVVVTNTIPQEDKMKHCSKIQVIDISM 294
Query: 481 IFAEAIRRIHYGESVSCLYNNL 546
I AEAIRR H GESVS L++++
Sbjct: 295 ILAEAIRRTHNGESVSYLFSHV 316
>sp|P21108|PRPS3_HUMAN Ribose-phosphate pyrophosphokinase III (Phosphoribosyl
pyrophosphate synthetase III) (PRS-III) (Phosphoribosyl
pyrophosphate synthetase 1-like 1)
Length = 318
Score = 78.2 bits (191), Expect = 2e-14
Identities = 38/89 (42%), Positives = 61/89 (68%), Gaps = 2/89 (2%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
F++PVDNL +E + WI++NI +W+ I S + A+RV ++A+ L V F LI+ E+K
Sbjct: 138 FDIPVDNLYAEPTVLKWIRENIPEWKNCIIVSPDAGGAKRVTSIADQLNVDFALIHKERK 197
Query: 182 EASEQ--IILVGDVFSRIAVILLDIIDNC 262
+A+E I+LVGDV R+A+++ D+ D C
Sbjct: 198 KANEVDCIVLVGDVNDRVAILVDDMADTC 226
Score = 67.4 bits (163), Expect = 3e-11
Identities = 34/82 (41%), Positives = 53/82 (64%)
Frame = +1
Query: 301 RLKEVGAAGVYVIATHGMLSERLMKQVDDSIITKLGVTHTICQEKYVKQSDKIACLDVSV 480
+L GA VY I THG+ S + +++ + + VT+TI Q++ +K KI +D+S+
Sbjct: 235 KLLSAGATRVYAILTHGIFSGPAISRINTACFEAVVVTNTIPQDEKMKHCSKIRVIDISM 294
Query: 481 IFAEAIRRIHYGESVSCLYNNL 546
I AEAIRR H GESVS L++++
Sbjct: 295 ILAEAIRRTHNGESVSYLFSHV 316
>sp|O60256|KPRB_HUMAN Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP
synthetase-associated protein 2) (41 kDa
phosphoribosypyrophosphate synthetase-associated
protein) (PAP41)
Length = 369
Score = 74.3 bits (181), Expect = 3e-13
Identities = 38/81 (46%), Positives = 57/81 (70%)
Frame = +1
Query: 304 LKEVGAAGVYVIATHGMLSERLMKQVDDSIITKLGVTHTICQEKYVKQSDKIACLDVSVI 483
LKE GA ++V+ATHG+LS +++++S I ++ VT+TI E Q KI +D+S+I
Sbjct: 285 LKERGAYKIFVMATHGLLSSDAPRRIEESAIDEVVVTNTIPHEVQKLQCPKIKTVDISMI 344
Query: 484 FAEAIRRIHYGESVSCLYNNL 546
+EAIRRIH GES+S L+ N+
Sbjct: 345 LSEAIRRIHNGESMSYLFRNI 365
Score = 44.3 bits (103), Expect = 3e-04
Identities = 30/119 (25%), Positives = 53/119 (44%), Gaps = 33/119 (27%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
FN+PVDNL + + +I++ I + I + + SA+R + A L++ +I+ E +
Sbjct: 156 FNIPVDNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQ 215
Query: 182 EASEQII---------------------------------LVGDVFSRIAVILLDIIDN 259
+A ++ +VGDV RIA+I+ DIID+
Sbjct: 216 DAESDLVDGRHSPPMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDD 274
>sp|Q8R574|KPRB_MOUSE Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP
synthetase-associated protein 2) (41 kDa
phosphoribosypyrophosphate synthetase-associated
protein) (PAP41)
Length = 369
Score = 72.8 bits (177), Expect = 8e-13
Identities = 38/81 (46%), Positives = 56/81 (69%)
Frame = +1
Query: 304 LKEVGAAGVYVIATHGMLSERLMKQVDDSIITKLGVTHTICQEKYVKQSDKIACLDVSVI 483
LKE GA ++V+ATHG+LS + +++S I ++ VT+TI E Q KI +D+S+I
Sbjct: 285 LKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKTVDISMI 344
Query: 484 FAEAIRRIHYGESVSCLYNNL 546
+EAIRRIH GES+S L+ N+
Sbjct: 345 LSEAIRRIHNGESMSYLFRNI 365
Score = 44.3 bits (103), Expect = 3e-04
Identities = 30/119 (25%), Positives = 53/119 (44%), Gaps = 33/119 (27%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
FN+PVDNL + + +I++ I + I + + SA+R + A L++ +I+ E +
Sbjct: 156 FNIPVDNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQ 215
Query: 182 EASEQII---------------------------------LVGDVFSRIAVILLDIIDN 259
+A ++ +VGDV RIA+I+ DIID+
Sbjct: 216 DAESDLVDGRHSPPMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDD 274
>sp|O08618|KPRB_RAT Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP
synthetase-associated protein 2) (41 kDa
phosphoribosypyrophosphate synthetase-associated
protein) (PAP41)
Length = 369
Score = 72.8 bits (177), Expect = 8e-13
Identities = 38/81 (46%), Positives = 56/81 (69%)
Frame = +1
Query: 304 LKEVGAAGVYVIATHGMLSERLMKQVDDSIITKLGVTHTICQEKYVKQSDKIACLDVSVI 483
LKE GA ++V+ATHG+LS + +++S I ++ VT+TI E Q KI +D+S+I
Sbjct: 285 LKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKTVDISMI 344
Query: 484 FAEAIRRIHYGESVSCLYNNL 546
+EAIRRIH GES+S L+ N+
Sbjct: 345 LSEAIRRIHNGESMSYLFRNI 365
Score = 44.3 bits (103), Expect = 3e-04
Identities = 30/119 (25%), Positives = 53/119 (44%), Gaps = 33/119 (27%)
Frame = +2
Query: 2 FNVPVDNLLSESCHISWIKKNISKWEEITIFSLNVTSAERVANMANTLKVRFGLIYVEKK 181
FN+PVDNL + + +I++ I + I + + SA+R + A L++ +I+ E +
Sbjct: 156 FNIPVDNLRASPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQ 215
Query: 182 EASEQII---------------------------------LVGDVFSRIAVILLDIIDN 259
+A ++ +VGDV RIA+I+ DIID+
Sbjct: 216 DAESDLVDGRHSPPMVRSVAAIHPSLEIPMLIPKEKPPITVVGDVGGRIAIIVDDIIDD 274
>sp|Q14558|KPRA_HUMAN Phosphoribosyl pyrophosphate synthetase-associated protein 1 (PRPP
synthetase-associated protein 1) (39 kDa
phosphoribosypyrophosphate synthetase-associated
protein) (PAP39)
Length = 356
Score = 72.4 bits (176), Expect = 1e-12
Identities = 36/81 (44%), Positives = 56/81 (69%)
Frame = +1
Query: 304 LKEVGAAGVYVIATHGMLSERLMKQVDDSIITKLGVTHTICQEKYVKQSDKIACLDVSVI 483
LKE GA +YV+ATHG+LS + +++S + ++ VT+T+ E Q KI +D+S+I
Sbjct: 272 LKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKTVDISLI 331
Query: 484 FAEAIRRIHYGESVSCLYNNL 546
+EAIRRIH GES++ L+ N+
Sbjct: 332 LSEAIRRIHNGESMAYLFRNI 352
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 73,877,872
Number of Sequences: 369166
Number of extensions: 1401504
Number of successful extensions: 3632
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 3375
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 3613
length of database: 68,354,980
effective HSP length: 107
effective length of database: 48,588,335
effective search space used: 5636246860
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)