Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_C02
(857 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathe... 313 3e-85
sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RS... 307 2e-83
sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [... 306 6e-83
sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (... 301 2e-81
sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [... 293 5e-79
sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase p... 283 6e-76
sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase p... 266 7e-71
sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6... 232 9e-61
sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precu... 217 4e-56
sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5... 214 3e-55
>sp|P07688|CATB_BOVIN Cathepsin B precursor [Contains: Cathepsin B light chain; Cathepsin
B heavy chain]
Length = 335
Score = 313 bits (803), Expect = 3e-85
Identities = 149/250 (59%), Positives = 179/250 (71%), Gaps = 1/250 (0%)
Frame = +1
Query: 109 PLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLNRVRL 285
PLS +L+N+VN TTWKAG +S ++K+ G ++ P KLP+R V L
Sbjct: 25 PLSDELVNFVNK-QNTTWKAGHNFYNVDLSYVKKLCGAILGGP---KLPQRDAFAADVVL 80
Query: 286 PTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLT 465
P +FDAR QWP C +I EIRDQ +CGSCWAFGAVEAI+DR CIHSNG +SAED+LT
Sbjct: 81 PESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLT 140
Query: 466 CCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTG 645
CCG CGDGCNGGFPSGAW++W GLV+GG Y +H+GC+ Y+ P C HHV G P CTG
Sbjct: 141 CCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTG 200
Query: 646 EFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFP 825
E TPKC K C+ GYS +Y EDK +G SSYSV +N++ IM EI NGPVE AFSVY+DF
Sbjct: 201 EGDTPKCNKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFL 260
Query: 826 SYKSGVYQHV 855
YKSGVYQHV
Sbjct: 261 LYKSGVYQHV 270
>sp|P00787|CATB_RAT Cathepsin B precursor (Cathepsin B1) (RSG-2) [Contains: Cathepsin B
light chain; Cathepsin B heavy chain]
Length = 339
Score = 307 bits (787), Expect = 2e-83
Identities = 143/253 (56%), Positives = 178/253 (70%), Gaps = 1/253 (0%)
Frame = +1
Query: 97 PIHTPLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLN 273
P PLS D+INY+N TTW+AG IS ++K+ G V+ PN LP+R
Sbjct: 21 PSSHPLSDDMINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGPN---LPERVGFSE 76
Query: 274 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 453
+ LP +FDAR QW C +I +IRDQ +CGSCWAFGAVEA++DR CIH+NG +SAE
Sbjct: 77 DINLPESFDAREQWSNCPTIAQIRDQGSCGSCWAFGAVEAMSDRICIHTNGRVNVEVSAE 136
Query: 454 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 633
DLLTCCG +CGDGCNGG+PSGAW++W GLV+GG Y +H+GC Y P C HHV G P
Sbjct: 137 DLLTCCGIQCGDGCNGGYPSGAWNFWTRKGLVSGGVYNSHIGCLPYTIPPCEHHVNGSRP 196
Query: 634 NCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 813
CTGE TPKC K C+AGYS +Y EDK YG +SYSV +++ IM EI NGPVE AF+V+
Sbjct: 197 PCTGEGDTPKCNKMCEAGYSTSYKEDKHYGYTSYSVSDSEKEIMAEIYKNGPVEGAFTVF 256
Query: 814 ADFPSYKSGVYQH 852
+DF +YKSGVY+H
Sbjct: 257 SDFLTYKSGVYKH 269
>sp|P10605|CATB_MOUSE Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 339
Score = 306 bits (783), Expect = 6e-83
Identities = 145/253 (57%), Positives = 178/253 (70%), Gaps = 1/253 (0%)
Frame = +1
Query: 97 PIHTPLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLG-VMKDPNNFKLPKRKPLLN 273
P PLS DLINY+N TTW+AG IS ++K+ G V+ P KLP R
Sbjct: 21 PSFHPLSDDLINYINK-QNTTWQAGRNFYNVDISYLKKLCGTVLGGP---KLPGRVAFGE 76
Query: 274 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 453
+ LP TFDAR QW C +IG+IRDQ +CGSCWAFGAVEAI+DR CIH+NG +SAE
Sbjct: 77 DIDLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAE 136
Query: 454 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 633
DLLTCCG +CGDGCNGG+PSGAW +W GLV+GG Y +H+GC Y P C HHV G P
Sbjct: 137 DLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRP 196
Query: 634 NCTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 813
CTGE TP+C K+C+AGYS +Y EDK +G +SYSV ++ + IM EI NGPVE AF+V+
Sbjct: 197 PCTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAFTVF 256
Query: 814 ADFPSYKSGVYQH 852
+DF +YKSGVY+H
Sbjct: 257 SDFLTYKSGVYKH 269
>sp|P07858|CATB_HUMAN Cathepsin B precursor (Cathepsin B1) (APP secretase) (APPS)
[Contains: Cathepsin B light chain; Cathepsin B heavy
chain]
Length = 339
Score = 301 bits (770), Expect = 2e-81
Identities = 141/253 (55%), Positives = 177/253 (69%)
Frame = +1
Query: 97 PIHTPLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR 276
P PLS +L+NYVN TTW+AG +S ++++ G K P+R
Sbjct: 21 PSFHPLSDELVNYVNK-RNTTWQAGHNFYNVDMSYLKRLCGTFL--GGPKPPQRVMFTED 77
Query: 277 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 456
++LP +FDAR QWP+C +I EIRDQ +CGSCWAFGAVEAI+DR CIH+N + +SAED
Sbjct: 78 LKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAED 137
Query: 457 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 636
LLTCCG CGDGCNGG+P+ AW++W GLV+GG Y +H+GC+ Y+ P C HHV G P
Sbjct: 138 LLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPP 197
Query: 637 CTGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYA 816
CTGE TPKC K C+ GYS TY +DK YG +SYSV ++++ IM EI NGPVE AFSVY+
Sbjct: 198 CTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYS 257
Query: 817 DFPSYKSGVYQHV 855
DF YKSGVYQHV
Sbjct: 258 DFLLYKSGVYQHV 270
>sp|P43233|CATB_CHICK Cathepsin B precursor (Cathepsin B1) [Contains: Cathepsin B light
chain; Cathepsin B heavy chain]
Length = 340
Score = 293 bits (749), Expect = 5e-79
Identities = 138/255 (54%), Positives = 171/255 (67%), Gaps = 1/255 (0%)
Frame = +1
Query: 94 IPIHTPLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLN 273
IP + PLS DL+N++N + TT +AG +S ++K+ G K P+R
Sbjct: 20 IPYYPPLSSDLVNHINKL-NTTGRAGHNFHNTDMSYVKKLCGTFL--GGPKAPERVDFAE 76
Query: 274 RVRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAE 453
+ LP TFD R QWP C +I EIRDQ +CGSCWAFGAVEAI+DR C+H+N + +SAE
Sbjct: 77 DMDLPDTFDTRKQWPNCPTISEIRDQGSCGSCWAFGAVEAISDRICVHTNAKVSVEVSAE 136
Query: 454 DLLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYP 633
DLL+CCGF CG GCNGG+PSGAW YW GLV+GG Y +H+GC+ Y P C HHV G P
Sbjct: 137 DLLSCCGFECGMGCNGGYPSGAWRYWTERGLVSGGLYDSHVGCRAYTIPPCEHHVNGSRP 196
Query: 634 NCTGE-FPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSV 810
CTGE TP+C + C+ GYS +Y EDK YG +SY V +++ IM EI NGPVE AF V
Sbjct: 197 PCTGEGGETPRCSRHCEPGYSPSYKEDKHYGITSYGVPRSEKEIMAEIYKNGPVEGAFIV 256
Query: 811 YADFPSYKSGVYQHV 855
Y DF YKSGVYQHV
Sbjct: 257 YEDFLMYKSGVYQHV 271
>sp|P43157|CYSP_SCHJA Cathepsin B-like cysteine proteinase precursor (Antigen Sj31)
Length = 342
Score = 283 bits (723), Expect = 6e-76
Identities = 132/254 (51%), Positives = 170/254 (66%), Gaps = 5/254 (1%)
Frame = +1
Query: 109 PLSFDLINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR---- 276
PLS ++I+++N WKA + RF S+ D R ++G K+ K R+P ++
Sbjct: 29 PLSDEMISFINEHPDAGWKADKSDRFHSLDDARILMGARKEDAEMKR-NRRPTVDHHDLN 87
Query: 277 VRLPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAED 456
V +P+ FD+R +WP CKSI +IRDQS CGSCWAFGAVEA+TDR CI S G Q+ +SA D
Sbjct: 88 VEIPSQFDSRKKWPHCKSISQIRDQSRCGSCWAFGAVEAMTDRICIQSGGGQSAELSALD 147
Query: 457 LLTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPN 636
L++CC CGDGC GGFP AW YWV G+VTGG H GCQ Y FPKC HH G YP
Sbjct: 148 LISCCK-DCGDGCQGGFPGVAWDYWVKRGIVTGGSKENHTGCQPYPFPKCEHHTKGKYPA 206
Query: 637 C-TGEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVY 813
C T + TP+CK+ CQ GY Y +DK YG SY+V +N++ I ++I+ GPVEAAF VY
Sbjct: 207 CGTKIYKTPQCKQTCQKGYKTPYEQDKHYGDESYNVQNNEKVIQRDIMMYGPVEAAFDVY 266
Query: 814 ADFPSYKSGVYQHV 855
DF +YKSG+Y+HV
Sbjct: 267 EDFLNYKSGIYRHV 280
>sp|P25792|CYSP_SCHMA Cathepsin B-like cysteine proteinase precursor (Antigen Sm31)
Length = 340
Score = 266 bits (679), Expect = 7e-71
Identities = 129/290 (44%), Positives = 180/290 (62%), Gaps = 5/290 (1%)
Frame = +1
Query: 1 LCLLILVVLAVSFVSSESVKWKDLTKSDKAPIPIHTPLSFDLINYVNYIAQTTWKAGPTT 180
LC+ L+ + +S ++ K++ PLS D+I+Y+N W+A +
Sbjct: 6 LCIASLITFLEAHISVKNEKFE--------------PLSDDIISYINEHPNAGWRAEKSN 51
Query: 181 RFQSISDIRKVLGVMKDPNNFKLPKRKPLLNR----VRLPTTFDARVQWPKCKSIGEIRD 348
RF S+ D R +G ++ + + KR+P ++ V +P+ FD+R +WP CKSI IRD
Sbjct: 52 RFHSLDDARIQMGARREEPDLRR-KRRPTVDHNDWNVEIPSNFDSRKKWPGCKSIATIRD 110
Query: 349 QSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCGFRCGDGCNGGFPSGAWHY 528
QS CGSCW+FGAVEA++DR CI S G Q +SA DLLTCC CG GC GG AW Y
Sbjct: 111 QSRCGSCWSFGAVEAMSDRSCIQSGGKQNVELSAVDLLTCCE-SCGLGCEGGILGPAWDY 169
Query: 529 WVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCTGE-FPTPKCKKACQAGYSKTYA 705
WV +G+VT H GC+ Y FPKC HH G YP C + + TP+CK+ CQ Y Y
Sbjct: 170 WVKEGIVTASSKENHTGCEPYPFPKCEHHTKGKYPPCGSKIYNTPRCKQTCQRKYKTPYT 229
Query: 706 EDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADFPSYKSGVYQHV 855
+DK GKSSY+V ++++AI +EI+ GPVEA+F+VY DF +YKSG+Y+H+
Sbjct: 230 QDKHRGKSSYNVKNDEKAIQKEIMKYGPVEASFTVYEDFLNYKSGIYKHI 279
>sp|P43510|CPR6_CAEEL Cathepsin B-like cysteine proteinase 6 precursor (Cysteine
protease-related 6)
Length = 379
Score = 232 bits (592), Expect = 9e-61
Identities = 124/256 (48%), Positives = 162/256 (63%), Gaps = 12/256 (4%)
Frame = +1
Query: 121 DLINYVNYIAQTTWKAGPTTRFQSI-SDIRKVLGVMKDPNNFKLP-KRKPLLNRVR---- 282
DLI+YVN Q W A RF S+ + K + N+ +L K K L++ +
Sbjct: 45 DLIDYVNE-NQNLWTAKKQRRFSSVYGENDKAKWGLMGVNHVRLSVKGKQHLSKTKDLDL 103
Query: 283 -LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDL 459
+P +FD+R WPKC SI IRDQS+CGSCWAFGAVEA++DR CI S+G +SA+DL
Sbjct: 104 DIPESFDSRDNWPKCDSIKVIRDQSSCGSCWAFGAVEAMSDRICIASHGELQVTLSADDL 163
Query: 460 LTCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHV----IGP 627
L+CC CG GCNGG P AW YWV DG+VTG Y A+ GC+ Y FP C HH P
Sbjct: 164 LSCCK-SCGFGCNGGDPLAAWRYWVKDGIVTGSNYTANNGCKPYPFPPCEHHSKKTHFDP 222
Query: 628 YPNCTGEFPTPKCKKACQAGYS-KTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAF 804
P+ +PTPKC+K C + Y+ KTY+EDK +G S+Y V + +AI +E++T+GP+E AF
Sbjct: 223 CPH--DLYPTPKCEKKCVSDYTDKTYSEDKFFGASAYGVKDDVEAIQKELMTHGPLEIAF 280
Query: 805 SVYADFPSYKSGVYQH 852
VY DF +Y GVY H
Sbjct: 281 EVYEDFLNYDGGVYVH 296
>sp|P25807|CPR1_CAEEL Gut-specific cysteine proteinase precursor
Length = 329
Score = 217 bits (552), Expect = 4e-56
Identities = 103/190 (54%), Positives = 127/190 (66%)
Frame = +1
Query: 283 LPTTFDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLL 462
+P TFD+R QW +CKSI IRDQ+ CGSCWAFGA E I+DR CI + G Q P IS +DLL
Sbjct: 85 VPATFDSRTQWSECKSIKLIRDQATCGSCWAFGAAEMISDRTCIETKGAQQPIISPDDLL 144
Query: 463 TCCGFRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIGPYPNCT 642
+CCG CG+GC GG+P A +W + G+VTGG+Y GC+ Y C+ NC
Sbjct: 145 SCCGSSCGNGCEGGYPIQALRWWDSKGVVTGGDYHG-AGCKPYPIAPCTS------GNCP 197
Query: 643 GEFPTPKCKKACQAGYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYADF 822
E TP C +CQ+GYS YA+DK +G S+Y+V N +I EI NGPVEAAFSVY DF
Sbjct: 198 -ESKTPSCSMSCQSGYSTAYAKDKHFGVSAYAVPKNAASIQAEIYANGPVEAAFSVYEDF 256
Query: 823 PSYKSGVYQH 852
YKSGVY+H
Sbjct: 257 YKYKSGVYKH 266
>sp|P43509|CPR5_CAEEL Cathepsin B-like cysteine proteinase 5 precursor (Cysteine
protease-related 5)
Length = 344
Score = 214 bits (544), Expect = 3e-55
Identities = 114/252 (45%), Positives = 146/252 (57%), Gaps = 9/252 (3%)
Frame = +1
Query: 124 LINYVNYIAQTTWKAGPTTRFQSISDIRKVLGVMKDPNNFKLPKRKPLLNRV---RLPTT 294
LI+YVN AQ W AG + K+ + D K + ++ +P
Sbjct: 32 LIDYVNS-AQKLWTAG-----HQVIPKEKITKKLMDVKYLVPHKDEDIVATEVSDAIPDH 85
Query: 295 FDARVQWPKCKSIGEIRDQSNCGSCWAFGAVEAITDRYCIHSNGTQTPRISAEDLLTCCG 474
FDAR QWP C SI IRDQS+CGSCWAF A EAI+DR CI SNG +S+EDLL+CC
Sbjct: 86 FDARDQWPNCMSINNIRDQSDCGSCWAFAAAEAISDRTCIASNGAVNTLLSSEDLLSCCT 145
Query: 475 --FRCGDGCNGGFPSGAWHYWVTDGLVTGGEYGAHLGCQDYAFPKCSHHVIG-PYPNCTG 645
F CG+GC GG+P AW +WV GLVTGG Y GC+ Y+ C V G +P C
Sbjct: 146 GMFSCGNGCEGGYPIQAWKWWVKHGLVTGGSYETQFGCKPYSIAPCGETVNGVKWPACPE 205
Query: 646 EF-PTPKCKKACQA--GYSKTYAEDKQYGKSSYSVDSNQQAIMQEILTNGPVEAAFSVYA 816
+ PTPKC +C + Y+ Y +DK +G ++Y+V + I EILTNGP+E AF+VY
Sbjct: 206 DTEPTPKCVDSCTSKNNYATPYLQDKHFGSTAYAVGKKVEQIQTEILTNGPIEVAFTVYE 265
Query: 817 DFPSYKSGVYQH 852
DF Y +GVY H
Sbjct: 266 DFYQYTTGVYVH 277
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 105,037,642
Number of Sequences: 369166
Number of extensions: 2325175
Number of successful extensions: 7237
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 6677
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 7062
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 8486520240
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)