Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_011_B04
(480 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|O96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 ... 99 4e-21
sp|Q8BTW9|PAK4_MOUSE Serine/threonine-protein kinase PAK 4 ... 99 5e-21
sp|Q13043|STK4_HUMAN Serine/threonine-protein kinase 4 (STE... 99 5e-21
sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (S... 98 9e-21
sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24 98 9e-21
sp|Q9JI10|STK3_MOUSE Serine/threonine-protein kinase 3 (STE... 97 2e-20
sp|Q13188|STK3_HUMAN Serine/threonine-protein kinase 3 (STE... 97 2e-20
sp|Q10056|SHK2_SCHPO Serine/threonine-protein kinase shk2 96 6e-20
sp|Q99JT2|MST4_MOUSE Serine/threonine-protein kinase MST4 (... 96 6e-20
sp|Q9P289|MST4_HUMAN Serine/threonine-protein kinase MST4 (... 95 7e-20
>sp|O96013|PAK4_HUMAN Serine/threonine-protein kinase PAK 4 (p21-activated kinase 4)
(PAK-4)
Length = 591
Score = 99.4 bits (246), Expect = 4e-21
Identities = 53/135 (39%), Positives = 76/135 (56%)
Frame = +1
Query: 1 ILLDEDDNVKLCDFGLSKILTDLAAKDFLNGAIQSSVGTPNYMAPEIMNEEPYGSSADVW 180
ILL D VKL DFG ++ + +S VGTP +MAPE+++ PYG D+W
Sbjct: 446 ILLTHDGRVKLSDFGFCAQVSKEVPRR------KSLVGTPYWMAPELISRLPYGPEVDIW 499
Query: 181 SFGATMVEMVTGFPPYHQMGVCKVMKIISESRKIEYNYPNNLSDNLKSFIDSCLQSEPAR 360
S G ++EMV G PPY K MK+I ++ + +S +LK F+D L +PA+
Sbjct: 500 SLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQ 559
Query: 361 RLTSKQLMNHPFLRK 405
R T+ +L+ HPFL K
Sbjct: 560 RATAAELLKHPFLAK 574
>sp|Q8BTW9|PAK4_MOUSE Serine/threonine-protein kinase PAK 4 (p21-activated kinase 4)
(PAK-4)
Length = 593
Score = 99.0 bits (245), Expect = 5e-21
Identities = 53/135 (39%), Positives = 75/135 (55%)
Frame = +1
Query: 1 ILLDEDDNVKLCDFGLSKILTDLAAKDFLNGAIQSSVGTPNYMAPEIMNEEPYGSSADVW 180
ILL D VKL DFG ++ + +S VGTP +MAPE+++ PYG D+W
Sbjct: 448 ILLTHDGRVKLSDFGFCAQVSKEVPRR------KSLVGTPYWMAPELISRLPYGPEVDIW 501
Query: 181 SFGATMVEMVTGFPPYHQMGVCKVMKIISESRKIEYNYPNNLSDNLKSFIDSCLQSEPAR 360
S G ++EMV G PPY K MK+I ++ + S +LK F+D L +PA+
Sbjct: 502 SLGVMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKASPSLKGFLDRLLVRDPAQ 561
Query: 361 RLTSKQLMNHPFLRK 405
R T+ +L+ HPFL K
Sbjct: 562 RATAAELLKHPFLTK 576
>sp|Q13043|STK4_HUMAN Serine/threonine-protein kinase 4 (STE20-like kinase MST1) (MST-1)
(Mammalian STE20-like protein kinase 1)
(Serine/threonine-protein kinase Krs-2)
Length = 487
Score = 99.0 bits (245), Expect = 5e-21
Identities = 53/141 (37%), Positives = 77/141 (54%)
Frame = +1
Query: 1 ILLDEDDNVKLCDFGLSKILTDLAAKDFLNGAIQSSVGTPNYMAPEIMNEEPYGSSADVW 180
ILL+ + + KL DFG++ LTD AK + +GTP +MAPE++ E Y AD+W
Sbjct: 155 ILLNTEGHAKLADFGVAGQLTDTMAKR------NTVIGTPFWMAPEVIQEIGYNCVADIW 208
Query: 181 SFGATMVEMVTGFPPYHQMGVCKVMKIISESRKIEYNYPNNLSDNLKSFIDSCLQSEPAR 360
S G T +EM G PPY + + + +I + + P SDN F+ CL P +
Sbjct: 209 SLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQ 268
Query: 361 RLTSKQLMNHPFLRKFELVFI 423
R T+ QL+ HPF+R + V I
Sbjct: 269 RATATQLLQHPFVRSAKGVSI 289
>sp|Q9Y6E0|STK24_HUMAN Serine/threonine-protein kinase 24 (STE20-like kinase MST3) (MST-3)
(Mammalian STE20-like protein kinase 3)
Length = 443
Score = 98.2 bits (243), Expect = 9e-21
Identities = 53/135 (39%), Positives = 80/135 (59%), Gaps = 2/135 (1%)
Frame = +1
Query: 1 ILLDEDDNVKLCDFGLSKILTDLAAKDFLNGAIQSSVGTPNYMAPEIMNEEPYGSSADVW 180
+LL E VKL DFG++ LTD K + VGTP +MAPE++ + Y S AD+W
Sbjct: 162 VLLSEHGEVKLADFGVAGQLTDTQIKR------NTFVGTPFWMAPEVIKQSAYDSKADIW 215
Query: 181 SFGATMVEMVTGFPPYHQMGVCKVMKIISESR--KIEYNYPNNLSDNLKSFIDSCLQSEP 354
S G T +E+ G PP+ ++ KV+ +I ++ +E NY S LK F+++CL EP
Sbjct: 216 SLGITAIELARGEPPHSELHPMKVLFLIPKNNPPTLEGNY----SKPLKEFVEACLNKEP 271
Query: 355 ARRLTSKQLMNHPFL 399
+ R T+K+L+ H F+
Sbjct: 272 SFRPTAKELLKHKFI 286
>sp|Q99KH8|STK24_MOUSE Serine/threonine-protein kinase 24
Length = 431
Score = 98.2 bits (243), Expect = 9e-21
Identities = 53/135 (39%), Positives = 80/135 (59%), Gaps = 2/135 (1%)
Frame = +1
Query: 1 ILLDEDDNVKLCDFGLSKILTDLAAKDFLNGAIQSSVGTPNYMAPEIMNEEPYGSSADVW 180
+LL E VKL DFG++ LTD K + VGTP +MAPE++ + Y S AD+W
Sbjct: 150 VLLSEHGEVKLADFGVAGQLTDTQIKR------NTFVGTPFWMAPEVIKQSAYDSKADIW 203
Query: 181 SFGATMVEMVTGFPPYHQMGVCKVMKIISESR--KIEYNYPNNLSDNLKSFIDSCLQSEP 354
S G T +E+ G PP+ ++ KV+ +I ++ +E NY S LK F+++CL EP
Sbjct: 204 SLGITAIELAKGEPPHSELHPMKVLFLIPKNNPPTLEGNY----SKPLKEFVEACLNKEP 259
Query: 355 ARRLTSKQLMNHPFL 399
+ R T+K+L+ H F+
Sbjct: 260 SFRPTAKELLKHKFI 274
>sp|Q9JI10|STK3_MOUSE Serine/threonine-protein kinase 3 (STE20-like kinase MST2) (MST-2)
(Mammalian STE20-like protein kinase 2)
Length = 497
Score = 96.7 bits (239), Expect = 2e-20
Identities = 51/141 (36%), Positives = 77/141 (54%)
Frame = +1
Query: 1 ILLDEDDNVKLCDFGLSKILTDLAAKDFLNGAIQSSVGTPNYMAPEIMNEEPYGSSADVW 180
ILL+ + + KL DFG++ LTD AK + +GTP +MAPE++ E Y AD+W
Sbjct: 152 ILLNTEGHAKLADFGVAGQLTDTMAKR------NTVIGTPFWMAPEVIQEIGYNCVADIW 205
Query: 181 SFGATMVEMVTGFPPYHQMGVCKVMKIISESRKIEYNYPNNLSDNLKSFIDSCLQSEPAR 360
S G T +EM G PPY + + + +I + + P SD+ F+ CL P +
Sbjct: 206 SLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKSPEQ 265
Query: 361 RLTSKQLMNHPFLRKFELVFI 423
R T+ QL+ HPF++ + V I
Sbjct: 266 RATATQLLQHPFIKNAKPVSI 286
>sp|Q13188|STK3_HUMAN Serine/threonine-protein kinase 3 (STE20-like kinase MST2) (MST-2)
(Mammalian STE20-like protein kinase 2)
(Serine/threonine-protein kinase Krs-1)
Length = 491
Score = 96.7 bits (239), Expect = 2e-20
Identities = 51/141 (36%), Positives = 77/141 (54%)
Frame = +1
Query: 1 ILLDEDDNVKLCDFGLSKILTDLAAKDFLNGAIQSSVGTPNYMAPEIMNEEPYGSSADVW 180
ILL+ + + KL DFG++ LTD AK + +GTP +MAPE++ E Y AD+W
Sbjct: 152 ILLNTEGHAKLADFGVAGQLTDTMAKR------NTVIGTPFWMAPEVIQEIGYNCVADIW 205
Query: 181 SFGATMVEMVTGFPPYHQMGVCKVMKIISESRKIEYNYPNNLSDNLKSFIDSCLQSEPAR 360
S G T +EM G PPY + + + +I + + P SD+ F+ CL P +
Sbjct: 206 SLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKCLVKNPEQ 265
Query: 361 RLTSKQLMNHPFLRKFELVFI 423
R T+ QL+ HPF++ + V I
Sbjct: 266 RATATQLLQHPFIKNAKPVSI 286
>sp|Q10056|SHK2_SCHPO Serine/threonine-protein kinase shk2
Length = 589
Score = 95.5 bits (236), Expect = 6e-20
Identities = 47/135 (34%), Positives = 77/135 (57%)
Frame = +1
Query: 1 ILLDEDDNVKLCDFGLSKILTDLAAKDFLNGAIQSSVGTPNYMAPEIMNEEPYGSSADVW 180
+LLD N+K+ DFG L++ K + VGTP +MAPE++ + YG+ D+W
Sbjct: 440 VLLDNSGNIKITDFGFCARLSNRTNKRV------TMVGTPYWMAPEVVKQNEYGTKVDIW 493
Query: 181 SFGATMVEMVTGFPPYHQMGVCKVMKIISESRKIEYNYPNNLSDNLKSFIDSCLQSEPAR 360
S G ++EM+ PPY + + + +I+++ PN +S NLKSF++SCL +
Sbjct: 494 SLGIMIIEMIENEPPYLREDPIRALYLIAKNGTPTLKKPNLVSKNLKSFLNSCLTIDTIF 553
Query: 361 RLTSKQLMNHPFLRK 405
R T+ +L+ H FL +
Sbjct: 554 RATAAELLTHSFLNQ 568
>sp|Q99JT2|MST4_MOUSE Serine/threonine-protein kinase MST4 (STE20-like kinase MST4)
(MST-4) (Mammalian STE20-like protein kinase 4)
Length = 416
Score = 95.5 bits (236), Expect = 6e-20
Identities = 53/138 (38%), Positives = 79/138 (57%), Gaps = 3/138 (2%)
Frame = +1
Query: 1 ILLDEDDNVKLCDFGLSKILTDLAAKDFLNGAIQSSVGTPNYMAPEIMNEEPYGSSADVW 180
+LL E +VKL DFG++ LTD K + VGTP +MAPE++ + Y S AD+W
Sbjct: 150 VLLSEQGDVKLADFGVAGQLTDTQIKR------NTFVGTPFWMAPEVIQQSAYDSKADIW 203
Query: 181 SFGATMVEMVTGFPPYHQMGVCKVMKIISESRKIEYNYPNNLSD---NLKSFIDSCLQSE 351
S G T +E+ G PP M +V+ +I ++ N P + D + K FID+CL +
Sbjct: 204 SLGITAIELAKGEPPNSDMHPMRVLFLIPKN-----NPPTLIGDFTKSFKEFIDACLNKD 258
Query: 352 PARRLTSKQLMNHPFLRK 405
P+ R T+K+L+ H F+ K
Sbjct: 259 PSFRPTAKELLKHKFIVK 276
>sp|Q9P289|MST4_HUMAN Serine/threonine-protein kinase MST4 (STE20-like kinase MST4)
(MST-4) (Mammalian STE20-like protein kinase 4)
(Serine/threonine-protein kinase MASK) (Mst3 and
SOK1-related kinase)
Length = 416
Score = 95.1 bits (235), Expect = 7e-20
Identities = 53/138 (38%), Positives = 79/138 (57%), Gaps = 3/138 (2%)
Frame = +1
Query: 1 ILLDEDDNVKLCDFGLSKILTDLAAKDFLNGAIQSSVGTPNYMAPEIMNEEPYGSSADVW 180
+LL E +VKL DFG++ LTD K + VGTP +MAPE++ + Y S AD+W
Sbjct: 150 VLLSEQGDVKLADFGVAGQLTDTQIKR------NTFVGTPFWMAPEVIQQSAYDSKADIW 203
Query: 181 SFGATMVEMVTGFPPYHQMGVCKVMKIISESRKIEYNYPNNLSD---NLKSFIDSCLQSE 351
S G T +E+ G PP M +V+ +I ++ N P + D + K FID+CL +
Sbjct: 204 SLGITAIELAKGEPPNSDMHPMRVLFLIPKN-----NPPTLVGDFTKSFKEFIDACLNKD 258
Query: 352 PARRLTSKQLMNHPFLRK 405
P+ R T+K+L+ H F+ K
Sbjct: 259 PSFRPTAKELLKHKFIVK 276
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,705,056
Number of Sequences: 369166
Number of extensions: 1147731
Number of successful extensions: 5748
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4326
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4588
length of database: 68,354,980
effective HSP length: 102
effective length of database: 49,512,010
effective search space used: 2822184570
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)