Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_010_N08
(778 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|Q9UKC9|FBXL2_HUMAN F-box/LRR-repeat protein 2 (F-box and... 182 1e-45
sp|Q8BH16|FBXL2_MOUSE F-box/LRR-repeat protein 2 (F-box and... 181 2e-45
sp|Q9QZH7|FXL20_RAT F-box/LRR-repeat protein 20 (F-box and ... 177 3e-44
sp|Q9CZV8|FXL20_MOUSE F-box/LRR-repeat protein 20 (F-box an... 177 3e-44
sp|Q96IG2|FXL20_HUMAN F-box/LRR-repeat protein 20 (F-box an... 177 4e-44
sp|P34284|YKK7_CAEEL Hypothetical F-box/LRR-repeat protein ... 158 1e-38
sp|Q9UJT9|FBXL7_HUMAN F-box/LRR-repeat protein 7 (F-box and... 106 8e-23
sp|Q9QZN1|FXL17_MOUSE F-box/LRR-repeat protein 17 (F-box an... 94 3e-19
sp|Q9UF56|FXL17_HUMAN F-box/LRR-repeat protein 17 (F-box an... 90 8e-18
sp|Q8NEE6|FXL13_HUMAN F-box/LRR-repeat protein 13 (F-box an... 80 5e-15
>sp|Q9UKC9|FBXL2_HUMAN F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein
2) (F-box protein FBL2/FBL3)
Length = 423
Score = 182 bits (461), Expect = 1e-45
Identities = 89/206 (43%), Positives = 128/206 (62%), Gaps = 2/206 (0%)
Frame = +2
Query: 161 VFCNVKPGYINEKLPKELIIMIFGYLDITALCRCSQVCKFWYEIAFDGSNWKTINLFDFQ 340
VF N G IN+KLPKEL++ IF +LDI LCRC+Q+ K W +A DGSNW+ I+LF+FQ
Sbjct: 2 VFSNNDEGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQ 61
Query: 341 KDITSNVVSKITEISGRFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNES 520
D+ VV I++ G FLR+L ++GCI + D +K A+ C IE L L+ C +T+ +
Sbjct: 62 IDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDST 121
Query: 521 CNSVTHKCINLTSLYIDSCTKINDDGIKEIG-NCKNLMKLDLSFCD-ISDDGLRYIARGC 694
C S++ C L L + SC I + +K I C+NL L+LS+CD I+ DG+ + RGC
Sbjct: 122 CYSLSRFCSKLKHLDLTSCVSITNSSLKGISEGCRNLEYLNLSWCDQITKDGIEALVRGC 181
Query: 695 PMLTFLRLKGCTKITSDGVSEIAKSC 772
L L L+GCT++ + + I C
Sbjct: 182 RGLKALLLRGCTQLEDEALKHIQNYC 207
Score = 72.0 bits (175), Expect = 2e-12
Identities = 37/132 (28%), Positives = 66/132 (50%), Gaps = 2/132 (1%)
Frame = +2
Query: 389 RFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYI 568
R L+ L ++GC + D+ +K++ C + L L C +T+E + C L +L +
Sbjct: 182 RGLKALLLRGCTQLEDEALKHIQNYCHELVSLNLQSCSRITDEGVVQICRGCHRLQALCL 241
Query: 569 DSCTKINDDGIKEIG-NCKNLMKLDLSFCD-ISDDGLRYIARGCPMLTFLRLKGCTKITS 742
C+ + D + +G NC L L+ + C ++D G +AR C L + L+ C IT
Sbjct: 242 SGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITD 301
Query: 743 DGVSEIAKSCPK 778
+ +++ CPK
Sbjct: 302 STLIQLSIHCPK 313
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/131 (28%), Positives = 64/131 (48%), Gaps = 5/131 (3%)
Frame = +2
Query: 395 LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYIDS 574
L+ L + GC +++D + L CP ++ L + C +LT+ + C L + ++
Sbjct: 236 LQALCLSGCSNLTDASLTALGLNCPRLQILEAARCSHLTDAGFTLLARNCHELEKMDLEE 295
Query: 575 CTKINDDGIKEIG-NCKNLMKLDLSFCD-ISDDGLRYIAR---GCPMLTFLRLKGCTKIT 739
C I D + ++ +C L L LS C+ I+DDG+ +++ G L L L C IT
Sbjct: 296 CILITDSTLIQLSIHCPKLQALSLSHCELITDDGILHLSNSTCGHERLRVLELDNCLLIT 355
Query: 740 SDGVSEIAKSC 772
D E ++C
Sbjct: 356 -DVALEHLENC 365
Score = 58.2 bits (139), Expect = 3e-08
Identities = 36/131 (27%), Positives = 57/131 (43%), Gaps = 4/131 (3%)
Frame = +2
Query: 395 LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYIDS 574
L+ L C H++D LA C +E + L EC+ +T+ + ++ C L +L +
Sbjct: 262 LQILEAARCSHLTDAGFTLLARNCHELEKMDLEECILITDSTLIQLSIHCPKLQALSLSH 321
Query: 575 CTKINDDGIKEIGNC----KNLMKLDLSFCDISDDGLRYIARGCPMLTFLRLKGCTKITS 742
C I DDGI + N + L L+L C + D C L L L C ++T
Sbjct: 322 CELITDDGILHLSNSTCGHERLRVLELDNCLLITDVALEHLENCRGLERLELYDCQQVTR 381
Query: 743 DGVSEIAKSCP 775
G+ + P
Sbjct: 382 AGIKRMRAQLP 392
Score = 38.5 bits (88), Expect = 0.021
Identities = 28/107 (26%), Positives = 49/107 (45%), Gaps = 5/107 (4%)
Frame = +2
Query: 473 IEDLTLSECVNLTNE----SCNSVTHKCINLTSLYIDSCTKINDDGIKEIGNCKNLMKLD 640
++ +TL C ++ + + + I+L + ID ++ ++ K G L KL
Sbjct: 27 LDIVTLCRCAQISKAWNILALDGSNWQRIDLFNFQIDVEGRVVENISKRCGGF--LRKLS 84
Query: 641 LSFC-DISDDGLRYIARGCPMLTFLRLKGCTKITSDGVSEIAKSCPK 778
L C + D L+ A+ C + L L GCTKIT +++ C K
Sbjct: 85 LRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSK 131
>sp|Q8BH16|FBXL2_MOUSE F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein
2)
Length = 423
Score = 181 bits (459), Expect = 2e-45
Identities = 86/206 (41%), Positives = 128/206 (62%), Gaps = 2/206 (0%)
Frame = +2
Query: 161 VFCNVKPGYINEKLPKELIIMIFGYLDITALCRCSQVCKFWYEIAFDGSNWKTINLFDFQ 340
VF N G IN+KLPKEL++ IF +LDI LCRC+Q+ K W +A DGSNW+ ++LF+FQ
Sbjct: 2 VFSNSDDGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRVDLFNFQ 61
Query: 341 KDITSNVVSKITEISGRFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNES 520
D+ VV I++ G FLR+L ++GCI + D +K A+ C IE L L+ C +T+ +
Sbjct: 62 TDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDST 121
Query: 521 CNSVTHKCINLTSLYIDSCTKINDDGIKEIG-NCKNLMKLDLSFCD-ISDDGLRYIARGC 694
C S++ C L L + SC + + +K I C+NL L+LS+CD I+ +G+ + RGC
Sbjct: 122 CYSLSRFCSKLKHLDLTSCVSVTNSSLKGISEGCRNLEYLNLSWCDQITKEGIEALVRGC 181
Query: 695 PMLTFLRLKGCTKITSDGVSEIAKSC 772
L L L+GCT++ + + I C
Sbjct: 182 RGLKALLLRGCTQLEDEALKHIQNHC 207
Score = 72.0 bits (175), Expect = 2e-12
Identities = 36/132 (27%), Positives = 66/132 (50%), Gaps = 2/132 (1%)
Frame = +2
Query: 389 RFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYI 568
R L+ L ++GC + D+ +K++ C + L L C +T++ + C L +L +
Sbjct: 182 RGLKALLLRGCTQLEDEALKHIQNHCHELVSLNLQSCSRITDDGVVQICRGCHRLQALCL 241
Query: 569 DSCTKINDDGIKEIG-NCKNLMKLDLSFCD-ISDDGLRYIARGCPMLTFLRLKGCTKITS 742
C+ + D + +G NC L L+ + C ++D G +AR C L + L+ C IT
Sbjct: 242 SGCSNLTDASLTALGLNCPRLQVLEAARCSHLTDAGFTLLARNCHELEKMDLEECVLITD 301
Query: 743 DGVSEIAKSCPK 778
+ +++ CPK
Sbjct: 302 STLVQLSIHCPK 313
Score = 57.4 bits (137), Expect = 4e-08
Identities = 35/131 (26%), Positives = 64/131 (48%), Gaps = 5/131 (3%)
Frame = +2
Query: 395 LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYIDS 574
L+ L + GC +++D + L CP ++ L + C +LT+ + C L + ++
Sbjct: 236 LQALCLSGCSNLTDASLTALGLNCPRLQVLEAARCSHLTDAGFTLLARNCHELEKMDLEE 295
Query: 575 CTKINDDGIKEIG-NCKNLMKLDLSFCD-ISDDGLRYIAR---GCPMLTFLRLKGCTKIT 739
C I D + ++ +C L L LS C+ I+D+G+ +++ G L L L C +T
Sbjct: 296 CVLITDSTLVQLSIHCPKLQALSLSHCELITDEGILHLSSSTCGHERLRVLELDNCLLVT 355
Query: 740 SDGVSEIAKSC 772
D E ++C
Sbjct: 356 -DASLEHLENC 365
Score = 56.2 bits (134), Expect = 1e-07
Identities = 35/131 (26%), Positives = 57/131 (43%), Gaps = 4/131 (3%)
Frame = +2
Query: 395 LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYIDS 574
L+ L C H++D LA C +E + L ECV +T+ + ++ C L +L +
Sbjct: 262 LQVLEAARCSHLTDAGFTLLARNCHELEKMDLEECVLITDSTLVQLSIHCPKLQALSLSH 321
Query: 575 CTKINDDGIKEIGNC----KNLMKLDLSFCDISDDGLRYIARGCPMLTFLRLKGCTKITS 742
C I D+GI + + + L L+L C + D C L L L C ++T
Sbjct: 322 CELITDEGILHLSSSTCGHERLRVLELDNCLLVTDASLEHLENCRGLERLELYDCQQVTR 381
Query: 743 DGVSEIAKSCP 775
G+ + P
Sbjct: 382 AGIKRMRAQLP 392
Score = 37.0 bits (84), Expect = 0.060
Identities = 19/52 (36%), Positives = 26/52 (50%), Gaps = 1/52 (1%)
Frame = +2
Query: 626 LMKLDLSFC-DISDDGLRYIARGCPMLTFLRLKGCTKITSDGVSEIAKSCPK 778
L KL L C + D L+ A+ C + L L GCTKIT +++ C K
Sbjct: 80 LRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSK 131
>sp|Q9QZH7|FXL20_RAT F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein
20) (F-box/LRR-repeat protein 2-like)
Length = 276
Score = 177 bits (449), Expect = 3e-44
Identities = 85/208 (40%), Positives = 131/208 (62%), Gaps = 2/208 (0%)
Frame = +2
Query: 161 VFCNVKPGYINEKLPKELIIMIFGYLDITALCRCSQVCKFWYEIAFDGSNWKTINLFDFQ 340
+F N IN+KLPKEL++ IF +LD+ LCRC+QV + W +A DGSNW+ I+LFDFQ
Sbjct: 15 MFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQ 74
Query: 341 KDITSNVVSKITEISGRFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNES 520
+DI VV I++ G FLR+L ++GC+ + D ++ A+ C IE L+L+ C T+ +
Sbjct: 75 RDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLSLNGCTKTTDAT 134
Query: 521 CNSVTHKCINLTSLYIDSCTKINDDGIKEIG-NCKNLMKLDLSFCD-ISDDGLRYIARGC 694
C S++ C L L + SCT I + +K + C L +L++S+CD ++ DG++ + RGC
Sbjct: 135 CTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGC 194
Query: 695 PMLTFLRLKGCTKITSDGVSEIAKSCPK 778
L L LKGCT++ + + I CP+
Sbjct: 195 GGLKALFLKGCTQLEDEALKYIGAHCPE 222
Score = 51.6 bits (122), Expect = 2e-06
Identities = 25/79 (31%), Positives = 40/79 (50%), Gaps = 1/79 (1%)
Frame = +2
Query: 395 LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYIDS 574
L+ L +KGC + D+ +K + CP + L L C+ +T+E ++ C L SL
Sbjct: 197 LKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASG 256
Query: 575 CTKINDDGIKEIG-NCKNL 628
C+ I D + +G NC L
Sbjct: 257 CSNITDAILNALGQNCPRL 275
>sp|Q9CZV8|FXL20_MOUSE F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein
20) (F-box/LRR-repeat protein 2-like)
Length = 436
Score = 177 bits (449), Expect = 3e-44
Identities = 85/208 (40%), Positives = 131/208 (62%), Gaps = 2/208 (0%)
Frame = +2
Query: 161 VFCNVKPGYINEKLPKELIIMIFGYLDITALCRCSQVCKFWYEIAFDGSNWKTINLFDFQ 340
+F N IN+KLPKEL++ IF +LD+ LCRC+QV + W +A DGSNW+ I+LFDFQ
Sbjct: 15 MFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQ 74
Query: 341 KDITSNVVSKITEISGRFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNES 520
+DI VV I++ G FLR+L ++GC+ + D ++ A+ C IE L+L+ C T+ +
Sbjct: 75 RDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLSLNGCTKTTDAT 134
Query: 521 CNSVTHKCINLTSLYIDSCTKINDDGIKEIG-NCKNLMKLDLSFCD-ISDDGLRYIARGC 694
C S++ C L L + SCT I + +K + C L +L++S+CD ++ DG++ + RGC
Sbjct: 135 CTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGC 194
Query: 695 PMLTFLRLKGCTKITSDGVSEIAKSCPK 778
L L LKGCT++ + + I CP+
Sbjct: 195 GGLKALFLKGCTQLEDEALKYIGAHCPE 222
Score = 75.1 bits (183), Expect = 2e-13
Identities = 39/130 (30%), Positives = 68/130 (52%), Gaps = 2/130 (1%)
Frame = +2
Query: 395 LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYIDS 574
L+ L +KGC + D+ +K + CP + L L C+ +T+E ++ C L SL
Sbjct: 197 LKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASG 256
Query: 575 CTKINDDGIKEIG-NCKNLMKLDLSFC-DISDDGLRYIARGCPMLTFLRLKGCTKITSDG 748
C+ I D + +G NC L L+++ C ++D G +AR C L + L+ C +IT
Sbjct: 257 CSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDST 316
Query: 749 VSEIAKSCPK 778
+ +++ CP+
Sbjct: 317 LIQLSIHCPR 326
Score = 66.2 bits (160), Expect = 9e-11
Identities = 42/148 (28%), Positives = 66/148 (44%), Gaps = 7/148 (4%)
Frame = +2
Query: 353 SNVVSKITEISGRF---LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESC 523
SN+ I G+ LR L + C ++D LA C +E + L ECV +T+ +
Sbjct: 258 SNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTL 317
Query: 524 NSVTHKCINLTSLYIDSCTKINDDGIKEIGN--CKN--LMKLDLSFCDISDDGLRYIARG 691
++ C L L + C I DDGI+ +GN C + L ++L C + D +
Sbjct: 318 IQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKS 377
Query: 692 CPMLTFLRLKGCTKITSDGVSEIAKSCP 775
CP + L C +IT G+ + P
Sbjct: 378 CPSFERIELYDCQQITRAGIKRLRTHLP 405
>sp|Q96IG2|FXL20_HUMAN F-box/LRR-repeat protein 20 (F-box and leucine-rich repeat protein
20) (F-box/LRR-repeat protein 2-like)
Length = 436
Score = 177 bits (448), Expect = 4e-44
Identities = 85/208 (40%), Positives = 130/208 (62%), Gaps = 2/208 (0%)
Frame = +2
Query: 161 VFCNVKPGYINEKLPKELIIMIFGYLDITALCRCSQVCKFWYEIAFDGSNWKTINLFDFQ 340
+F N IN+KLPKEL++ IF +LD+ LCRC+QV + W +A DGSNW+ I+LFDFQ
Sbjct: 15 MFSNSDEAVINKKLPKELLLRIFSFLDVVTLCRCAQVSRAWNVLALDGSNWQRIDLFDFQ 74
Query: 341 KDITSNVVSKITEISGRFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNES 520
+DI VV I++ G FLR+L ++GC+ + D ++ A+ C IE L L+ C T+ +
Sbjct: 75 RDIEGRVVENISKRCGGFLRKLSLRGCLGVGDNALRTFAQNCRNIEVLNLNGCTKTTDAT 134
Query: 521 CNSVTHKCINLTSLYIDSCTKINDDGIKEIG-NCKNLMKLDLSFCD-ISDDGLRYIARGC 694
C S++ C L L + SCT I + +K + C L +L++S+CD ++ DG++ + RGC
Sbjct: 135 CTSLSKFCSKLRHLDLASCTSITNMSLKALSEGCPLLEQLNISWCDQVTKDGIQALVRGC 194
Query: 695 PMLTFLRLKGCTKITSDGVSEIAKSCPK 778
L L LKGCT++ + + I CP+
Sbjct: 195 GGLKALFLKGCTQLEDEALKYIGAHCPE 222
Score = 75.1 bits (183), Expect = 2e-13
Identities = 39/130 (30%), Positives = 68/130 (52%), Gaps = 2/130 (1%)
Frame = +2
Query: 395 LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYIDS 574
L+ L +KGC + D+ +K + CP + L L C+ +T+E ++ C L SL
Sbjct: 197 LKALFLKGCTQLEDEALKYIGAHCPELVTLNLQTCLQITDEGLITICRGCHKLQSLCASG 256
Query: 575 CTKINDDGIKEIG-NCKNLMKLDLSFC-DISDDGLRYIARGCPMLTFLRLKGCTKITSDG 748
C+ I D + +G NC L L+++ C ++D G +AR C L + L+ C +IT
Sbjct: 257 CSNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDST 316
Query: 749 VSEIAKSCPK 778
+ +++ CP+
Sbjct: 317 LIQLSIHCPR 326
Score = 64.3 bits (155), Expect = 4e-10
Identities = 42/148 (28%), Positives = 66/148 (44%), Gaps = 7/148 (4%)
Frame = +2
Query: 353 SNVVSKITEISGRF---LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESC 523
SN+ I G+ LR L + C ++D LA C +E + L ECV +T+ +
Sbjct: 258 SNITDAILNALGQNCPRLRILEVARCSQLTDVGFTTLARNCHELEKMDLEECVQITDSTL 317
Query: 524 NSVTHKCINLTSLYIDSCTKINDDGIKEIGN--CKN--LMKLDLSFCDISDDGLRYIARG 691
++ C L L + C I DDGI+ +GN C + L ++L C + D +
Sbjct: 318 IQLSIHCPRLQVLSLSHCELITDDGIRHLGNGACAHDQLEVIELDNCPLITDASLEHLKS 377
Query: 692 CPMLTFLRLKGCTKITSDGVSEIAKSCP 775
C L + L C +IT G+ + P
Sbjct: 378 CHSLERIELYDCQQITRAGIKRLRTHLP 405
>sp|P34284|YKK7_CAEEL Hypothetical F-box/LRR-repeat protein C02F5.7
Length = 466
Score = 158 bits (400), Expect = 1e-38
Identities = 75/188 (39%), Positives = 117/188 (62%), Gaps = 2/188 (1%)
Frame = +2
Query: 188 INEKLPKELIIMIFGYLDITALCRCSQVCKFWYEIAFDGSNWKTINLFDFQKDITSNVVS 367
IN LPKE+++ +F +LD ALCR +QVC+ W +A DGSNW+ ++LF FQ+D+ + VV
Sbjct: 56 INRVLPKEVLLKVFSFLDTKALCRSAQVCRSWSILALDGSNWQRVDLFTFQRDVKTAVVE 115
Query: 368 KITEISGRFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCI 547
+ G FL+EL +KGC ++ D ++ +CP +E L+L C +T+ SC ++ C
Sbjct: 116 NLARRCGGFLKELSLKGCENVHDSALRTFTSRCPNLEHLSLYRCKRVTDASCENLGRYCH 175
Query: 548 NLTSLYIDSCTKINDDGIKEIGN-CKNLMKLDLSFCD-ISDDGLRYIARGCPMLTFLRLK 721
L L +++C+ I D +K IG+ C NL L++S+CD I D G++ I C L L L+
Sbjct: 176 KLNYLNLENCSSITDRAMKYIGDGCPNLSYLNISWCDAIQDRGVQIILSNCKSLDTLILR 235
Query: 722 GCTKITSD 745
GC +T +
Sbjct: 236 GCEGLTEN 243
Score = 66.6 bits (161), Expect = 7e-11
Identities = 42/157 (26%), Positives = 76/157 (48%), Gaps = 4/157 (2%)
Frame = +2
Query: 305 SNWKTINLFDFQ--KDITSNVVSKITEISGRFLRELRMKGCIHISDKDIKNLAEQCPLIE 478
SN K+++ + + +T NV + G +++L + C ++D ++N+A +E
Sbjct: 224 SNCKSLDTLILRGCEGLTENVFGSVEAHMGA-IKKLNLLQCFQLTDITVQNIANGATALE 282
Query: 479 DLTLSECVNLTNESCNSVTHKCINLTSLYIDSCTKINDDGIKEIG-NCKNLMKLDLSFCD 655
L +S C +++ S S+ NL L + CT + D+G + C+ L +LD+ C
Sbjct: 283 YLCMSNCNQISDRSLVSLGQHSHNLKVLELSGCTLLGDNGFIPLARGCRQLERLDMEDCS 342
Query: 656 -ISDDGLRYIARGCPMLTFLRLKGCTKITSDGVSEIA 763
ISD + +A C L L L C IT + + +A
Sbjct: 343 LISDHTINSLANNCTALRELSLSHCELITDESIQNLA 379
Score = 58.2 bits (139), Expect = 3e-08
Identities = 34/128 (26%), Positives = 67/128 (52%), Gaps = 2/128 (1%)
Frame = +2
Query: 395 LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYIDS 574
L L ++GC +++ ++ I+ L L +C LT+ + ++ + L L + +
Sbjct: 229 LDTLILRGCEGLTENVFGSVEAHMGAIKKLNLLQCFQLTDITVQNIANGATALEYLCMSN 288
Query: 575 CTKINDDGIKEIG-NCKNLMKLDLSFCDI-SDDGLRYIARGCPMLTFLRLKGCTKITSDG 748
C +I+D + +G + NL L+LS C + D+G +ARGC L L ++ C+ I+
Sbjct: 289 CNQISDRSLVSLGQHSHNLKVLELSGCTLLGDNGFIPLARGCRQLERLDMEDCSLISDHT 348
Query: 749 VSEIAKSC 772
++ +A +C
Sbjct: 349 INSLANNC 356
Score = 57.8 bits (138), Expect = 3e-08
Identities = 31/89 (34%), Positives = 49/89 (55%), Gaps = 1/89 (1%)
Frame = +2
Query: 389 RFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHK-CINLTSLY 565
R L L M+ C ISD I +LA C + +L+LS C +T+ES ++ K L L
Sbjct: 331 RQLERLDMEDCSLISDHTINSLANNCTALRELSLSHCELITDESIQNLASKHRETLNVLE 390
Query: 566 IDSCTKINDDGIKEIGNCKNLMKLDLSFC 652
+D+C ++ D + + +CK L ++DL C
Sbjct: 391 LDNCPQLTDSTLSHLRHCKALKRIDLYDC 419
Score = 30.8 bits (68), Expect = 4.3
Identities = 16/52 (30%), Positives = 23/52 (44%), Gaps = 1/52 (1%)
Frame = +2
Query: 626 LMKLDLSFCD-ISDDGLRYIARGCPMLTFLRLKGCTKITSDGVSEIAKSCPK 778
L +L L C+ + D LR CP L L L C ++T + + C K
Sbjct: 125 LKELSLKGCENVHDSALRTFTSRCPNLEHLSLYRCKRVTDASCENLGRYCHK 176
>sp|Q9UJT9|FBXL7_HUMAN F-box/LRR-repeat protein 7 (F-box and leucine-rich repeat protein
7) (F-box protein FBL6/FBL7)
Length = 491
Score = 106 bits (264), Expect = 8e-23
Identities = 59/209 (28%), Positives = 104/209 (49%), Gaps = 16/209 (7%)
Frame = +2
Query: 194 EKLPKELIIMIFGYLDITALCRCSQVCKFWYEIAFDGSNWKTINL------FDFQKDITS 355
++LP ++ IF +L LCRC++VC+ WY +A+D W+TI L D + +
Sbjct: 115 DRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINVDRALKVLT 174
Query: 356 NVVSKITEISGRFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVT 535
+ + T L + + GC ++D+ + +A+ CP + L +S C N++NE+ V
Sbjct: 175 RRLCQDTPNVCLMLETVTVSGCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEAVFDVV 234
Query: 536 HKCINLTSLYIDSCTKINDDGIKEIGNCK---------NLMKLDLSFCDI-SDDGLRYIA 685
C NL L + C+K+ + + K ++ LD++ C + D+GL IA
Sbjct: 235 SLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIA 294
Query: 686 RGCPMLTFLRLKGCTKITSDGVSEIAKSC 772
C LT L L+ C ++T +G+ + C
Sbjct: 295 AHCTQLTHLYLRRCVRLTDEGLRYLVIYC 323
Score = 84.7 bits (208), Expect = 3e-16
Identities = 44/148 (29%), Positives = 79/148 (53%), Gaps = 4/148 (2%)
Frame = +2
Query: 347 ITSNVVSKITEISGR--FLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNES 520
+T K++ + G+ +R L M C + D+ + +A C + L L CV LT+E
Sbjct: 256 LTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIAAHCTQLTHLYLRRCVRLTDEG 315
Query: 521 CNSVTHKCINLTSLYIDSCTKINDDGIKEIGNCKNLMK-LDLSFCD-ISDDGLRYIARGC 694
+ C ++ L + C ++D G++EI ++ ++ L ++ C ++D G+RY+A+ C
Sbjct: 316 LRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYC 375
Query: 695 PMLTFLRLKGCTKITSDGVSEIAKSCPK 778
L +L +GC IT GV +AK+C K
Sbjct: 376 SKLRYLNARGCEGITDHGVEYLAKNCTK 403
Score = 67.0 bits (162), Expect = 5e-11
Identities = 39/128 (30%), Positives = 62/128 (48%), Gaps = 2/128 (1%)
Frame = +2
Query: 395 LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYIDS 574
++EL + C +SD ++ +A+ + L+++ C +T+ V C L L
Sbjct: 326 IKELSVSDCRFVSDFGLREIAKLESRLRYLSIAHCGRVTDVGIRYVAKYCSKLRYLNARG 385
Query: 575 CTKINDDGIKEIG-NCKNLMKLDLSFCD-ISDDGLRYIARGCPMLTFLRLKGCTKITSDG 748
C I D G++ + NC L LD+ C +SD GL +A C L L LK C IT G
Sbjct: 386 CEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLALNCFNLKRLSLKSCESITGQG 445
Query: 749 VSEIAKSC 772
+ +A +C
Sbjct: 446 LQIVAANC 453
Score = 63.9 bits (154), Expect = 5e-10
Identities = 32/117 (27%), Positives = 62/117 (52%), Gaps = 8/117 (6%)
Frame = +2
Query: 368 KITEISGRF-------LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCN 526
++T++ R+ LR L +GC I+D ++ LA+ C ++ L + +C +++
Sbjct: 362 RVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLE 421
Query: 527 SVTHKCINLTSLYIDSCTKINDDGIKEI-GNCKNLMKLDLSFCDISDDGLRYIARGC 694
+ C NL L + SC I G++ + NC +L L++ C++S + LR++ R C
Sbjct: 422 CLALNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHC 478
>sp|Q9QZN1|FXL17_MOUSE F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein
17) (F-box only protein 13)
Length = 462
Score = 94.4 bits (233), Expect = 3e-19
Identities = 56/197 (28%), Positives = 101/197 (51%), Gaps = 3/197 (1%)
Frame = +2
Query: 197 KLPKELIIMIFGYLDITALC-RCSQVCKFWYEIAFDGSNWKTINLFDFQKDITSNVVSKI 373
+LP +++ IF L + C S VCK+W ++ D WK ++L Q+ +T ++ KI
Sbjct: 84 QLPPSILLKIFSNLSLNERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQ-VTDELLEKI 142
Query: 374 TEISGRFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINL 553
S + E+ + C +SD + LA +CP + T C L++ S +V C L
Sbjct: 143 ASRSQNII-EINISDCRSLSDSGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLL 201
Query: 554 TSLYIDSCTKINDDGIKEIGN-CKNLMKLDLSFC-DISDDGLRYIARGCPMLTFLRLKGC 727
+++ + K+ D+G+K++G+ C+ L + C ISD+G+ IA+ C L + ++
Sbjct: 202 QKVHVGNQDKLTDEGLKQLGSRCRELKDIHFGQCYKISDEGMIVIAKSCLKLQRIYMQEN 261
Query: 728 TKITSDGVSEIAKSCPK 778
+T V A+ CP+
Sbjct: 262 KLVTDQSVKAFAEHCPE 278
Score = 49.7 bits (117), Expect = 9e-06
Identities = 41/147 (27%), Positives = 72/147 (48%), Gaps = 4/147 (2%)
Frame = +2
Query: 347 ITSNVVSKITEISGRFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVN-LTNESC 523
+TS V +T++ R L L ++ + ++ + + ++C + L L C+N + N+ C
Sbjct: 289 VTSKGVIHLTKL--RNLSSLDLRHITELDNETVMEIVKRCKNLSSLNL--CLNWIINDRC 344
Query: 524 NSVTHK-CINLTSLYIDSCTKINDDGIKEIGNCK-NLMKLDLSFC-DISDDGLRYIARGC 694
V K NL LY+ SC KI D + IG + +D+ +C +I+D G IA+
Sbjct: 345 VEVIAKEGQNLKELYLVSC-KITDYALIAIGRYSVTIETVDVGWCKEITDQGATLIAQSS 403
Query: 695 PMLTFLRLKGCTKITSDGVSEIAKSCP 775
L +L L C K+ V ++ + P
Sbjct: 404 KSLRYLGLMRCDKVNELTVEQLVQQYP 430
>sp|Q9UF56|FXL17_HUMAN F-box/LRR-repeat protein 17 (F-box and leucine-rich repeat protein
17) (F-box only protein 13)
Length = 370
Score = 89.7 bits (221), Expect = 8e-18
Identities = 55/188 (29%), Positives = 96/188 (51%), Gaps = 3/188 (1%)
Frame = +2
Query: 224 IFGYLDITALC-RCSQVCKFWYEIAFDGSNWKTINLFDFQKDITSNVVSKITEISGRFLR 400
IF L + C S VCK+W ++ D WK ++L Q+ +T ++ KI S +
Sbjct: 1 IFSNLSLDERCLSASLVCKYWRDLCLDFQFWKQLDLSSRQQ-VTDELLEKIASRSQNII- 58
Query: 401 ELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYIDSCT 580
E+ + C +SD + LA +CP + T C L++ S +V C L +++ +
Sbjct: 59 EINISDCRSMSDNGVCVLAFKCPGLLRYTAYRCKQLSDTSIIAVASHCPLLQKVHVGNQD 118
Query: 581 KINDDGIKEIGN-CKNLMKLDLSFC-DISDDGLRYIARGCPMLTFLRLKGCTKITSDGVS 754
K+ D+G+K++G+ C+ L + C ISD+G+ IA+GC L + ++ +T V
Sbjct: 119 KLTDEGLKQLGSKCRELKDIHFGQCYKISDEGMIVIAKGCLKLQRIYMQENKLVTDQSVK 178
Query: 755 EIAKSCPK 778
A+ CP+
Sbjct: 179 AFAEHCPE 186
Score = 50.1 bits (118), Expect = 7e-06
Identities = 41/147 (27%), Positives = 73/147 (49%), Gaps = 4/147 (2%)
Frame = +2
Query: 347 ITSNVVSKITEISGRFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVN-LTNESC 523
+TS V +T++ R L L ++ + ++ + + ++C + L L C+N + N+ C
Sbjct: 197 VTSKGVIHLTKL--RNLSSLDLRHITELDNETVMEIVKRCKNLSSLNL--CLNWIINDRC 252
Query: 524 NSVTHK-CINLTSLYIDSCTKINDDGIKEIGNCKNLMK-LDLSFC-DISDDGLRYIARGC 694
V K NL LY+ SC KI D + IG ++ +D+ +C +I+D G IA+
Sbjct: 253 VEVIAKEGQNLKELYLVSC-KITDYALIAIGRYSMTIETVDVGWCKEITDQGATLIAQSS 311
Query: 695 PMLTFLRLKGCTKITSDGVSEIAKSCP 775
L +L L C K+ V ++ + P
Sbjct: 312 KSLRYLGLMRCDKVNEVTVEQLVQQYP 338
>sp|Q8NEE6|FXL13_HUMAN F-box/LRR-repeat protein 13 (F-box and leucine-rich repeat protein
13)
Length = 735
Score = 80.5 bits (197), Expect = 5e-15
Identities = 60/211 (28%), Positives = 100/211 (47%), Gaps = 4/211 (1%)
Frame = +2
Query: 152 DKTVFCNVKPGYINEKLPKELIIMIFGYLDITALCRCSQVCKFWYEIAFDGSNWKTINLF 331
D+T+ C++ LP+ I+ IF YL + + C QV W + S W I+
Sbjct: 148 DETLKCDIS------LLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFS 201
Query: 332 DFQKDITSN-VVSKITEISGRFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNL 508
+ I +VS + LR L +GC+ + K ++++ C +++L +S+C
Sbjct: 202 SVKNVIPDKYIVSTLQRWRLNVLR-LNFRGCL-LRPKTFRSVSH-CRNLQELNVSDCPTF 258
Query: 509 TNESCNSVTHKCINLTSLYIDSCTKINDDGIKEIGNCKNLMKLDLSFCD-ISDDGLRYI- 682
T+ES ++ C + L + + T N + NL L L++C +D GL+Y+
Sbjct: 259 TDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLN 318
Query: 683 -ARGCPMLTFLRLKGCTKITSDGVSEIAKSC 772
GC L +L L GCT+I+ G IA SC
Sbjct: 319 LGNGCHKLIYLDLSGCTQISVQGFRYIANSC 349
Score = 70.1 bits (170), Expect = 6e-12
Identities = 45/145 (31%), Positives = 74/145 (51%), Gaps = 2/145 (1%)
Frame = +2
Query: 341 KDITSNVVSKITEISGRFLRELRMKGCIHISDKDIKNLAE--QCPLIEDLTLSECVNLTN 514
K IT + + ++ + + L L + C+ I D +K + I +L LS CV L++
Sbjct: 437 KGITDSSLRSLSPL--KQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSD 494
Query: 515 ESCNSVTHKCINLTSLYIDSCTKINDDGIKEIGNCKNLMKLDLSFCDISDDGLRYIARGC 694
S ++ +C NL L + +C + GI I N +L+ +DLS DIS++GL ++R
Sbjct: 495 ASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRH- 553
Query: 695 PMLTFLRLKGCTKITSDGVSEIAKS 769
L L + C +IT DG+ KS
Sbjct: 554 KKLKELSVSECYRITDDGIQAFCKS 578
Score = 68.9 bits (167), Expect = 1e-11
Identities = 48/155 (30%), Positives = 74/155 (47%), Gaps = 29/155 (18%)
Frame = +2
Query: 395 LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLT--------------------- 511
+REL + C+ +SD + L+E+CP + L+L C +LT
Sbjct: 481 IRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGT 540
Query: 512 ---NESCNSVT-HKCINLTSLYIDSCTKINDDGIKEIGNCKN---LMKLDLSFCD-ISDD 667
NE N ++ HK L L + C +I DDGI+ CK+ L LD+S+C +SD
Sbjct: 541 DISNEGLNVLSRHK--KLKELSVSECYRITDDGIQAF--CKSSLILEHLDVSYCSQLSDM 596
Query: 668 GLRYIARGCPMLTFLRLKGCTKITSDGVSEIAKSC 772
++ +A C LT L + GC KIT + ++ C
Sbjct: 597 IIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKC 631
Score = 65.1 bits (157), Expect = 2e-10
Identities = 39/125 (31%), Positives = 64/125 (51%), Gaps = 2/125 (1%)
Frame = +2
Query: 395 LRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYIDS 574
L+EL + C I+D I+ + ++E L +S C L++ ++ CINLTSL I
Sbjct: 556 LKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAG 615
Query: 575 CTKINDDGIKEI-GNCKNLMKLDLSFCD-ISDDGLRYIARGCPMLTFLRLKGCTKITSDG 748
C KI D ++ + C L LD+S C ++D L + GC L L+++ CT I+
Sbjct: 616 CPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKA 675
Query: 749 VSEIA 763
++
Sbjct: 676 AQRMS 680
Score = 50.1 bits (118), Expect = 7e-06
Identities = 30/121 (24%), Positives = 56/121 (46%), Gaps = 1/121 (0%)
Frame = +2
Query: 404 LRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSLYIDSCTK 583
L + GC IS + + +A C I LT+++ LT+ ++ KC +TSL
Sbjct: 329 LDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPH 388
Query: 584 INDDGIKEIGNCKNLMKLDLSFCD-ISDDGLRYIARGCPMLTFLRLKGCTKITSDGVSEI 760
I+D + + CK L K+ ++D ++I + P L+ + + C IT + +
Sbjct: 389 ISDCTFRALSACK-LRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSL 447
Query: 761 A 763
+
Sbjct: 448 S 448
Score = 45.1 bits (105), Expect = 2e-04
Identities = 26/91 (28%), Positives = 44/91 (48%), Gaps = 1/91 (1%)
Frame = +2
Query: 383 SGRFLRELRMKGCIHISDKDIKNLAEQCPLIEDLTLSECVNLTNESCNSVTHKCINLTSL 562
S L L + C +SD IK LA C + L+++ C +T+ + ++ KC L L
Sbjct: 578 SSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHIL 637
Query: 563 YIDSCTKINDDGIKEIG-NCKNLMKLDLSFC 652
I C + D ++++ CK L L + +C
Sbjct: 638 DISGCVLLTDQILEDLQIGCKQLRILKMQYC 668
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,246,405
Number of Sequences: 369166
Number of extensions: 1721451
Number of successful extensions: 4791
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4368
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4643
length of database: 68,354,980
effective HSP length: 108
effective length of database: 48,403,600
effective search space used: 7260540000
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)