Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= Dr_sW_010_L11
(812 letters)
Database: Non-redundant SwissProt sequences
184,735 sequences; 68,354,980 total letters
Score E
Sequences producing significant alignments: (bits) Value
sp|P55266|DSRAD_RAT Double-stranded RNA-specific adenosine ... 74 4e-13
sp|Q99MU3|DSRAD_MOUSE Double-stranded RNA-specific adenosin... 73 8e-13
sp|P51400|RED1_RAT Double-stranded RNA-specific editase 1 (... 71 4e-12
sp|Q91ZS8|RED1_MOUSE Double-stranded RNA-specific editase 1... 70 9e-12
sp|P55265|DSRAD_HUMAN Double-stranded RNA-specific adenosin... 68 3e-11
sp|Q9NS39|RED2_HUMAN Double-stranded RNA-specific editase B... 66 1e-10
sp|Q9JI20|RED2_MOUSE Double-stranded RNA-specific editase B... 64 6e-10
sp|P97616|RED2_RAT Double-stranded RNA-specific editase B2 ... 62 1e-09
sp|P78563|RED1_HUMAN Double-stranded RNA-specific editase 1... 62 2e-09
sp|Q9NII1|ADAR_DROME Double-stranded RNA-specific editase A... 57 8e-08
>sp|P55266|DSRAD_RAT Double-stranded RNA-specific adenosine deaminase (DRADA)
Length = 1175
Score = 74.3 bits (181), Expect = 4e-13
Identities = 75/272 (27%), Positives = 122/272 (44%), Gaps = 2/272 (0%)
Frame = +1
Query: 1 GTVVAFGAGKGVNTKIDNTSNQPGYHLRNFDSLVLAKRSLQCFFYNQILLLLDKKRLHCK 180
G VV+ G G K D+ S + G + + + ++++R F Y++++ K H
Sbjct: 828 GVVVSLGTGNRC-VKGDSLSLK-GETVNDCHAEIISRRGFIRFLYSELM-----KYNHHT 880
Query: 181 GEKIYFEIGKNGY-VTLKYGCRLHLYMSHAPKGDCVESIPRGWEEPAKLPAREVERDRCG 357
+ FE+ + G + +K HLY+S AP GD +++ A E R
Sbjct: 881 AKNSIFELARGGEKLQIKKTVSFHLYISTAPCGDGAH-----FDKSCSDRAVESTESRHY 935
Query: 358 NMDPIMYMSYSNTALLKDPGHIRVLRNETDDEWISL-VSYRLRNKYNRDITMSPTDKLMA 534
+ T + G I V ++ W + + RLR TMS +DK++
Sbjct: 936 PVFENPKQGKLRTKVENGEGTIPVESSDIVPTWDGIRLGERLR-------TMSCSDKILR 988
Query: 535 WIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENIISNRGSYYDPVKF 714
W LG+QGALL+H + PVYL S+ G + H++RA+ CRV + G Y P
Sbjct: 989 WNVLGLQGALLTHFLQPVYLKSVTLGYLFSQGHLTRAICCRVTRDGNAFEDGLRY-PFIV 1047
Query: 715 FDPYIERITDVIGDEYQSDSHENSKVCCNWYL 810
P + R++ V + QS + + V NW L
Sbjct: 1048 NHPKVGRVS-VYDSKRQSGKTKETSV--NWCL 1076
>sp|Q99MU3|DSRAD_MOUSE Double-stranded RNA-specific adenosine deaminase (DRADA) (RNA
adenosine deaminase 1)
Length = 1178
Score = 73.2 bits (178), Expect = 8e-13
Identities = 75/274 (27%), Positives = 120/274 (43%), Gaps = 6/274 (2%)
Frame = +1
Query: 1 GTVVAFGAGKGVNTKIDNTSNQPGYHLRNFDSLVLAKRSLQCFFYNQILLLLDKKRLHCK 180
G VV+ G G K D+ S + G + + + ++++R F Y++++ K H
Sbjct: 831 GVVVSLGTGNRC-VKGDSLSLK-GETVNDCHAEIISRRGFIRFLYSELM-----KYNHHT 883
Query: 181 GEKIYFEIGKNGY-VTLKYGCRLHLYMSHAPKGDCV----ESIPRGWEEPAKLPAREVER 345
+ FE+ + G + +K HLY+S AP GD R E E
Sbjct: 884 AKNSIFELARGGEKLQIKKTVSFHLYISTAPCGDGALFDKSCSDRAVESTESRHYPVFEN 943
Query: 346 DRCGNMDPIMYMSYSNTALLKDPGHIRVLRNETDDEWISL-VSYRLRNKYNRDITMSPTD 522
+ G + T + G I V ++ W + + RLR TMS +D
Sbjct: 944 PKQGKL---------RTKVENGEGTIPVESSDIVPTWDGIRLGERLR-------TMSCSD 987
Query: 523 KLMAWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENIISNRGSYYD 702
K++ W LG+QGALL+H + PVYL S+ G + H++RA+ CRV + G Y
Sbjct: 988 KILRWNVLGLQGALLTHFLQPVYLKSVTLGYLFSQGHLTRAICCRVTRDGKAFEDGLRY- 1046
Query: 703 PVKFFDPYIERITDVIGDEYQSDSHENSKVCCNW 804
P P + R++ V + QS + + V NW
Sbjct: 1047 PFIVNHPKVGRVS-VYDSKRQSGKTKETSV--NW 1077
>sp|P51400|RED1_RAT Double-stranded RNA-specific editase 1 (dsRNA adenosine deaminase)
(RNA editing deaminase 1) (RNA editing enzyme 1)
Length = 711
Score = 70.9 bits (172), Expect = 4e-12
Identities = 57/197 (28%), Positives = 87/197 (44%)
Frame = +1
Query: 70 GYHLRNFDSLVLAKRSLQCFFYNQILLLLDKKRLHCKGEKIYFEIGKNGYVTLKYGCRLH 249
G L + + ++++RSL F Y Q+ L L+ K +K F+ + G LK + H
Sbjct: 387 GLALNDCHAEIISRRSLLRFLYAQLELYLNNKE---DQKKSIFQKSERGGFRLKDTVQFH 443
Query: 250 LYMSHAPKGDCVESIPRGWEEPAKLPAREVERDRCGNMDPIMYMSYSNTALLKDPGHIRV 429
LY+S +P GD P P + T + G I V
Sbjct: 444 LYISTSPCGDARIFSPHEPVLEGMAPDSHQLTEPADRHPNRKARGQLRTKIESGEGTIPV 503
Query: 430 LRNETDDEWISLVSYRLRNKYNRDITMSPTDKLMAWIHLGIQGALLSHLMNPVYLYSIQF 609
N + W ++ + R +TMS +DK+ W +GIQGALLS + P+Y SI
Sbjct: 504 RSNASIQTWDGVL------QGERLLTMSCSDKIARWNVVGIQGALLSIFVEPIYFSSIIL 557
Query: 610 GKDYMHEHISRALLCRV 660
G Y +H+SRA+ R+
Sbjct: 558 GSLYHGDHLSRAMYQRI 574
>sp|Q91ZS8|RED1_MOUSE Double-stranded RNA-specific editase 1 (dsRNA adenosine deaminase)
(RNA editing deaminase 1) (RNA editing enzyme 1)
Length = 711
Score = 69.7 bits (169), Expect = 9e-12
Identities = 56/197 (28%), Positives = 87/197 (44%)
Frame = +1
Query: 70 GYHLRNFDSLVLAKRSLQCFFYNQILLLLDKKRLHCKGEKIYFEIGKNGYVTLKYGCRLH 249
G L + + ++++RSL F Y Q+ L L+ K +K F+ + G LK + H
Sbjct: 387 GLALNDCHAEIISRRSLLRFLYAQLELYLNNKE---DQKKSIFQKSERGGFRLKDTVQFH 443
Query: 250 LYMSHAPKGDCVESIPRGWEEPAKLPAREVERDRCGNMDPIMYMSYSNTALLKDPGHIRV 429
LY+S +P GD P P + T + G I V
Sbjct: 444 LYISTSPCGDARIFSPHEPVLEGMTPDSHQLTEPADRHPNRKARGQLRTKIESGEGTIPV 503
Query: 430 LRNETDDEWISLVSYRLRNKYNRDITMSPTDKLMAWIHLGIQGALLSHLMNPVYLYSIQF 609
N + W ++ + R +TMS +DK+ W +GIQG+LLS + P+Y SI
Sbjct: 504 RSNASIQTWDGVL------QGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIIL 557
Query: 610 GKDYMHEHISRALLCRV 660
G Y +H+SRA+ R+
Sbjct: 558 GSLYHGDHLSRAMYQRI 574
>sp|P55265|DSRAD_HUMAN Double-stranded RNA-specific adenosine deaminase (DRADA) (136 kDa
double-stranded RNA binding protein) (P136) (K88DSRBP)
(Interferon-inducible protein 4) (IFI-4 protein)
Length = 1226
Score = 67.8 bits (164), Expect = 3e-11
Identities = 73/276 (26%), Positives = 119/276 (43%), Gaps = 6/276 (2%)
Frame = +1
Query: 1 GTVVAFGAGKGVNTKIDNTSNQPGYHLRNFDSLVLAKRSLQCFFYNQILLLLDKKRLHCK 180
G VV+ G G K D+ S + G + + + ++++R F Y++++ K
Sbjct: 882 GVVVSLGTGNRC-VKGDSLSLK-GETVNDCHAEIISRRGFIRFLYSELM-----KYNSQT 934
Query: 181 GEKIYFEIGKNGY-VTLKYGCRLHLYMSHAPKGDCV----ESIPRGWEEPAKLPAREVER 345
+ FE K G + +K HLY+S AP GD R E E
Sbjct: 935 AKDSIFEPAKGGEKLQIKKTVSFHLYISTAPCGDGALFDKSCSDRAMESTESRHYPVFEN 994
Query: 346 DRCGNMDPIMYMSYSNTALLKDPGHIRVLRNETDDEWISL-VSYRLRNKYNRDITMSPTD 522
+ G + T + G I V ++ W + + RLR TMS +D
Sbjct: 995 PKQGKL---------RTKVENGEGTIPVESSDIVPTWDGIRLGERLR-------TMSCSD 1038
Query: 523 KLMAWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRVPLENIISNRGSYYD 702
K++ W LG+QGALL+H + P+YL S+ G + H++RA+ CRV + G +
Sbjct: 1039 KILRWNVLGLQGALLTHFLQPIYLKSVTLGYLFSQGHLTRAICCRVTRDGSAFEDGLRH- 1097
Query: 703 PVKFFDPYIERITDVIGDEYQSDSHENSKVCCNWYL 810
P P + R++ + + QS + + V NW L
Sbjct: 1098 PFIVNHPKVGRVS-IYDSKRQSGKTKETSV--NWCL 1130
>sp|Q9NS39|RED2_HUMAN Double-stranded RNA-specific editase B2 (dsRNA adenosine deaminase
B2) (RNA dependent adenosine deaminase 3) (RNA editing
deaminase 2) (RNA editing enzyme 2)
Length = 739
Score = 65.9 bits (159), Expect = 1e-10
Identities = 57/189 (30%), Positives = 86/189 (45%), Gaps = 2/189 (1%)
Frame = +1
Query: 100 VLAKRSLQCFFYNQILLLLDKKRLHCKGEKIYFEIGKNGYVTLKYGCRLHLYMSHAPKGD 279
V+A+R+ F Y Q+ L L K+R + I+ + + GY L+ HLY+S +P GD
Sbjct: 435 VVARRAFLHFLYTQLELHLSKRREDSE-RSIFVRLKEGGY-RLRENILFHLYVSTSPCGD 492
Query: 280 CVESIPRGWEEPAKLPAREVERDRCGNMDPIM-YMSYSNTALLKDPGHIRVLRNETDDEW 456
P E+ D + + + + T + G + V W
Sbjct: 493 ARLHSPY-----------EITTDLHSSKHLVRKFRGHLRTKIESGEGTVPVRGPSAVQTW 541
Query: 457 IS-LVSYRLRNKYNRDITMSPTDKLMAWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEH 633
L+ +L ITMS TDK+ W LG+QGALLSH + PVYL SI G + H
Sbjct: 542 DGVLLGEQL-------ITMSCTDKIARWNVLGLQGALLSHFVEPVYLQSIVVGSLHHTGH 594
Query: 634 ISRALLCRV 660
++R + R+
Sbjct: 595 LARVMSHRM 603
>sp|Q9JI20|RED2_MOUSE Double-stranded RNA-specific editase B2 (dsRNA adenosine deaminase
B2) (RNA dependent adenosine deaminase 3) (RNA editing
deaminase 2) (RNA editing enzyme 2)
Length = 745
Score = 63.5 bits (153), Expect = 6e-10
Identities = 52/188 (27%), Positives = 87/188 (46%), Gaps = 1/188 (0%)
Frame = +1
Query: 100 VLAKRSLQCFFYNQILLLLDKKRLHCKGEKIYFEIGKNGYVTLKYGCRLHLYMSHAPKGD 279
++A+R+ F Y+Q+ L L K + + I+ + + GY L+ HLY+S +P GD
Sbjct: 441 IVARRAFLHFLYSQLELHLSKHQEDPE-RSIFIRLKEGGY-RLRENILFHLYVSTSPCGD 498
Query: 280 CVESIPRGWEEPAKLPAREVERDRCGNMDPIM-YMSYSNTALLKDPGHIRVLRNETDDEW 456
+ P E+ D + + + + T + G + V W
Sbjct: 499 ARVNSPY-----------EITTDLNSSKHIVRKFRGHLRTKIESGEGTVPVRGPSAVQTW 547
Query: 457 ISLVSYRLRNKYNRDITMSPTDKLMAWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHI 636
++ + ITMS TDK+ +W LG+QGALL H + PVYL+SI G + H+
Sbjct: 548 DGILLGE------QLITMSCTDKIASWNVLGLQGALLCHFIEPVYLHSIIVGSLHHTGHL 601
Query: 637 SRALLCRV 660
+R + R+
Sbjct: 602 ARVMSHRM 609
>sp|P97616|RED2_RAT Double-stranded RNA-specific editase B2 (dsRNA adenosine deaminase
B2) (RNA dependent adenosine deaminase 3) (RNA editing
deaminase 2) (RNA editing enzyme 2)
Length = 746
Score = 62.4 bits (150), Expect = 1e-09
Identities = 53/188 (28%), Positives = 89/188 (47%), Gaps = 1/188 (0%)
Frame = +1
Query: 100 VLAKRSLQCFFYNQILLLLDKKRLHCKGEKIYFEIGKNGYVTLKYGCRLHLYMSHAPKGD 279
++A+R+ F Y Q+ L L K + + I+ + + GY L+ HLY+S +P GD
Sbjct: 442 IVARRAFLHFLYTQLELHLSKHQEDPE-RSIFIRVKEGGY-RLRENILFHLYVSTSPCGD 499
Query: 280 CVESIPRGWEEPAKL-PAREVERDRCGNMDPIMYMSYSNTALLKDPGHIRVLRNETDDEW 456
+ P +E L ++ + R G++ T + G + V W
Sbjct: 500 ARLNSP--YEITIDLNSSKHIVRKFRGHL---------RTKIESGEGTVPVRGPSAVQTW 548
Query: 457 ISLVSYRLRNKYNRDITMSPTDKLMAWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHI 636
++ + +TMS TDK+ +W LG+QGALL H + PVYL+SI G + H+
Sbjct: 549 DGILLGE------QLVTMSCTDKIASWNVLGLQGALLCHFIEPVYLHSIIVGSLHHTGHL 602
Query: 637 SRALLCRV 660
+R + R+
Sbjct: 603 ARVMSHRM 610
>sp|P78563|RED1_HUMAN Double-stranded RNA-specific editase 1 (dsRNA adenosine deaminase)
(RNA editing deaminase 1) (RNA editing enzyme 1)
Length = 741
Score = 61.6 bits (148), Expect = 2e-09
Identities = 63/236 (26%), Positives = 97/236 (41%), Gaps = 39/236 (16%)
Frame = +1
Query: 70 GYHLRNFDSLVLAKRSLQCFFYNQILLLLDKKRLHCKGEKIYFEIGKNGYVTLKYGCRLH 249
G L + + ++++RSL F Y Q+ L L+ K ++ F+ + G LK + H
Sbjct: 387 GLALNDCHAEIISRRSLLRFLYTQLELYLNNKD---DQKRSIFQKSERGGFRLKENVQFH 443
Query: 250 LYMSHAPKGDCVESIPRGWEEPAKLPARE-----VERDRCGNMDPIMYMSYSNTALLKDP 414
LY+S +P GD P EP +R V+ G++ P LL DP
Sbjct: 444 LYISTSPCGDARIFSPH---EPILEGSRSYTQAGVQWCNHGSLQP------RPPGLLSDP 494
Query: 415 ----------------------------------GHIRVLRNETDDEWISLVSYRLRNKY 492
G I V N + W ++ +
Sbjct: 495 STSTFQGAGTTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVL------QG 548
Query: 493 NRDITMSPTDKLMAWIHLGIQGALLSHLMNPVYLYSIQFGKDYMHEHISRALLCRV 660
R +TMS +DK+ W +GIQG+LLS + P+Y SI G Y +H+SRA+ R+
Sbjct: 549 ERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRI 604
>sp|Q9NII1|ADAR_DROME Double-stranded RNA-specific editase Adar (Adenosine deaminases
that act on RNA) (dsRNA adenosine deaminase) (RNA
editing deaminase 1) (RNA editing enzyme 1) (Pre-mRNA
adenosine deaminase) (dADAR)
Length = 676
Score = 56.6 bits (135), Expect = 8e-08
Identities = 54/199 (27%), Positives = 88/199 (44%), Gaps = 2/199 (1%)
Frame = +1
Query: 70 GYHLRNFDSLVLAKRSLQCFFYNQILLLLDKKRLHCKGEKIYFEIGKNGY-VTLKYGCRL 246
G L + + ++++R L + Y Q+ L ++ + + I+ Y LK G
Sbjct: 365 GAVLNDSHAEIVSRRCLLKYLYAQLDLQCNQATAY---QSIFVRNTDGQYPYKLKSGVHF 421
Query: 247 HLYMSHAPKGDCVESIPRGWEEPA-KLPAREVERDRCGNMDPIMYMSYSNTALLKDPGHI 423
HLY++ AP GD P + K P R+ T + G I
Sbjct: 422 HLYINTAPCGDARIFSPHENDTGVDKHPNRKAR-------------GQLRTKIESGEGTI 468
Query: 424 RVLRNETDDEWISLVSYRLRNKYNRDITMSPTDKLMAWIHLGIQGALLSHLMNPVYLYSI 603
V ++ W ++ + R +TMS +DK+ W +GIQG+LLS ++ PVYL+SI
Sbjct: 469 PVKSSDGIQTWDGVLQGQ------RLLTMSCSDKIARWNIVGIQGSLLSSIIEPVYLHSI 522
Query: 604 QFGKDYMHEHISRALLCRV 660
G EH+ RA+ R+
Sbjct: 523 VLGSLLHPEHMYRAVCGRI 541
Database: Non-redundant SwissProt sequences
Posted date: Dec 6, 2005 7:40 AM
Number of letters in database: 68,354,980
Number of sequences in database: 184,735
Database: swissprot.01
Posted date: Dec 6, 2005 8:18 AM
Number of letters in database: 66,202,850
Number of sequences in database: 184,431
Lambda K H
0.318 0.134 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 91,736,657
Number of Sequences: 369166
Number of extensions: 1893160
Number of successful extensions: 4702
Number of sequences better than 10.0: 10
Number of HSP's better than 10.0 without gapping: 4501
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 4695
length of database: 68,354,980
effective HSP length: 109
effective length of database: 48,218,865
effective search space used: 7763237265
frameshift window, decay const: 40, 0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)